Oral mucosaLymphoidEpithelialSquamousMalignantMetaplasiaPoorly differentiated adenocarcinomaTumorEsophagusGlandsAtrophyChronic gastritisPancreasSmall intestinePyloriMALTEsophagealGastric acidAntrumGastritisDuodenumBarrett'sHistologicMucous layerMUC2DuctalDefectsDysplasiaAbnormalCellsNormalDistalHelicobacterIleumLesionsBiopsyProgressionPancreaticMiceMethodsCorrelationReadilySignificanceLesionCommonGenesDevelopmentCancerExpressionCases
Oral mucosa1
- regarding the association, in 2 patients, of a dis- 'tinctive type of melanin pigmentation of the oral mucosa, lips and digits with intestinal polyposis. (nih.gov)
Lymphoid4
- Although the polypoid lesions seen in this patient do not have the typical appearance of MALT (mucosa-associated lymphoid tissue) lymphoma, the possibility should at least be considered. (medscape.com)
- Moreover, gastric mucosa-associated lymphoid tissue lymphoma-like lesions in the stomach nearly disappeared in the treated mice 4 months after the therapy. (uibk.ac.at)
- ABSTRACT Both Helicobacter pylori and " Candidatus Helicobacter heilmannii" infections are associated with peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (MALT) lymphomas. (uibk.ac.at)
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene. (malt1inhibitor.com)
Epithelial2
- An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. (wikipedia.org)
- Some adenomas grow from epithelial tissue in nonglandular areas but express glandular tissue structure (as can happen in familial polyposis coli). (wikipedia.org)
Squamous4
- The mucosa has many different types of cells that include squamous cells, glandular cells, nerve cells, and infection-fighting cells. (cancer.org)
- Immunohistochemical PIGR expression was examined in a consecutive cohort of patients with surgically resected, radio-chemonaive adenocarcinoma of the esophagus, GE-junction and stomach (n = 173), including paired samples of benign-appearing squamous epithelium (n = 51), gastric mucosa (n = 114), Barrett's esophagus (BE) or intestinal metaplasia (IM) (n = 57) and lymph node metastases (n = 75). (biomedcentral.com)
- Background: Barrett's oesophagus (BO) is a pre-malignant condition in which normal squamous epithelium of the lower oesophagus and gastresophageal junction is replaced by columnar cells and progress to oesophageal adenocarcinoma. (cancer-genetics.org)
- Since the identification of Helicobacter pylori (H. pylori) , the incidences in gastric cancers have decreased worldwide, but there are reports of increases in esophageal squamous cell carcinomas (ESCC) as well as of adenocarcinomas of the esophago-gastral junction [ 5 ]. (springeropen.com)
Malignant2
- Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. (wikipedia.org)
- You have colorectal cancer when certain normal cells of the large intestine multiply abnormally to form malignant growths called glandular carcinoma or adenocarcinoma. (booboone.com)
Metaplasia4
- It is widely believed that this sequence of events -- progression from active chronic H pylori gastritis to gastric atrophy to intestinal metaplasia to dysplasia to cancer -- is the most common pathway of adenocarcinoma development in the stomach. (medscape.com)
- 2 cm, is not compatible with either the usually flat intestinal metaplasia or the usually focal adenocarcinoma. (medscape.com)
- Intestinal metaplasia of the gastric mucosa (Genta stain, 20x). (medscape.com)
- Eradication therapy for H. pylori and/or Barrett's metaplasia alone cannot be the sole explanation as metaplasia of the esophago-gastric mucosa results in just 2 % mortality within 10 years of diagnosis [ 7 ]. (springeropen.com)
Poorly differentiated adenocarcinoma2
- 1. Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma: A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry. (nih.gov)
- Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall ( linitis plastica ) without forming a distinct mass. (nih.gov)
Tumor6
- citation needed] Adenoma is a benign tumor of glandular tissue, such as the mucosa of stomach, small intestine, and colon, in which tumor cells form glands or gland like structures. (wikipedia.org)
- Each row in cpdb.ncintp.xls or cpdb.lit.xls represents a tissue-tumor combination for an experiment with a corresponding TD value. (nih.gov)
- The "idnum" field is the key that maps the tissue-tumor combination for an experiment to its associated doses and incidence. (nih.gov)
