Structural protein precursor. Medical search. Frequent questions

The viral core protein retains protease activity, needed for cleavage from a protein precursor. (virology.ws)
The viral protease cleavage sites have in common a set of basic proteins, K and R, accompanied by G, S, or A on the P1 placement (Lindenbach and Grain, 2003). (findadig.com)
2. Methods and Materials 2.1 Components The DENV2 NS2B-NS3pro expression plasmid encoding the protease precursor found in this research provides the hydrophilic domains of NS2B cofactor (48 proteins) as well as the NS3pro domains (185 residues) (Yon et al. (findadig.com)
In biology and biochemistry , protease inhibitors , or antiproteases , [1] are molecules that inhibit the function of proteases ( enzymes that aid the breakdown of proteins ). (wikipedia.org)
Many naturally occurring protease inhibitors are proteins . (wikipedia.org)
The viral genome encodes four structural capsid proteins (VP1 to VP4) and seven nonstructural (NS) proteins, the leader Lb/ab protease, and proteins encoded in the P2 (2B and 2C) and P3 (3A, 3B, 3C, and 3D) regions ( 9 ). (asm.org)
Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccines in the fight against the virus. (bvsalud.org)
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. (embl.de)

Replacements L38E and L41E, involving charge acquisition at residues predicted to contribute to the hydrophobic interface, reduced the dimerization signal in the protein ligation assay and prevented the detection of dimer/multimer species in both transiently expressed 3A proteins and in synthetic peptides reproducing the N terminus of 3A. (asm.org)
We compared the results in several categories, including the numbers of identified peptides, full-length mature neuropeptides among all identifications, and precursor proteins mapped by the identified peptides. (illinois.edu)

In particular, similarities in post-translational processing have invited comparisons to the signaling role of the surface receptor protein Notch. (wikipedia.org)
RNA genome can be translated to an individual polyprotein precursor which can be processed to create 10 adult proteins by co- and post-translational digesting (Rice and Lindenbach, 2003). (findadig.com)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Characterization of endogenous neuropeptides produced from post-translational proteolytic processing of precursor proteins is a demanding task. (illinois.edu)

This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. (nih.gov)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
IP3R mediated Ca(2+) release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. (ncbs.res.in)
2013. Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. (ocl-journal.org)
2003. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. (ocl-journal.org)

APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. (wikipedia.org)
Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause familial susceptibility to Alzheimer's disease. (wikipedia.org)
One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein. (embl.de)
The amyloid proteins isolated from neuritic plaques and the cerebrovasculature of Alzheimer's disease are self-aggregating moieties termed A4 protein and beta-protein, respectively. (embl.de)
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. (embl.de)
Interestingly, these variable regions determine the differential effects of Hsp70 isoforms on the aggregation or degradation of the Alzheimer's-disease-related protein tau [ 16 ] . (encyclopedia.pub)

Amyloid precursor protein (APP) is a transmembranal protein which is thought to regulate transcription. (proteopedia.org)
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. (proteopedia.org)
In a parallel study, I demonstrated that the beta-site cleaving enzyme 1 (BACE1), which cleaves the amyloid precursor protein (APP) to release the amyloid beta peptide (Abeta), is also involved in regulating synaptic plasticity. (umd.edu)
2012. The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. (ocl-journal.org)
Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties. (ocl-journal.org)
Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission. (uclouvain.be)
Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release. (uclouvain.be)
A putative A4 amyloid precursor (herein termed A4(695] has been characterized by analysis of a human brain complementary DNA. (embl.de)

2022. Differentiating between the sequence of structural events on alternative pathways of folding of a heterodimeric protein. . (ncbs.res.in)
2022. Evolutionarily conserved proline residues impede the misfolding of the mouse prion protein by destabilizing an aggregation-competent partially unfolded form . (ncbs.res.in)
2022. Heterogeneity in Protein Folding and Unfolding Reactions. . (ncbs.res.in)
2022. Native State Hydrogen Exchange-Mass Spectrometry Methods to Probe Protein Folding and Unfolding. . (ncbs.res.in)

2019. Mechanistic approaches to understand the prion-like propagation of aggregates of the human tau protein. . (ncbs.res.in)
Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. (encyclopedia.pub)

A very common motif among viral capsid proteins is called the single jelly roll , made up of eight beta strands in two four-stranded sheets. (virology.ws)
The extra sequences at the N-termini of viral jelly roll capsid proteins, involved in recognizing the viral genome, likely evolved after the capture of these proteins from cells. (virology.ws)
Given this information on the origin of viral capsid proteins, we can modify the three hypotheses for the origin of viruses into one. (virology.ws)

