Stromal cells germinal b cell. Medical search. Frequent questions

The primary B cell follicle matures in germinal centers. (wikipedia.org)
True lymphoid follicles, with or without germinal centers, are encountered in the stroma of both the ectocervix and endocervix. (medscape.com)
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
In addition, ectopic germinal centers characterized by CD21 + follicular dendritic cells were present in the renal interstitium. (biomedcentral.com)
The decreased megalin and cubilin expression may contribute to the proximal tubular reabsorption defect, possibly secondary to Th17 infiltration and formation of ectopic germinal centers. (biomedcentral.com)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)
The same antigen has also been shown to be expressed on CD4 + T cells derived from germinal centers. (lu.se)

The remaining follicular cells develop into a corpus luteum that produces E and progesterone (P). In turn, P promotes more proliferation within the uterus and vagina, and cornification in the vagina. (biomedcentral.com)

Antigens are also present on the surface of dendritic cells. (wikipedia.org)
In an inflammatory state, lymphatic endothelial cells increase their surface adhesion molecules, and dendritic cells express a surface CCR7 receptor. (wikipedia.org)
Due to this interaction, dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. (wikipedia.org)
Dendritic cells exhibit C-type lectin receptors (CLEC-2), which bind to gp38 on the surface of lymphatic endothelial cells. (wikipedia.org)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
These features may be responsible for the recruitment and activation of T cells, macrophages and dendritic cells, characterizing the stromal component of this lymphoma, and may point towards innate immunity and a tumor tolerogenic immune response in T-cell/histiocyte-rich large B-cell lymphoma. (haematologica.org)
Follicular dendritic cells (FDCs) are well characterized for their role in supporting B cell Ag encounter in primary follicles and in the GC LZ. (ox.ac.uk)
3. CXCR5 is the receptor for the chemokine CXCL13, secreted by follicular stromal cells and follicular dendritic cells in the B cell zones (i.e., lymphoid follicles) of secondary lymphoid organs. (justaaa.com)
The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen. (hindawi.com)
LT α is also required for the recruitment of dendritic cells, neutrophils, and macrophages to the mesentery in response to pristane [ 10 ]. (hindawi.com)
In addition to lymphocytes, dendritic cells can also produce LT α [ 15 ]. (hindawi.com)
TNF α plays an important role in the formation of primary B cell follicles and follicular dendritic cells [ 16 ]. (hindawi.com)
The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)

8 , 10 - 12 Recently, genome-wide analysis of isolated tumor cells from NLPHL and THRLBCL revealed further similarities between the tumors cells of the two lymphomas. (haematologica.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
Deletion of Lats1 results in low neonate survival and ovarian stromal tumors in surviving adults, but the effects of Lats1 on early follicular development are not understood. (appliedbioinfo.com)
Most of the testicular cancers arise from germinal cell tumors and spread rapidly. (planetayurveda.net)
These germ cell tumors are divided into seminomas and nonseminomas. (planetayurveda.net)
The mixed cell tumors are treated as nonseminomas as they grow and multiply like nonseminomas. (planetayurveda.net)
These Cells are generally involved in 40% of testicular tumors. (planetayurveda.net)

Diffuse large B-cell lymphomas (DLBCLs) are clinically heterogeneous and need a biomarker that can predict the outcome of treatments accurately. (oncotarget.com)

Antigen-presenting cells accumulate near high endothelial venules to process soluble antigens. (wikipedia.org)
Lymph node stromal cells express peripheral tissue-restricted antigens (PTAs) on their surface. (wikipedia.org)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. (water-bottle.ru)

