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  • type
  • One type of cells appear bland and arrange in a honeycomb pattern.The nuclei of the second cell type displays round to oval and spindled shaped nuclei that are somewhat hyperchromatic and scant amount of non-descript cytoplasm. (papsociety.org)
  • differentiation
  • Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation," Neuroscience , vol. 82, no. 4, pp. 1021-1028, 1997. (hindawi.com)
  • The BCSP clonally produces chondrocytes (cartilage-forming) and osteogenic (bone-forming) cells and at least three subsets of stromal cells that exhibit differential expression of cell surface markers, including CD105 (or endoglin), Thy1 [or CD90 (cluster of differentiation 90)], and 6C3 [ENPEP glutamyl aminopeptidase (aminopeptidase A)]. These three stromal subsets exhibit differential capacities to support hematopoietic (blood-forming) stem and progenitor cells. (nih.gov)
  • Although the 6C3-expressing subset demonstrates functional stem cell niche activity by maintaining primitive hematopoietic stem cell (HSC) renewal in vitro, the other stromal populations promote HSC differentiation to more committed lines of hematopoiesis, such as the B-cell lineage. (nih.gov)
  • GPR126 drives the differentiation of Schwann cells through inducing cAMP levels, which causes Oct6 transcriptional activities to promote myelin gene activity. (wikipedia.org)
  • The therapeutic properties of stem cells are mainly attributed to their secretome, which has been shown to modulate several biological processes in vitro and in vivo, such as cell proliferation, survival, differentiation, immunomodulation, anti-apoptosis, angiogenesis and stimulation of tissue adjacent cells. (wikipedia.org)
  • vitro
  • Adult bone marrow stromal cells differentiate into neural cells in vitro," Experimental Neurology , vol. 164, no. 2, pp. 247-256, 2000. (hindawi.com)
  • In addition, other antibiotics, such as clindamycin and rifampicin, have in vitro effects on osteoblasts or their progenitor cells [ 10 , 17 ]. (hindawi.com)
  • As a consequence, efforts have been made to synthesize specific stem cell secretomes efficiently, in vitro. (wikipedia.org)
  • As such, the main preconditioning mechanism to induce secretome (extracellular vesicles) production are stress-inducing methods, most prominently anoxia and hypoxia, but also pharmacological, physical or cytokine-related methods that force the cells to produce secretome in vitro. (wikipedia.org)
  • progenitor
  • Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice," PLoS ONE , vol. 8, no. 9, Article ID e73244, 2013. (hindawi.com)
  • Organs are composites of tissue types with diverse developmental origins, and they rely on distinct stem and progenitor cells to meet physiological demands for cellular production and homeostasis. (nih.gov)
  • Although cefazolin is the most commonly used antibiotic drug in arthroplasty antibiotic prophylaxis worldwide [ 3 , 14 ], there exist only a few reports of how it affects human osteoblasts and its progenitor cells and, therefore, how it may affect postoperative bone healing [ 15 , 16 ]. (hindawi.com)
  • Identification of a coronary vascular progenitor cell in the human heart," Proceedings of the National Academy of Sciences of the United States of America , vol. 106, no. 37, pp. 15885-15890, 2009. (hindawi.com)
  • cellular
  • Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. (springer.com)
  • Though not only stem cells possess a secretome which influences their cellular environment, their secretome currently appears to be the most relevant for therapeutic use. (wikipedia.org)
  • Sdf1
  • The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. (wikipedia.org)
  • proliferation
  • To better understand the effect of cefazolin on the early stages of bone healing, the modulation of cell migration and proliferation and its reversibility was evaluated and compared to cell cultures without drug administration. (hindawi.com)
  • Stroma
  • As a result, within the context of bone as a blood-forming organ, the BCSP plays a critical role in supporting hematopoiesis through its generation of diverse osteogenic and hematopoietic-promoting stroma, including HSC supportive 6C3(+) niche cells. (nih.gov)
  • According to one study, average keratocyte density in the human stroma is about 20500 cells per mm3, or 9600 in a column of 1 mm2 in section. (wikipedia.org)
  • Accelerated bone fracture healing was found when researchers implanted Sp7-expressing bone marrow stroma cells at a site of bone fracture. (wikipedia.org)
  • stimulate
  • HIF-1α causes the production of vascular endothelial growth factor, platelet derived growth factor B, erythropoietin and transforming growth factor alpha, which act to stimulate growth of cells within the tumor. (wikipedia.org)
  • Isolation
  • However, the controlled therapeutic use of the stem cell secretome demands high-quality standardization of isolation and analysis techniques to yield reproducible secretome preparations. (wikipedia.org)