2017. Identification and structural characterization of the precursor conformation of the prion protein which directly initiates misfolding and oligomerization. . (ncbs.res.in)
2021. Structural Characterization of the Cooperativity of Unfolding of a Heterodimeric Protein Using Hydrogen Exchange-Mass Spectrometry. . (ncbs.res.in)
In addition, the wide range of endogenous peptide concentrations as well as significant peptide complexity further challenge the structural characterization of neuropeptides. (illinois.edu)

2021. The Lys 280 ➔ Gln mutation mimicking disease-linked acetylation of Lys 280 in tau extends the structural core of fibrils and modulates their catalytic properties. . (ncbs.res.in)
2017. The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration. . (ncbs.res.in)
Nevertheless, while Q44R led to recovery of viruses that maintained the mutation, Q44D resulted in selection of infective viruses with substitution D44E with acidic charge but with structural features similar to those of the parental virus, suggesting that Q44 is involved in functions other than 3A dimerization. (asm.org)
Therefore, in this study, we analyze the variant distribution, hotspot mutation, and its impact on protein structure and function of SARS-CoV-2 from the collected samples from WJHL. (bvsalud.org)
Mutation analysis showed that mutations in structural protein might increase the stability of the protein. (bvsalud.org)
[ 19 ] The apparent lack of a second-hit mutation in the genome of FLCs supports the role of DNAJB1-PRACA fusion protein as a major driver of this tumor and as a key diagnostic and therapeutic target. (medscape.com)

Table 1 lists the major structural proteins coded for by the HIV genome. (cdc.gov)

It seems likely that viral structural proteins originated from cellular genes. (virology.ws)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
LOCUS LC556391 4808 bp RNA linear VRL 01-JUL-2020 DEFINITION Norovirus GII.14 2018/TH/S3_110_NGS ORF1, ORF2 and PRF3 genes for non-structural protein precursor, major capsid protein VP1 and minor capsid protein VP2, partial and complete sequence. (cdc.gov)

Amyloid-beta precursor protein is an ancient and highly conserved protein. (wikipedia.org)
The extracellular E2 domain, a dimeric coiled coil and one of the most highly conserved regions of the protein from Drosophila to humans. (handwiki.org)

Destabilization of polar interactions in the prion protein triggers misfolding and oligomerization. (ncbs.res.in)
2019. Ruggedness in the Free Energy Landscape Dictates Misfolding of the Prion Protein. . (ncbs.res.in)
2018. Mechanism of aggregation and membrane interactions of mammalian prion protein. . (ncbs.res.in)
2018. Structural mechanisms of oligomer and amyloid fibril formation by the prion protein. . (ncbs.res.in)
2017. Expression and purification of single cysteine-containing mutant variants of the mouse prion protein by oxidative refolding. . (ncbs.res.in)

Mouse ANG 3 cDNA encodes a 509 amino acid (aa) precursor protein with a 21 aa signal peptide. (reliatech.de)
Within the V region families, certain amino acid residues occurring at particular positions in the L-chain sequence render those chains are more amyloidogenic, with a combination of such residues increasing the chances of a particular L-chain protein being associated with tissue amyloid deposition. (medscape.com)

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins (PFPs) that function as executioners of specific cell death pathways: apoptosis regulator BAX (BAX), BCL-2 homologous antagonist/killer (BAK) and BCL-2-related ovarian killer protein (BOK) for apoptosis, gasdermins (GSDMs) for pyroptosis and mixed lineage kinase domain-like protein (MLKL) for necroptosis. (ugent.be)
The fusion transcript encodes a chimeric protein that couples a segment of the heat shock protein, DNAJB1, with the catalytic domain of protein kinase A (PKA) and exhibits full retention of PKA activity. (medscape.com)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Although the overall sensitivity and specificity of the Western blot for detection of antibodies to the various viral proteins are high, there has been substantial debate regarding the interpretive criteria. (cdc.gov)

Karki S, Shkumatov AV, Bae S, Kim H, Ko J, Kajander T. Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ. (helsinki.fi)
A molecular model of the FMDV 3A protein, derived from the nuclear magnetic resonance (NMR) structure of the poliovirus 3A protein, predicted a hydrophobic interface spanning residues 25 to 44 as the main determinant for 3A dimerization. (asm.org)
2012. Structural features of the KPI domain control APP dimerization, trafficking, and processing. (ocl-journal.org)

