• Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. (wikipedia.org)
  • rRNA is the physical and mechanical factor of the ribosome that forces transfer RNA (tRNA) and messenger RNA (mRNA) to process and translate the latter into proteins. (wikipedia.org)
  • Ribosomes are composed of approximately 60% rRNA and 40% ribosomal proteins by mass. (wikipedia.org)
  • Because of these configurations, rRNA can form tight and specific interactions with ribosomal proteins to form ribosomal subunits. (wikipedia.org)
  • Ribosomal proteins can also cross-link to the sugar-phosphate backbone of rRNA with binding sites that consist of basic residues (i.e. lysine and arginine). (wikipedia.org)
  • All ribosomal proteins (including the specific sequences that bind to rRNA) have been identified. (wikipedia.org)
  • Eukaryotic rRNA has over 70 ribosomal proteins which interact to form larger and more polymorphic ribosomal units in comparison to prokaryotes. (wikipedia.org)
  • LSU rRNA subtypes have been called ribozymes because ribosomal proteins cannot bind to the catalytic site of the ribosome in this area (specifically the peptidyl transferase center, or PTC). (wikipedia.org)
  • In this video, we will learn how to describe the components that make up RNA molecules and differentiate between tRNA, mRNA, and rRNA. (nagwa.com)
  • On the other hand, nostic method by the polymerase chain reaction (PCR) tar- simian malaria species that display structural similarity to geting the small subunit ribosomal RNA (SSU rRNA) those species commonly found in humans may be unno- genes of all four species of human malaria as reported (8). (cdc.gov)
  • Specifically, the role of the L11 region, comprising ribosomal protein L11 and its associated ribosomal RNA (rRNA) helices, was investigated. (columbia.edu)
  • Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. (colorado.edu)
  • Distel, D. L., DeLong, E. F., and Waterbury, J. Epub … Bacterial Identification by 16S rRNA Gene Sequence Analysis Background All bacteria contain 16S ribosomal RNA (rRNA) genes of approximately 1500 base pairs (bp) in length. (printerresource.com)
  • The most widely understood role of RNA is in protein synthesis, which includes messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA) (see Chapter 2). (printerresource.com)
  • To such effect, I want to perform an RNA-Seq experiment in order to analyze potential rRNA transcripts isoforms and processing sites. (printerresource.com)
  • rRNA genes contain regions of variable DNA sequence that are unique to the species carrying the … Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. (printerresource.com)
  • Base modifications occur primarily in tRNA and ribosomal RNA (rRNA), and occur after the RNA is transcribed. (printerresource.com)
  • 2) The ribosomal RNA (rRNA), which makes up the largest part (about 90%) of the cellular RNA, is part of the ribosomes. (biotionary.com)
  • The subunits of the ribosomes contain four different types of RNA as structural components, which differ in size and were originally divided according to their sedimentation behavior (their sinking speed in the ultracentrifuge): In eukaryotes these are 28 S, 18 S, 5.8 S and 5 S rRNA (S = Svedberg unit of sedimentation). (biotionary.com)
  • The site-specific cleavage of double-stranded (ds) RNA is a conserved early step in bacterial ribosomal RNA (rRNA) maturation that is carried out by ribonuclease III. (temple.edu)
  • The T. maritima genome encodes a ~5,000 nucleotide (nt) transcript, expressed from the single ribosomal RNA (rRNA) operon. (temple.edu)
  • This supports previous findings which indicated that position 2661 is part of a region of 23S rRNA that forms a recognition site for binding of the ternary complex in the ribosomal A site. (nebraska.edu)
  • The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. (icr.ac.uk)
  • The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). (icr.ac.uk)
  • Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. (wikipedia.org)
  • it makes up about 80% of cellular RNA despite never being translated into proteins itself. (wikipedia.org)
  • These ribosomal proteins contain basic residues (as opposed to acidic residues) and aromatic residues (i.e. phenylalanine, tyrosine and tryptophan) allowing them to form chemical interactions with their associated RNA regions, such as stacking interactions. (wikipedia.org)
  • These interactions along with the association of the small and large ribosomal subunits result in a functioning ribosome capable of synthesizing proteins. (wikipedia.org)
  • These are combined with ~50 ribosomal proteins to form ribosomal subunits. (wikipedia.org)
  • Ribosomes are nano-machines that translate information coded in a messenger RNA into proteins in all living organisms. (biorxiv.org)
  • Proteins provide the crucial structural elements of all cells and mediate the executive functions required for cell survival. (uni-muenchen.de)
