• Both cannabinoid receptors (CBRs) are, in fact, part of the heptahelical G protein-coupled receptor (GPCR) family and can inhibit adenyl cyclase activity or even stimulate mitogen-activated protein kinases (MAPKs), being, therefore, classified as Gi/0 receptors [ 3 - 5 ]. (irjournal.org)
  • The toxigenicity of cell extracts from each strain and variant was determined by tests of lethality in mice or of cytopathogenicity in cell cultures. (microbiologyresearch.org)
  • The role of the WI-38 cell strain in saving lives and reducing morbidity. (historyofmedicine.com)
  • Hayflick had found that his normal cell strain WI-38 was capable of growing all of the then known human viruses. (historyofmedicine.com)
  • We generated otsA and otsB mutant strains and found that these mutant strains reduced the bacterial trehalose concentration and HR induction on eggplant leaves compared to wild-type. (ppjonline.org)
  • The acyl lipids of strain 2/10 contain 16:0 and 16:1 as the major fatty acids, particularly in rich medium, when they comprise >90% of the total. (microbiologyresearch.org)
  • Highly inbred strains can be produced within one year. (sisef.it)
  • The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. (microbiologyresearch.org)
  • The disruption of this pathway could generate a strain incapable of surviving a typical human immune response and would represent an attractive candidate as an attenuated growth vaccine. (plos.org)
  • Both isolates are Gram-negative psychrotolerant (psychrotrophic) species growing well at 0 and 25 °C, but having very different optimum growth temperatures, of 97 °C for strain CR3/F/w/1/15 and 20·9 °C for strain CR3/F/w/2/10. (microbiologyresearch.org)
  • Purification and Characterization of a Stable,Membrane-Associated Peptidoglycan Responsive Adenylate Cyclase LRR Domain from Human Commensal Candida Albicans . (udel.edu)
  • Many donor strains were unstable and the limited availability of stable donor strains has limited the extent to which markers have been located. (microbiologyresearch.org)
  • This instability of donor strains is in marked contrast to the highly stable donor strains found in P. putida using the same plasmids. (microbiologyresearch.org)
  • Noradrenaline acts via beta-adrenoceptors to increase pineal cyclic AMP by activating adenylate cyclase, and the activation of pineal alpha 1-adrenoceptors potentiates beta-adrenergic stimulation not only of NAT but of both cyclic AMP and cyclic GMP. (nih.gov)
  • Cassel D., Selinger Z., Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site, Proc. (vetres.org)
  • The role of pertussis (PT) and Cya-A (adenylate cyclase) toxins is uncertain in the pathophysiology in human infants although the molecular characteristics of the substances have been described. (medscape.com)
  • The role of the WI-38 cell strain in saving lives and reducing morbidity. (historyofmedicine.com)