• The glucoincretin hormone glucagon-like peptide 1 (GLP-1) enhances glucose-stimulated insulin secretion and stimulates pancreatic β-cell mass expansion. (diabetesjournals.org)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • Serum levels of testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured. (frontiersin.org)
  • This test measures the level of follicle-stimulating hormone (FSH) in a sample of your blood. (medlineplus.gov)
  • The scientists also have shown that viability, proliferation and growth of cells is not affected by the nanogenerator. (nanowerk.com)
  • Because ion fluxes and cytosolic ionic changes are integral steps in the signaling cascade initiated when growth factors bind to their receptors, we hypothesized that the MAC-induced reversible changes in membrane permeability could stimulate cell proliferation. (jci.org)
  • The MAC enhances the mitogenic effects of serum and PDGF, and also stimulates cell proliferation in the absence of other exogenous growth factors. (jci.org)
  • MAC-induced mitogenesis represents a novel effect of the terminal complement complex that could contribute to focal tissue repair or pathological cell proliferation locally at sites of complement activation. (jci.org)
  • Among its diverse biological actions, the vasoactive peptide bradykinin (BK) induces the transcription factor AP-1 and proliferation of mesangial cells (S. S. El-Dahr, S. Dipp, I. V. Yosipiv, and W. H. Baricos. (nih.gov)
  • Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • We also identify SirT1 as a negative regulator of β-cell proliferation. (diabetesjournals.org)
  • Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
  • In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
  • Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
  • M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. (wikipedia.org)
  • It was postulated that cell proliferation may also be enhanced by fibrinogen binding to CD54 ( 21 ). (iiarjournals.org)
  • In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
  • However, there is no difference in the proportion of dormant cells when the p-i-n nanowires are coated with oxide, which suggests that carrier injection in the cell medium (in this case, the release of electrons from the tip of the nanowires) is an important factor for modulating cell proliferation on photovoltaic nanowires. (lu.se)
  • It is one of the three experimentally described colony-stimulating factors. (wikipedia.org)
  • Colony Stimulating Factors (CSF) stimulate stem cells in bone marrow to form specialised white blood cells that defend the body against infection from viruses and bacteria. (edu.au)
  • In this study, we sought to determine whether insulin stimulates the production and secretion of ET-1 as a possible basis for the association of hyperinsulinemia and vascular disease. (diabetesjournals.org)
  • We demonstrated that insulin significantly stimulates the gene expression and secretion of ET-1 from cultured BAEC, and that insulin increases ET-1 mRNA expressed in BBCEC. (diabetesjournals.org)
  • This stimulation probably occurred through the insulin receptor, because IGF-1 had no effect on ET-1 gene expression or secretion from these cells. (diabetesjournals.org)
  • It also stimulates insulin gene expression and insulin biosynthesis ( 6 ), in part via increased expression and activity of the β-cell-specific transcription factor Pdx1 ( 7 , 8 ). (diabetesjournals.org)
  • Insulin stimulates the tyrosine phosphorylation of caveolin. (rupress.org)
  • The specialized plasma membrane structures termed caveolae and the caveolar-coat protein caveolin are highly expressed in insulin-sensitive cells such as adipocytes and muscle. (rupress.org)
  • The stimulation of caveolin tyrosine phosphorylation was specific for insulin and was not observed with PDGF or EGF, although PDGF stimulated the tyrosine phosphorylation of the 29-kD caveolin-associated protein. (rupress.org)
  • Some protein and large polypeptide drugs (eg, insulin , therapeutic antibodies) can directly stimulate antibody production. (msdmanuals.com)
  • The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)
  • Here, we report that granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine with known trophic and neuroprotective properties in the brain, acts directly on dopaminergic circuits to enhance their function. (jneurosci.org)
  • This study suggests that circulating hyperinsulinemia might induce the production and secretion of ET-1, a powerful endogenous vasoconstrictor and mitogen for the vascular smooth muscle cell. (diabetesjournals.org)
  • It stimulates the production of antibodies in pregnant women, which are then passed through the placenta. (medicaldaily.com)