As part of the inflammatory cells in the tumor microenvironment, neutrophils play both pro- and anticancer roles [ 9 ]. (biomedcentral.com)
At the same time, cancer cells shape the tumor microenvironment by secreting various cytokines and chemokines, providing the necessary environmental conditions for the reprogramming of neutrophils, which may explain the varied functions of neutrophils in cancer [ 12 ]. (biomedcentral.com)
Follicular lymphoma (FL) is the prototypical model of indolent B cell lymphoma displaying a strong dependence on a specialized cell microenvironment mimicking normal germinal center. (hal.science)
Finally, deciphering the interplay between stromal cells and FL cells provides potential new therapeutic targets with the aim to mobilize malignant cells outside their protective microenvironment and increase their sensitivity to conventional treatment. (hal.science)
The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different. (haematologica.org)
Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
Gene expression profiling of lymphomas clearly illustrated that apart from the characteristics of the tumor cells, the microenvironment of the tumor also defines the profile of the lymphoma, and, more importantly, plays a role in predicting the prognosis. (haematologica.org)
2011 Thus a full understanding of the ontogeny and function of the stromal microenvironment still requires that we uncover the genetic and transcriptional programs underlying mesenchymal cell differentiation and elucidate the molecular repertoire that characterize each stromal subsets during normal and pathological conditions. (technologybooksindustrialprojectreports.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

Stromal cells originate from multipotent mesenchymal stem cells. (wikipedia.org)

These sinuses are cavities containing macrophages (specialised cells which help to keep the extracellular matrix in order). (wikipedia.org)
The loss of TNF α delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells. (hindawi.com)
Other cells identified within bone marrow included macrophages and plasma cells, and these were more numerous in samples with MRI bone oedema (p = 0.02 and 0.05 respectively). (bmj.com)

The models use isolated primary support cells cultured onto a biological scaffold and within a microfluidic system to create a niche and support the desired differentiation of epithelia, germ and somatic cells from patient-derived induced pluripotent stem cells. (biomedcentral.com)
2001 thus indicating that different signaling molecules and cell types may be required for proper FRC differentiation in different lymphoid organs. (technologybooksindustrialprojectreports.com)
In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. (omicsdi.org)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)
A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
This session will also highlight the biomaterials that can direct cell fate and promote differentiation. (biomaterials.org)
We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. (lu.se)
Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. (lu.se)

Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)

We stained a tissue microarray consisting of 170 patients, including 72 intrahepatic cholangiocarcinomas (iCCAs), 57 perihilar cholangiocarcinomas (pCCAs) and 41 distal cholangiocarcinomas (dCCAs) by immunohistochemistry and evaluated PD-L1 positivity in tumor and stromal cells. (biomedcentral.com)
Immunohistochemistry revealed decreased expression of megalin and cubilin, two important multiligand protein receptors on the brush border of proximal tubular epithelial cells. (biomedcentral.com)
Based on the expression levels of Bcl-6, CD10, and MUM-1 measured by immunohistochemistry, cases were subdivided into germinal center B-cell (GCB) and non-GCB types according to the Hans algorithm. (oncotarget.com)

The observation that most autoantibodies in traditionally autoantibody-mediated diseases are of the IgG isotype and carry somatic mutations strongly suggests T-cell help in the autoimmune B-cell response. (hindawi.com)
The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
LATS1, LATS2, and MOB1B were localized to both germ and somatic cells of primordial to antral follicles. (appliedbioinfo.com)
Interestingly, YAP1 was predominantly cytoplasmic, while WWTR1 was nuclear in oocytes and somatic cells. (appliedbioinfo.com)

The primary role of lymph node stromal cells is structural. (wikipedia.org)
The molecular signaling systems (chemokines) that distribute lymphocytes to appropriate localities within the lymph node (T and B cell segregation) are also created by lymph node stromal cells. (wikipedia.org)
Lymphocytes leave the lymph node, as effector immune cells, via the efferent lymph vessels. (wikipedia.org)
This means immune cells may leave the lymph node along a chemokine gradient. (wikipedia.org)
Most lymph node stromal cells preferentially express DF1, an Aire-like transcription modulator. (wikipedia.org)
The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)

