Structural proteins for extracellular matrix. Medical search. Frequent questions

In biology, the extracellular matrix (ECM), also called intercellular matrix, is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. (wikipedia.org)
In the extracellular matrix, especially basement membranes, the multi-domain proteins perlecan, agrin, and collagen XVIII are the main proteins to which heparan sulfate is attached. (wikipedia.org)
In fact, collagen is the most abundant protein in the human body and accounts for 90% of bone matrix protein content. (wikipedia.org)
Collagen is exocytosed in precursor form (procollagen), which is then cleaved by procollagen proteases to allow extracellular assembly. (wikipedia.org)
These genes each provide instructions for making one component of a protein called type VI collagen. (medlineplus.gov)
Type VI collagen makes up part of the extracellular matrix that surrounds muscle cells and connective tissue. (medlineplus.gov)
Research suggests that type VI collagen helps secure and organize the extracellular matrix by linking the matrix to the cells it surrounds. (medlineplus.gov)
Fibroblasts are most commonly found in connective tissue that synthesizes extra-cellular matrix and another main structural protein of animals, collagen. (medindia.net)
Collagen is the core structural protein present in cartilage, providing tensile strength and toughness to the tissue. (bioiberica.com)
The primary proteins present in the ECM and indeed the entire body are the collagen s, a family of proteins with at least 29 members. (axonmedchem.com)
A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. (news-medical.net)
Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair. (news-medical.net)
We present a protocol for the application of Brillouin light scattering spectroscopy to elastin and trypsin-purified type I collagen fibers of the extracellular matrix to extract their full elastic properties. (jove.com)
The overall goal of this procedure is to prepare a sample of extracellular matrix protein fiber, collagen, or elastin to be mounted in the sample compartment for Brillouin spectroscopy measurements. (jove.com)
Using this method, collagen and elastin fibers of the extracellular matrix can be obtained from connective tissues of animal origin for their use in Brillouin spectroscopy measurements. (jove.com)
Cartilage is made up of two main elements: cells within it known as chondrocytes and a gel-like substance called matrix, composed mostly of water and two types of proteins (collagen and proteoglycans). (clevelandclinic.org)
Functions include synthesizing and maintaining the extracellular matrix comprised of collagen and proteoglycans that help healthy cartilage grow and heal. (clevelandclinic.org)
Collagen is a structural protein found in many tissues such as skin, tendons and bone and is a key structural component of cartilage. (clevelandclinic.org)
Collagen is the single-most abundant protein in the body, comprising one-third of total proteins, and it forms the structural foundation upon which beauty is built. (healthy-sunshine.com)
Premium collagen peptides offer a clean, effective source of pure protein. (healthy-sunshine.com)
Initially, it consists of a network of Type III collagen, a weaker form of the structural protein that can be produced rapidly. (t-vox.org)
As it turns out, this solid matter is made up of some of the same insoluble structural proteins as fascia (elastin and collagen with some actin, myosin, and keratin) (see Fascia: The Big Picture ). (biotone.com)
Collagen is a delicate structural extracellular matrix protein that exists outside the cell in the extracellular space. (shapeyourface.com)
A cartilage cell is surrounded by extracellular matrix consisting of proteins (collagen fibers), non-proteoglycan polysaccharides (hyaluronic acid), and proteoglycan (aggrecan). (lu.se)
The extracellular remodeling and fibroblast transformation potential was evaluated by measuring collagen 1, alpha-smooth muscle actin, and TGF-B in PHF cells. (cdc.gov)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)

This fibrillar network is composed of many structural proteins, such as collagens, and adhesion proteins, including fibronectin and proteoglycans (perlecan, decorin) [ 13 , 14 ]. (springer.com)
For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)
Proteoglycans are complex molecules composed of protein and sugar combinations that are interwoven in the matrix of cartilage. (clevelandclinic.org)
Proteoglycans, which are protein core + glycosaminoglycan composites, contribute vital structural properties to vessel extracellular matrix and have important regulatory roles vis-à-vis vascular cells. (navbo.org)

Perlecan helps make the extracellular matrix, the proteins and other molecules that surround cells, stable and flexible so that cells can develop and function in an environment that is supportive without being rigid. (neurosciencenews.com)
Its substrates comprise several molecules central to structural synaptic plasticity, and studies in rodents have documented its role in cognition and the behavioral and neurobiological response to stress. (preprints.org)
Proteases secreted into the extracellular space can modify ECM molecules and thereby affect neurons. (rockefeller.edu)
The extracellular matrix is a network of proteins and sugar molecules and contains a large proportion of water. (lu.se)
By using this approach, we will explore how extracellular molecules collectively regulate cell fate. (lu.se)