- Each tissue-tumor combination in an experiment has a unique idnum. (nih.gov)
- Tissue length always equals tumor length since tissue is repeated for combinations of tumor types. (nih.gov)
- It is used to link the tissue-tumor combinations for an experiment in cpdb.ncintp.xls or cpdb.lit.xls to its associated doses in cpdb.ncintpdose.xls or cpdb.litdose.xls, respectively. (nih.gov)
Esophagus1
- Adenocarcinoma occurs in the distal esophagus. (msdmanuals.com)
Glands6
- However, over time, the inflammation extends to the deep glands and intraglandular area, causing progressive loss of glandular mass (atrophy). (medscape.com)
- Atrophic gastritis is a histopathologic entity characterized by chronic inflammation of the gastric mucosa with loss of the gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. (medscape.com)
- The bacteria lodge within the mucous layer of the stomach along the gastric surface epithelium and the upper portions of the gastric foveolae and rarely are present in the deeper glands (see the 3 images below). (medscape.com)
- Gastric cancer (GC) may coexist with alterations of the adjacent glands, featuring cyto-architectural (de)differentiation somewhere between that of the native mucosa and that of the concomitant carcinoma. (bmj.com)
- Gastritis cystica polyposa is relatively rare and characterized by polypoid hyperplasia and cystic dilatation of the gastric glands in stomach. (scipedia.com)
- Approximately 1000 minor glands, localized to the cheeks, lips, and other intraoral mucosa, contribute about 7% to the whole saliva volume. (medscape.com)
Atrophy3
- [ 1 ] Atrophy of the gastric mucosa is the endpoint of chronic processes, such as chronic gastritis associated with Helicobacter pylori infection, other unidentified environmental factors, and autoimmunity directed against gastric glandular cells. (medscape.com)
- Intestinal-type epithelium with numerous goblet cells (stained blue with the Alcian blue stain) replace the gastric mucosa and represent gastric atrophy. (medscape.com)
- Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that is disrupted in precancerous lesions (e.g. metaplasias, chronic atrophy). (biologists.com)
Chronic gastritis1
- H pylori gastritis typically starts as an acute gastritis in the antrum, causing intense inflammation and, over time, it may extend to involve the entire gastric mucosa, resulting in chronic gastritis. (medscape.com)
Pancreas1
Small intestine1
- The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. (lookformedical.com)
Pylori3
- H pylori protects itself from the acidity of the stomach through the production of large amounts of urease, an enzyme that catalyzes the breakdown of urea to the alkaline ammonia and carbon dioxide. (medscape.com)
- H pylori- associated atrophic gastritis is usually a multifocal process that involves both the antrum and the oxyntic mucosa of the gastric corpus and fundus, whereas autoimmune gastritis essentially is restricted to the gastric corpus and fundus. (medscape.com)
- H pylori are gram-negative bacteria that colonize and infect the stomach. (medscape.com)
MALT1
- Light microscopic observations revealed an accumulation of B lymphocytes along with destruction of glandular elements and the presence of lymphoepithelial lesions consistent with low-grade MALT lymphomas. (uibk.ac.at)
Esophageal2
- Staging Esophageal Adenocarcinoma. (msdmanuals.com)
- In contrast, there has been a 2.5-fold increase of gastro-esophageal junction (GEJ) adenocarcinoma (AC) over the last four decades [ 2 ]. (biomedcentral.com)
Gastric acid1
- Prostaglandins are chemicals responsible for maintaining the mechanisms that result in the protection of the mucosa from the injurious effects of gastric acid. (medscape.com)
Antrum1
- The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. (lookformedical.com)
Gastritis8
- [ 4 ] Although it begins as an antral-predominant gastritis, progression to the body, fundus, and cardia of the stomach over many decades is common and well-described. (medscape.com)
- Acute gastritis is a term that encompasses a broad spectrum of entities that induce inflammatory changes in the gastric mucosa. (medscape.com)
- The inflammation may involve the entire stomach (eg, pangastritis) or a region of the stomach (eg, antral gastritis). (medscape.com)