  • enhances
  • Forced GPR126 expression in COS-7 cells enhances cAMP levels by coupling to heterotrimeric Gαs/i proteins. (wikipedia.org)
  • Neural
  • Keratocytes are developmentally derived from the cranial population of neural crest cells, from whence they migrate to settle in the mesenchyme. (wikipedia.org)
  • Human
  • Drugs may have a significant effect on postoperative bone healing by reducing the function of human mesenchymal stromal cells (hMSC) or mature osteoblasts. (hindawi.com)
  • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4," Science , vol. 283, no. 5403, pp. 845-848, 1999. (hindawi.com)
  • Sp7 expression is decreased in mouse and human osteosarcoma cell lines as compared to normal osteoblasts. (wikipedia.org)
  • patients
  • It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close proximity to atypical tuboendometrial glands, and microglandular hyperplasia has been seen to arise from these lesions. (wikipedia.org)
  • In a phase I clinical study, vemurafenib (then known as PLX4032) was able to reduce numbers of cancer cells in over half of a group of 16 patients with advanced melanoma. (wikipedia.org)
  • organs
  • The loss of these stromal growth factors when the cancer moves throughout the body prevents the cancer from invading other organs. (wikipedia.org)
  • How diverse stem cell activity is coordinated within organs is not well understood. (nih.gov)
  • tissue
  • Cell Tissue Kinet. (springer.com)
  • BrdU) has been used widely to label cells in culture and in tissue. (nih.gov)
  • In the present study we tested a new thymidine analog, 5-ethynyl-2-deoxyuridine (EdU), for labeling and tracking of mesenchymal stromal cells (MSC), specifically adipose tissue-derived stem cells (ADSC). (nih.gov)
  • The lymph tissue in the lymph nodes consists of immune cells (95%), for example lymphocytes, and stromal cells (1% to 5%) The genesis of lymph nodes begins within the blood and the lymphatic system. (wikipedia.org)
  • In addition to inter-cell communication, the paracrine factors are also responsible for tissue development, homeostasis and (re-)generation. (wikipedia.org)
  • The other part, the parenchyma, consists of the cells that perform the function of the tissue or organ. (wikipedia.org)
  • Stromal tissue falls into the functional class that contributes to the body's support and movement. (wikipedia.org)
  • Fixed cells - cells that are permanent inhabitants of the tissue. (wikipedia.org)
  • functional
  • Accumulating preclinical literature has identified that bone marrow mesenchymal stromal cell (MSC) treatment of stroke improves neurological functional outcome after stroke. (springer.com)
  • The ECM has a functional structure, along with aid in the regulation of turgor, which acts as a protective barrier and communicates with other cells using signaling pathways. (wikipedia.org)
  • Mammalian
  • These calcium- and zinc-dependent proteases are activated at neutral pH and twenty-three have been found present in mammalian cells. (wikipedia.org)
  • regenerative
  • The first stage of this mechanism, known as the regenerative phase, corresponds to the replacement of damaged cells by cells of the same type, thus ensuring organ functionality. (hindawi.com)
  • With regard to orthopaedic conditions such as arthritis, the paracrine factors of stem cell-based therapies appeared to be responsible for the majority of regenerative effects. (wikipedia.org)
  • interactions
  • These immunomodulatory activities are mediated by both cell-cell interactions and secreted cytokines including interferon- (IFN-) γ , indoleamine 2,3-dioxygenase (IDO), transforming growth factor- (TGF-) β , interleukin (IL-) 6, IL-10, and prostaglandin E2 [ 20 - 23 ]. (hindawi.com)
  • stem cell
  • The stem cell secretome, (also referred to as the stromal cell secretome), is a collective term for the paracrine soluble factors produced by stem cells and utilized for their inter-cell communication. (wikipedia.org)
  • This is contrary to the historic hypothesis that stem cell migration and transdifferentiation is the primary mechanism of effect of stem cell injection therapies. (wikipedia.org)
  • This approach is also known as cell-free stem cell therapy. (wikipedia.org)
  • it involves the following stages: Pluripotential hemopoietic stem cell Myeloblast Promyelocyte Eosino/neutro/basophilic myelocyte Metamyelocyte Band cell (Stab cell) Granulocytes (Eosino/neutro/basophil) It can be stimulated by Candida albicans. (wikipedia.org)
  • immune cells
  • One hypothesis explains such rapid reaction by the need to stem the possible infection from spreading into the cornea, because due to the limitations of ocular immune system the immune cells take up to several hours to arrive at the site of injury. (wikipedia.org)
  • tumor
  • In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. (diva-portal.org)
  • Proliferation of vessel-forming endothelial cells is a limiting factor for tumor growth [ 4 - 7 ]. (hindawi.com)