  • Eukaryotic (i.e. nucleated) cells can produce ribosomes in enormous numbers, although each consists of about 80 proteins and 4 ribosomal RNAs (rRNAs). (uni-muenchen.de)
  • Their data reveals in detail how the ribosomal RNAs are progressively folded to provide the necessary binding sites for the cognate ribosomal proteins. (uni-muenchen.de)
  • Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin. (elifesciences.org)
  • This type of RNA is called a messenger RNA ( mRNA ), as it serves as a messenger between DNA and the ribosomes, molecular machines that read mRNA sequences and use them to build proteins. (khanacademy.org)
  • The eukaryotic ribosome consists of 4 ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs). (au.dk)
  • Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. (jefferson.edu)
  • SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
  • RNA-binding proteins (RBPs) exert a broad range of biological functions. (nature.com)
  • Only 60% of yeast and 73% of the human RBPs have functions assigned to RNA biology or structural motifs known to convey RNA binding, and many intensively studied proteins surprisingly emerge as RBPs (termed 'enigmRBPs'), including almost all glycolytic enzymes, pointing to emerging connections between gene regulation and metabolism. (nature.com)
  • RNA-binding proteins (RBPs) mediate pivotal cellular functions such as RNA transport, degradation or translation and represent key effectors of post-transcriptional gene regulation. (nature.com)
  • We show that this conserved RNA interactome harbours many proteins without previously assigned roles in RNA biology (enigmRBPs), including surprisingly many metabolic enzymes. (nature.com)
  • After cell lysis, polyadenylated RNAs were captured on oligo d(T) beads followed by stringent washes to remove non-crosslinked proteins. (nature.com)
  • With the help of special RNA (small nuclear RNA or snRNA) proteins catalyze the individual conversion steps. (biotionary.com)
  • Therefore, structural and biochemical studies of proteins from hyperthermophilic bacteria are providing essential insight on the sources of biomolecular thermostability, and how enzymes function at high temperatures. (temple.edu)
  • This is done by a complex of proteins and RNAs called spliceosome. (stemcelldaily.com)
  • Each RNA polymerase requires the assistance of several other proteins or protein complexes, called general (or basal) transcription factors, which must assemble into a complex on the promoter in order for RNA polymerase to bind and start transcription. (stemcelldaily.com)
  • The achievement, reported in Cell , reveals in unprecedented detail how strands of ribonucleic acid (RNA), cellular molecules that are inherently sticky and prone to misfold, are "chaperoned" by ribosomal proteins into folding properly and forming one of the main components of ribosomes. (scripps.edu)
  • This shows that we now can examine in detail how RNAs fold while they are being synthesized and proteins are assembling on them," says first author Olivier Duss, PhD, a postdoctoral research fellow in the Department of Integrative Structural & Computational Biology at Scripps Research. (scripps.edu)
  • The team used an advanced imaging technology called "zero-mode waveguide single-molecule fluorescence microscopy," which they have adapted in recent years for real-time tracking of RNAs and proteins. (scripps.edu)
  • Ribosomes are made of both RNA and proteins, reflecting a molecular partnership that is widely believed to go back nearly to the dawn of life on Earth. (scripps.edu)
  • The findings, according to the researchers, also hint at the existence of unknown RNA assembly factors, most likely proteins, that were not present in their lab-dish-type imaging experiments but are present in cells and boost the efficiency of RNA folding. (scripps.edu)
  • Our study indicates that in ribosomal RNA-folding, and perhaps more generally in RNA-folding in cells, many proteins help fold RNA though weak, transient and semi-specific interactions with it," Duss says. (scripps.edu)
  • The team will now be able to extend this research further to study not only the rest of ribosome assembly, which involves multiple RNA strands and dozens of proteins, but also the many other types of RNA-folding and RNA-protein interaction in cells. (scripps.edu)
  • Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance. (gzsys.org.cn)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
  • More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
  • A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
  • Prior to each round of protein synthesis in the cell, a functional ribosomal complex is assembled from its component parts at the start site of a messenger RNA (mRNA) template during the process of translation initiation. (columbia.edu)
  • 1) The messenger RNA (mRNA, messenger RNA) reaches the ribosomes after its synthesis and serves there as a template for protein biosynthesis. (biotionary.com)
