Strongly associated hla b antigens. Medical search. Frequent questions

However, the HLA alleles explain only part of the genetic susceptibility to CD. (helpforibs.com)
Multiple and unique human leukocyte antigens (HLA) class II alleles are associated with systemic sclerosis and specific antibodies profile. (statpearls.com)
Multiple genetic loci have been reported to be associated with AIH, in which human leukocyte antigen (HLA) alleles were strongly associated with disease onset and clinical manifestations for decades. (whocc.org.cn)
Patients with TRBV11-2 expansion shared HLA class I alleles A02, B35, and C04, indicating what we believe is a novel mechanism for CDR3-independent T cell expansion. (mendeley.com)
Rats transgenic for the human MHC molecule HLA-B27 were used to study the effect of two alleles, cim a and cim b , which are associated with peptide transport by the MHC-encoded Tap2 transporter, on the function of HLA-B27 as a restriction element for CTL recognition of the male H-Y minor H Ag and on the multisystem inflammatory disease characteristic of B27 transgenic rats. (elsevierpure.com)
Immuno-informatic analysis predicted that the identified T-cell antigens (AgA and AgD) bind more number of class I and class II HLA alleles as compared with the reference immuno-dominant antigens ESAT-6 and CFP-10 from the tuberculous mycobacterial species M. tuberculosis. (cdc.gov)
Collectively, our results imply that AgA and AgD are T-cell antigens with a high HLA binding frequency as well as population coverage for HLA alleles. (cdc.gov)
We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)

We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)

Narcolepsy is strongly associated with specific human leukocyte antigen (HLA) haplotypes, but the cause is not thought to be genetic. (msdmanuals.com)
For example, HLA DQB1*0301, DRB1*1104, and DQA1*0501 haplotypes were found to be strongly associated with systemic sclerosis. (statpearls.com)
We reported correlations between classical Human Leukocyte Antigen (HLA) haplotypes and bipolar disorders, schizophrenia and autism spectrum disorders ( rev in Tamouza et al, 2021 ). (inserm.fr)
HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)

That is, persons who have the human leukocyte antigen B27 (HLA-B27) are most susceptible. (wikipedia.org)
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. (rcsb.org)
Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02. (plos.org)
It is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02, indicating an autoimmune-mediated process [9] , [10] . (plos.org)
Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
In a recent meta-analysis using greater than 100 000 subjects, the 100 RA risk loci outside the human leukocyte antigen region explained only 5.5% and 4.7% of heritability in Europeans and Asians, respectively. (nature.com)
The neuropeptide hypocretin-1 is deficient in cerebrospinal fluid (CSF) of narcoleptic animals and most human patients, suggesting that the cause may be HLA-associated autoimmune destruction of hypocretin-containing neurons in the lateral hypothalamus. (msdmanuals.com)
Sm specific T cells play an important role in class switching anti-Sm autoantibodies and participate as disease effectors, and anti-Sm autoreactivity is strongly associated with the human leukocyte antigen (HLA)-DR15. (lupusresearch.org)
Limited expression of human being leucocyte antigen-G (HLA-G) to fetal extravillous trophoblast cells which invade the decidua during implantation suggests a role for HLA-G in placentation. (biotech2012.org)
As control we used a human leukocyte antigen DR (HLA DR) antibody with equal inhibitory capacities on cell proliferation. (biomedcentral.com)
Histocompatibility laboratories test compatibility of transplant candidate and organ donor tissues using the human leukocyte antigen (HLA) complex. (hrsa.gov)
CeD is triggered by gluten consumption in genetically susceptible individuals carrying certain major histocompatibility complex (MHC) class II human leukocyte antigen (HLA) variants ( 5 , 6 ). (frontiersin.org)
A large number of microsatellite genetic markers have been identified in the human leukocyte antigen (HLA) region. (geneticsmr.com)
To perform this function, DC are capable of capturing antigens, processing them, and presenting them on the cell surface complexed to major histocompatibility (MHC) molecules, for example, human leukocyte antigen- (HLA-) DR. Along with that, context-dependent expression of costimulatory molecules, such as CD80 and CD86, and secretion of cytokines occurs. (hindawi.com)
T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human leukocyte antigens) in humans. (bcm.edu)
Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behçet's disease (BD). (ox.ac.uk)
1. Genetic predisposition: Dermatitis herpetiformis is strongly associated with the human leukocyte antigen (HLA) gene, which is responsible for the body's immune system. (rarediseaseshealthcenter.com)
Molecular structure of human histocompatibility antigens: the HLA-C series. (ox.ac.uk)
TAMOUZA R, KRISHNAMOORTHY R, LEBOYER M. Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context. (inserm.fr)
Development of a number of common forms of inflammatory arthritis (the spondyloarthritides), which include Ankylosing Spondylitis is strongly associated with possession of the Human Leukocyte Antigen (HLA) class I allele HLA-B27. (ox.ac.uk)
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
As the MHC is encoded by highly polymorphic human leukocyte antigen (HLA) loci in humans, this process of thymic selection occurs within the context of an individual's HLA type. (biorxiv.org)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
Onset is typically in the third decade, with a higher incidence in Caucasians and an association with human leucocyte antigen (HLA)-B27. (hospitalprofessionalnews.ie)
These antigens also activated the human naïve CD4+ T cells in presence of autologous DCs as measured using ELISPOT for IFN-gamma. (cdc.gov)

Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)

Interestingly, the number of CD80 + pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. (hindawi.com)
T cells play essential effectors and regulatory roles in adaptive immune responses to tumors, viruses, bacteria, parasites, transplanted tissues, allergens and even to self antigens. (bcm.edu)

Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. (rcsb.org)
In fact, the HLA locus which is the main inherited genetic susceptibility factor for CeD, only accounts for ~ 40% of the genetic variance of the disease. (frontiersin.org)
A recent genome wide association study identified that two loci (SH2B3 and CARD10) increased susceptibility of AIH, in addition to the HLA loci. (whocc.org.cn)

however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
Nevertheless, autoantibodies can be induced by immunized healthy BALB/c mice with synthetic peptides of the mouse bullous pemphigoid antigen 2 NC16A domain. (medscape.com)

Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. (rcsb.org)
In Aim 1, we will define the dominant pathogenic Sm T cell epitopes by immunizing HLA-DR15 transgenic mice with overlapping peptides encompassing all nine Sm proteins, and determine if these epitopes are naturally presented by peptide elution MALDI-TOF mass spectrometry experiments. (lupusresearch.org)
In Aim 2, we will generate HLA-DR15 recombinant molecules covalently linked to the dominant Sm T cell epitopes. (lupusresearch.org)
This work will define the Sm T cell epitopes in the most clinically relevant HLA II in SLE, provide information including HLA II-epitope molecular structure and phenotype of Sm specific T cells, and push towards an antigen-specific therapeutic option for SLE. (lupusresearch.org)
Signals through certain CD45 epitopes are strongly immunosuppressive in vitro . (biomedcentral.com)
We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)
This first report on T-cell antigens and epitopes of M. immunogenum is significant as it is expected to open up avenues for understanding pathogenesis mechanisms and developing T-cell-based immunodiagnostic tools for this poorly investigated occupational lung disease. (cdc.gov)

CD is associated with HLA molecules DQ2 (90%-95%) and DQ8 (5%-10%), and in the continued presence of gluten the disease is self-perpetuating. (helpforibs.com)
2] Ultimately, the interaction between gliadin peptides and HLA molecules activates intestinal T cells. (helpforibs.com)
Using these molecules, we will solve the crystal structure to elucidate the molecular conformation that drives the anti-Sm T cell response, and generate HLA-DR15 tetramers to determine the frequency, phenotype of anti-Sm specific T cells as well as obtain clonally expanded paired Valpha and Vbeta T cell receptor (TCR) sequences from SLE patients with active disease. (lupusresearch.org)
HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
Stimulation with CD105+ EVs, but not with CD105- EVs, strongly reduced the costimulatory molecules such as CD80 (CD105+ EV Mo: 26.3? (woofahs.com)
Several environmental, genetic, and immune factors create a "perfect storm" for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. (frontiersin.org)
In this review, we will discuss how tissue destruction in the context of coeliac disease results from the complex interactions between gluten, HLA molecules, TG2, and multiple innate and adaptive immune components. (frontiersin.org)
However, while up to 40% of the general population in Western countries express one of the predisposing HLA molecules, the global prevalence of CeD is just 1% ( 8 ). (frontiersin.org)
In addition, we also uncovered an association between the immunomodulatory non-classical HLA molecules i.e. (inserm.fr)
Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)

