• Here, CaMKII activates MEK/ERK, which degrades the cell cycle arresting p27 protein In general, transformed cells proliferate in a calcium-independent manner, whereas non-transformed cells show high sensitivity to extra-cellular calcium concentration, suggesting oncogenic growth may include disruption of calcium signaling. (wikipedia.org)
  • CaM-kinase II (CaMKII) is a member of the CaMK family, and it is highly expressed in the cytosol of developing neurons, including the growth cone. (ijmrhs.com)
  • Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. (nih.gov)
  • Finally, we provide evidence that STP at the VD4-LPeD1 synapse requires presynaptic calcium/calmodulin dependent kinase II (CaMKII). (nartsignaling.com)
  • Taken together, our study identifies a novel form of STP which may provide the basis for both short- and long-term potentiation, in the absence of any protein synthesis-dependent steps, and involve CaMKII activity exclusively in the presynaptic cell. (nartsignaling.com)
  • CaMKII is a major synaptic protein that is activated during the induction of long-term potentiation (LTP) by the Ca 2+ influx through NMDARs. (biomedcentral.com)
  • Calmodulin then activates CaMKII, which phosphorylates the GluA1 subunits of AMPARs and an auxiliary subunit of AMPARs, stargazin. (biomedcentral.com)
  • Importantly, the amount of complex was increased substantially by stimulation that elevated intracellular Ca 2+ and thereby activated CaMKII. (biomedcentral.com)
  • Specifically, CaM was redistributed away from LTD- inducing proteins to bind the high affinity LTP-inducing protein, calmodulin dependent kinase II (CaMKII). (lincoln.ac.nz)
  • In this way, CaMKII acted as a dominant affecter and repressed activation of opposing CaM binding protein targets. (lincoln.ac.nz)
  • Abstract: The present study investigated whether oxidative stress and Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) activity are involved in triggering the Anrep effect. (uni-luebeck.de)
  • In snap-frozen WT hearts, force-pCa relationship, H 2 O 2 generation, CaMKII oxidation and phosphorylation of myofilament and Ca 2+ handling proteins were assessed. (uni-luebeck.de)
  • Force development of single WT cardiomyocytes was greater with elevated afterload at submaximal Ca 2+ concentration and associated with increases in CaMKII oxidation and phosphorylation of cardiac-myosin binding protein-C, myosin light chain and Ca 2+ handling proteins. (uni-luebeck.de)
  • CaMKII activity is involved in the regulation of the Anrep effect and associates with stimulation of oxidative stress, presumably starting a cascade of CaMKII oxidation with downstream phosphorylation of myofilament and Ca 2+ handling proteins. (uni-luebeck.de)
  • Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
  • Next, we observed that Acanthamoeba specifically activates phosphatidylinositol 3-kinase. (asm.org)
  • Upsurge in intracellular calcium mineral activates calcium mineral/calmodulin-dependent kinases, which impact splicing and/or localization of many splicing elements. (antiviralbiologic.com)
  • Glucose metabolism activates this pathway by means of increasing [Ca 2+ ] i via L-type voltage-dependent calcium channels (VDCCs) by affecting the electrical activity of the cell. (diabetesjournals.org)
  • This is because Ca²⁺- bound CaM activates both LTD- and LTP- inducing proteins. (lincoln.ac.nz)
  • In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced AP-1 and DNA replication in cultured rat mesangial cells. (nih.gov)
  • BK (10(-9) to 10(-7) M) stimulated a rapid increase in tyrosine phosphorylation of multiple proteins with an estimated molecular mass of 120-130, 90-95, and 44-42 kDa. (nih.gov)
  • Genistein, a specific tyrosine kinase inhibitor, prevented the phosphorylation of ERK2 by BK. (nih.gov)
  • In accord with the stimulation of Elk-1 phosphorylation, BK induced c-fos gene expression and the production of Fos/AP-1 complexes. (nih.gov)
  • AP-1 pathway and that BK mitogenic signaling is critically dependent on protein tyrosine phosphorylation. (nih.gov)
  • We furthermore demonstrate that p110δ is phosphorylated at residues Y524 and S1039 and that phosphorylation requires an intact binding site for PI3-kinase in c-Kit/D816V. (ku.dk)
  • The also acutely modulate the efficacy of basal synaptic transmission downstream actions of these cytoplasmic signals may increase at developing neuromuscular junctions in cell cultures (Lohof et phosphorylation of synaptic vesicle-associated proteins (Jo- al. (eddoctor24h.com)