Hyaluronic acid in the extracellular space confers upon tissues the ability to resist compression by providing a counteracting turgor (swelling) force by absorbing significant amounts of water. (wikipedia.org)
Versican is a large extracellular matrix proteoglycan that is present in a variety of tissues. (rndsystems.com)
Collagens are the most abundant family of proteins in the extra cellular matrix of connective tissues. (bioiberica.com)
The ECM provides much of the structural support available to parenchymal cells in tissues. (axonmedchem.com)
This fibrous protein of the extracellular matrix supports tissues including skin, and it supports hair and nails. (healthy-sunshine.com)
These insoluble structural proteins form the internal structure and framework of every cell (cytoskeleton), and some of these vital proteins extend across the cellular membrane to anchor the cell to the extracellular matrix/connective tissues. (biotone.com)
Isn't it fascinating that the cell's cytoskeleton, the extracellular matrix, and the connective tissues (collectively referred to by James Oschman as The Living Matrix) are all made of the same substances, are all anchored together in one continuous fabric, and have all been consistently ignored as unimportant by almost every discipline that studies the body? (biotone.com)

The dystophin protein provides a structural link between myocyte cytoskeleton and extracellular matrix functioning to link contractile proteins to the cell membrane. (escardio.org)
For cell-cell adhesion, β-catenin binds the cytoplasmic domain of cadherin adhesion receptors along with the actin binding protein, α-catenin, to bridge the extracellular adhesive activity of cadherins with the underlying actin cytoskeleton. (axonmedchem.com)
It plays a structural role in the linking the CYTOSKELETON to the EXTRACELLULAR MATRIX. (bvsalud.org)

Further study applying proteomic analysis confirmed that CAFs secrete more proteases, extra-cellular matrix proteins, and proteins that modify the basement membrane compared with NAFs, pointing to a remodeling role for CAFs in invasion. (medindia.net)
Suneel's group investigates extracellular matrix and matrix-degrading proteases in cell regulation, morphogenesis and human diseases, including cardiovascular disorders. (navbo.org)
Lab members have concentrated on the roles that proteases and extracellular matrix (ECM) proteins play in function and dysfunction in the nervous system. (rockefeller.edu)

Standing between a cancer cell in situ and the surrounding tissue of fibroblasts and extra-cellular matrix is the basement membrane, a thin sheet of fibers that normally cradles the cells above it. (medindia.net)
All such dystrophies are genetically recessive and result from mutations in a variety of different genes including those that encode for structural proteins of the basal membrane or the extracellular matrix of skeletal muscle fibers. (msdmanuals.com)

The articular cartilage consists of cartilage cells (also known as chondrocytes) surrounded by extracellular matrix. (lu.se)

Some single-celled organisms adopt multicellular biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS). (wikipedia.org)
Within all of these polymeric materials , there are structural flaws at the molecular level. (dpaonthenet.net)
Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down- regulation of specific genes. (cdc.gov)
A biofilm is an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix. (cdc.gov)

Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. (wikipedia.org)
The ECM is composed of an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs). (wikipedia.org)

Proteins on the muscle side of the synaptic connection remained, but the neuron side of the connection withered away. (neurosciencenews.com)
Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. (preprints.org)
SMOC1 and SPON1 proteins associated with Aß plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. (cdc.gov)
We found 32 dementia-associated plasma proteins that were involved in proteostasis, immunity, synaptic function, and extracellular matrix organization. (cdc.gov)

Additionally, we have demonstrated that extracellular matrix derived peptides can recruit endogenous cardiac stem cells. (ca.gov)

I was promoted to Reader in 2004 and moved to the University of Nottingham to found the Crystallography Laboratory which is within the Medicinal Chemistry and Structural Biology Research Division of the School of Pharmacy. (nottingham.ac.uk)
The structural biology laboratory utilises a variety of techniques including Protein Crystallography, Cryo-electron Microscopy and associated techniques such as Isothermal Titration Calorimetry, which are then combined with functional studies or serve as a basis for structure-based drug design. (nottingham.ac.uk)
Section D, Structural biology. (nottingham.ac.uk)
He has served the American Society for Matrix Biology in many roles, including organizing its 2014 biennial conference and chaired the 2013 Gordon Research Conference on Matrix Metalloproteinases. (navbo.org)

A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)

As it is the cartilage cells that produce and maintain the extracellular matrix, healthy cartilage cells are needed for the cartilage to function normally. (lu.se)

