Loading...
  • inhibits
  • Insulin-like growth factor 1 (IGF-1) inhibits the adriamycin-induced apoptosis of PC-3 human prostate cancer cells. (springer.com)
  • To find out if this drug inhibits colon cancer, researchers from University of Texas Health Sciences Center in Houston conducted a study involving unmodified indomethacin and indomethacin modified with phosphatidylcholine to protect against NSAID injury in the gastrointestinal tract. (eurekalert.org)
  • Ligation
  • Ligation of TRAIL to TRAIL-R1 and TRAIL-R2 induces apoptosis as these receptors contain functional death domains, whereas TRAIL interaction with the other three receptors does not induce apoptosis. (aacrjournals.org)
  • Ligation of the BCR with sol-IgM induced incomplete responses in both CLL subsets, resembling the pattern described for tolerant B cells. (bloodjournal.org)
  • Moreover, analysis of early signaling events induced by IgM ligation indicate that the 2 subsets may also differ in their capacity to transmit BCR-derived stimuli. (bloodjournal.org)
  • clinical
  • Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development. (frontiersin.org)
  • Clinical studies are currently in development to evaluate the role of proteasome inhibition as an important adjuvant to systemic chemotherapy. (aacrjournals.org)
  • In contrast to the initial studies that led to their Food and Drug Administration (FDA) approval for chemotherapy-induced anemia, recent clinical trials targeting restoration of hemoglobin to normal and even supraphysiologic levels have shown worse outcomes for cancer patients receiving ESAs compared with placebo. (aacrjournals.org)
  • nerve damage
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (adventisthealthcare.com)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (adventisthealthcare.com)
  • cancer
  • Inhibitors of the insulin-like growth factor-I (IGF-I) receptor have been widely studied for their ability to enhance the killing of a variety of malignant cells, but whether IGF-I signaling differentially protects the host and cancer cells against chemotherapy is unknown. (aacrjournals.org)
  • Cancer stem cells (CSC) are thought to be responsible for tumor initiation and tumor regeneration after chemotherapy. (aacrjournals.org)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (adventisthealthcare.com)
  • The standard therapy for ovarian cancer consists of surgery followed by chemotherapy. (jcancer.org)
  • exposure
  • In a new study, researchers from the University of Texas Health Science Center at San Antonio discovered that exposure to vinca alkaloids and taxanes chemotherapy drugs was associated with an immediate pain response activated through the peripheral nerves that detect pain stimuli. (eurekalert.org)
  • however
  • For instance, by using the hot-plate method of Ankier 4 , flinch, withdrawal and/or licking of either hind- and/or fore-paws is quantified as reflex latencies at constant high thermal stimuli (52-55 °C). However, animals that are hyperalgesic to thermal stimulus do not reproducibly show differences in reflex latencies using those supra-threshold temperatures 3,5 . (jove.com)
  • Prevent
  • Animal research suggests it might also be able to protect the liver against certain poisonous chemicals and prevent diabetes . (webmd.com)
  • side effects
  • Some early research suggests that taking AHCC might reduce some of the gastrointestinal side effects, such as nausea , related to chemotherapy use. (webmd.com)
  • The senescent cells remain chronically present where they can promote local and systemic inflammation that causes or exacerbates many side effects of the chemotherapy. (aacrjournals.org)
  • bone
  • We have previously demonstrated that tumor necrosis factor-α (TNF-α) is present locally in the bone marrow microenvironment and induces NF-κB-dependent up-regulation of adhesion molecules on both MM cells and bone marrow stromal cells, with resultant increased adhesion. (bloodjournal.org)