  • Monoclonal antibodies directed toward CD-18 inhibited 60% of PMN respiratory burst induced by stimulated T-cell membrane, while antibodies to CD11a,b,c and CD69 had no effect. (biomedcentral.com)
  • Antibodies are produced by a kind of white blood cell called a B cell. (cdc.gov)
  • The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
  • Endothelin, a vasoconstrictor peptide secreted from endothelial cells, has been thought to play a role in various forms of vascular disease. (diabetesjournals.org)
  • Antibody library-based tumor endothelial cells surface proteomic functional screen reveals migration-stimulating factor as an anti-angiogenic target. (monash.edu)
  • Materials and Methods: Human umbilical vein endothelial cells (HUVECs) isolated from umbilical cord, cultured in standard conditions, were harvested and passaged in 24-well plates. (iiarjournals.org)
  • While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. (nature.com)
  • Neither TNF soluble receptors nor IL-1 receptor antagonist interfered with ROS production induced by T-cell membranes. (biomedcentral.com)
  • While some signalling mechanisms have been proposed for individual recombinant orexin receptors in generic mammalian cell types, it is clear that the peripheral effects of orexin are spatially and temporally complex. (warwick.ac.uk)
  • We further show that at least some auxiliary receptors remain functional under diabetic conditions and their engagement by the pro-inflammatory cytokine CCL3, overrides the requirement for FPR signaling and substantially improves infection control by jumpstarting the neutrophil trafficking toward infection, and stimulates healing in diabetic wound. (elifesciences.org)
  • Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)
  • Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
  • Serum thyroid-stimulating hormone (TSH) and thyroxine (T4) levels will be used to assess thyroid function and will provide population-based reference information on these hormone levels. (cdc.gov)
  • However, most drugs act as haptens, binding covalently to serum or cell-bound proteins, including peptides embedded in major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced AP-1 and DNA replication in cultured rat mesangial cells. (nih.gov)
  • BK (10(-9) to 10(-7) M) stimulated a rapid increase in tyrosine phosphorylation of multiple proteins with an estimated molecular mass of 120-130, 90-95, and 44-42 kDa. (nih.gov)
  • PROCEDURES: Isolated thyroid cell membranes were treated with thyroid-stimulating hormone (TSH), and activation of G protein was quantified by measurement of the binding of guanosine triphosphate gamma labeled with sulfur 35 (GTPgamma(35)S). The separate effects of G-protein inhibitory (G(i)) and G-protein stimulatory (G(s)) proteins were determined by the use of pertussis toxin and cholera toxin, respectively. (avmi.net)
  • This electric pulse triggers the opening of the membrane ion-channels, which induces the pass of calcium from the culture medium into the cell. (nanowerk.com)
  • The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane permeability resulting in significant but transient intracellular ionic changes in the absence of cell lysis. (jci.org)
  • Membrane from PHA/PMA-stimulated human T lymphocytes and from T-cell line HUT-78 induced a dose-dependent ROS production by PMNs, demonstrating that stimulated T-cells are able to stimulate PMN respiratory burst by direct cell-cell contact. (biomedcentral.com)
  • The results indicated that the decrease in K+ uptake due to Ca2+ starvation was caused by the repression of the cation-stimulated ATPase activity associated with the plasma membrane fraction. (eurekamag.com)
  • β-Cells depend on the islet basement membrane (BM). (nature.com)
  • The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
  • Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
  • Pancreatic pericytes directly support β-cells through mostly unidentified secreted factors. (nature.com)
  • Dr. Rudnicki's team found that the Wnt7a protein, when introduced into mouse muscle tissue, significantly increased the population of these satellite stem cells and fueled the regeneration process, creating bigger and stronger muscles. (disabled-world.com)
  • Th22 cells were significantly higher in TPE than in blood. (atsjournals.org)
  • Results: MCP-1 concentration in supernatants from HUVECs was significantly lower 6 h after 4.5 J/cm 2 stimulation compared to IL-1β-stimulated cells. (iiarjournals.org)
  • Moreover, when EIS cell lines that were only capable of anchorage-dependent growth were grown in suspension, cell growth was suppressed and the levels of phosphorylated FAK, Src, and ErbB3 were significantly reduced. (preprints.org)