  • In contrast to healthy vessels, tumor vessels are immature, often mal-shaped, irregular, and have a tortuous structure with a leaky endothelial cell lining [ 13 , 14 ]. (hindawi.com)
  • The instability of tumor blood vessels is associated with the absence of a smooth muscle cell sheath [ 11 ]. (hindawi.com)
  • Investigators developed antibody fusion proteins consisting of an antibody specific for the DEC205 endocytic receptor on human dendritic cells (DCs) and various fragments of Wilms tumor protein 1 (WT1) as DC-targeting recombinant WT1 vaccines. (humanimmunologynews.com)
  • Ullrich is also Principal Investigator of Singapore Oncogenome Project at the Institute of Medical Biology aimed at identifying all oncogenic alterations in all protein tyrosine kinase (PTK) gene transcripts of a large number of tumor cell lines and primary tumors. (wikipedia.org)
  • These include all receptors for platelet-derived growth factor (PDGFR) and vascular endothelial growth factor receptors (VEGFR), which play a role in both tumor angiogenesis and tumor cell proliferation. (wikipedia.org)
  • The simultaneous inhibition of these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage. (wikipedia.org)
  • Tumor cells arise from two distinct classes of genomic instability: mutational instability arising from changes in the nucleotide sequence of DNA and chromosomal instability arising from improper rearrangement of chromosomes. (wikipedia.org)
  • It seems to be a paradox that FAK is not absolutely required for cell migration, and may play other roles in the cell, including the regulation of the tumor suppressor p53. (wikipedia.org)
  • The naming issue to a certain extent reflects histological characteristics and development of the tumors, in which the different types of tissues are believed to either develop separately and join into a single mass (the "collision" theory), that an adenocarcinoma stimulates the stroma to create a tumor (the "composition" theory), or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). (wikipedia.org)
  • receptors
  • Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. (diva-portal.org)
  • Simultaneously, they upregulate cell-surface receptors that act as co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. (wikipedia.org)
  • Superantigens bind first to the MHC Class II and then coordinate to the variable alpha or beta chain of T-cell Receptors (TCR) SAgs show preference for the HLA-DQ form of the molecule. (wikipedia.org)
  • PDGF
  • PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. (diva-portal.org)
  • Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. (diva-portal.org)
  • Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) signaling drives angiogenesis and recruitment of perivascular cells to surround the newly formed blood vessels [ 24 ]. (hindawi.com)
  • Platelet-derived growth factor (PDGF) coordinates pericyte coverage of vascular sprouts through PDGF-R β on vascular smooth muscle cells [ 27 ]. (hindawi.com)
  • diffuse large B-
  • Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic myelogenous leukemia in blast crisis (90%), diffuse large B-cell lymphoma (variable), follicular center cells (70%), hairy cell leukemia (10%), and myeloma (some). (wikipedia.org)
  • dendritic cell
  • Publications] Takahashi K: 'Differentiation of dendritic cell populations in macrophage colony stimulating factor-deficient mice homozygous for the osteopetrosis mutation. (nii.ac.jp)
  • Researchers present novel evidence that regulatory T cell-dendritic cell skewed CD4 + naive T cell polarization toward a regulatory phenotype and impaired CD8 + T cell allo-reactive responses, including their ability to induce target tissue damage in a unique in vitro human graft-versus-host disease skin explant model. (humanimmunologynews.com)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • Dendritic cells are present in those tissues that are in contact with the external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell) and the inner lining of the nose, lungs, stomach and intestines. (wikipedia.org)
  • That is, the dendritic cell has a very large surface area compared to the overall cell volume. (wikipedia.org)
  • They also upregulate CCR7, a chemotactic receptor that induces the dendritic cell to travel through the blood stream to the spleen or through the lymphatic system to a lymph node. (wikipedia.org)
  • Renal Cell Carc
  • NEDD9-binding regions in the miR-145 locus would allow the direct binding of the NEDD9 3'UTR to the genomic region of miR-145, and some studies suggests this miR regulates NEDD9 in glioblastoma prostate cancer, and renal cell carcinoma cells. (wikipedia.org)
  • receptor
  • Nature 2010;467:328 Kim, H-J, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD8+ T regulatory cells express the Ly49 class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. (wikipedia.org)
  • The domains have binding regions for the Major Histocompatibility Complex Class II (MHC Class II) and the T cell receptor (TCR), respectively. (wikipedia.org)
