• By retaining the same set of template DNA strands, adult stem cells would pass mutations arising from errors in DNA replication on to non-stem cell daughters that soon terminally differentiate (end mitotic divisions and become a functional cell). (wikipedia.org)
  • The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • A ligament is made up of multiple strands of connective tissue , similar to a nylon rope. (eorthopod.com)
  • The most common RNAi agents are double-stranded RNAs, which ultimately associate with proteins to form an RNA-induced silencing complex (RISC). (news-medical.net)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • The Phase 2 grant builds upon a successfully completed Phase 1 program that demonstrated the feasibility of using single-stranded antisense drugs to target the RNAi pathway. (news-medical.net)
  • Much of the work will focus on optimizing the chemical properties of single-stranded oligonucleotides that trigger the RNAi pathway. (news-medical.net)
  • This provides the opportunity to develop simplified single-stranded antisense drugs that can utilize the RNAi pathway to treat human disease. (news-medical.net)
  • We report a bottlenose dolphin in the eastern Mediterranean Sea that was found stranded and dead. (cdc.gov)
  • We report a bottlenose dolphin in the eastern Mediterranean Sea that was found stranded, dead, and had a severe case of chronic suppurative pneumonia and splenic lymphoid depletion caused by this pathogen. (cdc.gov)
  • Recovery rates of bottlenose dolphin (Tursiops truncates) carcasses estimated from stranding and survival rate data. (noaa.gov)
  • Hantaviruses are a genus in the family Bunyaviridae, which are lipid-enveloped viruses with a negative-stranded RNA genome composed of three unique segments. (cdc.gov)
  • It is the largest (220 nm in diameter) and most complex herpesvirus, with a 235,000 double-stranded DNA genome. (medscape.com)
  • Just as veins and arteries play different, but unified, roles in transporting essential elements via blood from one part of the human body to another, the phloem and xylem tissues consist of tubes that transport essential fluids and nutrients in sap, from one part of the plant to another. (newworldencyclopedia.org)
  • The Hong Kong cetacean stranding response program has incorporated postmortem computed tomography, which provides valuable information on the biological health and profile of the deceased animals. (jove.com)
  • Lungworm infestation is a relatively common finding in stranded cetaceans, and could be a major mortality factor for cetacean populations or presented as a self-limited lesion. (vin.com)
  • The authors thank to Dr. Chiou-Ju Yao of the National Museum of Natural Science, Taiwan for specimen storage, veterinary students and professors in National Pingtung University of Science and Technology for assisting the necropsy procedures, and all the people in Taiwan Cetacean Stranding Network including the costal guards, laboratory of cetacean research in National Taiwan University, and Taiwan Cetacean Society for animal rescue and shipment. (vin.com)
  • The West Coast Marine Mammal Stranding Network literature references for 2005-2020 are provided below. (noaa.gov)
  • Tissue specific cDNA libraries have generated over 700 EST sequences. (usda.gov)
  • The immortal DNA strand hypothesis was proposed in 1975 by John Cairns as a mechanism for adult stem cells to minimize mutations in their genomes. (wikipedia.org)
  • This hypothesis proposes that instead of segregating their DNA during mitosis in a random manner, adult stem cells divide their DNA asymmetrically, and retain a distinct template set of DNA strands (parental strands) in each division. (wikipedia.org)
  • A pulse of DNA label is given to adult stem cells under conditions where they have not yet delineated an immortal DNA strand. (wikipedia.org)
  • Once the immortal DNA strand is labelled and the adult stem cell has begun or resumed asymmetric divisions, the DNA label is chased out. (wikipedia.org)
  • If, however, cells are using an immortal DNA strand mechanism, then all the labeled DNA will continue to co-segregate with the adult stem cell, and after five (or more) divisions will still be detected within the adult stem cell. (wikipedia.org)
  • Under conditions of homeostasis, adult stem cells should be dividing asymmetrically so that the same number of adult stem cells is maintained in the tissue compartment. (wikipedia.org)