  • Transcription is the process of copying genetic information from DNA into RNA, especially mRNA, by the enzyme RNA polymerase. (stemcelldaily.com)
  • It is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase. (stemcelldaily.com)
  • This releases the upstream portion of the transcript, which will serve as the initial RNA prior to further processing (the pre-mRNA in the case of protein-encoding genes). (stemcelldaily.com)
  • During translation, mRNA molecules are incidentally damaged, leaving the ribosome unable to reach or recognize the stop codon and thus stalled with mRNA and a potentially harmful polypeptide product attached to tRNA in the ribosomal P-site. (lu.se)
  • The 50S subunit joining reaction is catalyzed by GTP-bound IF2 and results in formation of a 70S initiation complex (70S IC) that contains an initiator transfer RNA (tRNA) and is primed for formation of the first peptide bond. (columbia.edu)
  • 3) Transfer RNA (tRNA) consists of relatively small molecules with molecular weights between 23,000 and 30,000, which corresponds to about 80 nucleotides. (biotionary.com)
  • In bacteria, a process called trans-translation has evolved, where a protein-RNA complex (smpB-tmRNA) mimicks the role of aminoacyl charged tRNA in the ribosomal A-site. (lu.se)
  • deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ). (khanacademy.org)
  • and assignment of the genera Cardiobacterium, Dichelobacter, and Suttonella to Cardio-bacteriaceae fam nov in the gamma division of Proteobacteria based on 16S ribosomal ribonucleic acid sequence comparisons. (microbiologyresearch.org)
  • Ribonucleic acid, abbreviated as RNA by abbreviationfinder.org , polynucleotide whose monomer units consist of a pentose (ribose), a purine (adenine, guanine) or pyrimidine base (cytosine, uracil) and a phosphoric acid residue in a ratio of 1: 1: 1 exists. (biotionary.com)
  • For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
  • For the third funding period, particular emphasis is laid on understanding molecular mechanisms of assembly events of both maturating ribosomes and non-ribosomal RNPs and control of their function. (uni-regensburg.de)
  • The mutant plasmid was transformed into E. coli to determine the effect of the mutation on cell growth as well as the structural and functional properties of the mutant ribosomes in vivo and in vitro. (nebraska.edu)
  • Lindahl, M 2010, ' tmRNA to the rescue Structural motives for the salvage of stalled ribosomes ', RNA Biology , vol. 7, nr. 5, s. 577-581. (lu.se)
  • The mature small subunit can then bind to the large subunit, in association with a messenger RNA that provides the blueprint for protein synthesis. (uni-muenchen.de)
  • Before this information can be used for protein synthesis, however, an RNA copy (transcript) of the gene must first be made. (khanacademy.org)
  • Finding a similar 90° kink in a region of ribosomal RNA that binds factors necessary for the initiation of protein synthesis, the researchers speculate that the SARS virus may use the s2m element to hijack its host cell's protein synthesis machinery. (sciencedaily.com)
  • Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. (nature.com)
  • The involvement of RNA in such fundamental processes as protein synthesis and RNA processing has led to the idea that ribozymes were more common in early life. (printerresource.com)
  • Tetracyclines inhibit protein synthesis and, therefore, bacterial growth by binding with 30S and possibly 50S ribosomal subunits of susceptible bacteria. (medscape.com)
  • RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
  • Still other RNA molecules, such as tiny microRNAs ( miRNAs ), act as regulators of other genes, and new types of non-protein-coding RNAs are being discovered all the time. (khanacademy.org)
  • The targeted conversion of the sequence of RNA molecules (RNA editing), e.g. (biotionary.com)
  • The imaging feat clarifies how RNA molecules fold-and might one day translate into better medicines for a host of diseases. (scripps.edu)
  • More generally, the research offers biologists a powerful new approach to the study of RNA molecules, hundreds of thousands of which are active at any given time in a typical cell. (scripps.edu)
  • Transcription in eukaryotes is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. (stemcelldaily.com)
  • Eukaryotic RNA polymerases do not terminate transcription at a specific site but rather transcription can stop at varying distances downstream of the gene. (stemcelldaily.com)
  • Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
  • All 13 protein-coding genes use ATN or TTG as start codon, and end with TAA/G or incomplete stop codons (single T-). Twenty-one transfer RNA genes have the typical clover-leaf structures, while the dihydrouridine (DHU) arm of trnS1 is missing. (researchsquare.com)