4 Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany. (nih.gov)
In this Review, we discuss the structural rearrangements incurred by RCD-related PFPs and describe the mechanisms that manifest conversion from autoinhibited to membrane-embedded molecular states. (ugent.be)
P. Vandenabeele, G. Bultynck, and S. Savvides, "Pore-forming proteins as drivers of membrane permeabilization in cell death pathways," NATURE REVIEWS MOLECULAR CELL BIOLOGY , 2023. (ugent.be)
Using a combination of structural analyses and functional assays, we identify a molecular sensor within the S1 Ub-binding site of PLpro that serves as a key determinant of substrate specificity. (bvsalud.org)
A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)

10-Formyltetrahydrofolate dehydrogenase (FDH) converts 10-formyltetrahydrofolate, a precursor for nucleotide biosynthesis, to tetrahydrofolate. (rcsb.org)

The key pathological changes observed in AD brain tissue are amyloid beta (Aβ) peptide deposited and neuritic plaques, hyperphosphorylated tau protein and neurofibrillary tangles [ 4 , 5 ]. (oncotarget.com)

The matrix Z proteins of arenaviruses are related to cellular RING domain proteins, and the matrix proteins of some negative strand RNA viruses are related to cellular cyclophilin. (virology.ws)

The viral particle is composed of a protein capsid that contains a positive-sense RNA molecule of about 8,500 nucleotides that is infectious and encodes a single polyprotein, which is processed in infected cells by cis - and trans -acting viral proteases ( 55 ) to yield different polypeptide precursors and the mature viral proteins ( 9 , 62 ). (asm.org)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
In addition, the precursor cells contained various proteins of the extracellular matrix. (innovationorigins.com)
The extracellular matrix is the structural component of a tissue. (innovationorigins.com)
It is mediated by the contact of the precursor cell with the extracellular matrix and the mechanosensitive gene regulator YAP . (innovationorigins.com)
Finally, there have been no significant distinctions in renal interstitial fibrosis or appearance of extracellular matrix protein between wild-type and interleukin 6 knockout mice pursuing obstructive damage. (mdm-inhibitors.com)

These mechanisms involve protein-protein and protein-lipid interactions, proteolytic processing and phosphorylation. (ugent.be)

One example is syncytin , a retroviral protein used for the construction of the mammalian placenta. (virology.ws)

When expressed as a recombinant protein in transfected cells, PV 3A cofractionates with endoplasmic reticulum markers ( 66 ), and its single transient expression can disrupt the secretory apparatus ( 23 ) and decrease major histocompatibility complex (MHC) class I expression ( 22 ). (asm.org)
To introduce altered Drosophila Gap1 transgenes into flies, the sevenless ( sev ) enhancer/promoter cassette, an eye-specific promoter, was used to drive expression in cone cell precursors at appropriate levels. (sdbonline.org)
The 3A and 3AB proteins were expressed in the E. coli and baculovirus expression systems. (ncl.edu.tw)
Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)

An analysis of the sequence an structure of major virion proteins has identified likely ancestors in cellular proteins. (virology.ws)

Our recent study provides evidence that accumulation of myeloid fibroblast precursors in the kidney and development of renal fibrosis required chemokine CXCL16 induction in the renal tubular epithelial cells in a murine model of renal fibrosis induced by unilateral ureteral obstruction [10]. (mdm-inhibitors.com)

We have previously discussed the idea that viruses originated from selfish genetic elements such as plasmids and transposons when these nucleic acids acquired structural proteins (see A plasmid on the road to becoming a virus ). (virology.ws)

The effect of the most prevalent mutations from dominant variants on the stability of their corresponding proteins was examined. (bvsalud.org)
The MMADHC gene variants that cause homocystinuria result in a protein that cannot transport vitamin B12 to the cytoplasm, where MeCbl is produced. (medlineplus.gov)
The MMADHC gene variants that cause this condition result in a protein that cannot transport vitamin B12 to mitochondria for the production of AdoCbl. (medlineplus.gov)