  • Second, the slightly delayed recovery of SV is perhaps dependent on Ca 2+ /calmodulin-dependent protein kinase II activation caused by oxidation and myofilament phosphorylation (cardiac myosin-binding protein-C, myosin light chain 2), maximizing the recruitment of available strongly-bound myosin cross-bridges. (uni-luebeck.de)
  • The major downstream calcium effectors are the calcium-binding calmodulin protein and downstream calmodulin-dependent protein kinases I / II. (wikipedia.org)
  • Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
  • Furthermore, CaMK can phosphorylate proteins kinases A and C, which give food to in to the downstream MAPK pathway, ultimately phosphorylating ERK. (antiviralbiologic.com)
  • In this thesis, CaM activation by Ca²⁺ and calmodulin binding to downstream proteins was mathematically modelled using differential equations. (lincoln.ac.nz)
  • The morphology and motility of the growth cone depend on Ca2+ and the stimulation of Ca2+ dependent protein kinases (CaMK) in developing neurons. (ijmrhs.com)
  • Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. (rochester.edu)
  • We further demonstrate that, unlike previously described forms of STP, the synaptic potentiation between Lymnaea neurons does not involve postsynaptic receptor sensitization or presynaptic residual calcium. (nartsignaling.com)
  • A rise in internal calcium mineral level causes missing of exon 5 and exon 21 of NMDA receptor type 1 (NMDAR1) in hippocampal neurons (Han et al. (antiviralbiologic.com)
  • Treatment of neurons by different drugs boosts intracellular calcium mineral levels by impacting calcium mineral stations and pushes. (antiviralbiologic.com)
  • Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer's disease. (otago.ac.nz)
  • At the Wnt non-canonical pathway, HA/TCP group showed higher voltage-gated calcium channel ( Vgcc ), calmodulin-dependent protein kinase II, and Wnt5a genes expression, while HA/TCP + ES presented higher protein expression of VGCC and calmodulin (CaM) at the same period. (harvard.edu)
  • Structural genes encode proteins that are not involved in gene regulation. (p450inhibitors.com)
  • Furthermore to both of these genes, it's been proven that increasing calcium mineral within the cell through the use of these pharmacological real estate agents impacts the adjustments in splice site selection for most genes (to get a complete list discover Table 1 within the review by Xie, 2008). (antiviralbiologic.com)
  • Calmodulin dependent kinase II was shown to be the protein responsible for converting the Ca2+ influx signal into inhibition of CSF and activation of cyclin degradation machinery to degrade cyclin B, resulting in progression through meiosis II. (wikipedia.org)
  • Each of these effects was blocked by tyrosine kinase inhibition with genistein or herbimycin A. Similarly, antisense oligodeoxynucleotide targeting of ERK1/2 mRNA inhibited BK-stimulated DNA synthesis. (nih.gov)
  • In contrast, protein kinase C inhibition or depletion had no effect on BK-induced c-fos mRNA, AP-1-DNA binding activity, or DNA synthesis. (nih.gov)
  • Furthermore, inhibition of the lipid kinase activity of PI3-kinase led only to a slight inhibition of cell survival. (ku.dk)
  • These results could be reproduced by computer modeling of the border zone based on our knowledge of β-adrenergic receptor signaling pathways and their influence on intracellular calcium handling and ion channels. (frontiersin.org)
  • More specifically, substrates with certain FYVE domains (named after the first four proteins in this motif, Fab1, YotB, Vac1p, and EEA1) bind PIP, and these pathways have been implicated in vesicular trafficking or receptor-mediated endocytosis ( 5 ). (asm.org)
  • These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)
  • Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
  • To confirm that Rad loss modulates LTCC independently of ß-AR stimulation, we crossed a ß1,ß2-AR double-knockout mouse with cRadKO, resulting in a Rad-inducible triple-knockout mouse. (bvsalud.org)
  • Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
  • Here, Ca²⁺ binds the protein, calmodulin (CaM) which modulates synaptic plasticity in both directions. (lincoln.ac.nz)
  • Long-term potentiation (LTP) is the persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse . (wikidoc.org)
  • Here, we review these lines of evidence from multiple human genetic studies, and non-human primate and mouse experiments that support the conclusion that the MET receptor tyrosine kinase (RTK) functions to influence synapse development in circuits relevant to certain core behavioral domains of ASD. (biomedcentral.com)
