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  • colonization
  • Colonization of the nasopharynx by S. pneumoniae involves adherence of the bacterium to the epithelial surface via different surface molecules ( McCullers and Tuomanen, 2001 ). (frontiersin.org)
  • To mimic this aspect of COPD, a murine model of low-level pneumococcal colonization in the lung has been developed, in which S. pneumoniae persisted in the lungs for at least 28 days. (asm.org)
  • Models of nasopharyngeal colonization with S. pneumoniae have been described ( 13 ), but these do not mimic the colonization of the lower airways seen in COPD. (asm.org)
  • protective
  • Entry of blood-borne pathogens into the spleen elicits a series of changes in cellular architecture that culminates in the systemic release of protective antibodies. (biomedcentral.com)
  • These and other glycans were used to reverse-engineer a protective ST8 CPS-directed monoclonal antibody (mAb) by glycan microarray analysis. (fu-berlin.de)
  • immunity
  • S. pneumoniae is a significant human pathogen, being recognized as a major cause of pneumonia in the late 19th century, and is currently the subject of many humoral immunity studies. (acris-antibodies.com)
  • Immunofluorescence
  • Abgent's experienced staff custom validates more than 1,000 antibodies each month in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC) and additional applications. (abgent.com)
  • therapeutic
  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. (lsbio.com)
  • S. Therapeutic intervention in sepsis with antibody to endotoxin: is there a future? (springer.com)
  • phagocytosis
  • Importantly, antibodies specific for ICAM-1, PECAM-1 or LFA-1 efficiently blocked the phagocytosis of infected reticulocytes by monocytes. (jove.com)
  • toxin
  • 1. A continuous cell line which produces human anti-exotixin antibodies, comprising: a stable fused cell hybrid of a human peripheral blood lymphocyte immunized by a toxin, or an imunogenic fragment thereof, or a toxoid prepared from an exotoxin, or an immunogenic fragment thereof, and a mouse myeloma cell, in which the antibodies are capable of neutralizing exotoxin. (freepatentsonline.com)
  • 3. A continuous cell line which produces human anit-tetanus toxin antibodies, comprising: a stable fused cell hybrid of a tetanus toxin-immunized or toxoid-immunized human peripheral blood lymphocyte and a mouse myeloma cell, in which the anitbodies are capable of neutralizing tetanus toxin. (freepatentsonline.com)
  • The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and treatment of sepsis in humans as well as other animals. (freepatentsonline.com)
  • migrate
  • Here, marginal zone (MZ) B cells responding to streptococcus in the blood were observed to migrate along splenic nerves, arriving at the red pulp venous sinuses where they become antibody-secreting cells. (biomedcentral.com)
  • myeloma
  • These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. (thefreedictionary.com)
  • methods
  • The invention further provides methods for making the antibodies in a non-human animal and for expressing the antibodies in cells. (google.com)
  • Kits and pharmaceutical compositions comprising the antibodies are also provided in addition to methods of treating, inhibitng or preventing S. pneumoniae infection or conditions or disorders caused by such infection by administering to a patient the pharmaceutical compositions described herein. (google.com)