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  • anterior
  • Devices that can perform corneal tomography (not to be confused with optical coherence tomography), such as the Pentacam (Oculus), are helpful for these patients because they use "slit imaging" to analyze both anterior as well as posterior corneal surfaces in near three-dimensions. (reviewofoptometry.com)
  • Contrast this with reflective Placido ring-based topography systems, which precisely measure anterior corneal elevation and surface. (reviewofoptometry.com)
  • When the DMEK graft is dissected from the donor cornea, the graft forms a tight scroll, which can be difficult to unfold once it is injected into the anterior chamber. (healio.com)
  • The trabecular meshwork is the target tissue of glaucoma in the anterior chamber, and the development and progression of glaucoma are accompanied by accumulation of oxidative damage in this tissue. (arvojournals.org)
  • This study was conducted to comparatively evaluate the sensitivity to oxidative stress of anterior chamber tissues including the cornea, iris, and trabecular meshwork. (arvojournals.org)
  • Epithelial progenitor cells reside in niches at the anterior corneal limbus and ensure a continuous regeneration of the epithelium. (mdpi.com)
  • Synthetic material within the cornea can lead to an inflammatory response, potential interference with glucose, ionic diffusion into the anterior stroma above the implant, and peri-inlay deposits. (healio.com)
  • A trephine of an appropriate diameter is used to make a partial-thickness incision into the patient's cornea, followed by pneumodissection or manual dissection of the anterior stroma. (uiowa.edu)
  • Normal anatomy is restored with reattachment of Descemet membrane to the donor stroma after placement of an air bubble in the anterior chamber. (uiowa.edu)
  • Remove approximately 70% of the anterior stroma using a crescent blade or Devers dissector. (uiowa.edu)
  • Planes were analyzed numerically using software to identify collagen fiber angles relative to the corneal surface, stromal depth, and radial position within the anterior 250 μm of the stroma. (arvojournals.org)
  • The range of fiber angles and the fiber percentage having an angular displacement greater than ±3.5° relative to the corneal surface ("transverse fibers") was highest in the anterior stroma and decreased with depth. (arvojournals.org)
  • In both patients, a 8 mm diameter corneal graft was inserted into the recipient anterior chamber, positioned onto the posterior stroma and secured by an air filling of the anterior chamber. (escrs.org)
  • A method and system for reshaping Bowman's membrane, which lies directly below the anterior epithelial surface of the cornea, to provide correction of refractive errors in the eye by photoablation of selective regions of the Bowman's membrane without substantial penetration into the stroma of the eye. (google.co.uk)
  • refractive surgery
  • The lenticule from a healthy screened individual undergoing femtosecond laser-assisted small incision lenticule extraction refractive surgery for myopic correction is stored in corneal storage medium for later use. (healio.com)
  • Bowman's
  • controlling the laser radiation so that ablation terminates substantially within the Bowman's membrane and not the underlying stroma. (google.co.uk)
  • vivo
  • This paper evaluates the effects of adenoviral vector-mediated glial cell-derived neurotrophic factor (GDNF) gene delivery on survival of primary human corneal epithelial cells (PHCEC) established from limbal explants in vitro and the overexpression of GDNF gene in bioengineered human corneal constructs on substrate of corneal stromal discs followed by autograft ex vivo. (semanticscholar.org)
  • In the ex vivo autograft of the bioengineered human corneal constructs, outgrowth of enhanced green fluorescent protein (eGFP) positive cells on the recipient corneoscleral tissue was observed. (semanticscholar.org)
  • However, human corneal endothelial cells are notorious for their limited proliferative capability in vivo and are therefore prone to corneal endothelial dysfunction that eventually may lead to blindness. (medsci.org)
  • To characterize the expression of the visual system homeobox gene ( VSX1 ) in human corneal keratocytes both in vitro and in vivo. (arvojournals.org)
  • The results show that VSX1 is expressed in vitro and in vivo during human corneal wound healing, a process in which differentiation of corneal keratocytes into myofibroblasts occurs. (arvojournals.org)
  • To document the presence and location of new sensory nerve fibers after corneal neurotization using in vivo confocal microscopy (IVCM) in 2 patients with neurotrophic keratopathy (NK). (readbyqxmd.com)
  • Human corneal endothelial cells (HCECs) do not regenerate in vivo to a significant degree, arresting in G1-phase of the cell cycle. (arvojournals.org)
  • regeneration
  • Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. (stemsave.com)
  • This study shows that CSEM is biocompatible and provides an environment native to cornea to facilitate tissue regeneration. (arvojournals.org)
  • human
  • Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. (semanticscholar.org)
  • Our findings revealed that GDNF is a survival growth factor for cultured human corneal epithelium. (semanticscholar.org)
  • The use of bioengineered human corneal constructs containing GDNF-transduced epithelial cells represents a novel method for delivering of this gene to promote survival of transplanted corneal epithelium to treat various corneal surface diseases. (semanticscholar.org)
  • Human corneal endothelial cells have two major functions: barrier function mediated by proteins such as ZO-1 and pump function mediated by Na-K-ATPase which help to maintain visual function. (medsci.org)
  • Recent investigations of human corneal structure and biomechanics have shown that stromal collagen fibers (lamellae) are organized into a complex, highly intertwined three-dimensional meshwork of transverse oriented fibers that increases stromal stiffness and controls corneal shape. (arvojournals.org)
  • To characterize the main population of bone marrow-derived cells (BMCs) in human normal subconjunctiva and make a comparison with BMCs in the corneal stroma and epithelium. (arvojournals.org)
  • In addition to the existence of bone marrow-derived cells (BMCs) in normal mouse cornea, 2 3 4 we have previously characterized BMCs that reside in the normal human corneal stroma and epithelium. (arvojournals.org)
  • 5 The leukocytes that normally reside in human conjunctival tissues were used as normal controls for investigation of pathologic conditions, such as cicatricial pemphigoid, 8 9 10 vernal keratoconjunctivitis, 11 12 pterygium, 13 14 trachoma, 15 and Behçet disease. (arvojournals.org)
  • Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). (stemsave.com)
  • To assess the ability of the construct to support cell growth, the constructs were seeded with primary human or porcine corneal epithelial cells or fibroblasts. (arvojournals.org)
  • CEp, CS, CEn, limbal epithelium (LEp) and conjunctiva (Cj) of the human donor corneoscleral tissue. (arvojournals.org)
  • A pepsin-based protein extraction protocol to achieve high yield of cECM components from human corneal tissues was successfully implemented. (arvojournals.org)
  • A content of 1.4% sulfated glycosaminoglycans per dry weight of corneal proteins was found and is critical for corneal tissue behavior (cGAGs comprise 2 to 5 wt% in native human cornea. (arvojournals.org)
  • Human amniotic membrane (AM) has been shown to provide a substantial benefit in treating certain types of conjunctival and corneal disease. (aao.org)
  • Human corneal endothelial cell (HCEC) density decreases with age, surgical complications, or disease, leading to vision impairment. (arvojournals.org)
  • diseases
  • Donors are screened for transmissible diseases, and the AM is further treated with broad-spectrum antibiotics immediately after collection. (aao.org)
  • limbus
  • A very small piece of limbus from the healthy eye was split into multiple pieces, and applied to the bare corneal stroma with fibrin glue after pannus resection. (ovid.com)
  • membranes
  • These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. (mdpi.com)
  • Several types of collagen make up the basement membrane, including type VII collagen, which is also present in the conjunctival and corneal basement membranes. (aao.org)