• EMBL Grenoble shares the European Photon and Neutron (EPN) science campus with the European Synchrotron Radiation Facility (ESRF), the Institut Laue-Langevin (ILL, Europe's high flux neutron source), and the French Institut de Biologie Structurale (IBS). (embl.org)
  • We are now also aiming to understand molecular recognition and synapse formation in a disease context using a combination of protein biochemistry/biophysics, structural biology and mammalian cell biology approaches. (academictransfer.com)
  • The department features a strongly multidisciplinary and international team of scientists, whose research areas include single-molecule biophysics, synthetic biology, as well as (quantitative) cell biology. (academictransfer.com)
  • The Structural Biochemistry group at Freie Universität Berlin uses macromolecular crystallography (MX), single-particle cryo-electron microscopy (cryoEM) and analytical Biochemistry/Biophysics in combination with in vitro and in vivo functional assays to elucidate the molecular mechanisms, by which RNAs and proteins cooperate in molecular ribonucleoprotein (RNP) machineries. (fu-berlin.de)
  • Our group combines structural biology, computational biology, biophysics and virology techniques to study viral surface complexes and develop antiviral therapies. (pasteur.fr)
  • The Structural Biology of Infectious Diseases Unit is a lab dedicated to investigate the entry of large viruses into host cells combining structural biology, biophysics and virology approaches. (pasteur.fr)
  • The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
  • The Research Department of Structural and Molecular Biology (SMB) is an outstanding place to begin a research career. (ucl.ac.uk)
  • We use state-of-the-art facilities in X-ray crystallography, NMR spectroscopy, mass spectrometry, cryo-electron microscopy, imaging, biophysical and biochemical analysis, molecular and cell biology. (ucl.ac.uk)
  • Our research combines molecular-genetic, biochemical, biophysical and engineering approaches to investigate various basic and applied aspects of algal biology. (ucl.ac.uk)
  • Students who fulfil UK residency requirements and are interested in Research Council or Wellcome Trust studentships should visit the Institute of Structural and Molecular Biology website for further details, as competition for these studentships is administered centrally by the ISMB. (ucl.ac.uk)
  • The course considers the basic physical chemistry required in cellular and molecular biology but does not require a previous course in physical chemistry. (yale.edu)
  • In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. (yale.edu)
  • Structural mechanism of molecular motors. (berkeley.edu)
  • MBL Grenoble's researchers focus mainly on RNA biology and infection biology, in particular on the structural molecular biology of protein-RNA complexes involved in cellular gene expression and host-pathogen interactions. (embl.org)
  • With specialist research groups and teams in both scientific areas research at EMBL Grenoble focuses on structural biology and molecular cell biology. (embl.org)
  • Structural Biology of Bacterial Pathogenesis, by Gabriel Waksman, Michael Caparon, and Scott Hultgren, is a state-of-the-art treatise describing the known molecular mechanisms by which bacterial pathogens actively probe, sense, and respond to their environment through 2-component systems and through sigma and anti-sigma factors. (cdc.gov)
  • The ideal candidate has a background in structural biology and is interested in applying cryo-electron microscopy and complementary molecular/cellular techniques to neurobiological questions. (academictransfer.com)
  • Integrated Structural Biology Infrastructure for Europe (INSTRUCT) has been voicing the needs and priorities of the field and will likely play an important role for the future of molecular and cellular structural biology research in Europe in the coming years. (xray.cz)
  • Structural characterization of the kinase/phosphatase family has contributed significantly to our understanding of the molecular mechanisms that regulate their activities. (pharmiweb.com)
  • Structural biology is a discipline within the life sciences, one that investigates the molecular basis of life by discovering and interpreting the shapes of macromolecules. (rd-alliance.org)
  • In other words, computational systems biology needs to be paralleled by a quantitative description at the molecular level. (univr.it)
  • The cellPACK software integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. (confex.com)
  • It was a joint event with the "2014: Crystal (cl)Year" conference, held in the context of the celebrations for the UNESCO International Year of Crystallography 2014, and the annual meeting of the Centre for Complex Systems in Molecular Biology and Medicine of the University of Torino. (biomedcentral.com)
  • Since its inception, many awards have recognized achievements made in molecular biology, structural biology, and related research. (sdsc.edu)
