The risk of recurrence and death after complete surgical resection of clinically detectable primary cutaneous melanoma ranges from low, intermediate to high risk depending on the stage of disease at diagnosis. (amegroups.org)
For high-risk melanoma, adjuvant therapy aims at eradicating melanoma micrometastases in those patients that carry an unacceptable risk of mortality from melanoma recurrence. (amegroups.org)
Careful surveillance in high-risk individuals, early diagnosis and prompt surgical removal remain the mainstay of management surgically curable melanoma. (amegroups.org)
For high-risk melanoma, adjuvant therapy focuses on clinically invisible disease that may lead to future mortality from melanoma recurrence and presents an opportunity at curing this disease. (amegroups.org)
People with dysplastic nevus syndrome, also known as familial atypical multiple mole melanoma, are at increased risk for the development of melanoma. (wikipedia.org)
Having more than 50 moles indicates an increased risk in melanoma might arise. (wikipedia.org)
UV radiation exposure from tanning beds increases the risk of melanoma. (wikipedia.org)
Cancers1
Risk increases with age, but, unlike other cancers, prostate cancer has no "peak" age or modal distribution. (science-medic.com)
Population1
Moreover, life expectancy and the number of elderly patients are increasing, and this population has a high risk of surgical complications and mortality due to various comorbidities [ 4 , 5 ]. (pfmjournal.org)
Prostate10
SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
Age The risk of developing prostate cancer begins to increase at age 50 years in white men who have no family history of the disease and at age 40 years in black men and those who have a first-degree relative (father, brother) with prostate cancer. (science-medic.com)
Race The highest incidence of prostate cancer in the world is found in Ameri- can black men, who have approximately a 9.8% lifetime risk of developing this cancer. (science-medic.com)
Socioeconomic status appears to be unrelated to the risk of prostate cancer,and the explanation for racial variability is unknown. (science-medic.com)
Family history Men who have a first-degree relative with prostate cancer have approximately a twofold increased risk of developing prostate cancer during their lifetime. (science-medic.com)
An individual who has two first-degree relatives with prostate cancer has a ninefold increase in lifetime risk. (science-medic.com)
Sexual activity has beenhypothesized as a possible risk True hereditary prostate cancer occurs in a small number of men and tends to develop at Leitzmann et al may finally providean answer to this question. (science-medic.com)
In the Dietary fat Studies have suggested that di- etary fat may increase the risk of prostate can- cer. (science-medic.com)
However, no definitive proof of its role their history of ejaculationfrequency by filling out serial Vasectomy Several large epidemiologic stud- ies suggest that vasectomy may increase the relative risk of prostate cancer by as much as incidence of prostate cancer inthe group. (science-medic.com)
However, these same studies do not re- port an increased risk of dying from prostate cancer associated with vasectomy but do in- dicate a statistically increased risk of dying ejaculation frequency (greaterthan 21 ejaculations per month) from lung cancer. (science-medic.com)
Metastasis1
Therefore, radiologic, endoscopic and pathologic evaluation to predict the risk of lymph node metastasis and local recurrence has been evolving to determine the optimal treatment strategy in the patient-tailored medicine. (pfmjournal.org)
Recurrence1
In this paper, we aim to review various risk factors related to local recurrence and discuss the optimal treatment strategy for ERC. (pfmjournal.org)
Patients5
Kaplan-Meier analysis showed that these four DNA methylation markers could significantly distinguish high-risk and low-risk patients. (aging-us.com)
Moreover, there was a difference in the genetic mutations between high-risk and low-risk patients distinguished by the four-DNA methylation model, which can provide information for clinical treatment. (aging-us.com)
Therefore, to improve the clinical outcome of PDAC, identifying novel biomarkers that can stratify the risk of patients and predict their survival time is valuable for guiding therapy for PDAC. (aging-us.com)
In this study, patients with PDAC were divided into high-risk and low-risk groups according to the risk index. (aging-us.com)
The establishment of a specific model that identifies high-risk patients is urgent for clinical management of PDAC. (aging-us.com)
Increases1
Risk may be inversely related to ultraviolet light exposure, as the incidence increases the farther one lives from the equator. (science-medic.com)
Genetic1
A number of rare genetic conditions, such as xeroderma pigmentosum, also increase the risk. (wikipedia.org)
Cancer3
2018). The demographic distribution of this disease shows that some demographics have a higher risk of developing the cancer compared to others. (assignology.com)
This makes it a high-risk factor for cancer growth because it allows AML cells to affect other parts of the body, such as the liver, spleen, lymph nodes and testicles (Andreeff 2014). (assignology.com)
Pancreatic cancer is an insidious and rapidly progressing digestive system neoplasm. (aging-us.com)
Exposure1
Those who work in airplanes also appear to have an increased risk, believed to be due to greater exposure to UV. (wikipedia.org)
Management1
The updated system, which incorporates all of these 'non-anatomical' parameters, is an attempt to make staging more personalized and relevant to patient prognostication and management, and to align with the European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) risk stratification. (bmj.com)
Groups1
For example, older males are at a higher risk of having the disease compared to other age groups (Maksimovic et al. (assignology.com)
Cells1
Blood platelets and white blood cells may also decline significantlybecause of the same process, thereby increasing the risk of infection (Andreeff 2014). (assignology.com)
Family1
Those with many moles, a history of affected family members, and poor immune function are at greater risk. (wikipedia.org)
Tumor3
[ 35 ] In addition, it is important to note that before the routine use of immunohistochemistry, another embryonal neoplasm called atypical teratoid/rhaboid tumor, which generally occurs in children younger than 3 years and has a worse prognosis, was mistaken for medulloblastoma, further lowering survival numbers for the younger age group. (medscape.com)
The first variable concerns the presence of tumor cells in the CSF following surgery, with increased risk bestowed upon those with a positive lumbar tap. (medscape.com)
The extent of disease beyond the original tumor site has consistently proven to be a highly significant prognostic risk factor. (medscape.com)
Treatment1
Postoperative risk stratification and treatment of medulloblastoma. (medscape.com)
High-risk1
Survival rates in the high-risk category are lower, 43-70% event-free survival at 5 years, as well as the degree of compomise of neurocognitive function. (medscape.com)
Years3
Despite more than 20 years of insight into the molecular pathogenesis of medulloblastoma, risk assessment continues to be determined solely by clinical parameters. (medscape.com)
There is an almost linear relationship between smoking duration (in years), pack years and bladder cancer risk. (wikipedia.org)
Risk of bladder cancer decreases by 30% within 1-4 years and continues to decrease by 60% at 25 years after smoking cessation. (wikipedia.org)
Include1
Risk factors for bladder cancer include smoking, family history, prior radiation therapy, frequent bladder infections, and exposure to certain chemicals. (wikipedia.org)