The most well-studied of these genes is HLA-DQB1 , which provides instructions for making part of a protein that plays an important role in the immune system. (medlineplus.gov)
The HLA-DQB1 gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. (medlineplus.gov)
A variation of the HLA-DQB1 gene called HLA-DQB1*06:02 has been strongly associated with narcolepsy, particularly in people who also have cataplexy and a loss of hypocretins. (medlineplus.gov)
Most people with narcolepsy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes. (medlineplus.gov)
HLA-DQA1 and -DQB1 genotypes were also assigned in 45 of the SLE patients and 74 controls by PCR using sequence specific primers. (ox.ac.uk)
HLA-DQB1*0201 was not associated with development of the disease itself, but was associated with the presence of Ro antibodies (p = 0.01). (ox.ac.uk)
HLA-DRB1*03 was less strongly linked to DQB1*02 in this population than in white populations and was not associated with SLE. (ox.ac.uk)
Another gene, possibly HLA-DQB1*02, not linked to DR2 is involved in the subset of patients exhibiting Ro antibodies. (ox.ac.uk)
90-95% of CeD patients carry the HLA-DQ2.5 variant (DQA1*05:01, DQB1*02:01) that confers the highest risk of developing CeD while the remaining patients carry HLA-DQ2.2 (DQA1*02:01, DQB1*02:02) or HLA-DQ8 (DQA1*03, DQB1*03:02) ( 5 , 7 ). (frontiersin.org)
DQB1*0602 was weakly associated with disease in all patients, but was strongly increased among HPV16-seropositive patients compared to HPV16-seropositive controls. (nih.gov)

We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)
Circulation cytometry Monoclonal antibodies (mAbs) used in this study to bind HLA-G were G233 (Loke (1993) by amplifying a 141 or 155 bp region spanning the polymorphism using the primers 5′-GTAGTGTGAAACAGCTGCCC-3′ and 5′-AAGGAATGCAGTTCAGCATGA-3′ and resolving products by electrophoresis having a 3% low-melting-point agarose gel. (biotech2012.org)
In addition, rabbit antibodies raised against type VII collagen (epidermolysis bullosa acquisita antigen) are also capable of inducing blisters in mice. (medscape.com)

The HLA molecule forms a "groove" where short peptides (eg, a product of gliadin digestion) can be specifically linked. (helpforibs.com)
and the antigen presenting molecule HLA-DR (CD105+ EV Mo: 58.3? (woofahs.com)

We have previously shown that Scandinavian sarcoidosis patients expressing the HLA-DR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4+ T cells expressing the TCR AV2S3 gene segment. (jci.org)
ABC hypersensitivity, a potentially fatal reaction, is highly associated with the presence of the HLA-B*5701 allele. (hiv.gov)
However, we detect a significant correlation between increased HLA allele sharing and increased number of shared TCRβ clones, with each additional shared HLA allele contributing to an increase in ∼0.01% of the total TCRβ clones being shared, supporting a key role for HLA type in shaping the immune repertoire. (biorxiv.org)
Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. (cdc.gov)

IL-8 production was primarily seen in HLA-DR+ cells which are predominantly macrophages in our decidual leucocyte preparations (Gardner and Moffett 2003 IFN-γ was produced after 6 h stimulation with PMA confirming that dNK cells can produce this cytokine. (biotech2012.org)
The present authors have previously shown that the anatomical microlocalisation of macrophages in NSCLC strongly predicts patient survival, regardless of cancer stage 4 . (ersjournals.com)

By offering exquisite antigen specificity and sensitivity, it is suitable for basic and clinical study in a number of applications including cancer prevention, cancer therapy, cell and gene therapy, immunotherapy, drug / vaccine development, and non-cancer related immunology research. (bcm.edu)
Superantigen specificity for different Vβ chains results in Vβ skewing, whereby T cells with specific Vβ chains and diverse antigen specificity are overrepresented in the T cell receptor (TCR) repertoire. (mendeley.com)
Antigen recognition depends on both T-cell specificity and the molecular complex presenting the antigen. (biorxiv.org)

Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. (rcsb.org)
Desire to identify antigen-specific T cells through the MHC/peptide complex was always there. (bcm.edu)
We hypothesize that the role of HLA-B27 in spondyloarthropathy stems from its function in antigen presentation, either in peptide selection and binding or in other aspects of its cell biology. (ox.ac.uk)
These results indicate that RT1-linked Tap2 polymorphism in the rat strongly influences peptide loading of HLA-B27. (elsevierpure.com)
These two antigens were further predicted to be highly immunogenic for class I peptide MHC (pMHC) complex as compared to the reference antigens. (cdc.gov)