  • In the context of the United States' National Institutes countries of Health Roadmap for medical research, an initiative through public-private has been created to develop molecular libraries in order collaboration to facilitate the identification of drug targets and screening of compounds, to focus on structural biology, and to promote the development of bioinformatics, computational biology and nanomedicine. (who.int)
  • Our research focuses on major areas of modern biochemistry and molecular biology. (lu.se)
  • UCL is home to one of the largest concentrations in Europe of researchers in the exciting growth field of Bioinformatics and Computational Biology. (ucl.ac.uk)
  • CD BioSciences recruits a scientific team specializing in structural biology and bioinformatics, and offers state-of-the-art techniques and equipment, thus helping customers overcome challenges and bottlenecks in structural characterization. (pharmiweb.com)
  • CD BioSciences has extensive knowledge and years of experience in kinase/phosphatase biology, structural biology, bioinformatics, and drug development. (pharmiweb.com)
  • The fourteenth NETTAB workshop, NETTAB 2014, was devoted to a range of disciplines going from structural bioinformatics, to proteomics and to integrative systems biology. (biomedcentral.com)
  • Moreover, the usage of proteomic data for structural bioinformatics and integrative systems biology is not yet sufficiently explored. (biomedcentral.com)
  • The main purpose of a bioinformatics platform within SWEGENE should be to provide com- putational facilities and logistical support [databases & infrastructure] for scientists whose primary research in biology and medicine benefit from computational approaches. (lu.se)
  • The hopes in these documents are that a bioinformatics effort should cover a large part of the computational biology area, with islands of specific problem domains and very little discussion on how to coordinate a computational biology effort. (lu.se)
  • The first 18 months into the SWEGENE project, the fourth main effort within SWEGENE, bioinformatics, has not produced a proposal on how to meet the needs of the current bio- logical problem domain, or how they should advance into the near, and long term, future research areas within computational biology. (lu.se)
  • I was contacted to make a survey of the current status of the bioinformatics and compu- tational biology efforts within the groups and researchers with connections to SWEGENE facilities. (lu.se)
  • chemical biology, biochemistry, proteomics and cell biology to study the cellular impact of our small molecules in relevant cellular systems - for example cancer cells sensitive to the knockdown of the protein target in question, or model cell lines suitable for biological investigation of specific signalling pathways. (dundee.ac.uk)
  • CMPS is a highly integrated center comprising the divisions of Biochemistry and Structural Biology (Faculty of Science) and Biophysical Chemistry (Faculty of Engineering, LTH). (lu.se)
  • Rigorous introduction to the principles of macromolecular crystallography, aimed at students who are planning to carry out structural studies involving X-ray crystallography or who want to obtain in-depth knowledge for critical analysis of published crystal structures. (yale.edu)
  • The highly-experienced structural biology team at Jubilant Biosys supports structure-based drug discovery from gene to protein co-crystal structures with small-molecule compounds at high resolution using x-ray crystallography. (jubilantbiosys.com)
  • This book is enjoyable to read, is extensively referenced, and has 52 superb structural models in full color, based in part on x-ray crystallography. (cdc.gov)
  • The Cusack group uses X-ray crystallography and cryo electron-microscopy (cryoEM) to study the structural biology of protein-RNA complexes involved in RNA virus replication, innate immunity and cellular RNA metabolism. (embl.org)
  • The successful applicant will be the driver of a new project concerning detailed structural characterization of neurodegeneration at the neuronal synapse. (academictransfer.com)
  • CD BioSciences Introduces Structural Characterization Ser. (pharmiweb.com)
  • CD BioSciences, a leading US-based service supplier focused on kinase/phosphatase biology, now introduces a series of structure characterization services for kinase/phosphatase biology research and drug development. (pharmiweb.com)
  • CD BioSciences has an experienced team of scientists capable of providing different primary and advanced structural characterization strategies for various types of samples based on its advanced technology platform. (pharmiweb.com)
  • And now it provides comprehensive structure characterization services for kinase/phosphatase biology research and drug development, including crystallization and structure determination services, structural prediction and analysis services, as well as structure validation services. (pharmiweb.com)
  • Equipped with state-of-the-art facilities and technology, CD BioSciences is able to provide trusted and comprehensive structural characterization services to meet customer requirements, guaranteeing that any data or details customers provide will be kept strictly confidential. (pharmiweb.com)
  • We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate our structural understanding into further mechanistic and functional studies. (stanford.edu)
