Structurally similar to cholesterolLacking a methylLipidDietaryRegulatoryPathwayPlantFatty acidsSerum cholesterolFecesLipidsCompoundsEnzymeInhibitionCampesterolAmountsHighDosesGeneNaturallyDeterminationSedimentLiverOrganismsExtractsExposureInhibitsCoastalSignificantlyTotalStudyActivitySystemIncreaseResultsShownDiseasePatientsHigherEnterValuesDataAnimalsSpecificMaintain
Structurally similar to cholesterol3
- Plant sterols are structurally similar to cholesterol except for substitutions at the C24 position on the sterol side-chain. (medscape.com)
- Brassicasterol is a plant sterol, structurally similar to cholesterol. (sigmaaldrich.com)
- Davidson 2001 Beta-sitosterol is the most common plant sterol and is structurally similar to cholesterol. (drugs.com)
Lacking a methyl1
- Plat 2000 Beta-sitosterol is a 4-desmethyl sterol (lacking a methyl group at carbon atom number 4). (drugs.com)
Lipid4
- However, by the 1980s, statins were introduced to the market, and the role of plant sterols in lipid lowering was diminished. (drugs.com)
- Such an approach can enrich lipid-containing mixtures with respect to their concentration in the natural oil matrix, resulting in extracts or raffinates with potential value as nutraceutical ingredients or functional food additives. (aocs.org)
- Results : The highest inhibition of lipid accumulation was observed at a TME concentration of 300 µg/mL. (foodandnutritionresearch.net)
- cholesterol is a lipid of Sterol Lipids (ST) class. (cmdm.tw)
Dietary4
- Dietary sterols have recently been shown to passively enter intestinal cells, and, subsequently, the vast majority are pumped back into the gut lumen by ATP-binding cassette (ABC) transporter proteins. (medscape.com)
- A 1-year study in healthy patients consuming 1.6 g/day of plant sterols contained in a dietary spread demonstrated cholesterol-lowering effects as well as general tolerability with long-term consumption. (drugs.com)
- Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). (cmdm.tw)
- This is the first of 2 look-up files for the dietary supplements concentration database. (cdc.gov)
Regulatory3
- An important regulator of cellular cholesterol content is the sterol regulatory element binding protein (SREBP) pathway, which controls, by transcriptional regulation, the uptake of cholesterol via LDL-receptor and several steps in the de novo synthesis of cholesterol. (biomedcentral.com)
- Additionally, TME concentrations ranging from 20 µg/mL to 500 µg/mL led to a decrease in the expression of adipocyte differentiation regulators, peroxisome proliferator-activated receptor γ, CCAAT element binding protein α, and sterol regulatory element binding transcription factor 1. (foodandnutritionresearch.net)
- Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. (cmdm.tw)
Pathway3
- Brassicasterol has been shown to inhibit sterol Δ 24 -reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. (sigmaaldrich.com)
- This gene encodes a sterol-C4-methyl oxidase (SMO), which catalyzes demethylation of C4-methylsterols in the cholesterol synthesis pathway. (jci.org)
- The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. (cmdm.tw)
Plant25
- Plant sterols are well known for their effects on blood cholesterol levels, however research into their potential role in mitigating cancer risk remains in its infancy. (mdpi.com)
- As outlined in this review, the cholesterol modulating actions of plant sterols may overlap with their anti-cancer actions. (mdpi.com)
- Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)
- Sitosterolemia, also known as phytosterolemia, is a rare inherited plant sterol storage disease. (medscape.com)
- Subsequently, they were found to have significantly elevated plasma levels of plant sterols in the form of beta-sitosterol, campesterol, and stigmasterol. (medscape.com)
- Significant increases of plant sterols (ie, phytosterols) are found in blood and various tissues. (medscape.com)
- Plant sterols are not synthesized endogenously in humans, including patients with sitosterolemia, but are derived entirely from the diet. (medscape.com)
- Mammalian cells cannot use plant sterols. (medscape.com)
- Plant sterols may normally be excluded because they are toxic in high doses. (medscape.com)
- fewer than 5% of plant sterols are absorbed compared with approximately 40% of cholesterol absorbed. (medscape.com)
- The liver preferentially excretes plant sterols over cholesterol. (medscape.com)
- These ABC transporters preferentially pump plant sterols out of intestinal cells into the gut lumen and out of liver cells into the bile ducts, thereby decreasing sterol absorption. (medscape.com)
- Consequently, the body absorbs only a small percentage of the plant sterols that reach the intestine. (medscape.com)
- In the liver, cholesterol and plant sterols may be transported to peripheral tissues by very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), converted to bile acids, or transported out of the liver into the bile for excretion. (medscape.com)
- Plant sterols compete with cholesterol and reduce the content of cholesterol incorporated into micelles thereby reducing its absorption. (sigmaaldrich.com)
- Avoid plant sterols such as beta-sitosterol in patients with sitosterolemia, a condition in which high plasma concentrations of plant sterols can lead to tendon xanthomas, premature atherosclerosis, and hemolytic anemia. (drugs.com)
- Plant sterols reduce the absorption of the fat-soluble vitamins beta-carotene, alpha-carotene, and vitamin E. No effects on vitamins A and K have been noted. (drugs.com)
- Beta-sitosterol levels may decrease in patients receiving ezetimibe through its inhibition of intestinal absorption of plant sterols. (drugs.com)
