- Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmonary ionocytes exist throughout the cartilaginous airways of humans1,2, but limited presence and divergent biology in the proximal trachea of mice has prevented the use of traditional transgenic models to elucidate ionocyte functions in the airway. (bvsalud.org)
- Thus, rare pulmonary ionocytes perform critical CFTR-dependent functions in the proximal airway that are hallmark features of cystic fibrosis airway disease. (bvsalud.org)
- It was concluded that both proximal and distal airways were involved in asthma and that distal airways were the major determinant of airflow obstruction. (ersjournals.com)
- Both proximal and distal airways might be targeted either by delivering medications systemically or by aerosol of extra-fine particles. (ersjournals.com)
- Single-cell transcriptomics and in vivo lineage tracing revealed three subtypes of pulmonary ionocytes and a FOXI1-lineage common rare cell progenitor for ionocytes, tuft cells and neuroendocrine cells during airway development. (bvsalud.org)
- The usefulness and limitations of various techniques used for assessing distal airways were also evaluated, including pulmonary function tests and imaging. (ersjournals.com)
- Dedicated muscle tissue in multicellular organisms tends to exhibit a comforting structural homology, to effect that one could recognise striated muscle in a jellyfish and feel a warm kind of brotherly Verbundenheit, but it evolved probably at least four separate times in separate clades rather than arising from some early eumetazoan ancestor. (derangedphysiology.com)
- Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis. (biomedfrontiers.org)
- Our data uncover novel details about the differential contribution of B2 vs four integrins within the composite phenotype of chronic asthma development and contribute towards the understanding of mechanisms by which different cell subsets and molecular pathways participate in the pathophysiology and histopathology of chronic asthma. (sodiumchannel-signal.com)
- The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. (ersjournals.com)
- Musculoskeletal development - contributes the mechanical elements of ribs, intercostals and diaphragm required for breathing. (edu.au)
- Generic medicines manufacturers contribute between 7-17% of their total business in research and development. (yawatax.com)
- The present review is the summary of an expert workshop that took place in Vence (France) in 2007 on the role of distal airways in asthma. (ersjournals.com)
- Finally, the available data studying the benefit of treatment better targeting distal airways in asthma was examined. (ersjournals.com)
- Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. (ersjournals.com)
- Distal airways were poorly attained by conventional aerosol of asthma medications owing to their granulometry, being composed of 3-5 μm particles. (ersjournals.com)
- Thus, it is not surprising that the roles of distal airways in the natural history of asthma have long been neglected. (ersjournals.com)
- Our recent studies with conditionally ablated four knockout mice tested in parallel with B2 mice showed that, even though B2 integrins handle inflammatory migration in the airways, 4 integrins subvert the onset of acute asthma by curtailing the initial sensitization approach, too as by preventing cross speak amongst inflammatory leukocytes and their interaction together with the endothelium and lung stroma. (sodiumchannel-signal.com)
- Thus, making use of a repeated challenge protocol inside a far more chronic setting, selleckchem we assessed, in these genetic mouse models, modifications linked with structural remodeling from the airways to gain additional insight into the contribution of 4 and B2 integrins for the airway remodeling in chronic allergic asthma. (sodiumchannel-signal.com)
- Although these airways contribute little to airflow obstruction in normal airways, studies have revealed that distal airways accounted for up to 50-90% of total airflow resistance in asthmatics [ 1 ], implying that distal airways were the main site of airflow obstruction in asthmatics. (ersjournals.com)
- The pathologic sequence begins with short-term adaptations to cardiac injury followed by a profound maladaptation eventually resulting in adverse outcomes, including structural and functional remodeling of the neural structures that control the heart. (nih.gov)
- The intratumoral fibers likely have functional connectivity and contribute to increased electrical activity in the tumor bed. (bvsalud.org)
- Specifically, we explored the contribution of atrial fibrosis, epicardial adipose tissue, autonomic nervous system, hyper-coagulability, and focal drivers to adverse atrial remodelling and AF persistence. (medscape.com)
- Following cardiac injury, the alterations in this system characterized by sympathetic over-excitation and parasympathetic withdrawal contribute to progression of heart disease, including heart failure and arrhythmias. (nih.gov)
- Atrial fibrosis has been a common feature in remodelling due to various risk factors such as heart failure, hypertension, and obesity, contributing to the development of AF. (medscape.com)