  • T-cell binding region of the SAg interacts with the Variable region on the Beta chain of the T-cell Receptor. (wikipedia.org)
  • mantle cell lym
  • It tends to be negative in acute myeloid leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and marginal zone lymphoma. (wikipedia.org)
  • embryonic
  • Among its related pathways are Regulation of retinoblastoma protein and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers . (genecards.org)
  • For a period during embryonic development, the dorsal aorta produces hematopoietic stem cells, which will eventually colonise the liver and give rise to all mature blood lineages in the adult. (wikipedia.org)
  • Definitive haematopoiesis is the second wave of embryonic haematopoiesis and give rise to all hematopoietic stem cells in the adult hematopoietic system. (wikipedia.org)
  • first described a sequence tag corresponding to the NEDD9 3′ untranslated region based on the cloning of a group of genes predominantly expressed in the brain of embryonic, but not adult mice, a group of genes designated neural precursor cell expressed, developmentally down-regulated. (wikipedia.org)
  • phenotype
  • This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. (wikipedia.org)
  • overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). (wikipedia.org)
  • osteosarcoma cells
  • UMR-106, rat osteosarcoma cells and HTR8/SVneo, human trophoblast cells, were grown in Dulbecco modified Eagle medium (DMEM) supplemented with 10% FBS, 2 mM glutamine, 100 Units/ml penicillin and 100 [micro]g/ml streptomycin. (thefreedictionary.com)
  • migration
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • This "disappearance" correlates to the migration of these hematopoietic stem cells to the foetal liver, where it becomes the subsequent site of haematopoiesis. (wikipedia.org)
  • FAK tyrosine kinase activity can be activated, which plays a key important early step in cell migration. (wikipedia.org)
  • myeloid
  • The most common division of dendritic cells is "myeloid" vs. "plasmacytoid" (lymphoid): The markers BDCA-2, BDCA-3, and BDCA-4 can be used to discriminate among the types. (wikipedia.org)
  • proteins
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. (humanimmunologynews.com)
  • Immature dendritic cells phagocytose pathogens and degrade their proteins into small pieces and upon maturation present those fragments at their cell surface using MHC molecules. (wikipedia.org)
  • NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction pathways, regulating magnitude and duration of cell signaling cascades The overall structure of NEDD9 is represented graphically in Figure 1. (wikipedia.org)
  • Cancers
  • in other types, most notably lung cancers, neprilysin is downregulated, and thus unable to modulate the pro-growth autocrine signaling of cancer cells via secreted peptides such as mammalian homologs related to bombesin. (wikipedia.org)
  • inhibition
  • In addition to the pruning of immature blood vessels, inhibition of VEGF expression also increases pericyte cell coverage and vessel maturation [ 25 , 26 ]. (hindawi.com)
  • Scientists showed that Bcl6 is highly up-regulated in activated CD4 T cells following glucose deprivation (GD), and this pathway is insensitive to inhibition by IL-2. (humanimmunologynews.com)
  • Inhibition of follicular T helper cells by CD8+ Treg is essential for self tolerance. (wikipedia.org)
  • Lymphocyte
  • This experimental approach was also used to investigate other lymphocyte populations, including "natural killer" cells. (wikipedia.org)
  • B-cell activating factor (BAFF), also called B-lymphocyte stimulator (BLyS), is required for the development and survival of B cells. (wikipedia.org)
  • cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells and hypothesized to play a role in the process of T cell costimulation, designating this gene Cas-L (Crk-associated substrate-related protein, Lymphocyte type). (wikipedia.org)
  • inhibits
  • Similar to GD, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis, and 2DG induced Bcl6 expression in activated CD4 T cells. (humanimmunologynews.com)
  • Proc Natl Acad Sci USA 2011;108:2010 †Leavenworth JW, †Wang X, Wenander CS, Spee P, Cantor H. Mobilization of natural killer cells inhibits development of collagen-induced arthritis. (wikipedia.org)
  • regulation
  • Nature Immunology, 2004;5:516 Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. (wikipedia.org)
  • antigens
  • Boyse EA, Old LJ, Stockert E. An approach to the mapping of antigens on the cell surface. (wikipedia.org)
  • Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. (wikipedia.org)
  • The large number of activated T-cells generates a massive immune response which is not specific to any particular epitope on the SAg thus undermining one of the fundamental strengths of the adaptive immune system, that is, its ability to target antigens with high specificity. (wikipedia.org)