  • Although the number of transplants each year has grown rapidly over the past two decades, the demand for transplantation using human cells, tissues and organs has also increased significantly, resulting in a continuing shortage of human material, particularly organs. (who.int)
  • In this study, we investigated the potential role protective of ASTA, an antioxidant marine carotenoid, in restoring physiological conditions in U937 cells stimulated with LPS (10 µg/ml). (nih.gov)
  • This study dissects the different G-protein signalling and MAPK pathways activated in a pluripotent human adrenal H295R cell line capable of all the physiological steps involved in steroidogenesis. (warwick.ac.uk)
  • The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
  • Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
  • IgM is the first class of immunoglobulin that is made by immune cells when stimulated by antigen. (cdc.gov)
  • Each of these effects was blocked by tyrosine kinase inhibition with genistein or herbimycin A. Similarly, antisense oligodeoxynucleotide targeting of ERK1/2 mRNA inhibited BK-stimulated DNA synthesis. (nih.gov)
  • Furthermore, HDL inhibited stimulated T-cell induced PMN respiratory burst in a dose-dependent manner, allowing a complete inhibition for 200 μg/ml. (biomedcentral.com)
  • We also showed that IFN-α treatment of ISG15-deficient cells led to significant inhibition of global protein synthesis, leading us to ask whether resistance was due to the direct antiviral activity of ISGs or whether cells were nonpermissive because of translation defects. (st-andrews.ac.uk)
  • However, resistance could be induced if cells were pretreated with IFN-α for longer times, presumably because of inhibition of protein synthesis. (st-andrews.ac.uk)
  • Finally, combining cetuximab and a Src inhibitor produced an additive effect on the inhibition of EIS cell line growth. (preprints.org)
  • For the study, bone cells (osteoblasts) were cultivated on a substrate covered by nanogenerators. (nanowerk.com)
  • Carme Nogués, from the UAB, explains that "these kinds of channels are present in several excitable cells like neurons, muscle or bone cells, to which this same method could be applied. (nanowerk.com)
  • Although it has been shown that low-power laser illumination may stimulate bone healing ( 1 - 3 ), endothelial regeneration ( 4 ), smooth muscle relaxation ( 5 ) and reduce restenosis rate after coronary angioplasty procedures ( 6 - 9 ), little is still known about cellular mechanisms underlying these effects. (iiarjournals.org)
  • The clinical relevance of mobilizing endogenous bone marrow derived stem cells would be to increase the number migrating into damaged organs, becoming affective cells and contributing to tissue repair. (qxmd.com)
  • M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. (wikipedia.org)
  • Cellular contact with stimulated T cells are known to prime PMNs for respiratory burst, and direct cell-cell contact between T cells and monocytes is a major mechanism that triggers the production of inflammatory cytokines. (biomedcentral.com)
  • Similar inhibitory effects of HDL have previously been described in activation of monocytes by direct cell-contact. (biomedcentral.com)
  • These results emphasize the importance of direct cell-cell contact in inflammatory processes and strongly suggest that at the surface of T cells, similar molecules, although affected by different coactivators, are involved in the activation of both monocytes-macrophages and PMNs. (biomedcentral.com)
  • We found that bronchoalveolar lavage fluid (BALF) from 11 patients with idiopathic pulmonary alveolar proteinosis (IPAP) suppressed the growth of peripheral blood monocytes and TF-1 cells, a cell line dependent on either GM-CSF or interleukin-3 (IL-3). (wiley.com)
  • It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)
  • The antioxidant N-acetylcysteine mimicked the abrogative effect of TGZ on 4HPR action, while the exogenous oxidant H2O2 also stimulated ceramide production . (bvsalud.org)
  • Lack of asparagine synthetase activity results in cytotoxicity specific for leukemic cells that depend on an exogenous source of the amino acid asparagine. (medscape.com)
  • IFNs, produced during viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs). (st-andrews.ac.uk)
  • Innate immune cells integrate environmental signals to rapidly activate target genes and perform specialized cellular functions 5 . (nature.com)
  • It also may release other progenitor cells that appears to be playing a vital role in organ regeneration. (qxmd.com)
  • Disorders such as epilepsy, schizophrenia, Parkinson, Alzheimer or depressions can be treated by stimulating the nervous system or the vagus nerve. (nanowerk.com)
