Stimulates proliferation cell proliferation clone cells. Medical search. Frequent questions

One aspect of the viral immunosuppression is the proliferation inhibition in response to mitogens T-cell receptor cross-linking or recall antigens of IDH-C227 peripheral blood mononuclear cells (PBMC) isolated from patients (ex vivo) and in vitro. (careersfromscience.org)
MAb 4-58 stimulated the in vitro proliferation of leucocytes. (uni-muenchen.de)
MAk 4-58 regt in vitro Leukozyten zur Proliferation an, in denen nach der Stimulation mRNA von Interleukin-4 und Interferon gamma nachgewiesen werden konnte. (uni-muenchen.de)
To address whether the expression of the CD8 receptor on the cell membrane was associated to differences in the physiology of the T-cells, we isolated, from the same clone, CD4 single positive (SP) cells from those co-expressing CD4/CD8 receptors (DP cells) and stimulated them in vitro with antigen presenting cells (APC) carrying TSHR. (uninsubria.it)
To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
moreover, all Δ160p53 isoforms can stimulate proliferation and in vitro migration. (irb.hr)
In an alternate model, influenza vaccine peptide-bearing tetramers were able to detect influenza-specific T cells only after PBMC from influenza-vaccinated individuals were expanded in vitro by a 7-day culture with Ag ( 6 ). (aai.org)
Additional results showed that electroporation with in vitro transcribed mRNA led to more 90% electroporation efficiency and enabled finely modulated gene expression levels in CLL cells. (icymi.in)
To evaluate the leukemogenic role of RUNX1-MT in ASXL1 -mutated cells, we co-expressed RUNX1 -MT (R135T) and ASXL1 -MT (R693X) in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro functional analyses. (biomedcentral.com)
MIP-1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP-1 alpha has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo . (rndsystems.com)
The effects of BCRC-3 on cancer cells were explored by transfecting with plasmids in vitro and in vivo. (biomedcentral.com)
Proliferation of BC cells was suppressed by ectopic expression of BCRC-3 in vitro and in vivo. (biomedcentral.com)
In this report the role of versican was examined in adhesion of EOC spheroids and cells to peritoneal mesothelial cell monolayers in vitro as well as in formation of peritoneal tumors using an in vivo xenograft mouse model. (biomedcentral.com)

The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
Granulocyte colony stimulating factor (G-CSF) is a 20 kDa glycoprotein cytokine that stimulates growth and development of granulocyte progenitors in the bone marrow (Nagata et al. (allindianpatents.com)
EP0237545, published on 1987-09-23 by Lawrence M Souza discloses the production of pluripotent granulocyte colony stimulating factor using E.coli as a host organism. (allindianpatents.com)
Janus kinase 2 is a member of the type I tyrosine kinase family of enzymes and is involved in signal transduction for the erythropoietin , thrombopoietin, and granulocyte colony-stimulating factor (G-CSF) receptors. (msdmanuals.com)

This fibrosis destroys the normal hematopoietic cells and their supportive stromal cells. (medscape.com)
The bone marrow becomes infiltrated by collagen, reticulin, and other forms of fibrosis, which replace the normal, hematopoietic cells. (medscape.com)

Preliminary data suggests that mab 4-39 is binding to a lektin, that can be found mainly on B-Lymphocytes and endothelial cells. (uni-muenchen.de)
Mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a 21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. (thermofisher.com)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

Secondary myelofibrosis is due to implantation or invasion by malignant cancer cells that have metastasized because of implantation of blood-borne tumor cells from a distant cancer. (medscape.com)
The abstract reports results from early, nonclinical experiments on the potential effect of combining imetelstat and ruxolitinib on malignant myelofibrosis (MF) cells. (globenewswire.com)
As stated in the abstract, these findings suggest that an additive inhibitory activity against malignant myelofibrosis hematopoietic stem and progenitor cells can be achieved using a sequential treatment regimen of ruxolitinib followed by imetelstat. (globenewswire.com)
Early clinical data suggest imetelstat may have disease-modifying activity through the suppression of malignant progenitor cell clone proliferation, which allows potential recovery of normal hematopoiesis. (globenewswire.com)
Hence, the role of RI as a limiting factor for TGFβ sensitivity and the contribution of low RI levels to the malignant phenotype of GEO cells were examined. (nebraska.edu)
Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
18 Such advantages enable γδ T cells to rapidly respond against malignant transformation and pathogenic stress. (nature.com)
Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)
Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)
instead, we found that PDGF-DD stimulated bulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRβ. (lu.se)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells within the bone marrow. (oncotarget.com)
In summary, this study demonstrates the significance of MV shedding and MV-mediated intercellular communication on malignant plasma cell proliferation, and identifies the role of MV-enriched CD147 in this process. (oncotarget.com)
Over the last decade, significant investigation in the MM field has demonstrated that the interaction of malignant PCs with BM stromal cells within the microenvironment is essential for survival of the PC clone [ 5 , 6 ]. (oncotarget.com)
Acute leukemias Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)

Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. (sigmaaldrich.com)
The cell lines were established by conditional immortalization of primary murine marrow progenitors with an estrogen-regulated E2a/Pbx1-estrogen receptor fusion protein. (nih.gov)
2. Standard research tool to analyze a variety of molecular biology procedures, for example, cell senescence, cytokine induction, protein expression, apoptosis, and receptor-ligand interactions. (ubigene.us)
Recently we found that direct contact of the MV glycoproteins hemagglutinin (H) and fusion protein (F) with the cell surface of lymphocytes or lymphoid cell lines induces a dominant negative signal in the contacted cells leading to this proliferative inhibition (33 44 It is likely that this unfavorable signal is usually transduced by a receptor present on the surface of lymphoid cells. (careersfromscience.org)
CD46 (3 16 23 It has been exhibited that MV can efficiently be isolated from patients using B-cell lines such as B95a (19) which lack a complete CD46 (15 28 indicating the presence of another receptor. (careersfromscience.org)
To identify this receptor we selected a monoclonal antibody (MAb) directed to the surface of B95a cells which inhibits MV binding and contamination and identified the acknowledged molecule as SLAM (CD150). (careersfromscience.org)
Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). (ox.ac.uk)
Some of these cloned anti-clone cells proliferated after stimulation with irradiated Mx9/9 cells, but not after stimulation with other autologous cloned T cells or heterologous PBM, suggesting that these clones recognize the T cell receptor (TCR) of the Mx9/9 cells. (ox.ac.uk)
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) normally expressed at low levels in epithelial cells. (spandidos-publications.com)
In this study we characterized a subset of CD4+ clones, from a healthy donor, that is specific for the thyrotropin receptor (TSHR) and that showed cells co-expressing the CD8 receptor. (uninsubria.it)
Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)
According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstream of the T cell receptor. (nature.com)
Although low-affinity ligands induced phosphorylation of the Cd3 chains of the T cell receptor and the interaction of Cd3 with the Zap70 kinase as strongly as high-affinity ligands, they failed to activate Zap70 to the same extent. (nature.com)
T cells have the ability to sense and discriminate a wide range of antigenic peptides bound to major histocompatibility complex (pMHC) molecules according to their affinity for the T cell receptor (TCR). (nature.com)
Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
It was found that DPC-Exos increased cell viability and reduced apoptosis in HFSCs. (tressless.com)
Overexpression of LEF1 increased the expression of hair follicle development-related genes and proteins, enhanced HFSC proliferation, and reduced HFSC apoptosis. (tressless.com)
Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. (antibodyguide.com)

Maternal alloimmunization, also known as isoimmunization, occurs when a woman's immune system is sensitized to foreign erythrocyte surface antigens, stimulating the production of immunoglobulin G (IgG) antibodies. (medscape.com)
The incidence of fetuses at risk for anemia due to maternal alloimmunization to red cell antigens has decreased dramatically since the institution of routine anti-D immune globulin (RhoGAM) prophylaxis for Rh-negative women in the 1960s. (medscape.com)
In normal human subjects a small proportion of peripheral blood T-cells simultaneously express both CD4 and CD8 differentiation antigens. (uninsubria.it)
in general, innate i. is nonspecific and is not stimulated by specific antigens. (theodora.com)
T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens. (nature.com)

describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)
The anti-CD3 moiety of the BsAb bound to the T cell surface and stimulated the differentiation and proliferation of T cells in PBMCs. (biomedcentral.com)