  • colon
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • anterior
  • Immunological analyses confirmed the heterodimerization of A2 and B5 in transfected cells and their colocalization in the anterior pituitary. (jci.org)
  • These layers are Bowman's membrane, and the anterior corneal stromal lamellae. (wikipedia.org)
  • transgenic mice
  • As expected, some transgenic mice bearing 2kb or 6kb constructs showed tissue specific expression of LacZ gene in hair follicles, gut pacemaker cells and neurons where KL is expressed. (nii.ac.jp)
  • Immune Response
  • Congenital disorders of the stomach include pernicious anaemia, in which a targeted immune response against parietal cells results in an inability to absorb vitamin B12. (wikipedia.org)
  • Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response. (wikipedia.org)
  • For discovering the central role of dendritic cells in the adaptive immune response, Steinman was awarded the Albert Lasker Award for Basic Medical Research in 2007 and the Nobel Prize in Physiology or Medicine in 2011. (wikipedia.org)
  • B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE). (wikipedia.org)
  • survival
  • Factors that contribute to genome stabilization include proper cell-cycle checkpoints, DNA repair pathways, and other actions that ensure cell survival following DNA damage. (wikipedia.org)
  • In order to survive, B cells need survival factors. (wikipedia.org)
  • Researchers theorize that SLE is caused when autoimmune B cells proliferate, and survival factors protect them from cell suicide. (wikipedia.org)
  • Without the survival factor BAFF, B cells commit suicide, and no longer contribute to the autoimmune damage of SLE. (wikipedia.org)
  • This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival. (wikipedia.org)
  • body's
  • Compared to a normal antigen-induced T-cell response where 0.0001-0.001% of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. (wikipedia.org)
  • vascular smooth
  • Mature vasculature contains an endothelial cell lining with a surrounding sheath of pericytes/vascular smooth muscle cells (VSMCs). (hindawi.com)
  • ACTA2 is primarily expressed in vascular smooth muscle and anti-ACTA2 is commonly used to marker smooth muscle cells. (ptglab.com)
  • vivo
  • The heterodimer also stimulated cAMP production and thymidine incorporation by cultured thyroid cells and increased serum thyroxine levels in TSH-suppressed rats in vivo. (jci.org)
  • Metastatic
  • It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility. (wikipedia.org)
  • lymphoid
  • Hematopoetic progenitors expressing CD10 are considered "common lymphoid progenitors", which means they can differentiate into T, B or natural killer cells. (wikipedia.org)
  • gene
  • We found that 35bp upstream of TATA-box is sufficient for assigning CAT-gene expression in this cell line. (nii.ac.jp)
  • For example, a mutation in a caretaker gene coding for a DNA repair pathway that leads to the inability to properly repair DNA damage could allow uncontrolled cell growth. (wikipedia.org)
  • human
  • To profile the B-cell transcriptional responses underlying the activation of the germinal center activities leading to the generation of IgE, naïve human B-cells were stimulated with IL-4 and anti-CD40. (humanimmunologynews.com)
  • Effects of hormones and cytokines on stimulation of adenylate cyclase and intracellular calcium concentration in human and canine periodontal ligament cells. (dentisty.org)
  • Belimumab is a human antibody that binds to BAFF, preventing BAFF from binding to B cells. (wikipedia.org)
  • It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). (wikipedia.org)
  • A given SAg can activate a large proportion of the T-cell population because the human T-cell repertoire comprises only about 50 types of Vβ elements and some SAgs are capable of binding to multiple types of Vβ regions. (wikipedia.org)
  • mice
  • Experimental production of mice deprived of selected T-cell subclasses. (wikipedia.org)
  • Hu D, †Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 cells in mice deficient in the Qa-1 class Ib molecule. (wikipedia.org)
  • autologous
  • One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte transplantation (ACT). (wikipedia.org)
  • citation needed] A variation on the Carticel technique, called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable tissue which is implanted via an open or arthroscopic procedure. (wikipedia.org)
  • regulatory
  • Scientists showed that the proportion of peritoneal regulatory T cells increases as endometriosis progresses. (humanimmunologynews.com)
  • Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. (genecards.org)
  • Proc Natl Acad Sci USA 2011;108:14584 Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H. Amelioration of arthritis through mobilization of CD8+ regulatory T cells. (wikipedia.org)
  • Depending on the needs of the cell, regulatory mechanisms choose which exons, and sometimes introns, to join together. (wikipedia.org)