  • If, however, the adult stem cells are using an immortal DNA strand mechanism, they are obligated to retain the unlabeled 'immortal' DNA, and will release all the newly synthesized labeled DNA to their differentiating daughter cells in two divisions. (wikipedia.org)
  • Some scientists have combined the two approaches, by first using one DNA label to label the immortal strands, allowing to adult stem cells to begin dividing asymmetrically, and then using a different DNA label to label the newly synthesized DNA. (wikipedia.org)
  • histopathological examination revealed infiltration of adipose tissue cells within the muscle belly and tendon sheath of the deep digital flexor muscle. (thieme-connect.com)
  • Moreover, it is difficult to perform these methods in tissues and organs while maintaining their morphology. (nature.com)
  • Studies suggest that it also plays important roles in the development of the limbs, facial features, urinary system, and other organs and tissues. (medlineplus.gov)
  • Your knowledge and action may help alleviate the suffering of the thousands of people who die annually for lack of available donor organs and tissue while a multitude of healthy organs are being buried every day. (unos.org)
  • Tumors of thymic, lymphatic, or germ cell origin most commonly occur in this compartment, although aberrant parathyroid or thyroid tissue masses are sometimes found, along with vascular and mesenchymal tissue masses. (medscape.com)
  • Vascular plants are plants in the Kingdom Plantae that have specialized tissues for conducting water. (newworldencyclopedia.org)
  • The evolution of this vascular tissue allowed for an early dominance of these plants on land (first appearing 430 million years ago, during the Silurian period), giving them the ability to transport water and dissolved minerals through specialized strands of elongated cells that run from the plant root to the tips of the leaves . (newworldencyclopedia.org)
  • Vascular plants have water-carrying tissues, enabling the plants to become a larger size. (newworldencyclopedia.org)
  • Much like bryophytes , they reproduce with spores, but the sporophytes of these phyla are far more complex than those of the bryophyts, in that they have vascular tissue and well-differentiated leaves , roots , and stems. (newworldencyclopedia.org)
  • Specialized cells that transport water and other materials within a plant are found in vascular tissues. (slideserve.com)
  • The existence of vascular tissue allowed for larger and more-complex plants. (slideserve.com)
  • The larger, more complex plants have a vascular system,a system of well-developed vascular tissues that distribute materials more efficiently. (slideserve.com)
  • Symptoms of peripheral nerve tumors vary depending on where the tumors are located and the tissues affected. (mayoclinic.org)
  • Resection with surrounding dispensable normal tissues is the key to successful treatment of such tumors. (bvsalud.org)
  • We also found that DNA double-strand breaks (DSBs) induce the approach of the homologous loci with γ-irradiation. (nature.com)
  • Moreover, the distance between two homologous loci in the interphase nucleus was shortened by γ-irradiation, which induces DNA double-strand breaks (DSBs). (nature.com)
  • We hypothesized that this radiosensitization is caused by castration-mediated down-regulation of nonhomologous end joining (NHEJ) repair of DNA double-strand breaks (DSBs). (ox.ac.uk)
  • We show that patients receiving neoadjuvant castration treatment before radiotherapy had reduced amounts of the NHEJ protein Ku70, impaired radiotherapy-induced NHEJ activity, and higher amounts of unrepaired DSBs, measured by γ-H2AX foci in cancer tissues. (ox.ac.uk)
  • DNA double strand breaks (DSBs) have detrimental effects on cell survival and genomic stability, and are related to cancer and other human diseases. (elifesciences.org)
  • The symptoms of a peripheral nerve tumor develop from direct effects on the main nerve or from the tumor pressing on nearby nerves, blood vessels or tissues. (mayoclinic.org)
  • The bruising and swelling are due to ruptured blood vessels from the tearing of the soft tissues . (eorthopod.com)
  • Other strands called phloem carry organic nutrients from the leaves to wherever they are needed. (slideserve.com)
  • In the sea before him, the stranded beaked whale splashed its flukes on the water, vainly trying to swim. (latimes.com)
  • When the tumor can't be removed without damaging nearby healthy tissue and nerves, other treatments may be considered. (mayoclinic.org)