In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and its expression has been reported on mature germinal center B cells. (cytekbio.com)
2 , 3 , 9 Indeed, the atypical B cells of NLPHL and THRLBCL share many characteristics, including expression of pan-B-cell markers, germinal center B-cell origin and common chromosomal imbalances. (haematologica.org)
A large portion of germinal center and IgA+ B cells were lost via apoptosis during fasting. (listlabs.com)
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. (ox.ac.uk)
The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. (ox.ac.uk)
This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ectopic germinal center formation and megalin/cubilin down-expression. (biomedcentral.com)
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. (ox.ac.uk)
The germinal center (GC) is divided into a dark zone (DZ) and a light zone (LZ). (ox.ac.uk)
CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV. (thermofisher.com)

Only a few follicles in the human ovary survive to complete the cytodifferentiation process, with 99.9% dying by a programmed cell death mechanism called apoptosis. (glowm.com)
The results show that the hippo pathway is active in ovarian follicles and that LATS1 is required to maintain the pool of germ cells and primordial follicles. (appliedbioinfo.com)

Lymphotoxin alpha (LT α ) and TNF α were shown to induce the expression of homing chemokines in B and T cell areas of the spleen [ 13 ]. (hindawi.com)
As the two major cell types in the spleen, B cells and T cells produce cytokines and chemokines [ 18 ]. (hindawi.com)

Crosstalk LEC, lymphoid tissue inducer cells and mesenchymal stromal organizer cells initiate the formation of lymph nodes. (wikipedia.org)
lymphoid tissue stromal organizer cells. (technologybooksindustrialprojectreports.com)

The lymph tissue in the lymph nodes consists of immune cells (95%), for example lymphocytes, and stromal cells (1% to 5%) The genesis of lymph nodes begins within the blood and the lymphatic system. (wikipedia.org)
however, it needs to be emphasized that most autoimmune diseases are driven by a dysfunction in the immune network consisting of B cells, T cells, and other immune cells. (hindawi.com)
This review highlights the critical pathways involved in the direct tumor-promoting activity of stromal cells but also their role in the organization of FL cell niche through the recruitment of accessory immune cells and their polarization to a B cell supportive phenotype. (hal.science)
Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)

By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
13 Despite the similarities of their malignant cells, an important difference between the two lymphomas lies in their clinical presentation and prognosis. (haematologica.org)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin's malignant lymphoma comprising 30-40% of adult lymphomas [ 1 ] and is a clinically heterogeneous disease showing unpredictable outcomes [ 2 - 5 ]. (oncotarget.com)

Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)
Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)

Collectively, these data suggest that not all members of a B-CLL clone are frozen at the surface membrane Ig-expressing stage of B cell maturation, and that some members can switch to the production of non-IgM isotypes. (omicsdi.org)
GC B cells must cycle between these zones to achieve efficient Ab affinity maturation. (ox.ac.uk)
Kinex antibody microarray analyses was used to investigate the regulation of 188 protein kinases, 24 protein phosphatases, and 170 other regulatory proteins during meiotic maturation of immature germinal vesicle (GV+) pig oocytes to maturing oocytes that had completed meiosis I (MI), and fully mature oocytes arrested at metaphase of meiosis II (MII). (appliedbioinfo.com)
During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication. (bioone.org)

Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)
Actin filaments widely involve into multiple cellular processes such as nuclear positioning, germinal vesicle breakdown, spindle migration, chromosome segregation, spindle rotation and polar body extrusion in oocyte mammalian meiosis. (bioone.org)

and B cells exhibit CXCR5 receptors for chemokine CXCL13. (wikipedia.org)
Meanwhile, naive B cells migrated from PPs to the bone marrow during fasting and then back to PPs during refeeding when stromal cells sensed nutritional signals and upregulated CXCL13 expression to recruit naive B cells. (listlabs.com)
The cells were then fixed and permeabilized using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol, and stained with 0.06 µg of Rat IgG2a kappa Isotype Control, APC (Product # 17-4321-81) (left) or 0.06 µg of CXCL13 Monoclonal Antibody, APC (right). (thermofisher.com)

Stem Cell Reviews and Reports. (psu.edu)
Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured brain tissue. (lu.se)
Objectives: To evaluate the benefits and harms of stem cell-based interventions for prevention or treatment of GM-IVH and EoP in preterm infants. (lu.se)
MSCs versus stem cell-based interventions other than MSCs. (lu.se)
TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials and approaches for the regeneration of tissues through a convergence of engineering, medicine, developmental biology, and stem cell science. (biomaterials.org)