In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
Glucocorticoids also suppress the humoral immunity, causing B cells to express smaller amounts of IL-2 and IL-2 receptors. (wikipedia.org)
The info suggest that proliferation inhibition induced by MV get in touch with is in addition to the existence or absence of the virus-binding receptors SLAM and CD46. (careersfromscience.org)
Wild-type MV strains WTFb and Wü5679 (same as TC5679 in reference 35) were isolated from patients with acute measles (Erlangen Germany 1990 and Würzburg Germany 1996 respectively [35]) and propagated on BJAB cells since these cells in contrast to B95a cells do not IDH-C227 contain EBV and express CD46 and SLAM and therefore do not exert a selective pressure for one of the receptors. (careersfromscience.org)
These results suggest that the fast glycinergic spIPSCs in AII cells are probably mediated by 1 heteromeric receptors with a contribution from 1 homomeric receptors. (gasyblog.com)
Five different subunits (1C4, ) have been cloned, and functional glycine receptors are pentameric receptors, either homomers or heteromers. (gasyblog.com)
Indeed, it has been suggested that amacrine cells only express glycine receptors with sluggish kinetic properties (Frech 2001). (gasyblog.com)
In this study, we have investigated the functional characteristics of glycine receptors in the narrow-field AII amacrine cell. (gasyblog.com)
The binding of specific T cell receptors (TCR) to major histocompatibility complex (MHC)/antigen complexes on cancer cells induces the TCR/CD3-mediated signal transduction pathway and stimulates the release of specific toxins (perforin and granzyme) for cancer elimination [ 6 , 7 ]. (biomedcentral.com)

Interestingly, both MO-MDSCs and PMN-MDSCs suppressed antigen-specific T-cell responses, albeit using distinct effector molecules and signaling pathways. (ashpublications.org)
Collectively, the BsAb-armed T cell technology represents a simple, time-saving, and highly safe method to generate highly pure cancer-specific effector T cells, thereby providing an affordable T cell immunotherapy to patients. (biomedcentral.com)
However, most effector T cells generated using these established cultivation methods lack cancer specificity [ 8 ]. (biomedcentral.com)
In combination with anti-CD81 mAb, it can prime naive T cells to acquire effector function independently (6) or in combination(9) with TCR ligation. (ancell.com)
Small differences in binding kinetics between TCR ligands lead to marked differences in T cell effector function and differentiation. (nature.com)
The hallmark effector molecules of Th1 and Th2 cells, e.g. (thermofisher.com)

By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. (wikipedia.org)
This report describes clonal, granulocyte-macrophage colony-stimulating factor-dependent myeloid cell lines that exhibit these properties. (nih.gov)
Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs), alone or in combination, in the circulation and sometimes with fibrosis in the bone marrow and extramedullary hematopoiesis (cell production outside the marrow). (msdmanuals.com)
Mast cell activation syndrome is increased and inappropriate activation of mast cells without clonal. (msdmanuals.com)
Although proliferation of one or more hematopoietic cell types dominates the clinical picture in each of these disorders, all three are caused by clonal proliferation of a pluripotent hematopoietic stem cell, causing an increased proliferation of normal RBC, WBC, and platelet progenitors in the bone marrow. (msdmanuals.com)

In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. (thermofisher.com)
This abnormal clone does not, however, produce bone marrow fibroblasts, which can proliferate in a polyclonal, reactive, and reversible fashion in response to the abnormal stem cell. (msdmanuals.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

A549 is a model lung cancer cell line developed in 1972 by scientist Giard, through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old Caucasian male. (ubigene.us)
A549 cells are used in a variety of basic cell biology and biomedical studies involving lung cancer proliferation, corresponding inhibitors studies, tumor formation, and metastases. (ubigene.us)
However, A549 cells harbor oncogenic KRASG12S mutation as well as over 250 genetic mutations (COSMIC cell lines project), including some known oncogenes and tumor suppressors. (ubigene.us)
Key molecular studies performed with A549 cell as anti-tumor drug permeability and efficacy analysis, infection assays, respiratory immunotoxicity tests, cell senescence studies, and cytokine expression profiling. (ubigene.us)
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
As a result, there is an emergent need to explore previously unmapped mechanisms regulating distinct subpopulations of tumor cells and to understand their contribution to tumor progression and treatment response. (lu.se)
The presence of a subclonal population of tumor cells characterized by PDGFRβ expression was further validated in a cohort of human PanNET. (lu.se)
Lastly, vemurafenib-resistant melanoma cells showed an altered expression of p53 and p73 isoforms, namely an increased expression of potentially pro-oncogenic Δ40p53β and a decrease in tumor-suppressive TAp73β. (irb.hr)
There is a growing literature that tumor cells release biologically active microvesicles (MVs) that modify both local and distant microenvironments. (oncotarget.com)
Overall, our results describe a workflow to elaborate robust protocols for gene editing and expression in primary tumor cells," lead study author Federica Nardi, of the University of Siena and Fondazione Toscana Life Sciences, in Siena, Italy, and coauthors wrote in the poster. (icymi.in)
BCRC-3 functions as a tumor inhibitor to suppress BC cell proliferation through miR-182-5p/p27 axis, which would be a novel target for BC therapy. (biomedcentral.com)
Tumor growth diminished 5 times and tumor weight reduced 50-80% when compared with the anti-CAIX CAR T cells alone in a humanized mice model of ccRCC. (oncotarget.com)
The anti-PD-L1 IgG1 isotype, which is capable of mediating ADCC, was also able to recruit human NK cells to the tumor site in vivo . (oncotarget.com)
As an evasion mechanism, many tumors are able to stimulate the expression of immune checkpoint molecules, resulting in an exhausted phenotype of T cells that cannot restrain tumor progression [ 1 ]. (oncotarget.com)

