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  • Bioinformatics
  • Our integrative, information-driven, flexible docking approach HADDOCK [ 5 , 6 ] addresses this structural modeling problem by using the available experimental and bioinformatics data to drive the docking process in combination with a simple but robust scoring function for ranking. (springer.com)
  • complexes
  • Nearest neighbor searches examples were reported exemplifying the ability of 3DP-similarity to identify closely related biomolecules from small peptides to enzyme and large multiprotein complexes such as virus particles. (biomedcentral.com)
  • mimic
  • Although most prior research on PNA has focused on its nucleic acid-like character, recent developments of the peptide-like aspects of PNA promise to stimulate additionally the work on this fascinating DNA mimic. (schoolbag.info)
  • The Richelson laboratory has in development some peptide compounds that mimic the effects of neurotensin, but penetrate into brain, after being given outside the brain. (mayo.edu)
  • Protein
  • The goal of structural alignment techniques has been to compare individual structures, sets of structures, or an "all-to-all" comparison database that measures the divergence between every pair of structures present in the Protein Data Bank (PDB). (wikibooks.org)
  • methodologies
  • Divided conveniently into two distinct parts beginning with nucleic acid aptamers and ending with peptide aptamers, the volume provides methodologies for the isolation, characterization, and application of both types. (springer.com)
  • Contributions were made by the introduction of the Merriefield's solide phase peptide synthesis [ 8 ] and Carpino's protecting group methodologies [ 9 ]. (medsci.org)
  • chemistry
  • They are assembled using techniques adapted from peptide chemistry. (currentprotocols.com)
  • In this context our modified solid phase peptide chemistry using temperature shifts during synthesis is considered as an appropriate technology. (medsci.org)
  • The University of Strasbourg chemistry, life sciences and structural biology departments have excellent scientific records, with a multitude of collaborations world-wide. (weizmann.ac.il)
  • facilitate
  • After ligation to the modular peptide-based BioShuttle carrier, which was utilized to facilitate the delivery of the functional modules into the cells' cytoplasm, the modules were scrutinized. (medsci.org)
  • derivatives
  • The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. (ovid.com)