  • A phylogenetic analysis of 19 sibling taxa in the Vertigo gouldii group was conducted on 73 individuals sampled across North America using DNA sequence data of the mitochondrial genes cytochrome oxidase subunit 1 (CO1) and 16S ribosomal RNA (16S), and the internal transcribed spacer-2 of the nuclear ribosomal RNA (ITS-2) gene. (researchgate.net)
  • Baylis H.A. , Bibb M.J. Organization of the ribosomal RNA genes in Streptomjces coelicolor A3(2). (microbiologyresearch.org)
  • We report the crystal structure of a 58 nucleotide fragment of 23S ribosomal RNA bound to ribosomal protein L11. (proteopedia.org)
  • Zavialov, A. V., Buckingham, R. H. & Ehrenberg, M. A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3. (nature.com)
  • Although BUM-HMM generates statistically sound estimates of nucleotide accessibility at the nucleotide level, its probabilistic output does not represent an absolute value that quantifies the degree of accessibility of RNA at a particular nucleotide. (biomedcentral.com)
  • The ability to accurately detect nucleotide regions that differentially react with RNA structure probing reagents under diverse conditions, or due to the effect of mutations, is of great importance to researchers. (biomedcentral.com)
  • However, the ability of RNA to form complementary base pairs with DNA is incredibly important, during the formation of any type of RNA during transcription. (nagwa.com)
  • Third, the interplay of different RNPs is essential for RNP activity, as exemplified by the regulation of ribosome activity, by microRNA-containing protein complexes (miRNPs), or regulation of transcription by long non-coding RNA (lncRNA) containing complexes. (uni-regensburg.de)
  • The RNA is synthesized as a copy of a DNA segment with the help of special enzymes, the RNA polymerases (transcription). (biotionary.com)
  • Transcription is the process by which the information in a strand of DNA is copied into a new molecule of RNA. (stemcelldaily.com)
  • This involved the transcription, or copying out from its corresponding gene, of a ribosomal RNA, and initial interactions of this RNA strand with a ribosomal protein. (scripps.edu)
  • In the new study, the team extended this approach by tracking not only the transcription of a ribosomal RNA but also its real-time folding. (scripps.edu)
  • Sequencing and further analysis of the HDP2 DNA fragments of 19 Asiatic isolates of T. saginata and T. asiatica indicated that the HDP2 sequences of both species exhibited clear genomic variability, due to polymorphic variable fragments, that could correspond to the non-transcribed region of ribosomal DNA. (biomedcentral.com)
  • Diagnosis was con- a cottage and slept inside a mosquito net, he remembered firmed by the small subunit ribosomal RNA and the mito- being bitten frequently by mosquitoes, especially at dusk chondrial cytochrome b sequences. (cdc.gov)
  • LMU researchers have now structurally characterized late stages in the assembly of the human small ribosomal subunit, yielding detailed insights into their maturation principles. (uni-muenchen.de)
  • We have used cryo-electron microscopy to determine the structures of intermediate forms of the small ribosomal subunit isolated from human cells. (uni-muenchen.de)
  • The succession of precursors reveals that maturation of the small ribosomal subunit proceeds in several defined steps. (uni-muenchen.de)
  • So here, we have a molecule of RNA on the left and a molecule of DNA on the right. (nagwa.com)
  • Although the nitrogenous bases of RNA can base pair just like DNA, RNA generally doesn't form a double-stranded molecule like DNA. (nagwa.com)
  • A key finding was that the ribosomal protein partners guide the folding of the RNA strand through multiple temporary interactions with the strand, well before they nestle into their final places in the folded RNA-protein molecule. (scripps.edu)
  • This progression from DNA to RNA to protein is called the " central dogma " of molecular biology. (khanacademy.org)
  • The option to determine high-resolution structures of RNPs on-site and to synergistically combine these structural studies with biophysical, biochemical and cell biological approaches constitutes an excellent basis for our research that aims to understand and explore the structure-function relationships as well as mechanisms and dynamics in RNP biology. (uni-regensburg.de)
  • Understanding the structure of RNA is key to unravel its in vivo function, and it is also highly relevant to biomedicine, drug discovery, and synthetic biology [ 1 - 4 ]. (biomedcentral.com)
  • In contrast to what had been the dominant theory in the field, we revealed a far more chaotic process," says James R. Williamson, PhD , a professor in the Department of Integrative Structural & Computational Biology at Scripps Research. (scripps.edu)
  • RNA Biology , 7 (5), 577-581. (lu.se)
  • Section F, Structural biology communications. (lu.se)