Autologous clones were raised against Mx9/9 cells using the peripheral blood mononuclear (PBM) cells of the Mx9/9 clone donor (PBMjm). (ox.ac.uk)
G-CSF can be used to increase the numbers of circulating haemopoietic precursor cells which are then harvested by leucapheresis and used either as a supplement to or a substitute for aspirated bone marrow cells in autologous haemopoietic cell transplants. (allindianpatents.com)

It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD® CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
XOptx2 stimulates bromodeoxyuridine incorporation, and XOptx2 -induced eye enlargement is dependent on cellular proliferation. (xenbase.org)
CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
However, the roles of circRNAs in cellular proliferation in bladder cancer remain largely unknown. (biomedcentral.com)
One of the new emerging mechanisms associated with the progression of clear cell renal cell carcinoma (ccRCC) and other tumors is the immune checkpoint pathway, which consists of cellular interactions that prevent excessive activation of T cells under normal conditions. (oncotarget.com)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
The macrophage inflammatory proteins -1 alpha and -1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. (rndsystems.com)
Furthermore, IL-13 but not IL-4 synergistically enhanced colony formation of Lin-Sca-1+ progenitors in response to granulocyte/macrophage colony-stimulating factor (GM-CSF) (threefold), whereas both IL-4 and IL-13 enhanced G-CSF-induced colony formation (threefold), and neither of the two significantly affected CSF-1 and IL-3-induced proliferation. (ox.ac.uk)
This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. (cdc.gov)
An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. (cdc.gov)
The elevated levels of inflammatory cytokines and chemokines (e.g., interleukin [IL] 6, IL-8, macrophage inflammatory protein 1α and 1β, monocyte chemoattractant protein 1, and macrophage colony-stimulating factor) and immunomodulatory cytokines (e.g. (cdc.gov)

When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
Polyclonal antibodies inhibit T lymphocytes and cause their lysis, which is both complement-mediated cytolysis and cell-mediated opsonization followed by removal of reticuloendothelial cells from the circulation in the spleen and liver. (wikipedia.org)
Although anti-SLAM and/or anti-CD46 antibodies stop virus binding they don't hinder the contact-mediated proliferation inhibition. (careersfromscience.org)
It is rapidly induced on naive lymphocytes after activation and cross-linking antibodies to SLAM stimulate B-and T-cell proliferation (2 7 32 Since SLAM is usually a signal-transducing molecule the antiproliferative effect exerted by MV contact to the cell surface of lymphocytes could possibly be mediated by IDH-C227 SLAM. (careersfromscience.org)
MATERIALS AND METHODS Antibodies cells and viruses. (careersfromscience.org)
Antibodies of the clones 4-13, 4-58, 1-19 and 6-39 have been purified by protein G-sepharoses chromatography and, except mAb 4-58, biotinylated. (uni-muenchen.de)
By contrast the antibodies 1-19, 2-52, 4-36, 4-55 and 6-39 are B-cell-specific, since they were present on cells that were Ig-positive. (uni-muenchen.de)
The antibodies of clone 4-18 recognize an antigen on granulocyctes. (uni-muenchen.de)
These armed second-generation CAR T cells empowered to secrete human anti-PD-L1 antibodies in the ccRCC milieu to combat T cell exhaustion is an innovation in this field that should provide renewed potential for CAR T cell immunotherapy of solid tumors where limited efficacy is currently seen. (oncotarget.com)

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 6 , immunoprecipitation 3 , stimulation of NK cell proliferation 4 , blocking of phagocytosis 5 , and blocking of immunoglobulin binding to FcγRIII 7,8 . (biolegend.com)
Dysregulation of the NF-κB pathway in B cells from PPARγ +/- was indicated by spontaneous NF-κB activation, as well as increased IκBα phosphorylation and gel-shift activity following LPS stimulation. (jci.org)
The ability of clone Mx9/9 to proliferate after stimulation with anti-V beta 8 MoAb was inhibited when clone 121 cells were added to the cultures. (ox.ac.uk)
Flow cytometer analyses demonstrated an increased frequency following the stimulation with Concanavalin A. The frequency of mAb 4-13- and mAb 4-58-positive cells matched the total frequency of CD4- and CD8-positive cells. (uni-muenchen.de)
Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)