  • A scalp massage not only relaxes the nervous system but also stimulates the brain cells. (yogawiz.com)
  • We know that there are stem cells throughout the adult nervous system that are capable of repairing the damage caused by multiple sclerosis, but until now, we had no way to direct them to act," said Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and associate professor in the Department of Genetics & Genome Sciences at the Case Western Reserve School of Medicine. (innovationtoronto.com)
  • But here we asked if we could find a faster and less invasive approach by using drugs to activate native stem cells already in the adult nervous system and direct them to form new myelin. (innovationtoronto.com)
  • Hair stem cells can also be used to help regenerate damaged or dead hair follicles, which reduces the appearance of gray hair and promotes new hair growth. (leonaut.com)
  • Hair stem cells are also an excellent way for patients who have experienced hair loss due to medical treatment, chemotherapy or hair transplants to bring life back to their scalp and hair follicles. (leonaut.com)
  • Hair stem cells are specialized cells that are the source of hair follicles and their associated hair. (leonaut.com)
  • They can help stimulate blood flow to the head and provide the nutrients that hair follicles need to stimulate hair growth. (leonaut.com)
  • In the end, science and technology are advancing and there is no doubt that hair stem cells play an important role in the development of hair follicles, which leads to hair growth. (leonaut.com)
  • OBJECTIVE: To evaluate alterations in ligand-stimulated activity of G proteins in thyroid gland cells of hyperthyroid cats. (avmi.net)
  • CONCLUSIONS AND CLINICAL RELEVANCE: Ligand-stimulated activation of G proteins was the same in thyroid cell membranes obtained from hyperthyroid and euthyroid cats. (avmi.net)
  • However, how blood proteins polarize innate immune cells remains largely unknown. (nature.com)
  • However, how microglia integrate extracellular signals at sites of cerebrovascular damage and the specificity of blood proteins controlling innate immune cell polarization in disease remain poorly understood. (nature.com)
  • We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
  • To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
  • New way to stimulate muscle regeneration paves the way for new treatments for debilitating conditions such as muscular dystrophy. (disabled-world.com)
  • Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa have discovered a powerful new way to stimulate muscle regeneration, paving the way for new treatments for debilitating conditions such as muscular dystrophy . (disabled-world.com)
  • Most research in appendage regeneration has focused on identifying mechanisms that influence cell behaviors in the remaining stump tissue, immediately adjacent to the injury site. (biorxiv.org)
  • Here, we discovered a role for adrenaline in stimulating a body-wide stem cell activation response to amputation that drives limb regeneration. (biorxiv.org)
  • The two most potent drugs-one that currently treats athlete's foot, and the other, eczema-were capable of stimulating the regeneration of damaged brain cells and reversing paralysis when administered systemically to animal models of multiple sclerosis. (innovationtoronto.com)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)
  • To replace damaged cells, much of the stem cell field has focused on direct transplantation of stem cell-derived tissues for regenerative medicine, and that approach is likely to provide enormous benefit down the road," said Tesar, also a New York Stem Cell Foundation Robertson Investigator and member of the National Center for Regenerative Medicine . (innovationtoronto.com)
  • Hair stem cells are extremely important because they can be used to repair and renew scalp tissues, thus fighting grey hair and stimulating hair growth. (leonaut.com)
  • After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)
  • As few countries are approaching self- sufficiency in the provision of cells, tissues and organs for transplantation, new ways continue to be sought to increase the donation of human material. (who.int)
  • Likewise, commercial trade in cells, tissues and organs - and even trafficking involving human beings who are kidnapped or lured into other countries where they are forced to be "donors" - continues to be a serious problem, particularly in countries with substantial transplant tourism. (who.int)
  • Beta-glucan has been found in previous research to stimulate the immune system, promoting the activation of certain immune cells such as macrophages and neutrophils. (nutraceuticalsworld.com)
