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  • genetics
  • In his talk at the 9th International Conference AD/PD, which unfolded 11-15 March in the Czech capital of Prague, Moir, a feisty Aussie at the Genetics and Aging Research Unit at Massachusetts General Hospital in Charlestown, came to the defense of the much maligned protein. (alzforum.org)
  • modulate
  • 2005), could cooperate with the SH2-like domain to enhance clustering of RTK-GIV complexes at the PM. We propose that the SH2-like domain is key to achieve targeting and proximity of GIV to RTKs, which allows GIV to integrate incoming signals from these receptors and modulate them via activation of G proteins in the vicinity of the receptors. (nih.gov)
  • motif
  • However, in the P. aeruginosa protein, helices H3, H4 of this motif are located at the N-terminal part of the chain, while in M. tuberculosis AhpD, the corresponding helices H8, H9 are situated at the C-terminus. (biomedcentral.com)
  • envelope-spannin
  • This envelope-spanning protein has three transmembrane sequences, and interacts with TagL on the cytoplasmic side, and TssJ on the C-terminal, periplasmic side . (kenyon.edu)
  • antibodies
  • During a virus infection, host antibodies are raised against viral proteins that are recognized as foreign, although most of these antibodies do not neutralize the virus. (asm.org)
  • vicinity
  • Examples of such interdomain collaborations were reported in the case of other multimodular signal transducers that bridge RTKs and small G proteins, such as Ras-GAP (Schlessinger and Lemmon, 2003), which inactivates Ras in the vicinity of ligand-activated receptors. (nih.gov)
  • stability
  • Overall, all hydrogels show suitable structural stability, good swellability, high porosity and pore interconnectivity, and maintenance of mechanical integrity during 3-week-long hydrolytic degradation. (bioportfolio.com)
  • One of the methods that have been proposed is a multiobjective optimization, in which protein stability and catalytic activity are simultaneously optimized [ 4 , 5 ]. (hindawi.com)
  • Several methods have been proposed to design novel stable proteins, such as multi-objective optimization, in which protein stability and catalytic activity are simultaneously optimized. (hindawi.com)
  • Finally, collagen's association with the bone matrix provides added stability to the collagen proteins. (reasons.org)
  • Domains
  • The previously presented structural models in conjunction with the protein, lipid, and carbohydrate information reported here reveal that STIV is strikingly similar to viruses associated with the Bacteria and Eukarya domains of life, further strengthening the hypothesis for a common ancestor of this group of dsDNA viruses from all domains of life. (asm.org)
  • lipid
  • The protein shell is blue and has been removed from one quarter of the particle to reveal the inner lipid layers (yellow). (asm.org)
  • Major
  • CPV and FPV are conserved in sequence, with little variation in most of the major viral capsid protein ( 24 ). (asm.org)
  • Hcp, or Hemolysin Coregulated Protein, is homologous to the major tail protein, gpV, in phage . (kenyon.edu)
  • This suggestion is supported by the shared general architecture of this group of viruses and the common fold of their major capsid protein. (asm.org)
  • The electron cryomicroscopy (cryo-EM) reconstruction revealed a capsid with pseudo-T=31 icosahedral symmetry that is composed primarily of a 37-kDa major capsid protein, plus at least three additional capsid proteins at the fivefold vertices ( 38 ). (asm.org)
  • carbohydrate
  • This value depends on the quantity of a food which is digested and absorbed and the amounts of the essential nutrients (protein, fat, carbohydrate, minerals, vitamins) which it contains. (bioportfolio.com)
  • binds
  • Rev binds to an RNA structural element called the Rev response element (RRE) and mediates nuclear export through the leucine-rich nuclear export signal (NES) pathway. (umassmed.edu)
  • Prediction
  • (July 15th, 2014) I presented our paper "New Directions for Diffusion-Based Network Prediction of Protein Function: Incorporating Pathways with Confidence" at ISMB 2014. (tufts.edu)
  • degree
  • These proteins have a high degree of conservation across type six secretion systems, and have been experimentally determined to be required for T6SS function, but their exact purpose remains unclear . (kenyon.edu)
  • host
  • In short, host resistance (R) proteins are responsible for the indirect recognition of pathogen effectors by means of "guarding" a virulence target and initiating an effective defense response. (plantphysiol.org)
  • Using a proteomics-based approach, we identified nine viral and two host proteins from purified STIV particles. (asm.org)
  • Two features in particular stand out: the turrets, which are proposed to function in host recognition and DNA translocation, and two electron-dense layers sandwiched between the protein capsid and the packaged genome that may be composed of lipids ( 30 ) (Fig. 1 ). (asm.org)
  • defense
  • Thus, alkyl hydroperoxidase D is an adaptor protein completing the AhpC/AhpD-dependent system, exhibits peroxidase activity and is involved in the antioxidant defense mechanism. (biomedcentral.com)
  • Of the two primary signaling components required for the activation of R protein-mediated resistance, the role of EDS1 in defense signaling is best understood. (plantphysiol.org)
  • entry
  • The tip of VgrG is too narrow to allow the passage of protein substrates, and therefore VgrG probably dissociates upon entry to the recipient cell, exposing the hollow Hcp tubule . (kenyon.edu)
  • evolution
  • In convergent evolution, nonhomologous proteins evolve in separate biological contexts to catalyze the same or similar reactions. (hindawi.com)
  • significant
  • The Type VI Secretion System is the most recently discovered of the six mechanisms for effector secretion elucidated in gram-negative bacteria, particularly notable for its significant structural homology with T4 bacteriophage . (kenyon.edu)
  • the most significant structural component of the bacteriophage baseplate . (kenyon.edu)