• The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
  • This review is a holistic picture on actinobacter-derived cytotoxic compounds against CRC that provides a good perspective for drug development and design in near future. (frontiersin.org)
  • These FAM-peptide-FMK compounds are both cell permeable and non-cytotoxic during the course of the assay and thus allow the detection of active caspases in living cell systems. (immunochemistry.com)
  • Our results characterized trifluridine and adefovir dipivoxil as strong poxvirus antiviral compounds and further validate the VACV Gaussia luciferase assay as a highly efficient and reliable reporter tool for identifying poxvirus inhibitors. (cdc.gov)
  • The cytotoxic T lymphocytes (CTLs) typically susceptible to antigenic variation. (cdc.gov)
  • As expected, the team found that immune cells known as CD8+ T-lymphocytes, also known as cytotoxic T cells, are a powerful force in the life of SIV when it first causes infection. (rochester.edu)
  • Crowe discussed 4 different mechanisms of tissue injury that might apply to the pathogenesis of vasculitis: immune complexes, direct antibody-mediated damage, delayed hypersensitivity, and cytotoxic T lymphocytes. (medscape.com)
  • Using a combination of experimental methods they show that a cytotoxic C-terminal truncated form of the alpha-synuclein protein that is abundant in vivo, aggregates into more strongly twisted fibrils that are more exposed to water. (uva.nl)
  • EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P BAD ). (nature.com)
  • PRIMA-1(MET) was able to reduce mutated p53 protein in a proportion of TP53-mutated CLL samples, and this reduction correlated with a significantly stronger viability decrease and apoptosis induction than samples with stable p53 levels. (muni.cz)
  • The resulting TETAR responded to both epitopes with cytokine secretion and cytotoxic function. (nih.gov)
  • This nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle enhances antigen delivery and cross-presentation, generates a strong cytotoxic T-cell response with low systemic cytokine expression, and leads to potent tumor growth inhibition in melanoma, colon cancer and HPV tumor models. (utsouthwestern.edu)
  • Subjects must have received no more than 2 lines of prior systemic therapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the locally advanced or metastatic setting. (mayo.edu)
  • Tumor-specific neoantigens, which are expressed on tumor cells, can induce an effective antitumor cytotoxic T-cell response and mediate tumor regression. (wjgnet.com)
  • This collaboration to date has shown that DAVANAT® activates tumor-specific cytotoxic T-cells allowing them to kill tumor cells. (prnewswire.com)
  • Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. (anaspec.com)
  • Villagra and his research team found new non-canonical regulatory properties of these epigenetic drugs, discovering that the inhibition of HDAC6 has a powerful and strong effect on the immune system unrelated to the previously cytotoxic properties attributed to HDAC inhibitors. (newswise.com)
  • W]e have identified an immune cell signature combining CD8 cytotoxic T-cells and a distinct TAM subset reflecting anti- and pro-tumorigenic immune reactions," they report. (genomeweb.com)
  • We know that the virus confronts such a strong response from the body's immune system that the virus evolves quickly to cope with it. (rochester.edu)
  • A combination of thymol and carvacrol at equimolar concentrations to those present in the extract was less cytotoxic. (hindawi.com)
  • At physiologically relevant concentrations, Survanta produced well dispersed SWCNT without causing a cytotoxic or fibrogenic effect. (cdc.gov)
  • Conclusions: The results indicate that Survanta was effective in dispersing SWCNT in biological media without causing cytotoxic effects at the test concentrations used in this study. (cdc.gov)
  • This study was carried out to identify the main components of Origanum vulgare from Mt. Parnon, Southern Greece, assess the cytotoxic, antioxidant, and antimicrobial properties of the oregano extract, and delineate the contribution of the extract's major components towards such effects. (hindawi.com)
  • When both TCRs were transfected simultaneously, strong competitive effects occurred that were overcome by replacing the human constant domains of one TCR with murine counterparts and adapting the amounts of TCR-RNA used for transfection. (nih.gov)
  • This research demonstrates for the first time that HDAC6 inhibitors can both improve response to immunotherapy and diminish the invasiveness of breast cancer, with minimal cytotoxic effects. (newswise.com)
  • Histologically, we see significant cytotoxic effects with this agent, and preclinical experiments have shown strong synergy with a PD-1 antibody. (ahdbonline.com)
  • By elucidating the key structural aspects of the two fibrillar species, especially of the more cytotoxic 1-108-αS fibrils, the researchers hope to provide clues contributing to an understanding of molecular mechanisms underlying Parkinson's and other related amyloid diseases. (uva.nl)
  • In molecular biology, the sea anemone cytotoxic proteins are lethal pore-forming proteins, known collectively as actinoporins, a sub-class of cytolysins. (wikipedia.org)
  • However, the molecular characteristics of cytotoxic R-loops are not yet precisely defined. (ens-lyon.fr)
  • Non-cytotoxic assay arrests further apoptotic activity via caspase inhibition. (immunochemistry.com)