The shortage of donors and the potential of universal HLA-null platelet products have stimulated research on the ex vivo differentiation of human pluripotent stem cells (hPSCs) to platelets. (hokudai.ac.jp)
However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
The CAR-T cell manufacturing platform is based on the ex vivo genetic engineering of a patient's T cells to express CAR, followed by the reinfusion of the T cells into the patient. (biomedcentral.com)
Patient-derived cancer cells can be used to study the biology of a disease and are favorable to immortalized cell lines because they are more like in vivo environments. (icymi.in)

The 3G8 antibody clone blocks neutrophil phagocytosis and stimulates NK cell proliferation. (biolegend.com)

They induce the lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. (wikipedia.org)
Anti-V beta 8 MoAbs activate and induce cell proliferation of this clone. (ox.ac.uk)
Divalent ANC28.1 can induce Antigen Independent T cell proliferation (5). (ancell.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

[ 2 ] to the presence of a few teardrop-shaped red blood cells and early myeloid precursor cells in the peripheral blood smear. (medscape.com)
This blood film at 1000X magnification demonstrates a leukoerythroblastic blood picture with the presence of precursor cells of the myeloid and erythroid lineage. (medscape.com)
Agnogenic myeloid metaplasia is a stem cell abnormality associated with myeloproliferative diseases. (medscape.com)
These myeloid cell lines provide tools for examining the biochemical and genetic pathways that accompany normal differentiation as well as a system in which to dissect how other leukemic oncoproteins interfere with these pathways. (nih.gov)
The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
The expression of RUNX1 mutant in ASXL1 -mutated myeloid cells augmented proliferation, blocked differentiation, and increased self-renewal activity. (biomedcentral.com)

Potential features that attract the investigators are epithelial cells with squamous nature and responsible for the diffusion of substances, such as water and electrolytes, across the alveoli of the lungs. (ubigene.us)
A549 cells used as a type II pulmonary epithelial cell model for drug metabolism and as a transfection host. (ubigene.us)
RON was found to be primarily expressed in cells of epithelial origin such as colon, breast and skin ( 9 ). (spandidos-publications.com)

Thus, the cloning frequency in response to SCF + IL-13 was at least 20-fold higher in the Lin-Sca-1+ than the Lin-Sca-1- progenitor cell population. (ox.ac.uk)

Human peripheral blood lymphocytes were stained with anti-human CD56 Brilliant Violet 421™ and anti-human CD16 (clone 3G8) Spark YG™ 581 (left), or only stained with anti-human CD56 Brilliant Violet 421™ (right). (biolegend.com)
Therefore, we developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. (nature.com)
γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
In this study, we developed a non-genetic engineering technology for rapidly manufacturing a large amount of cancer-specific T cells by utilizing a unique anti-cancer/anti-CD3 bispecific antibody (BsAb) to directly culture human peripheral blood mononuclear cells (PBMCs). (biomedcentral.com)
To that end, investigators first created optimal electroporation conditions for CRISPR/Cas9-based gene knockout and mRNA-driven gene overexpression in B cells that were newly taken from the peripheral blood or bone marrow of patients with CLL. (icymi.in)
High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. (thermofisher.com)

Furthermore, the study examined the effects of cooperating oncoproteins such as Ras or Bcr/Abl, which allowed for both factor-independent proliferation and differentiation, or Bcl-2, which permitted factor-independent survival but not proliferation. (nih.gov)
It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
B-cell survival and green fluorescent protein signal were assessed by cytofluorimetry. (icymi.in)
The cell survival rate was measured using the principle of water-soluble tetrazolium salt-1 assay, which is a measurement method for cell survival rate. (researchgate.net)

This decrease in cytokine production reduces T cell proliferation. (wikipedia.org)
IL-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. (biolegend.com)

The expression levels of circRNAs, mRNAs and miRNAs in human tissues and cells were detected by quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
BCRC-3 was lowly expressed in bladder cancer tissues and cell lines. (biomedcentral.com)
Successful colonization of the abdomen by EOC cells and spheroids to a large extent depends on their ability to attach to mesothelial surfaces of the peritoneal organs and tissues. (biomedcentral.com)
Mastocytosis and Mast Cell Activation Syndrome Mastocytosis is mast cell proliferation with infiltration of skin or other tissues and organs. (msdmanuals.com)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Tissues and Cells. (lu.se)

Failure of spheroids lacking versican to disaggregate as efficiently as controls could be attributed to a reduced cell migration that was observed in the absence of versican expression. (biomedcentral.com)

Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. (ox.ac.uk)
The recently cloned interleukin 13 (IL-13) shares most investigated biological activities on B lymphocytes and monocytes with IL-4. (ox.ac.uk)
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. (thermofisher.com)

Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)
We observed that melanoma cell lines expressed a wide array of p53 and p73 isoforms, with Δ160p53α as the most variable one. (irb.hr)

Differentiation was normal and terminal as evidenced by morphology, cell surface markers, gene expression, and functional assays. (nih.gov)
They also showed reduced growth and clonogenicity in plating efficiency and soft agarose assays, whereas RII-transfected cells did not show any differences from the NEO control cells in these assays. (nebraska.edu)
Assays with LFA- or OspA-DR4 monomers revealed that higher concentrations of LFA-DR4 were needed to stimulate dual-reactive T cell hybrids. (aai.org)

It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. (biolegend.com)

These fractions consisted of either mononuclear cells (MO-MDSCs), resembling inflammatory monocytes, or low-density polymorphonuclear cells (PMN-MDSCs), akin to immature neutrophils. (ashpublications.org)

In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
Furthermore, the canine-to-murine xenotransplantation model accurately predicted results in canine-to-canine muscle cell transplantation. (biomedcentral.com)
Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)

Together, these data suggest that CXCR4 plays an important role in donor cell engraftment. (biomedcentral.com)
Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. (biomedcentral.com)
We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)
Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)
We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)

Janeczko K. The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain. (amarpharma.com)
Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
We analyzed the expression of p53 and p73 isoforms both at the RNA and protein level in a panel of melanoma-derived cell lines with different TP53 and BRAF status, in normal conditions or upon treatment with common anti-cancer DNA damaging agents or targeted therapy. (irb.hr)
A marked Ab and T cell response to Bb outer surface protein A (OspA) often develops during prolonged episodes of arthritis. (aai.org)
We have analyzed the Ag-specific CD4 + T cells in treatment-resistant Lyme arthritis, using class II tetramers, and have shown that arthritis-associated Borrelia burgdorferi ( Bb) sensu stricto outer surface protein A (OspA)-specific T cells can be identified with this technology. (aai.org)
Green fluorescent protein mRNA was electroporated into primary CLL B cells using 12 different electroporation settings. (icymi.in)
Here, we used time-resolved high-throughput proteomic analyses to identify and quantify the phosphorylation events and protein-protein interactions encoding T cell ligand discrimination in antigen-experienced T cells. (nature.com)

IDH-C227 To raise MAbs to enriched surface proteins of B95a cells we biotinylated 107 cells with sulfo-d-biotin-and removal of monocytes by adherence. (careersfromscience.org)

Ubigene exclusive KO Cell Line Bank, over 5000 KO cell lines, covering thousands of genes from 8 popular signaling pathways and nearly 100 diseases. (ubigene.us)
In particular, it is unclear whether ligand affinity uniformly affects the different signaling pathways involved in T cell activation. (nature.com)

The study investigated the role of exosomes derived from dermal papilla cells (DPC-Exos) in hair follicle stem cell (HFSC) proliferation. (tressless.com)
Promotes dermal fibroblast proliferation and wound repair. (antibodyguide.com)

Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (medscape.com)
Induces maturation of dendritic cells and monocyte cell adhesion. (antibodyguide.com)
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. (thermofisher.com)

Altered expression of neuronal cell adhesion molecules induced by nerve harm and restore. (amarpharma.com)
The mechanism of binding of neural cell adhesion molecules. (amarpharma.com)
Cancer, inflammation, and the evolution of antibiotic-resistant pathologies, together with other human diseases, are continuously stimulating the search for new bioactive molecules from natural sources. (frontiersin.org)
These cells, among other functions, provide a protective barrier against invading pathogens and secrete surfactant molecules to provide a non-adhesive surface. (biomedcentral.com)

It is related to an abnormal stem cell clone that stimulates increased myelofibrosis and damage. (medscape.com)

and promotes mast cell proliferation in combination with IL-4. (biolegend.com)
The aim of the present study was to locate mast cells in chronic periapical lesions (granulomas and cysts) by using histochemical techniques and toluidine blue staining. (bvsalud.org)
Mast cells were found in 13 (61.9%) of the periapical cyst cases, located in the capsule of the lesion. (bvsalud.org)
In the periapical granuloma cases, mast cells were found in eight cases (50%), located in the granulation tissue. (bvsalud.org)
Mast cells were detected in both cysts and periapical granuloma, located in the capsule and granulation tissue, respectively. (bvsalud.org)
Mast cells were more prevalent in periapical cysts than in periapical granuloma. (bvsalud.org)
Mast cells. (bvsalud.org)
The exact mechanism associated with this growth and expansion remains unclear, although it is known that several types of cells, including mast cells, do play a role in such phenomena 4 . (bvsalud.org)
Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)