Isolated neuroendocrine epithelial cells of argentaffin type or argyrophil type are admixed with the normal endocervical cells. (medscape.com)
The three main types start in different cells: epithelial, stromal or germ cells. (cancercouncil.com.au)
Renal biopsy revealed tubulointerstitial nephritis, with tubular epithelial cell degeneration, tubular atrophy, interstitial inflammation and focal fibrosis. (biomedcentral.com)
Characteristic pathological changes are focal lymphocytic infiltration around the epithelial ducts and production of autoantibody by hyperactive B cells [ 2 ]. (biomedcentral.com)
Fanconi syndrome, the result of proximal tubule epithelial cell (PTEC) injury leading to proximal RTA (type II RTA), hypophosphatemia, hypouricemia, aminoaciduria, glycosuria and urine loss of low molecular weight proteins, is a rare manifestation of pSS. (biomedcentral.com)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)

in endothelial cells (Prox1genes and that ablation of PDGFRβ+ cells induces AS 602801 (Bentamapimod) the collapse of FDC networks. (technologybooksindustrialprojectreports.com)
The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)

The T-cell/histiocyte-rich large B-cell lymphoma signature is hallmarked by up-regulation of CCL8, interferon-γ, indoleamine 2,3 dioxygenase, VSIG4 and Toll-like receptors. (haematologica.org)
The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses. (elifesciences.org)

For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. (wikipedia.org)
This type of receptor interacts with the chemokine CCL21, produced by fibroblastic reticular cells. (wikipedia.org)

At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)

Recently, a novel class of small molecules was developed to inhibit the association of programmed cell death ligand 1 (PD-L1) with its receptor programmed cell death protein 1 (PD-1). (biomedcentral.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
1. The pre-B-cell receptor provides an important signal that induces transition of pro-B cells to pre-B. (justaaa.com)
E. It signals without requiring the B-cell receptor signaling kinase, BTK. (justaaa.com)
This means when the conversion process takes place changing the pro B-cells to pre B-cells, the receptor provides an important signal and it has that particular configuration which leads to the process of conversion. (justaaa.com)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4 + /CD57 - cells normally do so. (lu.se)

Applications Tested: This SN5c antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. (cytekbio.com)
A small subpopulation of CD4 + T cells found in peripheral blood coexpresses the CD57 + marker normally found on, e.g. (lu.se)
The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4 + T cells. (lu.se)

Deposited immune complexes can activate complement and effector cells. (hindawi.com)
These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)
Moreover they induce the upregulation of activating FcR on effector cells. (hindawi.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)

Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)

Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)

Recent work identified a novel stromal population of Cxcl12-expressing reticular cells (CRCs) in murine GC DZs. (ox.ac.uk)
CRCs are gp38(+) with low to undetectable expression of FDC markers, but CRC-like cells in the DZ are lineage marked, along with FDCs and fibroblastic reticular cells, by CD21-Cre- and Ccl19-Cre-directed fluorescent reporters. (ox.ac.uk)

c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Chronic lymphocytic leukemia (CLL) usually involves the expansion of a clone of CD5+ B cells synthesizing IgM antibodies. (omicsdi.org)