  • Recent highlights include: the structure and function of long non-coding RNAs , the structure of the integrator complex , the determination of the mechanism of action of secreted Legionella effector proteins , and the structural and mechanistic analysis of the transcription/replication machines of influenza virus and lassa virus . (embl.org)
  • In this review , we discuss recent structural and mechanistic aspects of MCR-1 function, its variants and homologs, and how they are relevant to polymyxin resistance. (bvsalud.org)
  • Structural Insights into the Mechanism of Dynamin Superfamily Proteins. (nih.gov)
  • Structural biologists are particularly interested in proteins because they do so much of the work in the body. (nih.gov)
  • Jubilant Biosys offers high-quality proteins for enzymatic assays, high throughput screening, biophysical and structural studies. (jubilantbiosys.com)
  • This work confirms the feasibility of using a particle accelerator as a structural biology tool to obtain, in a single laser "flash", a photograph of unique particles (viruses, bacteria, proteins, cells, etc.) and represents a "historical" step forward in the structural biology field. (nanowerk.com)
  • Proteins provide the crucial structural elements of all cells and mediate the executive functions required for cell survival. (uni-muenchen.de)
  • Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. (yale.edu)
  • The project should involve both studies of protein function by the applicant researchers and structural studies by the PSI:Biology network. (nih.gov)
  • Structural biology has a strong tradition of data sharing, expressed by the founding of the Protein Data Bank (PDB) in 1971 (PDB, 1971). (rd-alliance.org)
  • The work presented in this seminar uncovers structural and energetic aspects of components of the cellular cascade. (univr.it)
  • We are pioneering both multi-disciplinary approaches aimed to bridge across the scales of biology, and methods to integrate disparate data across the disciplines. (ucl.ac.uk)
  • The Czech structural biology community is characterized by a wide spectrum of experimental and computational approaches but limited capacity and sub-critical mass in many techniques. (xray.cz)
  • Faculty of this division also participate in interdepartmental programs in structural biology, chemical biology, microbiology and toxicology. (berkeley.edu)
  • The potential impact of these investigations are directly in the area of translational chemical biology and drug discovery. (dundee.ac.uk)
  • UCL and the Department of Biological Sciences at Birkbeck created the Institute for Structural Biology (ISMB), one of the largest research centres for research in multidisciplinary research around structural biology in the world. (ucl.ac.uk)
  • Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. (yale.edu)
  • Activities at EMBL Grenoble focus on integrated structural biology research, and on developing state-of-the art instrumentation, methods and services. (embl.org)
  • The four institutes join forces in the Partnership for Structural Biology (PSB), which provides a uniquely comprehensive range of state-of-the-art structural biology platforms for sample production, sample characterisation and structure determination for both in house research and external users. (embl.org)
  • Formation of a national structural biology platform to foster the future development in this field and represent the needs and benefits of this research field in communication with the Czech Ministry of Education, Youth and Sports and INSTRUCT has been agreed on at the first National User Group meeting in Prague in December 2009. (xray.cz)
  • We collaborate with several research groups within the School, including the Divisions of BCDD, MRC-PPU, GRE, and CSI, to deploy our chemical tools to interrogate the biology of targets of interest and to dissect the functional consequences of disrupting the signalling networks in which they are involved. (dundee.ac.uk)
  • With years of experience, CD BioSciences has established a strong scientific research team and a fully integrated kinase/phosphatase biology platform, providing one-stop service and customized solutions to fully meet the specific needs of customers. (pharmiweb.com)
  • The culture of structural biology is therefore already in line with perspective of the European Commission that data from publicly funded research projects are public data (COM(2011) 882 final). (rd-alliance.org)
  • The report proposed as an "RDA Supporting Output" summarizes the European situation in research data management in some fields of structural biology. (rd-alliance.org)
  • Combined proteomic technologies can indeed produce complex, integrated datasets that may also constitute a sound support for systems biology research. (biomedcentral.com)
  • We are a team of structural and chemical biologists aiming to answer these questions at the level of ångstroms, nanometers, and micrometers. (stanford.edu)
  • This document reports how structural biologists perform these tasks, and recommends improvements to the infrastructure available to them. (rd-alliance.org)
