Streptidine, a metabolic derivative produced after administration of streptomycin in vivo, is vestibulotoxic in rats. (entecho.cz)
Except for streptomycin, where the ring is streptidine, all aminoglycosides have a 2-deoxy streptamine ring. (pharmacygyan.com)
Generally in most medically utilized aminoglycosides the last mentioned is 2-deoxystreptamine which is streptidine in streptomycin and derivatives and fortamine within the fortimicin series (Fig. (biomasswars.com)
They are the polycationic compounds that contain an aminocyclitol, usually 2-deoxystreptamine, or streptidine in streptomycin and related compounds, with cyclic amino-sugar attached by glycosidic linkages. (pharmacygyan.com)
The aminotransferase activity was demonstrated for the first time by identification of the overproduced and purified StsC protein as the L- glutamine:scyllo-inosose aminotransferase, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin. (unipr.it)
Dihydrostreptosyltransferase1
DTDP-dihydrostreptose---streptidine-6-phosphate dihydrostreptosyltransferase (EC 2.4.2.27, thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase) is an enzyme with systematic name dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase. (wikipedia.org)
Streptomycin4
This protein inactivates streptomycin by transferring an adenyl group to position six of the streptidine moiety. (nih.gov)
Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase. (nih.gov)
Except for streptomycin, where the ring is streptidine, all aminoglycosides have a 2-deoxy streptamine ring. (pharmacygyan.com)
The aminoglycosides can be distinguished on the basis of whether their aminocyclitol unit is streptidine or 2-deoxystreptamine. (medscape.com)
Enzyme2
DTDP-dihydrostreptose---streptidine-6-phosphate dihydrostreptosyltransferase (EC 2.4.2.27, thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase) is an enzyme with systematic name dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase. (wikipedia.org)
This enzyme catalyses the following chemical reaction dTDP-L-dihydrostreptose + streptidine 6-phosphate ⇌ {\displaystyle \rightleftharpoons } dTDP + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate Kniep B, Grisebach H (March 1980). (wikipedia.org)