• Self-immolative polymers (SIPs) are molecules that depolymerize in a controlled manner due to the cleavage of stimuli-responsive end groups. (uwo.ca)
  • Focusing on the most advanced materials and technologies, evaluation methods, and advanced synthesis techniques stimuli-responsive polymers, the book is an essential reference for scientists with an interest in drug delivery vehicles. (elsevier.com)
  • Sections focus on innovation, development and the increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery. (elsevier.com)
  • Detailed experimental investigations of the effects of the nanofillers on the funtional properties and the effect of the processing conditions will result in new fundamental insights for the structure-processing-property relationships of conductive stimuli-responsive polymers, which in turn will allow the design of such materials for a broad range of applications and will generate a thorough understanding for the optimization of developed materials and applications. (vub.be)
  • Thiol groups and/or disulfide linkages can be incorporated into polymers to produce stimulus-responsive and/or self-healing materials. (encyclopedia.pub)
  • In the last decade stimuli-responsive polymers attracted enormous attention for a range of important applications. (uni-freiburg.de)
  • Such polymers are capable of changing their conformation, solubility, or they can even break or form covalent bonds upon a change of temperature or pH value, upon light irradiation, by using electrochemical stimuli or by the presence of an electrical or magnetic field, or by combinations thereof. (uni-freiburg.de)
  • The aim of this contribution is to introduce a thermo- and water-responsive shape memory polymer (SMP), which could lay the foundation for a new type of aligner therapy. (mdpi.com)
  • A self-healing coating that is able to maintain its original appearance and Stimuli-responsive polyurethane-urea polymer for protective coatings performance after damage is attractive for a huge scope of applications. (european-coatings.com)
  • Neutron refl ectivity measurements are able to characterize temperature-responsive polymer brushes, now evaluated by a novel method involving polymer brush theory. (lu.se)
  • Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. (researchgate.net)
  • More specifically, endogenous chemical stimuli include environmental pH, redox reactions, and chemical gradients, each of which are typically out of physiological range or unique to a specific or diseased tissue, which provides the ability to achieve target specificity using these particular stimuli for release. (wikipedia.org)
  • Researchers have worked to develop numerous types of drug delivery systems that harness a response to endogenous chemical stimuli to achieve targeted delivery and controlled release of drug into a specific environment. (wikipedia.org)
  • Many of these systems rely on the application and manipulation of click chemistry to achieve stimulated response The field of endogenous chemical-responsive systems has developed greatly within the last 20 years and continues to grow as researchers determine new applications for the field, including the development of chemically responsive systems for diagnostic purposes. (wikipedia.org)
  • Endogenous chemical stimuli-responsive drug delivery systems are important in the field of drug delivery because of their ability to harness chemical phenomena within the body to overcome traditional therapeutic release limitations such as temporal release and tissue permeability. (wikipedia.org)
  • Herein, we report the construction of a novel composite coating by incorporating multifunctional nanosensors (graphene oxide-zeolitic imidazole frameworks loaded with 1,10-phenanthroline) into a thermo-responsive polyurethane. (rsc.org)
  • Thermo-responsive Fibrinogen Nanogels: a Viable Thermo-responsive Drug Delivery Agent for Breast Cancer Therapy? (amrita.edu)
  • P(MMA/NIPAM)] copolymers are shown to be thermo-responsive, whereas [P(MMA/NIPAM/AAc)] copolymers are shown to be pH-responsive. (korea.ac.kr)
  • Confocal micrographs of the lock-and-key self-assembly into colloidal molecules with thermo-responsive valence. (lu.se)
  • The patient was drowsy, had an average build, was responsive to painful stimuli, and had no organomegaly. (medscape.com)
  • Smart internal stimulus-responsive nanocarriers for drug and gene delivery / Mahdi Karimi, Parham Sahandi Zangabad, Amir Ghasemi and Michael R. Hamblin. (iitd.ac.in)
  • Unless the theranostic system meets with the internal stimuli in tumor cells, fluorescence is quenched due to AuNP-Verteporfin and Verteporfin-Verteporfin interactions. (sabanciuniv.edu)
  • In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. (iitd.ac.in)
  • 7. Responsive block copolymers for drug delivery applications. (elsevier.com)
  • As of 2013, a redox-responsive therapy targeting metastatic breast cancer had been approved by the FDA but was not yet currently in use. (wikipedia.org)