  • It has been proposed by Frey and Morris that late LTP involves the setting of a molecular tag during LTP induction, which subsequently allows the activated synapse to capture the proteins responsible for late LTP. (biomedcentral.com)
  • As opposed to plasticity being controlled only locally at the target synapse (as with frequency-dependent protocols) or globally via a backpropagating action potential (as with spike timing-dependent plasticity, STDP), our results indicate that plasticity can be controlled in a sophisticated hierarchical and branch-dependent manner. (eneuro.org)
  • Subthreshold stimulation induced spinal long-term potentiation in GluA1 phosphomimetic mutant mice, but not in wild-type mice. (jneurosci.org)
  • The majority of inositol lipids reside in membranes and serve as substrates for kinases, phosphatases, and phospholipases. (asm.org)
  • Calcium ion (Ca2+) and Calmodulin (CaM) are important signaling molecules that have been shown to play a significant role in a wide variety of neuronal functions, including neurite outgrowth of axon and dendrites. (ijmrhs.com)
  • Phosphatidylinositol 3-kinases (PI3Ks) are important signaling molecules that phosphorylate the 3′ OH position of the inositol ring of phosphoinositides (PIs), generating the second messengers PI(3)P, PI(3,4)P 2 , and PI(3,4,5)P 3 ( 4 , 17 ). (asm.org)
  • Unexpectedly, we find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1). (nature.com)
  • Inactivation of LTCC is controlled to fine-tune calcium flux and is governed by voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). (bvsalud.org)
  • However, these studies used pharmacological inactivation or electrical stimulation techniques, which lack temporal precision and neuronal specificity. (jneurosci.org)
  • Many types of opioid receptors (e.g., μ , κ , δ ) exist in the nervous system, and they are all typical inhibitory G protein-coupled receptors (GPCRs) [ 30 ]. (hindawi.com)
  • Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
  • This get the job done demonstrates a novel complicated concerning FE65, VLDLR, and APP, which assists elucidate the part of FE65 in regulating transmem brane proteins like ApoE receptors and APP while in the CNS. (mirnasynthesis.com)
  • Agonists of NMDA receptors, such as for example NMDA, and glutamate can boost calcium mineral influx with the NMDA receptors, whereas antagonists such as for example MK801 can inhibit the influx of calcium mineral through NMDA receptors. (antiviralbiologic.com)
  • Using a synaptic model that implements calcium-based long-term plasticity via two sources of Ca 2+ - NMDA receptors and voltage-gated calcium channels (VGCCs) - we show in dendritic cable simulations that the interplay between these two calcium sources can result in a diverse array of heterosynaptic effects. (eneuro.org)
  • We hypothesize that the border zone is most vulnerable to alternans, that β-adrenergic receptor stimulation can suppresses this, and investigate the consequences in terms of arrhythmogenic mechanisms. (frontiersin.org)
  • β-Adrenergic receptor stimulation with norepinephrine (1 μmol/L) attenuated alternans by 60 [52-65]% [interquartile range] and this was reversed with metoprolol (10 μmol/L, p = 0.008). (frontiersin.org)
  • Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
  • While high levels of overall cardiac sympathetic drive are a negative prognostic indicator of mortality following MI and during heart failure, β-adrenergic receptor stimulation in the infarct border zone reduced spatially heterogeneous alternans, and prevented conduction block and propagation of extrasystoles. (frontiersin.org)
  • Rad is a monomeric G protein that regulates ICa,L and has recently been shown to be critical to ß-adrenergic receptor (ß-AR) modulation of ICa,L. Our previous work showed that cardiomyocyte-specific Rad knockout (cRadKO) resulted in elevated systolic function, underpinned by an increase in peak ICa,L, but without pathological remodeling. (bvsalud.org)
  • Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. (otago.ac.nz)
  • Neurotrophins serve long-term trophic functions by with activation of Trk receptor tyrosine kinase (Lohof et al. (eddoctor24h.com)
  • G protein-coupled receptor 155 [So. (gsea-msigdb.org)
  • The role of calcium in condensation was independent of CAMK function, suggesting a purely structural role of Ca2+ in chromatin compaction. (wikipedia.org)
  • Exquisite control of intracellular calcium dynamics are required, as calcium appears to play a role at multiple cell cycle checkpoints. (wikipedia.org)
  • Historically, one of the most well characterized roles of intracellular calcium is activation of the ovum after sperm fertilization. (wikipedia.org)