A major limitation in approaching this problem has been the lack of suitable cell lines that exhibit normal, terminal, and synchronous differentiation in the absence of endogenous oncoproteins and in response to physiologic cytokines, and whose differentiation can be arrested by ectopically expressed human oncoproteins. (nih.gov)
To date, a large number of human non-small cell lung cancer cell lines are being used for both basic research and drug discovery. (ubigene.us)
A549 cells are well-characterized among the human lung carcinoma/alveolar cell lines as well as having KRAS mutation and wild type EGFR. (ubigene.us)
These cells also utilized to study a variety of molecular characteristics for human tumors in culture. (ubigene.us)
The human RON gene was originally cloned from keratinocytes ( 1 ). (spandidos-publications.com)
Another form of recombinant human G-CSF called lenograstim is synthesised in Chinese hamster ovary (CHO) cells. (allindianpatents.com)
Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed. (tressless.com)
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss. (tressless.com)
A human colon carcinoma cell line, designated GEO, is marginally responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells, which are highly responsive to TGFβ. (nebraska.edu)
To analyze the nature of response to OspA and LFA-1α L , we used OspA-specific T cell hybrids from DR4 transgenic mice, as well as cloned human cells specific for OspA 165-184 , the immunodominant epitope, from five DRB1*0401 + patients, using OspA-MHC class II tetramers. (aai.org)
Although OspA 165-184 stimulated nearly all OspA-specific human T cell clones tested to proliferate and secrete IFN-γ and IL-13, LFA-1α L326-345 stimulated ∼10% of these clones to proliferate and a greater percentage to secrete IL-13. (aai.org)
A variety of human autoimmune diseases are thought to be mediated by CD4 T cells ( 1 , 2 ). (aai.org)
Herein we present clear evidence that not only do both patient MM cells and human MM cell lines (HMCLs) release MVs, but that these MVs stimulate MM cell growth. (oncotarget.com)
Notably, the BsAb-armed T cells did not cause obvious cytokine release syndrome or tissue toxicity in SCID mice bearing human tumors. (biomedcentral.com)
Human MIP-1 alpha refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. (rndsystems.com)
Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. (ancell.com)
Antibody ANC28.1 recognizes CD28 expressed on T cells and also on BHK cells transfected with human CD28. (ancell.com)
Data from nonhuman primate models and human autopsy cases suggest that EVD severity is not a direct effect of tissue damage resulting from destruction of infected cells because only foci of necrosis are observed ( 1 , 2 ). (cdc.gov)

We investigated the virus-mediated SLAM modulation and the effect of SLAM engagement around the viral contact-mediated proliferation inhibition of lymphocytes. (careersfromscience.org)
In contrast, although stable transfection of an RII expression vector into the same GEO cells increased TGFβ 1 binding to RII, growth inhibition by exogenous TGFβ 1 was not altered. (nebraska.edu)

Tumorigenicity in athymic nude mice was significantly delayed in RI-transfected cells. (nebraska.edu)
Importantly, both spheroids and cells with reduced expression of versican demonstrated significantly impaired ability to generate peritoneal tumors when injected intraperitoneally into athymic nude mice. (biomedcentral.com)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)

[ 1 ] Bone marrow failure resulting from secondary infiltration is a possible cause of lack of blood cell production (as differentiated from a primary cause of failure). (medscape.com)
With regard to Gaucher disease, infiltration by cells with "onion-peel" cytoplasm, called Gaucher cells, is caused by a lipid storage disorder (ie, glucosylceramide lipidosis). (medscape.com)
Foam-cell infiltration and visceromegaly are common features in all forms, but neurologic involvement occurs only in types A and C and not in type B. (medscape.com)

Bone marrow cells are completely replaced by large carcinoma cells with clear nucleoli. (medscape.com)
Leukemic cells, such as those occurring in chronic leukemias in which the expanding cells are mature and coexist peacefully with the normal bone marrow cells, show no evidence of myelophthisis, and marrow damage does not occur. (medscape.com)
Mice transduced with both ASXL1 and RUNX1 mutations enhanced inhibitor of DNA binding 1 (ID1) expression in the spleen, liver, and bone marrow cells. (biomedcentral.com)