A new study discovered the critical role that Perlecan, a protein, plays in maintaining the structural integrity of neurons, particularly the long branches called axons. (neurosciencenews.com)
Perlecan aids in stabilizing the extracellular matrix that surrounds cells, ensuring a supportive yet flexible environment for cell development. (neurosciencenews.com)
Perlecan, a protein, is significantly present in the neural lamella, a structure that maintains the integrity of axon bundles. (neurosciencenews.com)
If that long, thin projection ever seems like it could be vulnerable, a new MIT study shows that its structural integrity may indeed require the support of a surrounding protein called Perlecan. (neurosciencenews.com)
That suggested that a lack of Perlecan might not be a problem at the synapse, but instead causes trouble along axons due to its absence in the extracellular matrix surrounding nerve bundles. (neurosciencenews.com)
Instead, they were investigating a hypothesis that Perlecan might help organize some of the protein components in synapses that fly nerves develop to connect with muscles. (neurosciencenews.com)

ii) Determination of the platelet receptor glycoprotein Ib extracellular domain and von Willebrand factor A1 domain structures (iii) determination of the coagulation factor xi structure. (nottingham.ac.uk)
Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. (nottingham.ac.uk)
CD44 is an 80-95 kDa type I transmembrane glycoprotein, also known as Phagocytic glycoprotein-1 (Pgp-1), or Extracellular matrix receptor type III (ECMR-III). (bdbiosciences.com)
Tenascin is a large, disulfide-bonded glycoprotein of the extracellular matrix. (duke.edu)

This matrix is an intricate lattice that forms in the space between cells and provides structural support. (medlineplus.gov)
In their new studies, the MIT researchers want to look at nanoscale interactions between cells and specific protein sequences found in the extracellular matrix, which provides structural support for cells. (dpaonthenet.net)

Poly-L-lysine (PLL) of extracellular matrix proteins is a small natural homopolymer of the essential amino acid L-lysine that is used to coat culture substrates. (hindawi.com)
Various growth factors, cytokines, and extracellular matrix proteins are substrates for meprins. (embl-heidelberg.de)

Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)
Immunohistochemical staining was performed to confirm the expression of related proteins in OA and non‑OA tissue samples. (spandidos-publications.com)
The primary function of fibroblasts is the maintenance of structural integrity within the connective tissue. (news-medical.net)
They achieve this by secreting extracellular matrix precursors required for formation of the connective tissue and various fibres. (news-medical.net)
Meprins are mammalian tissue-specific metalloendopeptidases of the astacin family implicated in developmental, normal and pathological processes by hydrolysing a variety of proteins. (embl-heidelberg.de)
Current projects include applying biomimetic structural designs to create tough hydrogels that can potentially function as tissue adhesives or extracellular matrices for tissue repair and regeneration, and coatings to control biointerface of biomaterials that can prevent non-specific absorption of proteins, cells, and bacteria. (mtu.edu)
The extracellular matrix of granulation tissue is created and modified by fibroblasts. (t-vox.org)
Fibroblasts, the main cells that deposit granulation tissue, depend on oxygen to proliferate and lay down the new extracellular matrix. (t-vox.org)
The Living Matrix (you could also call it the Connective Tissue Fabric) is the ONLY system that connects to every cell in the body. (biotone.com)

It is in this form that HS binds to a variety of protein ligands and regulates a wide variety of biological activities, including developmental processes, angiogenesis, blood coagulation, and tumour metastasis. (wikipedia.org)
Research interests include determining protein structures and studying the structure/function of complexes formed with drugs and natural ligands. (nottingham.ac.uk)
As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)
The extracellular matrix is a dynamic environment where a plethora of structural proteins, ligands, enzymes, inorganic ions, and secreted factors are stored. (lu.se)

The animal extracellular matrix includes the interstitial matrix and the basement membrane. (wikipedia.org)
Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). (wikipedia.org)
Amyloid plaques form when levels of the monomeric, soluble Aβ peptide build up in the extracellular interstitial fluid (ISF) in the brain. (axonmedchem.com)