  • In deuterosome eggs (mammals, fish, amphibians, ascidians, sea urchins, etc.), successful sperm entry leads to a distinct rise in intracellular calcium ions (Ca2+), with mammals and ascidians displaying a series of intracellular calcium spikes required for completion of meiosis. (wikipedia.org)
  • Open up in another window Shape 1 Stimulation of the cell using different drugs can boost or lower intracellular calcium mineral by affecting different stations and BMP8B pumps connected with calcium mineral influx. (antiviralbiologic.com)
  • Thapsigargin boosts intracellular calcium mineral by inhibiting the sarco/endoplasmic reticulum calcium mineral pump, whereas usage of dantrolene can inhibit the discharge from the calcium mineral through the sarco/endoplasmic reticulum (Yoneyama et al. (antiviralbiologic.com)
  • Intracellular calcium ([Ca 2+ ] i ) appears to be an important mediator of this process ( 3 , 6 - 10 ). (diabetesjournals.org)
  • Isolation of naive T cells from a murine model of lupus revealed increased levels of CaMK4 following stimulation with Th17-inducing cytokines but not following Treg, Th1, or Th2 induction. (jci.org)
  • Calcium acts both to modulate intracellular signaling as a secondary messenger and to facilitate structural changes as cells progress through division. (wikipedia.org)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
  • However, mutation of this binding site had little effect on the PI3-kinase activity in the cells, suggesting that c-Kit/D816V-mediated cell survival is dependent on PI3-kinase but not its kinase activity. (ku.dk)
  • Knockdown of the predominant PI3-kinase isoform p110δ in c-Kit/D816V-expressing Ba/F3 cells led to reduced cell transformation both in vitro and in vivo without affecting the overall PI3-kinase activity. (ku.dk)
  • Biotin labeled cell surface proteins COS7 cells were transiently transfected with VLDLR and vector or VLDLR and FE65 in Fugene six and cultured 24 hrs in DMEM containing 10% FBS. (mirnasynthesis.com)
  • These results were further confirmed using brain microvascular endothelial cells expressing dominant negative forms of phosphatidylinositol 3-kinase. (asm.org)
  • Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
  • We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
  • Depleting internal calcium stores inhibits initiation of DNA synthesis. (wikipedia.org)
  • I have a lot of experience in the following methodologies: protein isolation, protein synthesis assays, Western blotting, genotyping, RNA isolation and qPCR miRNA/mRNA arrays, bioinformatics and statistical analyses. (otago.ac.nz)
  • For example, LTP and long-term memory are rapidly induced, each depends upon the synthesis of new proteins , each has properties of associativity, and each can potentially last for many months. (wikidoc.org)
  • Synaptic plasticity is controlled at a molecular by Ca²⁺-mediated protein signalling. (lincoln.ac.nz)
  • Delta-catenin binds AMPA-binding protein (ABP), leading to the LTP-induced increase in AMPA channel content. (biomedcentral.com)
  • During the induction of LTP, Ca 2+ enters through the NMDAR and binds to calmodulin [ 2 ]. (biomedcentral.com)
  • Combining immunopurification and subsequent analytical mass spectrometry, hundreds of proteins, including synaptic vesicle proteins, components of the presynaptic fusion and retrieval machinery, proteins involved in intracellular and extracellular signaling and a large variety of adhesion molecules, were identified. (mdpi.com)
  • Moreover, the use of electrical stimulation (ES) has overcome the lack of bioelectricity at the bone defect site and compensated the endogenous electrical signals. (harvard.edu)
  • Excitotoxic production of ROS elevates death-associated protein kinase (DAPK) activity, which provokes neuronal apoptosis in cerebral ischemia and seizure models 8 . (nature.com)
  • Both of these splicing events, that are governed by calcium mineral signaling, have already been INCB018424 (Ruxolitinib) manufacture researched in INCB018424 (Ruxolitinib) manufacture much details and the outcomes have provided essential insights into how splicing legislation by calcium mineral signaling can impact neuronal features and illnesses (Xie, 2008). (antiviralbiologic.com)
  • A breakthrough for the identification of the proteome of the presynaptic active zone was the successful employment of antibodies directed against a cytosolic epitope of membrane integral synaptic vesicle proteins for the immunopurification of synaptic vesicles docked to the presynaptic plasma membrane. (mdpi.com)
  • We identified three new T3SS putative SB431542 effectors in M. loti MAFF303099 (proteins encoded by mlr6331, mlr6358, and mlr6361) (Sánchez et al. (p450inhibitors.com)