In this study, we reveal from the gene expression profiles of several MKCL clones that the proliferation arrest is correlated with the expression levels of specific cyclin-dependent kinase inhibitors. (hokudai.ac.jp)
The results demonstrated that CD8 co-expression has a profound effect on the physiology of T helper (Th) cells. (uninsubria.it)
Tetracycline repressed RI expression in transfected cells and reversed the reduction in plating efficiency of RI-transfected clones, confirming that growth effects were due to increased RI expression in transfected cells. (nebraska.edu)
TGFβ 1 neutralizing antibody stimulated the proliferation of RI-transfected cells but had little effect on GEO control cells, indicating that increased autocrine-negative TGFβ activity also resulted from increased RI expression. (nebraska.edu)
CRISPR/Cas9 and mRNA-based gene editing and expression was found to be feasible in evaluating primary chronic lymphocytic leukemia cells. (icymi.in)
CRISPR/Cas9 and mRNA-based gene editing and expression was found to be feasible in evaluating primary chronic lymphocytic leukemia (CLL) cells, according to findings from a study that was presented at the 2021 International Workshop on CLL . (icymi.in)
The expression of PD-L1 and Ki67 in the tumors decreased and an increase in granzyme B levels was found in CAR T cells. (oncotarget.com)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

Ubigene has modified over 5000 genes from more than 200 cell lines with our exclusive innovation CRISPR-U™ technology. (ubigene.us)
Electroporation with RNPs or mRNA does not impact cell viability and does not require prior expansion, which is particularly relevant for studies that aim to assess function of genes regulating B-cell proliferation and differentiation," concluded the authors. (icymi.in)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Silencing CDKN1A and p53 with the overexpression of MBX was effective at stably inducing imMKCLs that generate functional platelets irrespective of the hPSC clone. (hokudai.ac.jp)

CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). (biolegend.com)
Mice primed with either ovalbumin or methylated BSA also showed enhanced antigen-specific immune response of both T and B cells, an immunological abnormality that exacerbated antigen-induced arthritis. (jci.org)
The proliferation of the Mx9/9 stimulated cloned anticlone cells was blocked by anti-class II MoAbs, indicating that the autoreactive clones recognize their target antigen in conjunction with HLA Class II products. (ox.ac.uk)

Obtained mRNA was introduced into CLL B cells by electroporation. (icymi.in)
T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. (ancell.com)

The experiments explored the hypothesis that the combination of imetelstat and ruxolitinib might create a treatment regimen for MF that could be more efficacious than using either drug alone in reducing myelofibrosis hematopoietic stem cells and hematopoietic progenitor cells. (globenewswire.com)
Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. (biomedcentral.com)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

In agnogenic and secondary myelofibrotic disorders, megakaryocytes release platelet-derived growth factors, which are fibroblastic stimulants for growth and proliferation. (medscape.com)

The differentiation of the cells could be arrested by heterologous oncoproteins including AML1/ETO, PML/RARalpha, PLZF/RARalpha, Nup98/HoxA9, and other Hox proteins. (nih.gov)

The expanding number and volume of pathologic cells and the release of suppressive cytokines can eventually lead to bone marrow failure without the characteristic morphologic features of myelophthisis. (medscape.com)
Cytotoxins (perforin and granzyme) and cytokines (TNF-α and IFN-γ) were dramatically released from the BsAb-armed T cells after engaging cancer cells, resulting in a remarkable anti-cancer efficacy. (biomedcentral.com)

SLAM is usually a glycoprotein belonging to the CD2 subset of the immunoglobulin (Ig) superfamily and is expressed on the surface of a proportion of primary B cells and Epstein-Barr computer virus (EBV)-transformed B cells activated T cells memory T cells T-cell clones and immature thymocytes (39). (careersfromscience.org)

Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)
Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. (biomedcentral.com)

Anatomy42

Organisms14

Diseases13

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes58

Disciplines and Occupations1

Information Science3

Vitro14

Granulocyte colony4

Hematopoietic cells2

Endothelial cells3

Malignant14

Receptor17

Apoptosis4

Antigens5

Differentiation and proliferation2

Receptors9

Effector6

Clonal5

Fibroblasts3

Tumor15

Autologous2

Cellular7

Macrophage6

Antibodies9

Stimulation5

Vivo4

Antibody clone1

Induce4

Myeloid7

Epithelial3

Progenitor cell1

Peripheral6

Survival5

Cytokine production2

Tissues6

Migration1

Interleukin3

Melanoma cell2

Assays3

Macrophages1

Mononuclear1

Murine4

Donor6

Protein7

Monocytes1

Signaling pathways2

Dermal2

Maturation3

Molecules4

Abnormal stem cell1

Mast9

Human18

Inhibition2

Significantly3

Infiltration3

Bone marro3

Expression9

Genes3

Functional1

Antigen3

MRNA2

Stem cells3

Fibroblastic1

Heterologous1

Cytokines2

Immunoglobulin1

Clinical4