  • This work challenges the predominant conceptual framework considering the injury site alone in the regenerative response, arguing instead for body-wide stem cell activation as a priming step upon which molecular cues at the injury site then build tissue. (biorxiv.org)
  • The TSH-stimulated activation of G(s) and G(i) was not different between euthyroid and hyperthyroid cats. (avmi.net)
  • We will review the mechanisms involved with stem cell release and activation and present two new natural triggers for this release and possible differentiation. (qxmd.com)
  • These data Suggest multiple roles for orexin-mediated MAPK activation in an adrenal cell-line, this complexity may help to explain the diverse biological actions of orexins with wide-ranging consequences for Our understanding of the mechanisms initiated by these steroidogenic molecules. (warwick.ac.uk)
  • An accumulation of lymphocytes, especially CD4 + T cells, in TPE has been well documented ( 2 ). (atsjournals.org)
  • In neurons, it allows to stimulate a neuronal circuit, and in striated muscle cells, the muscular contraction. (nanowerk.com)
  • In the future, this kind of electrical stimulation could be applied to other cells, such as neurons or muscle cells, opening the way for bioelectronic therapies and a change of paradigm, different from the current one based on pharmacological treatments", Gonzalo Murillo says. (nanowerk.com)
  • Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis. (innovationtoronto.com)
  • Photovoltaic nanowires have, for instance, been used to stimulate neurons. (lu.se)
  • Obtaining an autonomous and very small generator is the achievement of the work developed by the scientists at the IMB-CSIC and the UAB, which has been selected for the cover in the June 21st issue of the Advanced Materials journal ( 'Bioelectronics: Electromechanical Nanogenerator-Cell Interaction Modulates Cell Activity' ). (nanowerk.com)
  • Each sample was separately homogenized and centrifuged and the supernatants were diafiltered to isolate the low-molecular-mass fraction containing endothelial-cell-stimulating angiogenic activity. (portlandpress.com)
  • 4. These findings suggest that endothelial-cell-stimulating angiogenic activity in muscle is either inversely or not related to the local capillary density, which may be at or near a maximum in physiologically contracting, predominantly oxidative muscles. (portlandpress.com)
  • Our data show that GLP-1 increases FoxO1 acetylation, decreases the binding of SirT1 to FoxO1, and stunts SirT1 activity in β-INS832/13 cells. (diabetesjournals.org)
  • GLP-1 decreases both the NAD + -to-NADH ratio and SirT1 expression in INS cells and isolated islets, thereby providing possible mechanisms by which GLP-1 could modulate SirT1 activity. (diabetesjournals.org)
  • Our study shows for the first time that the glucoincretin hormone GLP-1 modulates SirT1 activity and FoxO1 acetylation in β-cells. (diabetesjournals.org)
  • The effect of interleukin 1 (IL-1) on glucose transport activity in isolated rat adipose cells was examined. (eurekamag.com)
  • The chemoattractant activity of chemokines produced by PMCs for Th22 cells was observed. (atsjournals.org)
  • Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer's disease, schizophrenia, and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function--without changes in food intake or daily activity. (bioquicknews.com)
  • Thyroid cell membranes from hyperthyroid and euthyroid cats had a concentration-dependent increase in TSH-stimulated GTPgamma(35)S binding over the TSH range of 0 to 100 mU/mL, with maximal activity at 1 to 100 mU/mL for both. (avmi.net)
  • The MCP-1 and vWF activity in cell supernatants was measured with an enzyme-linked immunosorbent assay (ELISA) kit. (iiarjournals.org)
  • vWF activity after illumination was comparable to that of unstimulated cells. (iiarjournals.org)
  • Conclusion: Low-power laser illumination diminishes the pro-inflammatory and pro-coagulant activity of IL-1β-stimulated HUVECs. (iiarjournals.org)
  • Knockdown of IFIT1 restored parainfluenza virus 5 infection in IFN-α-pretreated, ISG15-deficient cells, confirming that resistance was due to the direct antiviral activity of the IFN response. (st-andrews.ac.uk)
  • Chronic exposure to vibration is predicted to decrease mast cell number and result in untempered vasospastic activity. (cdc.gov)
  • However, the effects of the photovoltaic activity on cells are still poorly understood and characterized. (lu.se)
  • Here, we investigate the effects of the photovoltaic activity of p-i-n nanowire arrays on A549 human lung adenocarcinoma cells. (lu.se)