  • Tissue sections from chemotherapy-treated DA WTs (n = 12) were compared with chemotherapy-treated nonanaplastic WTs (n = 15) in a tissue microarray system, enabling analysis of 769 tumor regions. (lu.se)
  • Nerves are strands of tissue that transmit signals from the brain to the rest of the body. (mayoclinic.org)
  • Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair. (ox.ac.uk)
  • The other is twisted protein strands or tangles. (healthline.com)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Strikingly, some of these cells display selective template-DNA strand segregation during mitosis in the muscle fibre in vivo, as well as in culture independent of their niche, indicating that genomic DNA strands are nonequivalent. (nih.gov)
  • Inflammation, tissue shrinkage, and loss of connection between brain cells are other clues that Alzheimer's may develop. (healthline.com)
  • The 140g patty, which cost more than 250,000 euros (S$420,600) to produce, was made using strands of meat grown from muscle cells taken from a live cow. (asiaone.com)
  • The team in Maastricht took cells from organic cows and placed them in a nutrient solution to create muscle tissue. (asiaone.com)
  • Today, most plants have strands of specialized cells that transport materials. (slideserve.com)
  • Increased numbers of apoptotic cells were found in lung tissue treated with either the SS fume or the positive control, Cr(VI), as compared to lungs from saline-treated animals. (cdc.gov)
  • In conclusion, we suggest that chemoresistance of DA WTs may be partly explained by a high proliferative capability of anaplastic cells, which also have a high burden of double-stranded DNA breaks and CNAs, and that there is a gradual emergence of anaplasia in WT. (lu.se)
  • AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. (lu.se)
  • Two main assays are used to detect immortal DNA strand segregation: label-retention and label-release pulse/chase assays. (wikipedia.org)
  • Although most currently practiced methods of inducing the RNAi mechanism utilize double-stranded RNAs, RISC requires only the antisense strand to function. (news-medical.net)
  • Some strands carry water and mineral nutrients from the roots to the leaves. (slideserve.com)
  • This study describes 8 image rendering techniques that are essential for the identification and visualization of postmortem findings in stranded cetaceans, which will help clinicians, veterinarians and stranding response personnel worldwide to fully utilize the radiological modality. (jove.com)
  • Here was an exceptional mass stranding involving marine mammals spread across 100 miles. (latimes.com)
  • 2015. The Northern Oregon/Southern Washington marine mammal stranding program. (noaa.gov)
  • Challenges for the Northern Oregon/Southern Washington Marine Mammal Stranding Network. (noaa.gov)
  • National Marine Animal Health and Stranding Network Conference. (noaa.gov)
  • Marine mammal stranding response along the West Coast: a collaborative approach to strandings on Snowy Plover beaches. (noaa.gov)
  • 2013. Spatial and temporal analysis of killer whale (Orcinus orca) strandings in the North Pacific Ocean and the benefits of a coordinated stranding response protocol. (noaa.gov)
  • Indeed, baleen whales strand less commonly than toothed whales but their chances of survival when they do so are minimal. (oregonstate.edu)
  • In the label-retention assay, the goal is to mark 'immortal' or parental DNA strands with a DNA label such as tritiated thymidine or bromodeoxyuridine (BrdU). (wikipedia.org)
  • Evidence for the immortal DNA strand hypothesis has been found in various systems. (wikipedia.org)
  • Studies are ongoing to determine if the apoptotic event is associated with an increase in oxidative DNA damage in lung tissue. (cdc.gov)
  • Two were inferred from genetic sequences detected by reverse transcriptase polymerase chain reaction (RT-PCR) in lung tissue from HPS patients. (cdc.gov)
  • I found a pack of orange balloons and green tissue paper, and put together this pumpkin garland. (babiekinsmag.com)
  • This differentiates between intermuscular and intramuscular lipomas, describing not only their anatomical location but also their biological behaviour: that is, expansive, benign growth between muscle bellies for the intermuscular type and with tissue infiltration within the muscle compartment for the intramuscular type. (thieme-connect.com)