  • An in-depth analysis of macromolecular structure and its elucidation using modern methods of structural biology and biochemistry. (yale.edu)
  • The Journal of Structural Biology is a peer-reviewed scientific journal concerning the structural analysis of biological materials at all levels of organization and the functional consequences of such observations. (wikipedia.org)
  • Structural and functional studies of receptor/ligand interactions relevant to human health and disease in immunity, infection, and neurobiology. (stanford.edu)
  • Genomics describes the determination of the nucleotide sequence and many further analyses to discover functional and structural information on all the genes of an organism. (yale.edu)
  • The structural biology team provides the following functional services that help to accelerate small-molecule drug discovery and have a track record serving more than 20 pharmaceutical/biotech companies worldwide. (jubilantbiosys.com)
  • Our structural work on influenza polymerase has opened up the area of structure-based drug design of novel anti-virals targeting multiple functional sites on the polymerase. (embl.org)
  • The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors. (stanford.edu)
  • Structural biology is the study of how biological molecules are built. (nih.gov)
  • Structural studies have also shown how misshapen molecules make us sick, and as a result, these studies have prompted new treatments for many diseases. (nih.gov)
  • The workshop aimed at representing a virtual bridge between these two events, showing how to manage and elaborate structural and high-throughput proteomics data so that it may be integrated with information from other life sciences disciplines with the aim of reaching a richer description and a deeper understanding of mechanisms and interactions in the involved system: the human being and its physiological and pathological states. (biomedcentral.com)
  • This FOA encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. (nih.gov)
  • For smaller centres this is onerous - it is desirable that a standard package is provided enabling them to use the European e-infrastructure resources, in a way that integrates with other structural biology resources. (rd-alliance.org)
  • Structural studies on bioactive compounds. (rcsb.org)
  • We complement structural studies with in vitro polymerase enzymology and in-cell studies using mini-replicon systems, and, in collaborations, recombinant viruses and live-cell imaging. (embl.org)
  • Specifically, we discuss work on polymyxin -mediated disruption of the outer and inner membranes , computational studies on the catalytic mechanism of MCR-1, mutagenesis and structural analysis concerning residues important for substrate binding in MCR-1, and finally, advancements in inhibitors targeting MCR-1. (bvsalud.org)
  • Nanowerk News ) An international interdisciplinary consortium of more than 20 laboratories (1) , including the CNRS laboratory Information Génomique et Structurale, has achieved an extraordinary feat: producing an ultra powerful X-ray laser beam to visualize a single viral particle in a single flash lasting several femtoseconds (10 -15 seconds). (nanowerk.com)
  • Researchers could thus explore, for the first time, the existence of structural polymorphism of viral particles. (nanowerk.com)
  • The cell counters RNA viruses with innate immune pattern-recognition receptors, such as the RNA helicase RIG-I, which recognise particular viral RNA structural motifs (e.g. 5′ triphosphate-dsRNA) as non-self, thus activating a signalling pathway leading to interferon production and establishment of the anti-viral state. (embl.org)
  • However, the data infrastructure for structural biology is not a perfect match for this workflow. (rd-alliance.org)
  • Cambridge) Christopher Dobson (University of Cambridge) Structural Genomics: Udo Heinemann (Max-Delbrueck-Centrum, Berlin) Janet Thornton (EMBL-EBI, Cambridge) Robert Konrat (University of Vienna) Stephen Burley (Structural GenomiX, Inc.) Free Electron Lasers in Structural Biology: Janos Hajdu (Uppsala University) Hodgson (Stanford University) Participation Fees: Early Fee (before 1st August 2003) Regular. (bio.net)
  • Georgios Skiniotis is a structural biologist with expertise in electron cryo-microscopy (cryoEM). (stanford.edu)
  • These services can help validate structures in databases or structural data provided by customers, from crystallization to structure validation, to save scientists' investigation time and cost. (pharmiweb.com)
  • Informal applications are welcome from students who wish to study for a PhD in an aspect of algal biology or biotechnology, particularly those students who have an independent source of funding (e.g. a government scholarship). (ucl.ac.uk)
  • The structural work has been showcased through publications in peer-reviewed international journals (where the Biosys team is co-authored with clients). (jubilantbiosys.com)
  • In addition, a number of technology-focused instrumentation teams provide an invaluable resource of technical know-how and support to aid the scientific community in the structural biology realm. (embl.org)