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  • genome
  • Using whole genome sequencing data from 13 classical laboratory and 4 wild-derived mouse inbred strains, we developed a comprehensive catalogue of 103,798 polymorphic TE variants. (biomedcentral.com)
  • Characterization of the cell type-specific determinant in the genome of minute virus of mice. (asm.org)
  • 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. (jax.org)
  • Sequence relationships between the genome segments of human and animal rotavirus strains. (asm.org)
  • Polypurine tract adjacent to the U3 region of the Rous sarcoma virus genome provides a cis-acting function. (asm.org)
  • replication
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • To address this issue, primary and immortalized human cells were tested for their ability to be infected by MCF packaged defective vectors as well as replication competent MCF virus. (umassmed.edu)
  • The cellular tropism of MPAC-packaged retroviral vectors was the same as replication competent MCF viruses. (umassmed.edu)
  • In addition, I show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication. (umassmed.edu)
  • A replication competent MCF virus containing a bacterial amber suppressor tRNA gene ( supF ) was used to investigate the changes in the enhancer region following injection of MCF containing one enhancer in the LTR. (umassmed.edu)
  • Newborn AKR mice were injected with the supF tagged replication competent virus and observed for signs of leukemia development (ruffled fur, lethargy, and tumor development). (umassmed.edu)
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Human immunodeficiency virus type 1 (HIV-1) exhibits a highly restricted host cell tropism and is only capable of efficient replication in primary or immortalized human T cells and macrophages. (asm.org)
  • The discovery of human gene products that are expressed in these cells and are essential for virus replication has raised the possibility that nonhuman organisms, particularly rodents, might be engineered to express these molecules, thereby rendering them able to support a productive HIV-1 replication cycle ( 8 , 20 , 26 ). (asm.org)
  • Abelson murine leukemia virus (Ab-MLV) is a replication-defective retrovirus that transforms pre-B cells and NIH 3T3 cells in vitro and induces a pre-B cell lymphoma in vivo (reviewed in reference 40 ). (asm.org)
  • provirus
  • Fv1 acts by targeting the capsid of the incoming virus and prevents the establishment of an integrated provirus ( 11 , 19 , 23 , 32 ). (asm.org)
  • gene
  • A strain characteristic of A/J is a late onset (four to five months) progressive muscular dystrophy as a result of a homozygous retrotransposon insertion in the dysferlin ( Dysf ) gene. (jax.org)
  • Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene. (springer.com)
  • Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants. (asm.org)
  • Mapping and identification of the vaccinia virus thymidine kinase gene. (asm.org)
  • mink
  • Mink cell focus-inducing (MCF) viruses are polytropic MuLVs that by definition infect cells from a wide variety of species. (umassmed.edu)
  • Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. (asm.org)
  • albino
  • Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A/J inbred strain is widely used in cancer and immunology research. (jax.org)
  • The AKR/J strain is albino, and so its fur is completely white. (mazeengineers.com)
  • The BUB/BnJ inbred strain originated from randomly bred albino mice of unknown ancestry. (jax.org)
  • gross
  • emv-14 is of particular interest because spleen cells expressing emv-14 virus escape recognition by anti-AKR/Gross virus-specific cytotoxic T lymphocytes. (dartmouth.edu)
  • susceptibility
  • We introduced several mutations disrupting two putative but noncanonical glyco-gag proteins in the leader sequence region in XMRV and found that those mutations did not affect virus release nor susceptibility to the antiviral activity of hA3G (human APOBEC3G). (biomedcentral.com)
  • Genetic
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • By comparing the composite allozyme genotype of different inbred and outbred mouse strains, the "genetic distance" statistic was derived. (nova.edu)
  • The genetic distance computed between molossinus and AKR is large, nearly 5-10 times the distance between known related populations and strains (e.g. (nova.edu)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus. (asm.org)
  • viral
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • This indicates that some human cells express a protein on their surface that acts as a receptor for MCF viruses and allows MCF viral entry. (umassmed.edu)
  • cytotoxic
  • Changes in the surface of virus-infected cells recognized by cytotoxic t cells. (jax.org)
  • The CD8+ cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+ cells. (ucsf.edu)
  • develop leukemia
  • Since this agent is vertically transmitted, it is expected that germfree mice would also develop leukemia, unless the presence of a microbial flora, or other horizontally transmitted viruses, contribute to its development. (springer.com)
  • proteins
  • Endogenous retrovirus (ERV) genomes integrated into the chromosomal DNA of the host were first detected in chickens and mice as Mendelian determinants of Gag and Env proteins and of the release of infectious virus particles. (royalsocietypublishing.org)
  • Distinctive properties of the hepatitis B virus envelope proteins. (asm.org)
  • Monoclonal antibody to spleen focus-forming virus-encoded gp52 provides a probe for the amino-terminal region of retroviral envelope proteins that confers dual tropism and xenotropism. (asm.org)
  • Characterization
  • Characterization of the 5'-terminus of murine leukemia virus rna. (jax.org)
  • Biologic, serologic, and molecular characterization of several HIV-1 and HIV-2 strains has revealed their extensive heterogeneity and how viruses can evolve differently in the same individual in the immune system, bowel, and the brain. (ucsf.edu)
  • restriction
  • Because of this and the fact that precisely the same saturation phenomenon that was described in the context of murine Fv1-mediated restriction is also observed in human cells ( 36 ), it is probable that humans also express an inhibitor, termed Ref1, that exhibits restriction specificity similar to that of Fv1 b . (asm.org)
  • homozygous
  • This strain is homozygous for Cdh23 ahl , the age related hearing loss 1 mutation, and ahl4, which on this background result in progressive hearing loss with onset between three and five months of age. (jax.org)
  • This strain is homozygous for Cdh23 ahl and Pde6b rd1 . (jax.org)
  • species
  • Within a species, the viruses isolated can display considerable diversity of biological properties. (springer.com)
  • Herpes simplex virus mRNA species mapping in EcoRI fragment I. (asm.org)