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  • RhoA
  • Therefore, combined interaction of the astrocyte αvβ3-integrin-syndecan-4 receptor pair with Thy-1, promotes adhesion to the underlying matrix via PKCα- and RhoA-dependent pathways. (biologists.org)
  • The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. (springer.com)
  • lamellipodia
  • Introduction of constitutively active SRF-VP16 into Srf( − / − ) ES cells, on the other hand, strongly induced expression of FA components and F-actin synthesis, leading to a dramatic reorganization of actin filaments into stress fibers and lamellipodia. (rupress.org)
  • Rho, Rac, and Cdc42 have been the most extensively characterized family members and were originally implicated in the signal transduction pathways that control actomyosin assembly in stress fibers, lamellipodia, and filopodia, respectively. (jneurosci.org)
  • endothelial
  • At the National Cardiovascular Center, vascular cell types include endothelial cells and smooth muscle cells have been exposed to hydrodynamic sheer stress and mechanical distension, which have studied focusing cytoskeletal arrangement and phenotype alteration. (nii.ac.jp)
  • Furthermore, LPA stimulated DLD1 cell adhesion to collagen type I (2.0-fold increase at 10 μ m ) and also stimulated the secretion of both vascular endothelial growth factor (1.4-fold increase at 20 μ m ) and interleukin 8 (19-fold increase at 20 μ m ) by ELISA. (aacrjournals.org)
  • 1995
  • Epithelial cadherin (E-cadherin) is the main cell-cell adhesion molecule in epithelial tissues and is regarded as a master organizer of the epithelial phenotype ( Takeichi, 1995 ). (rupress.org)
  • dynamics
  • Study of osteoclast adhesion to cortical bone surfaces: A correlative microscopy approach for concomitant imaging of cellular dynamics and surface modifications. (weizmann.ac.il)
  • cells
  • In studies conducted in collaboration with Joachim Spatz and colleagues at the University of Heidelberg and the Max Planck Institute for Intelligent Systems (Stuttgart, Germany) it was demonstrated that cells also respond to the spacing of adhesion ligands. (weizmann.ac.il)
  • The cells interact with Au nanodot patterns with Au dot spacing of 58 nm (f) and 73 nm (g). (h) Projected cell adhesion area per cell adhering to different ligand (dot) separation. (weizmann.ac.il)
  • These cells spread and develop actin stress fibres when they are on substrates with E ≥ 5 kPa, but do not when E ≈ 1 kPa or less [ 6 - 8 ]. (royalsocietypublishing.org)
  • Cell adhesion is an important mechanism by which cells interact with the extracellular environment. (rupress.org)
  • In vivo , cells depend on the ECM to provide both biochemical cues (e.g. cytokines) and biomechanical cues (e.g. anchorage-dependent mechanical stress) to guide their behaviour. (royalsocietypublishing.org)