  • We have cultured A549 cells on top of vertical arrays of indium phosphide p-i-n nanowires (photovoltaic nanowires), with and without illumination to assess the effects of the nanowire photovoltaic activity. (lu.se)
  • Four transcript variants encoding three different isoforms (a proteoglycan, glycoprotein and cell surface protein) have been found for this gene. (wikipedia.org)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
  • Analysis using signalling and MAPK inhibitors as well as receptor-specific antagonists determined the precise mediators of the orexin response in these cells. (warwick.ac.uk)
  • The inhibitors of de novo ceramide synthesis, fumonisin B1 and myriocin, blocked the ceramide response to 4HPR and partially reversed the apoptotic response, but did not prevent the overall decline in cell survival . (bvsalud.org)
  • Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
  • Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury. (stembook.org)
  • In conclusion, hair stem cells can help stimulate hair growth by delivering essential nutrients to the follicles, helping to stimulate blood flow and promoting greater hair growth. (leonaut.com)
  • Selective killing of leukemic cells it thought to be due to depletion of plasma asparagine, the amino acid required for protein synthesis. (medscape.com)
  • Nanowerk News ) A work led by Gonzalo Murillo, scientist at the CSIC's Instituto de Microelectrónica de Barcelona (IMB-CNM), and Carme Nogués, scientist at the Department of Cellular Biology, Physiology and Immunology of the Universitat Autònoma de Barcelona (UAB), shows that the use of piezoelectric nanogenerators to stimulate living cells electrically is possible. (nanowerk.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Cellular immunity, particularly of CD4 + T cells, IFN-γ and tumor necrosis factor (TNF)-α, has a central role in the control of and protection against Mycobacterium tuberculosis (MTB) infection ( 1 ). (atsjournals.org)
  • Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
  • The Stem Cell Network, established in 2001, brings together more than 80 leading scientists, clinicians, engineers, and ethicists from universities and hospitals across Canada with a mandate to investigate the immense therapeutic potential of stem cells for the treatment of diseases currently incurable by conventional approaches. (disabled-world.com)
  • We accordingly hypothesize that ASTA has therapeutic properties protecting U937 cells from LPS-induced inflammatory and oxidative stress. (nih.gov)
  • Hence, recapitulating the islet ECM in both isolated islets and stem-cell-derived β-cells is of high therapeutic value. (nature.com)
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
  • Substances that can stimulate an immune response. (cdc.gov)
  • How primary sensitization occurs and how the immune system is initially involved is unclear, but once a drug stimulates an immune response, cross-reactions with other drugs within and between drug classes can occur. (msdmanuals.com)
  • Tumor buster - where will the CAR-T cell therapy 'missile' go? (aacrjournals.org)
  • IL-1β, IL-6, and/or tumor necrosis factor-α promoted Th22-cell differentiation from CD4 + T cells. (atsjournals.org)
  • Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect this growth. (medscape.com)
  • With their many regenerative properties and ability to stimulate hair growth, hair stem cells are a promising option to help those suffering from gray or thinning hair and strengthen the scalp. (leonaut.com)
  • These findings, published online October 7, 2021 in the Journal of Clinical Investigation , reveal that a chemical inhibitor of the enzyme PDE9 stimulates cells to burn more fat. (bioquicknews.com)
  • First, we found that there were EGFR-inhibitor sensitive (EIS) and EGFR-inhibitor resistant cell lines. (preprints.org)
  • The pancaspase inhibitor Z-VAD fmk reduced the decrease in cell survival caused by 4HPR, but did not affect the ceramide response. (bvsalud.org)
  • We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
  • It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. (wjgnet.com)
  • However, differentiation and immune regulation of Th22 cells in tuberculous pleural effusion (TPE) remain unknown. (atsjournals.org)
  • Glu-4, a relatively inactive IL-1 beta analogue in most cells, stimulated glucose uptake in a time and dose dependent manner with kinetics indistinguishable from those of IL-1 beta. (eurekamag.com)
  • The present study shows CGRP in some mast cells, but it is unknown whether this represents associated nerve fibers and/ or uptake with re-release during vasoregulation. (cdc.gov)
  • ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development. (frontiersin.org)
  • Using purified terminal complement components we have documented a mitogenic effect of the MAC for quiescent murine 3T3 cells. (jci.org)