- Occasionally, acute abdominal pain can be a presenting symptom, as in cases of phlegmonous gastritis (gangrene of the stomach) in which severe abdominal pain accompanied by nausea and vomiting of potentially purulent gastric contents can be the presenting symptoms. (medscape.com)
- This partly explains the development of acute gastritis distally over or near the greater curvature of the stomach in the case of orally administered NSAIDs. (medscape.com)
- Our present case highlights the rare clinical and endoscopic condition of gastritis cystica polyposa in an unoperated stomach. (scipedia.com)
- T. Huang, T. Tu, S. Huang, C. Lee and C. Wu, Gastritis cystica polyposa in an unoperated stomach, Advances in Digestive Medicine (2014). (scipedia.com)
- Gastritis cystica polyposa (GCP) is a rare disease characterized by polypoid hyperplasia of the gastric mucosa. (scipedia.com)
Duodenum2
- The mucosa otherwise was normal, as was the duodenum. (nih.gov)
- Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY. (lookformedical.com)
Barrett's1
- Aims: This study examined the role of Campylobacter concisus isolated from Barrett's and adenocarcinoma patient samples as one of possible environmental factors in the progression of Barrett's oesophagus to oesophagus adenocarcinoma. (cancer-genetics.org)
Histologic2
- The poor correlation between the endoscopic appearance of gastric mucosa and histologic abnormalities seen on biopsy is readily acknowledged. (medscape.com)
- [ 1 ] Gastric mucosa that appears "normal" on endoscopy is associated with impressive and diagnostic histologic abnormalities in approximately one third of cases. (medscape.com)
Mucous layer1
- The bacterium imbeds itself in the mucous layer, a protective layer that coats the gastric mucosa. (medscape.com)
MUC23
- Expression of MUC1, MUC2, MUC5AC, and MUC6 in normal mucosa and in 42 cases. (nih.gov)
- 17. Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression. (nih.gov)
- In sharp contrast to MUC1, MUC2 is almost never detectable in PanINs or conventional adenocarcinomas, but instead, it is commonly expressed in a rare but distinctive set of tumours that appear to form a distinct and indolent pathway of carcinogenesis. (bmj.com)
Ductal1
- Furthermore, it is abundant in almost all examples of conventional ductal adenocarcinoma. (bmj.com)
Defects1
- It occurs when there are defects in the MUCOSA barrier. (lookformedical.com)
Dysplasia1
- 3- 5 The World Health Organisation (WHO) has recently redefined dysplasia as non-invasive neoplasia (NiN) and longterm follow up studies have shown that, in the natural history of GC, NiN precedes invasive adenocarcinoma. (bmj.com)
Abnormal1
- the other 95%-98% of pancreatic neoplasms Neoplasms New abnormal growth of tissue. (lecturio.com)
Cells6
- 4. A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. (nih.gov)
- Electron microscopic observation revealed numerous " Candidatus Helicobacter heilmannii" bacilli in the fundic glandular lumen, the intracellular canaliculi, and the cytoplasm of intact cells, as well as damaged parietal cells. (uibk.ac.at)
- The tissue is checked for cancer cells. (cancer.org)
- The cancer cells in the biopsy tissue might be tested for genes or proteins such as PD-L1. (cancer.org)
- Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. (lookformedical.com)
- AGUS stands for atypical glandular cells of undetermined significance. (com.ng)
Normal2
- Because substantial amounts of DA present in normal stomach tissues has been implicated in several gastric functions, we therefore investigated the role, if any, of this neurotransmitter in the growth and progression of gastric cancer. (aacrjournals.org)
- Results: We found that expression of the RIN1 protein was downregulated in the HCC samples compared with the corresponding normal tissues. (malt1inhibitor.com)
Distal2
- adenocarcinoma is the most common in the distal one third. (msdmanuals.com)
- On the other hand, there has been a shift of distal gastric carcinomas to the proximal area of subcardial adenocarcinoma of the esophago-gastral junction (AEG Type III) and cardia localization (AEG Type II) over an 80-year period. (springeropen.com)
Helicobacter1
- ABSTRACT Triple-agent therapy with lansoprazole (15 mg/kg)-clarithromycin (50 mg/kg)-amoxicillin (50 mg/kg) twice daily for 7 days fully cleared " Candidatus Helicobacter heilmannii" from infected mouse stomachs. (uibk.ac.at)
Lesions3