  • Ligaments are tough bands of tissue that help connect bones together. (eorthopod.com)
  • This study demonstrates that chemical castration impairs NHEJ activity in prostate cancer tissue, explaining the improved response of patients with prostate cancer to radiotherapy after chemical castration. (ox.ac.uk)
  • Inside shredded tissues, coarse, thread-like mycelial strands are observed, followed by the appearance of small black dots (sporangia). (unl.edu)
  • They then grew them into small strands of meat, 20,000 of which were required to make the patty. (asiaone.com)
  • RNA was harvested from tissue/cell samples using the Qiagen Rneasy Mini Kit. (nih.gov)
  • Strands of fungus invade the larval tissue and the larva dies, frequently after the cell has been capped. (blogarama.com)
  • Although the density of a soft tissue mass is similar to anterior mediastinal structures, the silhouette sign, in which there is a loss of normal anatomical borders, helps make the diagnosis. (medscape.com)
  • At age 40 years, the thymus is nearly completely replaced with fat, and only slight residual nodular density of thymic tissue remains. (medscape.com)
  • A large anterior mediastinal mass is readily identified by chest radiography, as it typically appears as an extra soft tissue mass or opacity. (medscape.com)
  • The term sprain signifies injury to the soft tissues, usually the ligaments, of the ankle. (eorthopod.com)
  • The doctor will move your ankle in different positions in order to check the ligaments and other soft tissues around the ankle. (eorthopod.com)
  • Computed tomography of the lesion showed a large well defined encapsulated homogeneously hypodense soft tissue swelling of size 3.3 cm (ML) X 5.6 cm (AP) X 4.4 cm (SI) in the minor salivary gland of buccal mucosa near the superficial lobe of parotid gland in the antero-inferior part of the right parotid gland extending more anteriorly. (bvsalud.org)
  • It was extending into the soft tissue of cheek (figures 3 , 4 ). (bvsalud.org)
  • Magnetic Resonance Imaging showed hypo-intense soft tissue with few hyper-intense areas on T1 weighted MR image. (bvsalud.org)
  • Hyper-intense soft tissue was seen with hypo-intense areas on T2 weighted MR images (figures 5 , 6 ). (bvsalud.org)
  • Tissue from brain metastasis from Cardiac Injection. (nih.gov)
  • Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)
  • Results indicate a wide variety of bacteria associated with healthy colonies and an even higher diversity associated with those corals presenting tissue necrosis, which displayed nearly 25% more microorganisms. (nature.com)
  • Mellhammar E, Dahlbom M, Axelsson J, Strand S-E. Counting Rate Characteristics and Image Distortion in Preclinical PET Imaging During Radiopharmaceutical Therapy. (lu.se)
  • In the current study, SS fume at the same concentration caused plasmid DNA strand breakage in vitro under similar conditions. (cdc.gov)
  • Lipomas are common benign neoplasms originating from subcutaneous tissue adipocytes, with no tendency to metastasize. (thieme-connect.com)
  • Most people are not aware of their religious group's doctrine or position regarding organ and tissue donation. (unos.org)
  • The multi-year grant will fund research by Isis to improve the stability and tissue distribution of RNAi drugs. (news-medical.net)
  • This study aims to assess different image rendering techniques in the postmortem computed tomography for the evaluation of biological health and profile in stranded cetaceans in Hong Kong waters. (jove.com)
  • Eight image rendering techniques consist of both 2-D and 3-D rendering are routinely applied to each stranded cetaceans for the biological health and profile investigation. (jove.com)
  • The spores contaminating the brood food develop into bacteria that penetrate the gut wall and multiply in the larval body tissues. (blogarama.com)
  • As the decision is being made, the question often arises, "What is my religion's stance on organ and tissue donation? (unos.org)
  • For ethylene oxide, there ylene oxide), nasal tissue (formal- chemicals and chemicals that are was limited evidence of carcinogen- dehyde), and the kidney (TCE). (who.int)
  • in which strands of tissue partially or completely fuse the upper and lower eyelids. (medlineplus.gov)
  • Using next-generation sequencing, we sought to understand the relationship between T. tagusensis tissue necrosis and its microbiota. (nature.com)
  • Apoptosis was examined in the tissue sections by TUNEL assay. (cdc.gov)