  • Further, progression through division requires the presence of calcium (G1/S, G2/M, and metaphase/anaphase), suggesting checkpoints require a calcium-dependent signaling mechanism Entry into S-phase is calcium dependent. (wikipedia.org)
  • We find that in patDp/+ mice delay eyeblink conditioning-a form of cerebellum-dependent motor learning-is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. (nature.com)
  • The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14-22) amide, indicating partial mediation via a cAMP/PKA pathway. (diabetesjournals.org)
  • Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. (springer.com)
  • This suggests that p110δ has a lipid-kinase-independent role in c-Kit/D816V-mediated cell transformation. (ku.dk)
  • Taken together, our results demonstrate an important lipid-kinase-independent role of p110δ in c-Kit/D816V-mediated cell transformation. (ku.dk)
  • cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. (rochester.edu)
  • Wada N , Funabiki K , Nakanishi S . Role of granule-cell transmission in memory trace of cerebellum-dependent optokinetic motor learning. (neurotree.org)
  • Calcium was found to concentrate on condensed DNA to much higher levels compared to normal cytosolic calcium concentration. (wikipedia.org)
  • In this framework, synapses change their strength depending on the cytosolic calcium concentration ([Ca 2+ ]) at the postsynaptic dendritic spine. (eneuro.org)
  • Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain. (rochester.edu)
  • Following myocardial infarction (MI), the myocardium is prone to calcium-driven alternans, which typically precedes ventricular tachycardia and fibrillation. (frontiersin.org)
  • Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. (jci.org)
  • Evidence points to this signaling cascade as a major mediator of calcium signaling in cell division. (wikipedia.org)
  • The proteins identified in the K. pneumoniae CX-5461 ic50 OMVs were predicted to occur in the extracellular space (n = 13), outer membrane (n = 24), periplasmic space (n = 25), inner membrane (n = 13) and cytoplasm (n = 84). (nartsignaling.com)
  • Moreover, we showed that Acanthamoeba produces severe HBMEC cytotoxicity by secreting extracellular proteases, as well as using contact-dependent mechanisms such as phagocytosis ( 12 ), which may play an important role in blood-brain barrier perturbations. (asm.org)
  • The L-type Ca2+ channel (LTCC) provides trigger calcium to initiate cardiac contraction in a graded fashion that is regulated by L-type calcium current (ICa,L) amplitude and kinetics. (bvsalud.org)
  • very latest study signifies that Hu protein, upon binding with their focus on sequences for the pre-mRNA, impact the acetylation position of histones H3 and H4 resulting in a localized modification in transcription elongation price that further influences exon missing of a minimum of two substitute exons (Zhou et al. (antiviralbiologic.com)
  • In addition to evoking spontaneous Ca 2+ transients, stimulation of ventricular myocytes with the Ins(1,4,5) P 3 ester caused a positive inotropic effect. (biologists.com)
  • The two viruses were obtained from Dr. John Bell and had been tagged with green fluorescent protein to enable assessment of infection 48 hours right after addition of virus. (mirnasynthesis.com)
  • Calcium plays a crucial role in regulating the events of cellular division. (wikipedia.org)
  • lt;div class="textblock">PI3-kinase has a crucial role in transformation mediated by the oncogenic c-Kit mutant D816V. (ku.dk)
  • Numerous proteins regulating the rearrangement of the cytoskeleton are indicative of the functional and structural dynamics of the presynapse. (mdpi.com)
  • Repetitive tactile stimulation is a well-established tool for inducing somatosensory cortical plasticity and changes in tactile perception. (nartsignaling.com)
  • A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. (curehunter.com)
  • 2009) and determined the NodD/flavonoid-transcriptional regulation for another putative Selleck Etoposide effector previously described for M. loti MAFF303099 (a protein encoded by mlr6316) (Hubber et al. (p450inhibitors.com)
  • In general, PLC enzymes stimulate calcium release by internal stores through the breakdown of PIP2 into IP3 and DAG. (wikipedia.org)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • Moreover, developmental elimination of surplus climbing fibres-a model for activity-dependent synaptic pruning-is impaired. (nature.com)
  • Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca(2+)-ligated calmodulin. (nih.gov)