- [ 2 , 3 ] In our patient, the focal polypoid lesions combined with the more subtle diffuse gastric mucosal abnormalities strongly suggest that a significant disease is present in the patient's stomach. (medscape.com)
- The gastric endoscopic findings in a postoperative stomach or in a patient taking NSAIDs often include marked color change, irregularity, and focal raised lesions. (medscape.com)
- We observed a gradual increase in the surface area of protrusive lesions in almost all infected C57BL/6 mouse fundic stomachs 6 months after infection. (uibk.ac.at)
Biopsy1
- EGD showed diffuse giant folds extending from the lower to the upper body of the stomach with nodularity and an intact surface ( Fig. 1 ), and the texture appeared soft during punch with a biopsy forceps. (scipedia.com)
Progression1
- Conclusion: Findings indicate that C. concisus could be as a new challenge in the progression of BO to adenocarcinoma. (cancer-genetics.org)
Pancreatic1
- In addition, pancreatic tissue from mice expressing this variant show de-differentiation and activation of signaling factors that initiate pancreatic cancer (PMID: 15093544, 25623042). (varsome.com)
Mice1
- On the basis of our observation of inverse correlation between stomach DA and gastric cancer growth, we determined the effect of pharmacological dose of DA on the angiogenesis and growth of MNNG induced gastric cancer in rats and Hs746T human gastric cancer in nude mice. (aacrjournals.org)
Methods2
- Methods: RIN1 expression was detected in paired HCC tissues by real-time polymerase chain reaction, Western blot analysis, and immunohistochemistry. (malt1inhibitor.com)
- only cancers of the lung and stomach result in more deaths worldwide.1 Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers.2 It devel- ops mostly in cirrhotic livers, and the risk factors include chronic infection by hepatitis B and C viruses and nonvi- ral liver diseases.3 The prognosis of HCC has improved because of significant enhancements in surgical techniques and diagnostic methods in recent years. (malt1inhibitor.com)
Correlation1
- Our study demonstrates that there is an inverse correlation between endogenous stomach DA and gastric cancer and indicates that DA already in clinical use for other purposes might have a role as an antiangiogenic agent in the treatment of gastric cancer. (aacrjournals.org)
Readily1
- Methylation of a target CpG island in even 0.1% of a cell population obtained from fixed/frozen tissues or body fluids can be detected readily. (biomedcentral.com)
Significance1
- In the present study, we examined the expression, clinicopathological correlates and prognostic significance of PIGR expression in an extended cohort of adenocarcinoma of the upper gastrointestinal tract. (biomedcentral.com)
Lesion1
- This variant has been reported in the literature as a somatic event (present in tissue from a lesion but not in non-lesional tissue or peripheral blood) in individuals with nevus sebaceous syndrome (PMID: 23255105, 22683711, 23096712, 26521233). (varsome.com)
Common1
- The common mechanism of injury is an imbalance between the aggressive and the defensive factors that maintain the integrity of the gastric lining (mucosa). (medscape.com)
Genes1
- Well-documented examples include the silencing of tissue-specific genes, gene imprinting, inactivation of parasite DNA and X-chromosome. (biomedcentral.com)
Development1
- Only a few case reports have noted its development in an unoperated stomach. (scipedia.com)
Cancer3
- For this test, the doctor takes out a small piece of tissue, with surgery or a needle, where the cancer seems to be. (cancer.org)
- Initially, the status of DA and tyrosine hydroxylase, the rate-limiting enzyme required for DA synthesis, were determined in human gastric cancer tissues and in N -methyl- N ′-nitro- N -nitrosoguanidine (MNNG)-induced gastric cancer tissues of rats. (aacrjournals.org)
- DA and tyrosine hydroxylase were absent in both human and rat gastric cancer tissues. (aacrjournals.org)
Expression3
- 14. Relationship between mucin expression of gastric intramucosal signet ring cell carcinoma and its background mucosa. (nih.gov)
- High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract. (biomedcentral.com)
- Ki67 and BCL2 expression was assessed in 276 gastric adenocarcinoma tissue microarrays. (karger.com)
Cases1
- Most cases are related to previous gastric surgeries, but a few cases have been reported in unoperated stomachs. (scipedia.com)