  • These results will be applied to a model for cell cycle specific cancer chemotherapy with cytotoxic and cytostatic agents. (aimsciences.org)
  • Molecularly targeted agents, such as HDAC6 inhibitors, have been widely described in the research literature as cytotoxic - toxic to both cancerous and healthy cells. (newswise.com)
  • Furthermore, we also report here our preliminary analysis of the use of CuTe nanocrystals as cytotoxic and photothermal agents. (icmab.es)
  • When cytotoxic agents alone are administered, the majority of the drug leaks out of the tumor. (ahdbonline.com)
  • All of the chemicals discussed of this chemical was raised to carci- lung and the nasal cavity were iden- here are IARC Group 1 agents and nogenic to humans (Group 1) based tified as target organs in humans as such can be characterized as on strong mechanistic evidence and rats, respectively. (who.int)
  • In several instances, tumour sites cytotoxic agents. (who.int)
  • A novel intratumoral chemotherapy agent delivered by direct injection permits the dispersion of cytotoxic drugs into cancer cells to eradicate tumors. (ahdbonline.com)
  • Background: Accumulating evidence indicate that the degree of dispersion of nanoparticle s has a strong influence on their biological activities. (cdc.gov)
  • This study was conducted to identify the major constituents of the ethanolic Origanum vulgare extract and examine the cytotoxic, antioxidant, and antibacterial properties of the extract but more importantly the contribution of its specific major constituent(s) or their combination to the overall extract biological activity. (hindawi.com)
  • Herbs and spices contain a wide array of phytochemicals with strong biological and pharmacological properties [ 1 ]. (hindawi.com)
  • Previous study has shown that kenaf seed oil extracted by SFE (KSO-SFE) is cytotoxic towards human cervical cancer cell line [ 7 ]. (hindawi.com)
  • Together, these results suggest a strong possibility of synergistic efficacy of GSE and Dox combination for breast cancer treatment, independent of estrogen receptor status of the cancer cell. (nih.gov)
  • The overall outcome of the thymic selection is the maintenance of a T-cell repertoire that has sufficient, but not too strong, affinity for any self-pMHC complex ( 29 ). (frontiersin.org)
  • [ 1 ] With the limited knowledge we have about PACNS, no strong evidence supports any of these mechanisms in the pathogenesis of this disease, although the granulomatous nature of inflammation suggests a role of cell-mediated immunity. (medscape.com)
  • Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
  • Compared with peers, JSKN003 demonstrated stronger bystander effect and the better serum stability. (cbinsights.com)
  • We show that JYNNEOS elicits a strong orthopoxvirus (OPXV)-specific antibody response in participants that peaks around day 42, or 2weeks after the second vaccine dose. (cdc.gov)
  • GSE plus Dox combination showed a very strong and significant G1 arrest in MDA-MB468 cells when compared with Dox alone, however, it was less than that observed with GSE alone. (nih.gov)
  • In conclusion, the oregano extract has cytotoxic, antioxidant, and antibacterial activities mostly attributed to carvacrol and thymol. (hindawi.com)
  • Studies examining the antioxidant activities of different forms of oregano (fresh, dry, and ready-to-use herb blend pastes) showed that oregano retains its strong antioxidant capacity in both fresh and dry form [ 2 ]. (hindawi.com)
  • 16.01.2014 - Strong Start - After beginning its investment in a brand-new cytotoxic molecule facility in Biasca, Switzerland, in 2011, Helsinn started production in July 2012. (chemanager-online.com)
  • This marker-defined signature had a strong prognostic impact in at least five main solid tumor types and a response predictive relevance in three tested tumor types. (genomeweb.com)
  • While scientists have known that the CD8 attack on the virus is strong, the latest work quantifies the body's response. (rochester.edu)
  • JSKN003 targets HER2 and triggers internalization and release the cytotoxic drug. (cbinsights.com)
  • It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. (harvard.edu)
  • CuTe nanocrystals display a strong near-infrared optical absorption associated with localized surface plasmon resonances. (icmab.es)
  • Sufficient conditions for the strong local optimality of a controlled reference bang-bang trajectory will be formulated in terms of solutions to associated sensitivity equations. (aimsciences.org)
  • A. Agrachev, G. Stefani and P. L. Zezza, A Hamiltonian approach to strong minima in optimal control, in Differential Geometry and Control , (G. Ferreyra, et al. (aimsciences.org)
  • Este artículo revisa los estudios experimentales centrados en el desarrollo de vacunas para el control de la toxocariasis, y se presta especial atención a los estudios epidemiológicos relevantes sobre la importancia de los caninos domésticos en la toxocariasis humana. (scielo.org.co)
  • In contrast, the novel INT230-6 formulation enables cytotoxic drugs to disperse and stay within the tumor, which has resulted in prolonged disease control in several patients with different tumor types," said Dr Thomas. (ahdbonline.com)
  • Their formation is likely to be a tell-tale sign of strong local topological constraints in the DNA. (ens-lyon.fr)
  • In addition, the Company has a strong management team, which is led by CEO Dr. Peter Traber , the former Chief Medical Officer of GlaxoSmithKline plc . (prnewswire.com)