It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or ECM proteins. (wikipedia.org)
The extracellular matrix is necessary for cell stability and growth. (medlineplus.gov)
among them were the abundance of repetitive low complexity domains (RLCD-containing), extracellular matrix and cell surface proteins. (thefishsite.com)
The extracellular matrix (ECM) provides structural and biochemical support to the surrounding cells, and it has been used as a coating substrate for cell culture. (hindawi.com)
The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
Extracellular matrix and cell signaling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (axonmedchem.com)
Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)
They promote cell survival by the activation of downstream protein kinases and, finally, transcription factors of the NF-kB and AP-1 family. (embl-heidelberg.de)
Strategies to improve efficiency and effectiveness of stem cell therapy include the use of extracellular matrix proteins (components that make up the structural aspect of the heart) to increase the survival of the cells or the use of antibodies to direct and link the cells to the damaged heart muscle. (ca.gov)
Taken collectively, endurance coaching altered the degrees of host proteins concerned in SARS-CoV-2 cell entry in an organ-dependent method. (aidstar-one.com)
The pathways related to cell protein folding and degradation need to be elucidated because of training was set. (ijpsonline.com)
The results showed that chaperonin containing tailless complex polypeptide the large number of proteins involved, the complex relationship between proteins and the lack of research on the effects of movement and cell protein folding and degradation. (ijpsonline.com)
To elucidate the extracellular landscape controlling cell fate in vivo. (lu.se)
Current stem cell models that possess different types of extracellular matrix, have improved our understanding of cell fate vastly. (lu.se)
These models need to be modified continuously for each cell type, as many proteins and polysaccharide components are absent in engineered or decellularized ECM. (lu.se)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

In accordance, systemic injection of dopamine receptor D1 agonists in vivo promote rapid cleavage of the ECM protein brevican 16 . (nature.com)
On this examine, a therapeutic technique was developed through the use of extracellular vesicles (EVs) with decoy receptor ACE2 for neutralization of SARS-CoV-2. (aidstar-one.com)

The basement membrane is also the frontline physical barrier that keeps primary tumors from spreading into the matrix below. (medindia.net)
But there are also carcinoma-associated fibroblasts (CAF) whose matrix proteinases could come in handy in breaking the membrane barrier. (medindia.net)
Researchers at the Institut Curie in Paris now say that they have evidence of a coordinated attack on the basement membrane by cancer cells in situ and CAF cells in the extra-cellular matrix that begins long before the actual trans-location of cancer cells. (medindia.net)
The Schnell/Chou model, based on solution NMR, had the drug binding to the outside of the channel, within the membrane (at a 4:1 drug:protein ratio). (scienceblogs.com)

Fibroblasts are originally derived from primitive mesenchyme and therefore display the filament protein vimentin, which acts as a marker of mesodermal origin. (news-medical.net)

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. (nih.gov)

Chaperonin Containing Tailless Complex Polypeptide 1 (CCT-1) is one of the important elements of protein folding pathway in cells and proteasome is an important component of Adenosine Triphosphate (ATP) dependent protein degradation pathway in cells. (ijpsonline.com)
They are involved in the formation of protein folding/degradation signalling pathway, maintaining the normal spatial structure and normal biological function of protein [ 3 ]. (ijpsonline.com)
The degradation of articular cartilage in osteoarthritis (OA) is the result of an imbalance in the construction (anabolism) and the degradation (catabolism) of the extracellular matrix. (lu.se)
This gradual degradation of extracellular matrix creates cartilage damage. (lu.se)

Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)

My study of the fibronectin coatings using fluorescence recovery after photobleaching (FRAP) on the different polymer surfaces suggested that the mobility of the polymer substrate is translated to the interfacial protein layer. (gla.ac.uk)

This happens when the cartilage cells do not build up extracellular matrix at the same rate it is broken down. (lu.se)

Novel hydrogel actuator inspired by reversible mussel adhesive protein chemistry" Advanced Materials , 26 , 3415-3419, (2014). (mtu.edu)

The new study may help explain how neurons are affected in the condition, Littleton said, and also deepen scientists' understanding of how the extracellular matrix supports axon and neural circuit development. (neurosciencenews.com)

Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1. (imperial.ac.uk)

This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)

Dystrophin protein is integral to the structural stability of the myofiber. (medscape.com)
A macromolecular complex of proteins that includes DYSTROPHIN and DYSTROPHIN-ASSOCIATED PROTEINS. (bvsalud.org)

This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)

Source of all serum proteins is from USDA inspected abattoirs located in the United States. (bdbiosciences.com)

Collagens are the most abundant protein in the ECM. (wikipedia.org)
Collagens are present in the ECM as fibrillar proteins and give structural support to resident cells. (wikipedia.org)

Erhard Hohenester is a structural biologist investigating the assembly, structure, and function of extracellular matrix. (imperial.ac.uk)
These proteins are vital to normal platelet adhesion and hemostatic function. (nottingham.ac.uk)
In order for cells to function, they must be properly supported, having contacts with neighboring cells and/or the extracellular matrix ECM). (axonmedchem.com)
It is primarily made up of water and proteins whose primary function is to reduce friction in the joints and serve as a 'shock absorber. (clevelandclinic.org)
The ECM provides the substrate on which neurons reside, and in addition to having structural importance, also influences neuronal survival and function. (rockefeller.edu)
As the expression vector of life information, the specific spatial structure formed by protein folding is the basis of its biological function. (ijpsonline.com)