  • 4. Redox-responsive micro/nanocarriers -- 4.1. (iitd.ac.in)
  • Redox-responsive nano drug/gene delivery systems -- 4.2. (iitd.ac.in)
  • Stimuli responsive biopolymer. (nih.gov)
  • In this comprehensive review, we categorized donors by the biological stimulus that triggers their H2S liberation and provided detailed releasing mechanisms. (wfu.edu)
  • In Chapter III, a new and general design strategy was described for increasing the rate, efficiency, and selectivity of H2S liberation from thioamide-based donors through intramolecular nucleophilic assistance, triggered by a specific biological stimulus. (wfu.edu)
  • Importantly, we predict this general scaffold can be modified to access a wide variety of thioamide-based donors that are selectively responsive to various biological stimuli. (wfu.edu)
  • Three basic stimuli are identified: physical, chemical and biological. (rsc.org)
  • The aim of this study is in radical copolymerization of stimuli-responsive poly(methyl methacrylate/N-isopropyl acrylamide) [P(MMA/NIPAM)] and poly(methyl methacrylate/N-isopropyl acrylamide/acrylic acid) [P(MMA/NIPAM/AAc)] copolymers with an enhanced longevity in aqueous surroundings. (korea.ac.kr)
  • Zhang, Y & Yarin, AL 2009, ' Stimuli-responsive copolymers of n-isopropyl acrylamide with enhanced longevity in water for micro- and nanofluidics, drug delivery and non-woven applications ', Journal of Materials Chemistry , vol. 19, no. 27, pp. 4732-4739. (korea.ac.kr)
  • The evidence that platelets are capable of de novo protein synthesis in response to stimuli raised the issue of how megakaryocyte-derived mRNAs are regulated in these anucleate cell fragments. (nature.com)
  • Owing to their super magnetic capabilities, biocompatibility, high specialized region, appropriate nano-sized particulates, and lower toxic effects, Fe2O3 nanomaterials are one of the most promising alternatives for magnetic-responsive devices according to the researchers [31, 103, 104] (Figure 3). (researchgate.net)
  • Extreme hypoactivity, immobile, minimally responsive to stimuli. (rochester.edu)
  • Verbally unresponsive or minimally responsive. (rochester.edu)
  • TGFb1, PCNA, Myog) in young rats following injury, yet these same genes were minimally responsive in old rats. (cdc.gov)
  • Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles. (bvsalud.org)
  • Stomata are less responsive to environmental stimuli in high background ozone in Dactylis glomerata and Ranunculus acris. (apis.ac.uk)
  • Historically it has been suggested that the skull is less responsive than the rest of the skeleton to stimuli that affect BMD but there are few published data to support this notion. (ox.ac.uk)
  • Moreover, when the large surface area, excellent electron transfer, and electrochemical catalysis abilities of GRO were combined with the responsive characteristics of PVCL, temperature-triggered reversible electrocatalysis of TZN with enhanced sensitivity has been proved. (dgist.ac.kr)
  • Rossner, C, Glatter, O & Vana, P 2017, ' Stimulus-Responsive Planet−Satellite Nanostructures as Colloidal Actuators: Reversible Contraction and Expansion of the Planet− Satellite Distance ', Macromolecules , vol. 50, pp. 7344-7350. (elsevierpure.com)
  • Traditional stimuli-responsive actuators enable reversible deformation under external stimuli. (eurekalert.org)
  • This reversible temperature-responsive dynamic self-association process can be seen as the colloidal analogue of adaptive chemistry. (lu.se)
  • Stimuli-responsive biomaterials offer a unique advantage over traditional local drug delivery systems in that the drug elution rate can be controllably increased to combat developing symptomology or maintain high local elution levels for disease treatment. (nih.gov)
  • These chemically responsive drug delivery systems can be created using a wide variety of materials and carriers, including lipid, protein, or polymeric materials to create degradable scaffolds or depots and micelles and nanoparticles. (wikipedia.org)
  • Through the stimulus-responsive trigger, these materials can decompose rapidly in response to triggers, such as UV light irradiation. (uwo.ca)
  • Stimuli-responsive materials: definition, classification and descriptions Stimuli-responsive materials have the particularity to change one or more of their properties under a defined stimulus: through a transition phenomenon, they will turn an input, or stimulus, into an output, or response. (polimi.it)
  • To get a perspective on stimuli-responsive materials and the possibilities they offer, the first step has been to class them according to their transition phenomenon. (polimi.it)
  • After having proposed this classification of stimuli-responsive materials, the next step of the work is to get more detailed information about their behavior, and to organize and represent this information in a coherent and efficient way. (polimi.it)
  • This information is now being summed up in a database, which is organized with different tables and tree-structures that will describe stimuli-responsive materials, transition phenomena and the link between them. (polimi.it)