The Transcription factor Aire (autoimmune regulator) that controls the expression of PTAs on mTEC cells in the thymus is only expressed at low levels by uncharacterized double negative stromal cells. (wikipedia.org)
For PD-L1 antibody clone SP263, 5% of iCCAs, 4% of pCCAs and 3% of dCCAs exhibited PD-L1 expression on tumor cells, thereby showing the highest frequencies of PD-L1 positivity. (biomedcentral.com)
Statistical analyses of PD-L1 expression (clone SP263) on tumor cells with clinicopathological data revealed a positive correlation with shortened overall survival in CCA patients. (biomedcentral.com)
Description: The eBioSN5c monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALLs). (cytekbio.com)
CD10 expression is also found on normal donor granulocytes and bone marrow stromal cells. (cytekbio.com)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
IL-17 secreted by Th17 subtype effector T cells was diffusely detected in the renal proximal tubule, with a negative correlation of IL-17 and megalin expression. (biomedcentral.com)
Our findings establish CRCs as a major stromal cell type in the GC DZ and suggest that CRCs support critical activities of GC B cells in the DZ niche through Cxcl12 expression and direct cell-cell interactions. (ox.ac.uk)
To assess the prognostic significance of the cell-of-origin type for DLBCLs, we applied the Lymph2Cx assay using a NanoString gene expression platform on formalin-fixed paraffin wax-embedded pretreatment tissues obtained from 82 patients with de novo DLBCL, not otherwise specified. (oncotarget.com)
Metformin also significantly (p0.05) increase in kidney expression of CD45 positive immunostaining cells. (bvsalud.org)
The distance of sensory nerve regeneration and the expression of S100B protein in Schwann cells were analyzed. (bvsalud.org)

The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
The principal immunological abnormalities described for this syndrome include hypogammaglobulinaemia, B-cell lymphopaenia, CD4/CD8 ratio inversion, low T CD4 lymphocyte counts, and alteration of the mitogenic T cell response [ 4 ]. (ecancer.org)

At present it remains unclear whether FRCs originate from a common embryonic mesenchymal progenitor or AS 602801 (Bentamapimod) if different lineages of mesenchymal cells generate the FRC network. (technologybooksindustrialprojectreports.com)
The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ). (ox.ac.uk)

In the nodules, T lymphocytes are located in the T cell zone. (wikipedia.org)
B lymphocytes are located in the B cell follicle. (wikipedia.org)
Supplementary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. (technologybooksindustrialprojectreports.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)

Ovarian cancer starts when cells in one or both ovaries, the fallopian tubes or the peritoneum become abnormal, grow out of control and form a lump called a tumour. (cancercouncil.com.au)
Specialized hypothalamic neurons secrete pulses of gonadotropin-releasing hormone (GnRH) into the portal blood vessels, which acts on the gonadotrophs to cause a pulsatile release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which act on ovarian follicle cells to control folliculogenesis. (glowm.com)

Interactions between stromal and hematopoietic cells are important for the development of lymph nodes. (wikipedia.org)

In the medulla are hematopoietic cells (which contribute to the formation of the blood) and stromal cells. (wikipedia.org)
They form a scaffold for hematopoietic cells and assist their movement along it. (wikipedia.org)

Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
It is also involved in cell cycle arrest and apoptosis [17]. (termedia.pl)
Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries. (appliedbioinfo.com)
The hippo signaling pathway is essential for regulating proliferation and apoptosis in mammalian cells. (appliedbioinfo.com)
Deletion of Lats1 caused an increase in germ cell apoptosis from 1.7% in control ovaries to 3.6% in Lats1 mutant ovaries and a 58% and 32% decrease in primordial and activated follicle numbers in cultured mutant ovaries. (appliedbioinfo.com)

Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
T cells are primed by antigen-presenting cells in the T cell zones of the periarteriolar lymphoid sheaths of the spleen, the paracortex of LNs, and the dome area of Peyer's patches (PPs) * lining the intestine. (rupress.org)

Within malignant cell niches in invaded lymph nodes and bone marrow, external stimuli provided by infiltrating stromal cells make a pivotal contribution to disease development, progression, and drug resistance. (hal.science)
B cells were present in lower numbers, but B cell aggregates were identified in some samples with MRI bone oedema. (bmj.com)
Lymphocytic aggregates containing CD45RO+ T cells and B cells within bone marrow have been identified in subchondral bone in RA, 8 and a recent immunohistochemical study reported an association between bone marrow inflammation and osteoclasts in RA subchondral bone. (bmj.com)

Additionally it is unidentified at what stage during lineage diversification mesenchymal cells become completely committed toward a specific fate and whether distinct stromal cell subsets arise from single multipotent progenitors or if different precursors exists for each stromal cell type. (technologybooksindustrialprojectreports.com)
It is of great significance to gain insight into the classification of γδ T cell subsets. (explorationpub.com)