  • Development in the area of structural biology methods combined with new computational possibilities has highlighted the importance of combining different methods in order to maximize the output. (lu.se)
  • With the rapid progress and improvements in the fields of macromolecular crystallography, Cryo-EM, small angle scattering, electron diffraction and use of XFELs, the new LINXS theme INTEGRATIVE STRUCTURAL BIOLOGY is formed to advance cutting-edge research and to encourage new users to utilize integrative structure biology to address key scientific questions. (lu.se)
  • Both experienced specialists and researchers with more recently established interests in integrative structural biology are expected to greatly benefit from the symposium. (lu.se)
  • Berg K.L. , Squires C. , Squires C.L. Ribosomal RNA operon anti-termination Function of leader and spacer region box B-box A sequences and their conservation in diverse microorganisms. (microbiologyresearch.org)
  • Combinations of the 2661 tion with various mutations in ribosomal protein S12 also demonstrate that elements of both ribosomal subunits work in concert to form this binding site. (nebraska.edu)
  • This is why DNA is preferred by organisms as a support for genetic information, and short-lived RNA is preferred for transient messages in the cell. (nagwa.com)
  • Before we get into this, let's first review how RNA can transmit genetic information contained in DNA to the rest of the cell. (nagwa.com)
  • Some viruses use RNA, not DNA, as their genetic material, but aren't technically considered to be alive (since they cannot reproduce without help from a host). (khanacademy.org)
  • Two other major roles for noncoding RNA are in genome defense and in genetic regulation. (printerresource.com)
  • Using an RNA genome, many viruses are known to encode their genetic information. (printerresource.com)
  • Nucleic acids (DNA & RNA) are the building blocks of genetic material. (bankofbiology.com)
  • RNA is the genetic material in some viruses. (bankofbiology.com)
  • Only in the case of RNA viruses is the RNA (as is usually the case with DNA) the carrier of genetic information. (biotionary.com)
  • During 50S subunit joining, IF2-GTP establishes interactions with RNA and protein components of the 50S subunit's GTPase-associated center (GAC), which play an important role in subunit recruitment as well as the subsequent activation of GTP hydrolysis by IF2. (columbia.edu)
  • Techniques such as selective chemical modification, fluorescence labeling and mutations are cumbersome for the whole ribosome but readily applicable to model RNAs, which are readily crystallized and often give rise to higher resolution crystal structures suitable for detailed analysis of ligand-RNA interactions. (escholarship.org)
  • Structural Insights into ribosome recycling factor interactions with the 70S ribosome. (jefferson.edu)
  • Second, a functional network of many RNA-binding, RNA-modifying and RNA-folding complexes participates to mature emerging RNPs. (uni-regensburg.de)
  • However, in many cases, the RNA needs further processing before it is functional. (printerresource.com)
  • The primary RNA (heterogeneous nuclear RNA or hnRNA) synthesized on the DNA is often subject to various processes of maturation up to the formation of the functional RNA. (biotionary.com)
  • The biochemical behavior of RNase III of the hyperthermophilic bacterium Thermotoga maritima is analyzed using purified recombinant enzyme and the cognate pre-ribosomal RNAs as substrates. (temple.edu)
  • About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. (gzsys.org.cn)
  • Advancing RNA structural probing techniques with next-generation sequencing has generated demands for complementary computational tools to robustly extract RNA structural information amidst sampling noise and variability. (biomedcentral.com)
  • It results in a complementary, antiparallel RNA strand called a primary transcript. (stemcelldaily.com)
  • Here, I present results from different biological projects where SANS has played a crucial role by providing unique restraints for structural refinement and interpretation, complementary to other techniques (NMR, EM, crystallography). (lu.se)
  • First, the regulated synthesis of the RNA component is critical for RNP formation and significantly influences RNA-maturation steps in space and time. (uni-regensburg.de)
  • Eukaryotes have three types of RNA polymerases (I, II and III), each responsible for transcribing different types of RNA. (stemcelldaily.com)
  • RL11_THEMA ] This protein binds directly to 23S ribosomal RNA. (proteopedia.org)
  • While the C-terminal domain of L11 binds RNA tightly, the N-terminal domain makes only limited contacts with RNA and is proposed to function as a switch that reversibly associates with an adjacent region of RNA. (proteopedia.org)
  • Recently developed unbiased high content techniques to identify RBPs in vivo yielded information on differences in cell type-specific expression and/or RNA-binding activity of RBPs in mammalian cells 2 , 3 . (nature.com)
  • RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
  • The genome of the SARS virus is a single strand of RNA that folds into regular repeating patterns to form secondary structures such as helices. (sciencedaily.com)
  • But could the structure of the RNA genome itself also be a target for antiviral drugs? (sciencedaily.com)
  • This and other putative roles need to be tested experimentally, but given that the s2m element is absent in the human genome, its unusual structural features could be an attractive target for the design of antiviral therapeutic agents. (sciencedaily.com)
  • A. Ribosomal RNA analysis StructRNAfinder - predicts and annotates RNA families in transcript or genome sequences. (printerresource.com)
  • In Chapter 1, I provide a structural and biochemical framework for understanding one of the key events of the initiation pathway: docking of the large (50S) ribosomal subunit with the small subunit 30S initiation complex (30S IC). (columbia.edu)
  • In this study we used culture-dependent and RNA-based pyrosequencing to investigate the bacterial community structure of Masa Agria samples produced in the south west of Colombia. (who.int)
  • Analyses of the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP. (nature.com)
  • We also determined the RNA targets of an RNA-binding mitochondrial enzyme and show its specificity in RNA binding. (nature.com)
  • Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). (icr.ac.uk)
  • It has only been within the last decade that technical advances (specifically in the field of Cryo-EM) have allowed for preliminary investigation into ribosomal behavior in other eukaryotes. (wikipedia.org)
  • All three types of RNA are synthesized in eukaryotes in the nucleus and migrate from there into the cytoplasm. (biotionary.com)
  • To address the second, we investigated RNAs bound by the metabolic enzyme hydroxysteroid dehydrogenase 17-β 10 (HSD17B10). (nature.com)
  • The hydroxy group in RNA is what makes this sugar a ribose. (nagwa.com)
  • Image of the components of DNA and RNA, including the sugar (deoxyribose or ribose), phosphate group, and nitrogenous base. (khanacademy.org)
  • Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. (gzsys.org.cn)
  • We'll start with the pentose sugar that's in RNA. (nagwa.com)
  • The nascent chain (NC), emerges into the cellular milieu via the ribosomal exit tunnel, which is an active component that regulates the NC passage. (biorxiv.org)
  • Ribosomal RNA organizes into two types of major ribosomal subunit: the large subunit (LSU) and the small subunit (SSU). (wikipedia.org)
  • Nascent chains (NC) can begin to acquire secondary structural elements in a co-translational manner during emergence via the ribosome exit tunnel within the large subunit of the ribosome 7, 8. (biorxiv.org)
  • Valenzuela A, Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. (springer.com)
  • Recent biochemical and structural studies revealed La-related protein 1 (LARP1) as a key new player in RP production. (au.dk)
  • Crystal structure of minihelix with 3' puromycin bound to a-site of the 50s ribosomal subunit. (edu.pl)
  • A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit. (colorado.edu)
  • Anderson B.J. , Bills M.M. , Egerton J.R. , Mattick J.S. Cloning and expression in E coli of the gene encoding the structural subunit of Bacteroides nodosus fimbriae. (microbiologyresearch.org)
  • Tapprich, WE & Dahlberg, AE 1990, ' A single base mutation at position 2661 in E. coli 23S ribosomal RNA affects the binding of ternary complex to the ribosome ', EMBO Journal , vol. 9, no. 8, pp. 2649-2655. (nebraska.edu)
  • RNA is normally single-stranded, while DNA is double-stranded. (nagwa.com)
  • Notice that RNA has one sugar phosphate backbone because it's single-stranded, while DNA has two because it's double-stranded. (nagwa.com)
  • The difference to DNA is that the RNA is usually not in a double-stranded structure. (biotionary.com)
  • RESULTS: We surveyed 106 axenic cultures of L. pyrrhocoris and found that 64 (60%) of these displayed 2-12 double-stranded RNA fragments. (bvsalud.org)
  • Arkov, A. L. & Murgola, E. J. Ribosomal RNAs in translation termination: facts and hypothesis. (nature.com)
  • Seit-Nebi, A., Frolova, L., Justesen, J. & Kisselev, L. Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosomal binding but not for stop codon recognition. (nature.com)
  • Structural insights into initial and intermediate steps of the ribosome-recycling process. (jefferson.edu)
  • In principle, this research will yield insights into how RNAs misfold and how such events could be corrected. (scripps.edu)
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
  • In the next step, the non-coding sequences (introns) are cut out with the help of enzymes and the coding sequences (exons) are linked to form the mature RNA. (biotionary.com)