  • Stimuli-responsive materials are such smart materials, which exhibit adaptability in respons of environmental stimuli. (vub.be)
  • Thiol-and Disulfide-Based Stimulus-Responsive Soft Materials" Encyclopedia , https://encyclopedia.pub/entry/10756 (accessed December 02, 2023). (encyclopedia.pub)
  • Our work on stimuli-responsive materials featured on the front cover of Advanced Theory and Simulations! (berkeley.edu)
  • Enzyme-responsive materials in drug delivery -- 3.4. (iitd.ac.in)
  • Carnivorous plants have inspired innovations of advanced stimuli-responsive actuators and lubricant-infused slippery surfaces. (eurekalert.org)
  • A representative set of stimuli are identified and the chemistry of the response is discussed based on the specific stimulus. (rsc.org)
  • Scientists at the Divisions of Physical Chemistry and Theoretical Chemistry at Lund University have investigated the association between oppositely charged thermos-responsive synthetic lock and key particles. (lu.se)
  • These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. (iitd.ac.in)
  • Within the broad field of drug delivery, the development of stimuli-responsive drug delivery systems has created the ability to tune drug delivery systems to achieve more controlled dosing and targeted specificity based on material response to exogenous and endogenous stimuli. (wikipedia.org)
  • The system was efficiently internalized by SKOV-3 cells and demonstrated high specificity towards its stimuli. (sabanciuniv.edu)
  • Specifically, in this chapter we demonstrated that both disulfide- and diselenide-linked thioamides are responsive to biologically relevant concentrations of glutathione and release H2S via a cyclization reaction that notably enhances the rate and efficiency of sulfide delivery in both buffer and live human cells. (wfu.edu)
  • Glutathione-responsive -- 5.7. (iitd.ac.in)
  • Here, a novel PEGylated poly( alpha-lipoic acid ) graft combretastatin A4 (PALA-g-mPEG/CA4) nanoparticle with glutathione (GSH) stimulus responsive ability was prepared from alpha-lipoic acid in a simple approach, which can accumulate and release CA4 selectively in a tumor site. (bvsalud.org)
  • pH-responsive nanocapsules suffered a complete burst at pH values close to 7.4 while enzyme-responsive nanocapsules were destroyed in the presence of MMP2 or MMP9 metalloproteinases. (europa.eu)
  • 3. Enzyme-responsive nanocarriers -- 3.1. (iitd.ac.in)
  • 4 different macroemulsifiers with different stimuli responsiveness were designed: non-, pH-, enzyme- and dual-responsive. (europa.eu)
  • Stimuli responsiveness was also demonstrated. (europa.eu)
  • Monodisperse chiral nematic droplets and particles were made, using the monomer mixtures established together with the microfluidic technique developed, and concluded with an investigation of the responsiveness of the particles to external stimuli. (lancs.ac.uk)
  • They owe their stimulus-responsiveness to covalent disulfide bonds, which can be broken and re-formed under mild conditions. (encyclopedia.pub)
  • Droplets were produced using a homemade microfluidic technique and photo-polymerised into particles, followed by an analysis of the responsive properties. (lancs.ac.uk)
  • Naturally, the review evolves to more complex architectures, from one-dimensional to three-dimensional magneto-responsive systems, demonstrating higher complexity and multifunctionality, and consequently, higher interest for clinical practice. (researchgate.net)
  • The extent of reactivity, and, thus, the stimulus-responsive behavior depends on the nature of the groups flanking the disulfide bond, as well as interactions with stimuli such as light, heat, mechanical force, and changes in the pH or redox state [ 1 ] . (encyclopedia.pub)
  • A stimuli-responsive fluorophore, encompassing a Lewis acid-base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. (rsc.org)
  • Herein, we review the development of magneto-responsive devices for cancer theranostics, starting from the most straightforward architecture, single nanoparticles. (researchgate.net)
  • These magneto-responsive devices can be used for a multitude of biomedical applications, from diagnostic to the treatment of tumors, and are actively being developed and tested for cancer theranostics. (researchgate.net)
  • Initially the patient was not awake, but was responsive (he moaned) to a verbal stimulus. (nols.edu)
  • Structural switching in response to the applied stimulus was investigated by means of small-angle X-rayscattering and dynamic light scattering. (elsevierpure.com)
  • However, in most cases, simple bending deformation cannot trap insects because of the slow response to environmental stimuli or the lack of surface wettability control. (eurekalert.org)
  • Among the approximately 1000 differentially responsive genes expressed in both injured groups, there was an intense upregulation of genes related to the inflammatory response (i.e. (cdc.gov)