Lymphoid cells concerned with humoral immunity. (lookformedical.com)

Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. (biomedcentral.com)
Diffuse large B-cell lymphoma (DLBCL) is a common aggressive form of non-Hodgkin's lymphoma. (biomedcentral.com)
Stromal cell contribution to human follicular lymphoma pathogenesis. (hal.science)
4 In the World Health Organization (WHO) classification of 2001, T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is defined by the presence of a limited number of scattered large B cells in a background rich in T cells, with or without histiocytes. (haematologica.org)
Lymphoma b cell. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

In addition these CD86 findings also showed that PDGFRβ+ perivascular cells from non-lymphoid organs have the capacity to differentiate into FDCs and in vivo thus suggesting that this cell population may be the source of AS 602801 (Bentamapimod) FDC in tertiary lymphoid organ formation (Krautler et al. (technologybooksindustrialprojectreports.com)

stromal cells - form connective (supporting) tissue within the ovaries, and make the hormones oestrogen and progesterone. (cancercouncil.com.au)
On other occasions, they may appear with a paraneoplastic syndrome [ 2 ], including myasthenia gravis, pure red cell aplasia, connective tissue disorders, and hypogammaglobulinaemia/Good's syndrome [ 1 , 2 ]. (ecancer.org)

Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)

In DLBCL, tumor-associated neutrophils contribute to the survival, growth, and drug resistance of malignant B cells [ 13 ]. (biomedcentral.com)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)

These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. (omicsdi.org)
The cDNA VH-D-JH gene sequence was joined with that of the C alpha gene in the B cells of the three IgA CLLs, and with that of the C gamma gene in the IgG CLL B cells. (omicsdi.org)
In all five CLLs, the pattern of C mu DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the C mu exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. (omicsdi.org)
These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. (omicsdi.org)
They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
Checkpoint kinase 2 (CHEK2), a cell cycle checkpoint regulator gene, codes for a kinase protein activated in response to radiation and other agents that cause breaks in the DNA. (termedia.pl)

The decision to return to the DZ and undergo clonal expansion is controlled by T helper cells in the GC LZ, which discern between LZ B cells based on the amount of antigen captured and presented. (ox.ac.uk)

The molecular data indicate that approximately 50% of B-CLL patients have amplifications of IgM+ B cells that undergo an isotype class switch. (omicsdi.org)
The cellular data indicate that B cells with lesser amounts of surface membrane IgD and higher IgM/IgD ratios are more likely to undergo this switching process. (omicsdi.org)

Greater than 95%of testicular cancers start with germ cells. (planetayurveda.net)
The normal sertoli cells generally support and nourish the sperm making germ cells and the same like leydig cells do not respond well to chemotherapy or radiation. (planetayurveda.net)

Anatomy51

Organisms14

Diseases15

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Centers7

Follicular cells1

Dendritic cells15

Tumors10

Diffuse large B-cell lymp1

Antigens4

Matrix Hemorrhage1

Microenvironment10

Mesenchymal stem1

Macrophages3

Differentiation9

Formation of ectopic1

Immunohistochemistry3

Somatic4

Lymph node6

Center9

Follicles2

Chemokines2

Organizer cells2

Immune cells6

Lymphomas5

Secondary lymphoid organs2

Maturation4

Vesicle2

CXCL133

Stem7

Epithelial11

Endothelial3

Receptors2

Chemokine2

Phenotypic1

Receptor7

Peripheral3

Effector cells4

Thymic1

Cytokine2

MSCs2

Reticular cells2

Antibodies2

Expression12

Lymphocyte3

Remains unclear2

Lymphocytes6

Ovarian2

Interactions1

Hematopoietic cells2

Apoptosis5

Antigen prese2

Bone3

Subsets2

Immunity1

Lymphoma6

Pathways1

FDCs1

Connective2

Adaptive1

Malignant2

Gene6

Clonal expansion1

Undergo2

Germ2