  • The binding makes the protein-drug complex immunogenic, stimulating antidrug antibody production, T-cell responses against the drug, or both. (msdmanuals.com)
  • IL-22-producing helper T cells (Th22 cells) have been reported to be involved in tuberculosis infection. (atsjournals.org)
  • Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (wikipedia.org)
  • ISG15-deficient cells pretreated with IFN-α were resistant to paramyxovirus infection. (st-andrews.ac.uk)
  • Hair stem cells occur naturally in the human body and can be found in many parts of the scalp. (leonaut.com)
  • It was found that PMCs expressed CCL20, CCL22, and CCL27, and that TPE and PMC supernatants were chemotactic for Th22 cells. (atsjournals.org)
  • Satellite stem cells are specialized muscle stem cells that live in adult skeletal muscle tissue and have the ability to both replicate and differentiate into various types of muscle cells. (disabled-world.com)
  • Two studies recruit patients with unmet need in sickle cell disease. (fda.gov)
  • In a study on people who had at least four common colds in the preceding year, supplementing with a beta-glucan ingredient branded as PureMune by AIDP's partner Immudyne resulted in increased production of immune cells. (nutraceuticalsworld.com)
  • Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
  • In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
  • Thus, we hypothesized that pericytes regulate β-cells through the production of BM components. (nature.com)
  • Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity. (bvsalud.org)
  • N-(4-hydroxphenyl) retinamide induced a dose -dependent decline in cell growth and survival associated with a maximal 10-fold increase in ceramide production at 10 microM. (bvsalud.org)
  • The research, to be published in the June 5 issue of Cell Stem Cell , shows for the first time that a protein called Wnt7a increases the number of stem cells in muscle tissue, leading to accelerated growth and repair of skeletal muscle. (disabled-world.com)
  • Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells. (jci.org)
  • We are pleased to announce that Dr. Gail Naughton and the principals of Hitstogen Inc., the developers of Hair Stimulating Complex (HSC), will be providing The American Hair loss Association with exclusive video commentary, news and Video Q&A through this forum. (baldtruthtalk.com)
  • From Histogeninc.com Histogen's Hair Stimulating Complex (HSC) is a proprietary liquid formula created by the culturing of newborn fibroblasts in. (baldtruthtalk.com)
  • Laser influence on HUVEC inflammatory response was measured by stimulating them with Interleukin-1β (IL-1β) followed by laser light illumination. (iiarjournals.org)
  • No changes in MCP-1 levels after IL-1β stimulation plus 1.5 J/cm 2 illumination, compared to IL-1β stimulated HUVECs were noted. (iiarjournals.org)
  • A new alternative is to harvest the biomechanical energy of the patient and use it to charge the devices, but these are still hundreds of times larger than human cells. (nanowerk.com)
  • Led by researchers at Case Western Reserve University , a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory. (innovationtoronto.com)
  • Although IL-22-producing helper T (Th22) cells have been reported to be involved in human tuberculosis, the mechanisms by which Th22 cells differentiate and are recruited into the pleural space are unknown. (atsjournals.org)
  • We analysed the direct induction of the respiratory burst in human PMNs upon contact with stimulated T cells. (biomedcentral.com)
  • We have recapitulated these effects in cultured human A549-ISG15−/− cells and (using A549-UBA7−/− cells) confirmed that posttranslational modification by ISG15 (ISGylation) is not required for regulation of the type I IFN response. (st-andrews.ac.uk)
  • Interleukin-1 stimulates glucose transport in rat adipose cells. (eurekamag.com)
  • This paper will not discuss umbilical cord or adipose tissue derived stem cells, but rather peripheral blood stem cells (PBSC). (qxmd.com)
  • Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
  • M-CSF binds to the colony stimulating factor 1 receptor. (wikipedia.org)
  • SAMPLE POPULATION: Membranes of thyroid gland cells isolated from 5 hyperthyroid cats and 3 age-matched euthyroid (control) cats immediately after the cats were euthanatized. (avmi.net)
  • RESULTS: Thyroid cell membranes from hyperthyroid cats had higher basal GTPgamma(35)S binding than did thyroid cell membranes from euthyroid cats. (avmi.net)
  • The percentage increase in GTPgamma(35)S binding stimulated by TSH was similar in magnitude between the membranes from hyperthyroid and euthyroid cats. (avmi.net)