  • These data suggest that, at the molecular level, old rats may be desensitized to launch an appropriate response to an injury stimulus compared with young rats, and the disparity in these specific molecular signals could impact recovery kinetics following contraction-induced injury with aging. (cdc.gov)
  • The review ends with the main challenges in the design and engineering of magneto-responsive devices for cancer theranostics and future trends in this biomedical field. (researchgate.net)
  • The concept of stimuli-responsive drug delivery systems can actually be seen as ahead of this time, since the first pH-responsive drug coating was used in the late 1950s in Europe. (wikipedia.org)
  • The development of stimuli-responsive drug carriers was not popularized until the mid-1980s by researchers at Utah University, who created thermally-responsive drug delivery systems. (wikipedia.org)
  • Since the eruption of this field, substantial research has been conducted to tune stimuli-responsive drug delivery systems despite several limitations. (wikipedia.org)
  • Much work is still being done to continue the development of this field in hopes of one day making stimuli-responsive drug delivery systems commonplace in medical practice. (wikipedia.org)
  • pH responsive drug delivery systems respond to the environmental pH of a tissue, which, when existing within a certain acidic range, can lead to structural and chemical changes of the drug delivery system. (wikipedia.org)
  • M. Rawal, in Stimuli-responsive Drug Delivery Systems, ed. (rsc.org)
  • These molecules have so-called responsive properties. (tue.nl)
  • Surface-coated AuNPs were modified with Cathepsin B cleavable peptide (stimuli responsive linker) and Verteporfin (photosensitizer and fluorescence imaging agent). (sabanciuniv.edu)
  • In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external. (iitd.ac.in)
  • The emerging assembly rules could provide new routes to the creation of higher order hierarchical structures, which can be reversibly controlled by external stimuli. (lu.se)
  • The Dionaea muscipula preys actively through a stimuli-responsive actuation mechanism. (eurekalert.org)
  • Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)
  • The research team demonstrated a moisture-responsive shape-morphing slippery surface that can contact droplets actively and let them slide away passively. (eurekalert.org)
  • Liu now presents an artificial skin: a smart surface that can actively and repeatedly release and reabsorb substances under environmental stimuli, in this case radio waves. (tue.nl)
  • Various applications exploiting the stimulus-responsive nature of ELPs have been reported, and here we discuss our findings in the context of controlling particle aggregation. (aiche.org)
  • This makes it a suitable platform for various applications that can benefit from stimuli-mediated degradation, such as tissue engineering and drug delivery. (uwo.ca)
  • Resistance to passive movement which is proportional to strength of the stimulus, appears automatic rather than willful. (rochester.edu)
  • We combined the slippery surfaces (passive prey) and stimuli-responsive actuation (active prey), so we proposed a hybrid bionic moisture deformable slippery surface-based GO, which enables both active and passive droplet manipulation. (eurekalert.org)
  • A second representation has been made starting from the first graph, but adding a link to the user of a product which use a stimuli-responsive material. (polimi.it)
  • Because disulfide linkages are often the weakest covalent bonds in an organic molecule, they provide an avenue to tune the properties of a material under mild reaction or stimulus conditions. (encyclopedia.pub)
  • Dual stimuli-based delivery systems -- 6.3. (iitd.ac.in)
  • Triple stimuli-based delivery systems -- 7. (iitd.ac.in)
  • Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. (iitd.ac.in)
  • The concept of the hybrid bionic model is the combination of the two tapping behaviors within one synthetic smart surface here, which the research team called a stimuli deformable slippery surface. (eurekalert.org)
  • These promising preliminary results indicate clinical potential for use in stimuli-controlled drug delivery. (nih.gov)
  • In this study, we developed a highly specific, hybrid theranostic agent that is only activated when it meets with its stimuli at the site of interest. (sabanciuniv.edu)
  • In particular, stimuli-responsive nanosystems provide the advantage of not only being target-specific but also less cytotoxic. (rsc.org)
  • 2. The aim of this work was to investigate how hypoxia affects human lung epithelial cells in combination with profibrotic stimuli and its correlation to pathogenesis. (lu.se)
  • The bronchial epithelium appears more responsive to changes in oxygen levels and remodelling processes compared to the alveoli, suggesting that hypoxia may be a driver of pathogenesis in chronic lung disorders. (lu.se)