METHODS: HLA-DRB1 genotype frequencies assigned by polymerase chain reaction (PCR) amplification and sequence specific oligonucleotide probes were compared between 49 black SLE patients from Baragwanath Hospital and 87 ethnically matched controls. (ox.ac.uk)

The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). (medlineplus.gov)
We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
In this direction, purified recombinant form of five of the seroreactive proteins (reported in our initial study), including three cell wall-associated (arbitrarily designated as antigens A through C) and two secretory (AgD & AgE), were examined for their potential to activate antigen-presenting cells (APCs) viz. (cdc.gov)

One of the immune cells' main targets is a portion of the cell nucleus referred to as the Smith antigen. (lupusresearch.org)
Regulatory T cells that recognize the Smith antigen might be able to shut down these harmful immune cells. (lupusresearch.org)
Their work will identify which parts of the Smith antigen that immune cells respond to. (lupusresearch.org)
Though only present in 30-40% of SLE patients, compared to less specific autoantibody targets, Sm represents the best opportunity for antigen-specific immune regulation in SLE. (lupusresearch.org)
Conclusions In conclusion, the results of the present study indicate that renal cancer cells and in particular CSCs and derived EVs impair maturation of DCs and T cell immune response by a mechanism involving HLA-G. Electronic supplementary material The online version of this article (doi:10.1186/s12885-015-2025-z) contains supplementary material, which is available to authorized users. (woofahs.com)
This finding suggests that these HLA variants contribute to, but are not sufficient for, the development of the disease and that additional genetic and environmental factors are needed to mount a pathogenic immune response against gluten ( 9 ). (frontiersin.org)
These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbiota. (biomedcentral.com)
T cells that encounter their specific cognate MHC-presented antigen will bind and proliferate, leading to an immune response. (biorxiv.org)
Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)
The T lymphocyte-mediated immune lung disease hypersensitivity pneumonitis (HP) in machinists is poorly understood for disease mechanisms and diagnosis due in part to lack of information on causative T-cell antigens of the etiological agent Mycobacterium immunogenum (MI). (cdc.gov)

In untreated HIV infection, associations between HLA genetic polymorphism and disease progression were identified in several studies, using both candidate gene (reviewed in Carrington and O'Brien, 2003 ), and genome-wide strategies ( The International HIV Controllers Study, 2010 ). (frontiersin.org)
HLA gene distribution correlates with increased questions. (cdc.gov)

HLA class II antigens associated with systemic lupus erythematosus in black South Africans. (ox.ac.uk)

The presence of HLA-B27 antigen is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disease of the axial musculoskeletal system, and a few other rheumatic disorders (Reiter's syndrome, acute anterior uveitis, and inflammatory bowel disease). (bdbiosciences.com)
In Aim 3, we will retrovirally transduce Sm-specific TCR sequences onto polyclonally expanded Tregs ex vivo and investigate the efficacy of these Sm antigen specific Tregs compared to polyclonal Tregs in suppressing pro-inflammatory Sm specific autoreactivity. (lupusresearch.org)
For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
T cell immunity is at the center of the disease contributing to the inflammatory process through the loss of tolerance to gluten and the differentiation of HLA-DQ2 or HLA-DQ8-restricted anti-gluten inflammatory CD4 + T cells secreting pro-inflammatory cytokines and to the killing of intestinal epithelial cells by cytotoxic intraepithelial CD8 + lymphocytes. (frontiersin.org)
Researchers have long studied the phenomenon of why certain forms of HLA are associated with autoimmune and inflammatory disorders and the severity of those disorders. (neurosciencenews.com)
The antigen for MRP 8/14 has been found in inflammatory tissues only and shown to be absent from normal resident mononuclear phagocytes 13 . (ersjournals.com)

CD is strongly associated with HLA class II antigens, and approximately 90% of cases show a particular DQ2 alpha/beta heterodimer, with the remaining cases being HLA DQ8-positive. (helpforibs.com)
Given these indications that the reported findings of IFN-γ and IL-8 production by dNK cells are in response to stimulation we tested dNK cell degranulation when cultured with HLA class I-null target cells (Fig.?4C). (biotech2012.org)
OBJECTIVE: To assess the associations of HLA class II antigens with systemic lupus erythematosus (SLE) in black South Africans. (ox.ac.uk)

Reactive arthritis is a complication strongly associated with a particular genetic make-up. (wikipedia.org)
therefore, reactive arthritis is strongly associated with HLA-B27. (medscape.com)
Because of its association with HLA-B27 and its clinical overlap with ankylosing spondylitis and psoriatic arthritis, reactive arthritis is classified as a seronegative (for rheumatoid factor) spondyloarthropathy. (medscape.com)