MSCs naturally reside in a specialized niche in vivo , which mainly consists of the extracellular matrix (ECM). (hindawi.com)
In our research, we use an in vivo model, where the extracellular matrix is maintained in its native state. (lu.se)

It plays important structural roles, forming loose, hydrated matrices during development and disease. (rndsystems.com)
Another cytoplasmic protein, β-Catenin , plays essential roles in two different cellular processes: calcium-dependent intercellular adhesion and Wnt-mediated transcriptional activation. (axonmedchem.com)

As the importance and continuity of these structural components have come to light, research has begun to demonstrate that the nervous, hormonal, and chemical systems only account for a portion of the communications occurring in the body. (biotone.com)

This structure revealed the molecular basis of the contacts formed between cells and the extracellular matrix. (nottingham.ac.uk)
The findings show how a crucial enzyme in our blood, known as ADAMTS13, works like a pair of molecular scissors to carefully cut back the clotting effects of a key protein, von Willebrand factor (VWF). (nottingham.ac.uk)
So, when I opened my January copy of The Science Teacher, I was thrilled to see an article on Siamese cat colors and proteins AND molecular genetics (1). (scienceblogs.com)
Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)

In the vertebrate brain, long-lasting structural tenacity of neuronal networks is supported by the extracellular matrix (ECM). (nature.com)

The protein encoded by this gene ensures the structural integrity of the zona pellucida. (nih.gov)
Direct and indirect ionization of DNA is ultimately responsible for the DNA alterations that adversely affect the structural and genetic integrity of the system. (cdc.gov)

In a study in the Journal of Biological Chemistry , researchers in the U.K. biochemically and structurally characterized a protein that might protect nitrogenases from oxygen inactivation. (asbmb.org)

He is known for his work on laminins - huge proteins that are a key component of all basement membranes. (imperial.ac.uk)

They found that the genes encoding secreted proteins that evolved before the evolution of mollusks are being continually "co-opted" into the mantle gene regulatory network through the evolution of mollusks. (thefishsite.com)

Versican is a member of the lectican protein family that also includes Aggrecan, Brevican, and Neurocan. (rndsystems.com)
Inside this "armour" lies the protein aggrecan, whose role is to bind water and keep the cartilage soft and elastic so that it swells and becomes a "cushion" in the joint. (lu.se)

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life. (cdc.gov)
Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults. (cdc.gov)

In this work, we present a novel approach to fabricate such coatings, which specifically involves the use of surface-adsorbed, nanoscale-designed protein polymers to prepare reproducible, customized surfaces. (frontiersin.org)
The proteins are synthesized using recombinant, genetic engineering techniques, allowing for the creation of biocompatible polymers with nanoscale precision that impart highly specific protein functionalities. (frontiersin.org)

Computational Implementation, Polarity Index in Proteins-A Bioinformatics Tool (2016) 1: 33. (benthamscience.com)

The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics. (pharmtech.com)

We trained a Bayesian machine learning neural network model to generate a neuroimaging phenotype and AD score representing the probability of AD using structural MRI data in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort (cut-off 0.5, AUC 0.92, PPV 0.90, NPV 0.93). (cdc.gov)

Multi-walled carbon nanotube (MWCNT) composites have vastly superior mechanical and structural properties compared to conventional materials. (cdc.gov)

Anatomy38

Organisms27

Diseases3

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes47

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Collagen25

Accumulation of extracellular1

Proteoglycans4

Molecules5

Tissues7

Cytoskeleton3

Proteases3

Fibers2

Known as chondrocytes1

Polymeric4

Fibrous2

Synaptic4

Peptides1

Biology4

Elastin1

Healthy cartilage1

Perlecan6

Glycoprotein4

Provides structural support2

Substrates2

Tissue10

Ligands4

Interstitial3

Cell16

Receptor2

Membrane4

Fibroblasts1

Surrounds1

Degradation4

Pathway1

Fibronectin1

Cartilage cells1

Adhesive1

Axon1

Glycosaminoglycan1

Enzymes2

Dystrophin2

Serine1

Serum1

Collagens2

Function6

Vivo2

Roles2

Components1

Molecular4

Neuronal1

Integrity2

Chemistry1

Basement1

Genes1

Aggrecan2

Proteomics2

Polymers2

20161

Therapeutic1

Neural1

Composites1