Dactinomycin is an intravenously administered, antineoplastic antibiotic that is used in the treatment of solid tumors in children and choriocarcinoma in adult women. (nih.gov)
Daunorubicin is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus. (pediatriconcall.com)
COSMEGEN1
Dactinomycin is available as a solution or lyophilized powder for injection in vials of varying concentrations under the commercial name Cosmegen and must be given by the intravenous route, avoiding tissue extravasation. (nih.gov)
Parvullus2
Actinomycin D, later named dactinomycin, was isolated from Streptococcus parvullus and was identified as a promising antineoplastic agent. (nih.gov)
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. (nih.gov)
Chemotherapy3
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. (wikipedia.org)
Chemotherapy with dactinomycin in combination with other agents is associated with serum enzyme elevations in a high, but variable proportion of patients depending upon the dose, other agents used as well as the frequency of monitoring and criteria used to define elevations. (nih.gov)
The time to onset is typically within 3 to 6 weeks after the initial dose, often arising 5 to 10 days after the 2nd or 3rd course of cyclic chemotherapy with dactinomycin. (nih.gov)
Bacteria2
Non-Streptomyces actinomycetes, filamentous fungi, and non-filamentous bacteria, have also yielded important antibiotics. (wikipedia.org)
Dactinomycin (dak" tin oh mye' sin) is one of the actinomycins, anticancer antibiotics that were discovered by Selman Waksman and colleagues in the 1940s using fermentation exacts from bacteria (Streptomyces). (nih.gov)
Synthesis1
As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (nih.gov)
Typically1
Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium. (wikipedia.org)
Streptomyces coelicolor has shown useful for the heterologous expression of proteins. (wikipedia.org)
Subsequently, dactinomycin was shown to have antitumor effect against a broad array of solid tumors. (nih.gov)
Higher2
Streptomyces offers potential advantages including superior secretion mechanisms, higher yields, a simpler end-product purification process, making Streptomyces an attractive alternative to E. coli and Bacillus subtilis. (wikipedia.org)
The syndrome is more common in younger children and with higher doses of dactinomycin. (nih.gov)