Genotyping was performed using an ABI PRISM 7900HT instrument and HLA-SE genes were identified using PCR sequence-specific primers. (nih.gov)
The single-nucleotide polymorphism in the 3′-UTR of HLA-G in the miR-148a/b-binding site was typed by PCR with the primers 5′-TCTCCTGCAACAAATCAGCAC-3′ and 5′-AAGGGGCTGGGATGTC-TCCG-3′ and sequencing of products using the same primers and an ABI 3730 DNA analyzer (Applied Biosystems). (biotech2012.org)

The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)

peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
Peptides bound to HLA-B*51:01 were eluted and analyzed by mass spectrometry. (ox.ac.uk)

Autoantibodies specific for the Sm antigen are strongly associated with disease severity in SLE. (lupusresearch.org)
Moreover, we showed that antigen specific Tregs are of much greater potency than polyclonal expanded Tregs, suppress autoimmune disease in an antigen specific manner, and, importantly, block the expansion of antigen specific T follicular helper cells, the key T cell subset for the development of autoantibodies. (lupusresearch.org)
Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. (cdc.gov)

As a result, VDJ recombination, HLA restriction, and antigen exposure collectively contribute to a largely private TCRβ repertoire. (biorxiv.org)

We then refined pivotal GWAS-based observation strongly implicating the major histocompatibility complex (MHC) in the development of psychiatric disorders. (inserm.fr)
Foreign antigens are first processed and presented by an individual's major histocompatibility complex (MHC). (biorxiv.org)

Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. (rcsb.org)
Once they know that, they will be able to genetically engineer regulatory T cells to protect cells carrying the Smith antigen in mice. (lupusresearch.org)
Here, we propose to determine the molecular mechanism for anti-Sm autoimmunity, potentially leading to a novel way to develop Sm antigen specific regulatory T cells (Tregs) to treat patients with SLE. (lupusresearch.org)
We then measured functional DB07268 reactions of dNK cells with LILRB1 when stimulated by HLA-G in both monomeric and dimeric conformations. (biotech2012.org)
Degranulation interferon-γ and interleukin-8 production by dNK cells freshly isolated from your 1st trimester implantation site were either undetected or not affected by HLA-G. These findings should be considered when inferring the activity of cells NK cells from results acquired with cell lines peripheral NK or cultured dNK cells. (biotech2012.org)
Pulse chase and immunoprecipitation 721.221 cells transfected with HLA-G were starved for 30 min in the medium lacking cysteine and methionine labelled for 20 min with 0.1 mCi/ml l-[35S]methionine and l-[35S]cysteine (Promix GE Healthcare) and chased in a regular medium for the indicated times. (biotech2012.org)
Decidual leucocytes from normal first trimester pregnancies were analysed immediately after isolation by intracellular flow cytometry for the production of IFN-γ … We then sought to investigate modulation by HLA-G of dNK cell degranulation responses to target cells. (biotech2012.org)
Neither monomeric nor dimeric forms of HLA-G affected degranulation of dNK cells (Fig.?5D). (biotech2012.org)
Degranulation of PBNK cells was inhibited by HLA-G consistent with previous reports (Perez-Villar by flow cytometry on EVT cells isolated from 70 normal first trimester pregnancies. (biotech2012.org)
This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
The system has been mainly related to the expression of HLA-G by tumor cells and to its release in a form associated to EVs. (woofahs.com)
DC are professional antigen-presenting cells with the unique capacity to polarize the differentiation of T cells, thereby regulating the balance between inflammation and tolerance [ 12 ]. (hindawi.com)
In the 1994-1995, this problem was solved by the development of a revolutionized technique called "MHC Tetramer", which bind strongly to antigen-specific T cells due to an increased avidity effect. (bcm.edu)
We first described the ability of HLA-B27 to form homodimers and have shown that these homodimers are present on the surface of spondyloarthritis patients' cells as well as in B27 transgenic models of disease, and identified cellular receptors for B27 homodimers including KIR3DL2. (ox.ac.uk)
Successful antigen recognition requires T cells to effectively recognize the body's MHC and coordinate a response. (biorxiv.org)
These cells are reported to express the CD163 antigen 7 , 8 . (ersjournals.com)