Although most known xenobiotic estrogens show little structural similarity, they do produce predictable physiological responses. (astm.org)
The core proteins of alphaviruses (think Semliki Forest virus) has structural similarity with chymotrypsin-like serine proteases. (virology.ws)
As expected, domain 1 shares the same Rossmann fold as the related enzymes, methionyl-tRNA-formyltransferase and glycinamide ribonucleotide formyltransferase, but, unexpectedly, the structural similarity between the amino-terminal domain of 10-formyltetrahydrofolate dehydrogenase and methionyl-tRNA-formyltransferase extends to the C terminus of both proteins. (rcsb.org)

A number of different structural domains that fold mostly on their own have been found in the APP sequence. (wikipedia.org)
The protein must then fold during or after the translocation process. (elifesciences.org)

Comparison between receptors reveals ICL2 as a key domain forming dynamic G protein interactions in a receptor- and ligand-specific manner. (nih.gov)
The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). (nih.gov)
This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. (nih.gov)
Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)

Many cell proteins have jelly role motifs, and some form 60-subunit virus-like particles in cells. (virology.ws)
At some point these genetic elements acquired structural proteins from the cells and became bona fide virus particles. (virology.ws)
We know that viral proteins can be returned to cells, where they serve useful functions. (virology.ws)
NS proteins are involved in crucial aspects of the viral cycle and pathogenesis, such as rearrangements of intracellular membranes required for endomembrane recruitment and the lysis of host cells ( 1 , 12 , 14 , 18 , 73 ). (asm.org)
To do this, they applied precursor cells to glass plates. (innovationorigins.com)
It is particularly exciting for us that our data answer a question that has been driving our field of research for decades," says Henrik Semb, explaining how some precursors mature into scaffold cells, while others become endocrine cells through activation of the so-called Notch signaling pathway. (innovationorigins.com)
We show that GP determines the apical release of Lassa computer virus from epithelial cells, presumably by recruiting the matrix protein Z to the site of computer virus assembly, which is usually in turn essential for nucleocapsid incorporation into virions. (esbiomech2012.org)
The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)
Principal cells are responsible for formation of the colloid (iodothyroglobulin), whereas parafollicular cells produce the hormone calcitonin, a protein central to calcium homeostasis. (medscape.com)

Phylogenetic reconstruction, based on capsid and were used in RT-PCR to differentiate GI and GIII JEV precursor membrane or envelope (E) structural protein (Table). (cdc.gov)
In contrast, antibodies to the envelope (ENV) precursor protein gp160 and the final ENV proteins (gp120 and gp41) can be detected in specimens from virtually all HIV-infected persons regardless of clinical stage (4-9). (cdc.gov)

Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. (wikipedia.org)

ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. (novusbio.com)
Variations within the S1 sensor specifically alter cleavage of Ub substrates but not of the Ubl interferon-stimulated gene 15 protein (ISG15). (bvsalud.org)
The MMADHC gene provides instructions for making a protein that helps convert vitamin B12 (also called cobalamin) into one of two molecules, adenosylcobalamin (AdoCbl) or methylcobalamin (MeCbl). (medlineplus.gov)
Together with another protein called MMACHC (produced from the MMACHC gene), MMADHC transports vitamin B12 to regions of the cell in which each cofactor is needed: specialized structures that serve as energy-producing centers (the mitochondria), where AdoCbl functions, or the fluid inside the cell (the cytoplasm), where MeCbl functions. (medlineplus.gov)

Spiropoulou, J. finding that, when expressed individually, both the glycoprotein GP and matrix protein Z form virus-like particles. (esbiomech2012.org)
This colloid (pink on hematoxylin and eosin [H&E] stain) contains an iodinated glycoprotein, iodothyroglobulin, a precursor of thyroid hormones. (medscape.com)

They are short (~50 residue) alpha/beta proteins with few secondary structures. (embl.de)

2021. Mapping Distinct Sequences of Structure Formation Differentiating Multiple Folding Pathways of a Small Protein. . (ncbs.res.in)
2021. Microsecond dynamics during the binding-induced folding of an intrinsically disordered protein. . (ncbs.res.in)

1992). The NS2B can be an essential membrane protein in the endoplasmic reticulum (Clum et al. (findadig.com)
This ability to exploit structure within a pre-protein is an unexplored area of protein transport, which may apply to other protein transporters, such as those of the endoplasmic reticulum and mitochondria. (elifesciences.org)

Retroviral structural proteins also appear to have originated from cell proteins, with clear homologies with matrix, capsid, and nucleocapsid proteins. (virology.ws)
The genomic regions with the highest number of mutations are the spike, NSP3, nucleocapsid, NSP12, and ORF3a protein. (bvsalud.org)

Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold. (helsinki.fi)

Homologous proteins have been identified in other organisms such as Drosophila (fruit flies), C. elegans (roundworms), and all mammals. (wikipedia.org)

Based on sequence data available in databases, we analyzed the mutational potential of this protein. (bvsalud.org)
We report here the sequence of a closely related amyloid cDNA, A4(751), distinguished from A4(695) by the presence of a 168 base-pair (bp) sequence which adds 57 amino acids to, and removes one residue from, the predicted A4(695) protein. (embl.de)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)

Lysine - this one also plays an important role in protein synthesis, enzyme production, and last but certainly not least, the absorption of calcium. (australiansportsnutrition.com.au)
Furthermore, a strong positive genetic interaction occurs between Gap1 and phospholipase Cgamma (PLCgamma), an enzyme that generates inositol-1,4,5-trisphosphate, a precursor for IP4 and a second messenger for intracellular Ca2+ release. (sdbonline.org)
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). (novusbio.com)
This enzyme helps break down certain protein building blocks (amino acids), fat building blocks (fatty acids), and cholesterol. (medlineplus.gov)

Oppositely, mutations in non-structural protein might lead to a decrease in protein stability. (bvsalud.org)
However, further research to study the impact of mutations on the function of SARS-CoV-2 proteins are required. (bvsalud.org)

However, common conformational reorganization of ECL2, linked to reorganization of ICL2, modulates G protein contacts. (nih.gov)
2018. The Osmolyte TMAO Modulates Protein Folding Cooperativity by Altering Global Protein Stability. . (ncbs.res.in)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

Class B G protein-coupled receptors (GPCRs) are important therapeutic targets for major diseases. (nih.gov)
2023). Identification of potential selective autophagy receptors from protein-content profiling of autophagosomes. (unimedizin-mainz.de)

The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins such as furocoumarins and pyranocoumarins. (benthamscience.com)
In its simplest form, amino acids are compounds that combine to form proteins. (australiansportsnutrition.com.au)
The body uses methionine to make proteins and other important compounds. (medlineplus.gov)

Inactive precursors of PFPs are converted into pore-forming entities through activation, membrane recruitment, membrane insertion and oligomerization. (ugent.be)

The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's native-state biological functions. (wikipedia.org)
A five-residue motif for the design of domain swapping in proteins. (ncbs.res.in)
Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo. (nih.gov)
It has the characteristic structural motifs of angiopoietins including the coiled coiled domain near the amino-terminus and a fibrinogen like domain at the C-terminus. (reliatech.de)
The protein comprises two functional domains: a hydrolase domain that removes a formyl group from 10-formyltetrahydrofolate and a NADP(+)-dependent dehydrogenase domain that reduces the formyl to carbon dioxide. (rcsb.org)
Taxonomic distribution of proteins containing KU domain. (embl.de)
The complete taxonomic breakdown of all proteins with KU domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing KU domain in the selected taxonomic class. (embl.de)

2017. Graded Structural Polymorphism in a Bacterial Thermosensor Protein. . (ncbs.res.in)
2017. Chemical Denaturants Smoothen Ruggedness on the Free Energy Landscape of Protein Folding. . (ncbs.res.in)
2017. A Dry Transition State More Compact Than the Native State Is Stabilized by Non-Native Interactions during the Unfolding of a Small Protein. . (ncbs.res.in)
2017. Modulation of the Extent of Cooperative Structural Change During Protein Folding by Chemical Denaturant. . (ncbs.res.in)

Recombinant human ALAD protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. (novusbio.com)

SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)

Due to the high energies involved in collisional activation, analytes tend to disrupt and undergo major structural change, which becomes visible in the ion mobility spectra of the precursor and/or product ions. (nature.com)

Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
Threonine - this one is found in structural proteins like collagen and elastin, and as such, plays an important role in skin and connective tissue health. (australiansportsnutrition.com.au)
and tissue factor pathway inhibitor precursor. (embl.de)
Our outcomes indicate that interleukin 6 will not play a substantial function in the recruitment of bone tissue marrow-derived fibroblast precursors as well as the advancement of renal fibrosis. (mdm-inhibitors.com)

The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)

Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. (asm.org)

Lipid and protein content profiling of isolated native autophagic vesicles. (unimedizin-mainz.de)

Anatomy29

Organisms68

Diseases4

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology1

Phenomena and Processes51

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20224

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20212

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20174

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