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  • modulation
  • Differential modulation of platelet adhesion and spreading, by adhesive ligand density. (weizmann.ac.il)
  • Systematic molecular modulation of the adhesion sites is used in an attempt to decipher the mechanisms whereby the adhesion-based molecular machinery integrates complex environmental information and triggers a coherent and robust response. (weizmann.ac.il)
  • Modulation of the focal adhesion plaque provides a mechanism for the regulation of cellular adhesive strength. (rupress.org)
  • 1988 ). Determining the molecular basis underlying this adhesion modulation became an important research objective during the following decade (see below). (springer.com)
  • EMT-induced modulation of E-cadherin and cell adhesion molecule 1 (CADM1) mediated increased susceptibility to NK cytotoxicity. (jci.org)
  • endothelial
  • At the National Cardiovascular Center, vascular cell types include endothelial cells and smooth muscle cells have been exposed to hydrodynamic sheer stress and mechanical distension, which have studied focusing cytoskeletal arrangement and phenotype alteration. (nii.ac.jp)
  • Furthermore, LPA stimulated DLD1 cell adhesion to collagen type I (2.0-fold increase at 10 μ m ) and also stimulated the secretion of both vascular endothelial growth factor (1.4-fold increase at 20 μ m ) and interleukin 8 (19-fold increase at 20 μ m ) by ELISA. (aacrjournals.org)
  • 1995
  • Epithelial cadherin (E-cadherin) is the main cell-cell adhesion molecule in epithelial tissues and is regarded as a master organizer of the epithelial phenotype ( Takeichi, 1995 ). (rupress.org)
  • Actomyosin
  • Rho, Rac, and Cdc42 have been the most extensively characterized family members and were originally implicated in the signal transduction pathways that control actomyosin assembly in stress fibers, lamellipodia, and filopodia, respectively. (jneurosci.org)
  • cells
  • Introduction of constitutively active SRF-VP16 into Srf( − / − ) ES cells, on the other hand, strongly induced expression of FA components and F-actin synthesis, leading to a dramatic reorganization of actin filaments into stress fibers and lamellipodia. (rupress.org)
  • In studies conducted in collaboration with Joachim Spatz and colleagues at the University of Heidelberg and the Max Planck Institute for Intelligent Systems (Stuttgart, Germany) it was demonstrated that cells also respond to the spacing of adhesion ligands. (weizmann.ac.il)
  • The cells interact with Au nanodot patterns with Au dot spacing of 58 nm (f) and 73 nm (g). (h) Projected cell adhesion area per cell adhering to different ligand (dot) separation. (weizmann.ac.il)
  • Cell adhesion is an important mechanism by which cells interact with the extracellular environment. (rupress.org)
  • These cells spread and develop actin stress fibres when they are on substrates with E ≥ 5 kPa, but do not when E ≈ 1 kPa or less [ 6 - 8 ]. (royalsocietypublishing.org)
  • Using syndecan-4 null cells, we observed that ADAMTS1 proteolytic action mimics the outcome of genetic deletion of this proteoglycan with regards to focal adhesion. (nih.gov)
  • In vivo , cells depend on the ECM to provide both biochemical cues (e.g. cytokines) and biomechanical cues (e.g. anchorage-dependent mechanical stress) to guide their behaviour. (royalsocietypublishing.org)
  • Cytoplasm
  • Immunofluorescent staining of human cell line U-2 OS with TRIP6 polyclonal antibody (Cat # PAB29450) at 1-4 ug/mL concentration shows positivity in plasma membrane, cytoplasm and focal adhesion sites. (abnova.com)
  • mechanical
  • The international collaborative study between National Cardiovascular Center and University of Wisconsin have launched to deepen understanding of vascular cell types under mechanical stress field and its potential applications to tissue-engineered and artificial organs such as vascular vessels and hearts. (nii.ac.jp)
  • Our results demonstrate that the LIM domain moiety of zyxin functions autonomously to mediate responses to mechanical stress and provide in vivo evidence for a role of zyxin in neuronal development. (biologists.org)
  • dynamics
  • Study of osteoclast adhesion to cortical bone surfaces: A correlative microscopy approach for concomitant imaging of cellular dynamics and surface modifications. (weizmann.ac.il)