The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1). (ox.ac.uk)
Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. (ox.ac.uk)
This unconventional group of HLA-B*51:01-bound peptides was relatively enriched for 8-mers (with relatively fewer 9-mers) compared with the Pro2 and Ala2 subpeptidomes and had similar N-terminal and C-terminal residue usages to Ala2 peptides (with the exception of the less abundant leucine at position Ω). (ox.ac.uk)
Also, whereas essentially all of the HLA-A and B antigens and about half of the HLA-CW2 antigen were adsorbed strongly by Lens culinaris lectin-Sepharose, the remaining HLA-CW2 antigen was bound much more weakly and did not require sugar for elution. (ox.ac.uk)

We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)

Despite extensive studies, the pathogenic role of HLA-B27 in the spondyloarthritides remains unknown. (ox.ac.uk)

These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA. (rcsb.org)
HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. (cdc.gov)

receptor B1 DB07268 (LILRB1) which binds dimeric HLA-G strongly. (biotech2012.org)

Surprisingly, we find that shared antigen exposure to CMV leads to fewer shared TCRβ clones, even after controlling for HLA, indicative of a largely private response to major viral antigenic exposure. (biorxiv.org)

These include possible molecular mimicry as some of these viruses contain antigens that were found to share immunogenicity with endothelial peptides. (statpearls.com)
Each antigen comprised a glycosylated polypeptide of 43 000 molecular weight that is noncovalently associated with beta2-microglobulin (beta2m). (ox.ac.uk)

Now, we propose a novel method, using the latest technologies, to determine the structure/function relationship between HLA-DR15 and anti-Sm autoimmunity in SLE, and generate Sm antigen specific Tregs. (lupusresearch.org)

The major component of the genetic predisposition to CD resides in the HLA region of chromosome 6. (helpforibs.com)

However, certain factors such as low junctional diversity, thymic selection, and T-cell proliferation upon antigen exposure can affect TCR sharing among individuals. (biorxiv.org)

Firocoxib HLA-G blockade significantly reduced the inhibitory effect of EVs on DC differentiation. (woofahs.com)

Autoreactivity to the Smith (Sm) antigen is pathognomonic of SLE. (lupusresearch.org)

CONCLUSIONS Heavy cigarette smoking, but not smoking itself, is strongly associated with RA requiring hospital follow up and is markedly more prevalent in patients with RA without a family history of RA. (bmj.com)
HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex and area of residence. (nih.gov)
Intratumoral CD8 T cell infiltration and the immunogenic capacity of the host have been strongly correlated to survival in patients with MCC. (biomedcentral.com)

Association of BRC with the HLA-A29 major tissue histocompatibility (MHC) antigen was first reported in 1982, 2 years after the entity was originally described. (bmj.com)
7 , 8 LeHoang et al 9 found that BRC was associated with the HLA-A29-2 subtype, with a subsequent study confirming this link as well as an association with the HLA-A29-1 subtype. (bmj.com)
this follows earlier work demonstrating the structure-function association of HLA-DR4 and anti-CCP in RA (J Exp Med, 2013). (lupusresearch.org)
To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Västerbotten county of Northern Sweden. (nih.gov)

We can now identify and localize the risks within this complex HLA region more accurately than ever before, which opens the door to further developments. (neurosciencenews.com)
Later, the studies focused on the CD4-TCR-MHC II ternary complex where it was demonstrated that the presence of L3-12 TCR strongly supported the CD4-MHC II interaction by increasing the local density of MHC II inside the cell-SLB contacts. (lu.se)

132.03) for developing RA than the combination of the T variant and HLA-SE (OR = 7.85). (nih.gov)

Anatomy17

Organisms17

Diseases16

Chemicals and Drugs140

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes25

Disciplines and Occupations2

Humanities2

Information Science4

Named Groups2

Health Care5

Alleles10

Histocompatibility antigen1

Haplotypes4

Human26

Humans1

Self-antigens2

Susceptibility3

Mouse bullous pemphigoid antigen2

Epitopes9

Molecules10

DQB110

Antibodies3

Molecule2

Allele4

Macrophages2

Specificity3

Peptide5

Genotype1

Proteins3

Immune10

Gene2

Associated with systemic1

Inflammatory6

Class3

Reactive arthritis3

Primers2

Pathogenesis1

Peptides bound2

Autoantibodies3

Collectively1

Major histoco2

Cells17

Bound6

Ligands1

Pathogenic1

DRB12

Receptor1

Viral1

Molecular2

Autoimmunity1

Chromosome1

Junctional diversity1

Inhibitory1

Autoreactivity1

Patients3

Association4

Complex2

Variant1