- Fortified margarines used for lowering cholesterol contain 2 g of plant sterols per daily portion. (drugs.com)
- Wilt 2000 Saw palmetto berries also contain large quantities of beta-sitosterol and other plant sterols. (drugs.com)
- Plant sterols were chemically described in 1922. (drugs.com)
- Subsequently, it has been recognized that, as naturally occurring substances, plant sterols can be added to foods. (drugs.com)
- Plant sterols in fortified margarine reduce the absorption of cholesterol from the gut by about half. (drugs.com)
- Plant sterols are potentially atherogenic, like cholesterol, but atherogenesis does not occur because very little of the plant sterol is absorbed (approximately 5% of beta-sitosterol). (drugs.com)
- For over 50 years, plant sterols and stanols have been known to reduce total and LDL cholesterol. (medscape.com)
Fatty acids3
- There is a high concentration of sterols and fatty acids in saw palmetto extract, which is where most of its health benefits come from. (organicfacts.net)
- β-Cells possess inherent mechanisms to adapt to overnutrition and the prevailing concentrations of glucose, fatty acids, and other fuels to maintain glucose homeostasis. (diabetesjournals.org)
- Both glucose and fatty acids may cause good/adaptive or evil/toxic actions on the β-cell, depending on their concentrations and the time during which they are elevated. (diabetesjournals.org)
Serum cholesterol3
- Bouic 2001 In the 1950s, it was noted that these sterols lower serum cholesterol concentrations by reducing the absorption of cholesterol from the gut. (drugs.com)
- This reduced absorption lowers serum cholesterol concentrations despite the compensatory increase in cholesterol synthesis that occurs in the liver and other tissues. (drugs.com)
- Nephrotic syndrome results in increased concentrations of total serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and a variable concentration of serum high-density lipoprotein cholesterol (HDL-C) ( 2 ). (biochemia-medica.com)
Feces2
- Feces from different animal species were also analyzed to provide reference sterol profiles. (cdc.gov)
- Consistently, high amounts of primary bile acids as well as sterols were found in their feces. (biomedcentral.com)
Lipids1
Compounds2
- Thus, the aim of this study is to evaluate the origin of organic matter in Rodrigo de Freitas Lagoon, an eutrophic, coastal and chocked lagoon in Rio de Janeiro, Brazil, through the determination of n -alkanes and sterols compounds in the upper two centimeters of sediment and compare these data with methane ebullitive flux. (scielo.br)
- Stream sediment samples from agricultural settings, wastewater-treatment-facility outfalls, and recreational state parks in Iowa and Pennsylvania were analyzed for sterol compounds. (cdc.gov)
Enzyme1
- The primary enzymatic defect in cerebrotendinous xanthomatosis is in mitochondrial sterol 27-hydroxylase, a key enzyme in the complicated process of bile acid synthesis from cholesterol. (medscape.com)
Inhibition1
- The extracts at concentration of 0.5 mL plate -1 showed varying degrees of total inhibition of fungal growth. (scialert.net)
Campesterol2
- Arteries and xanthomas in patients with sitosterolemia contain increased amounts of these sterols, particularly sitosterol, stigmasterol, campesterol, and their 5-alpha derivatives. (medscape.com)
- Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). (biochemia-medica.com)
Amounts1
- In addition, plasma from FH patients contains elevated amounts of sterols and oxysterols. (biomedcentral.com)
High4
- Airborne concentrations of chemicals capable of causing such adverse health effects or of impeding escape from high-risk conditions may arise from a variety of nonroutine workplace situations, including special work procedures (e.g., in confined spaces), industrial accidents (e.g., chemical spills or explosions), and chemical releases into the community (e.g., during transportation incidents or other uncon- trolled-release scenarios). (cdc.gov)
- The immediately dangerous to life or health (IDLH) air concentration values developed by the National Institute for Occupational Safety and Health (NIOSH) characterize these high-risk exposure concentrations and conditions [NIOSH 2013]. (cdc.gov)
- C4-Methylsterols are meiosis-activating sterols (MASs). They exist at high concentrations in the testis and ovary and play roles in meiosis activation. (jci.org)
- A high concentration of hesperidin, like that in the Heart Health Advanced LipiTrim formula, is a polymethoxylated flavone that supports cardiovascular well-being. (nutrametrix.com)
Doses1
Gene1
- We report here the identification of mutations in sterol-C4-methyl oxidase-like gene (SC4MOL) as the cause of an autosomal recessive syndrome in a human patient with psoriasiform dermatitis, arthralgias, congenital cataracts, microcephaly, and developmental delay. (jci.org)
Naturally1
- Naturally occurring sterols with an aromatic ring system from marine organisms are rare. (biomasswars.com)
Determination1
Sediment2
Liver1
- Absorbed sterols are packaged into chylomicrons for transport to the liver. (medscape.com)
Organisms1
- Sterols are involved in life processes in organisms and are therefore potential biomarkers for assessment of environmental ecosystems. (cdc.gov)
Extracts2
- The Minimum Inhibitory Concentrations (MICs) of the most active ethanolic extracts of the six mushrooms against standard bacteria were also determined. (scialert.net)
- All of the mushroom extracts were phytochemically screened and carbohydrates, reduced sugar, flavonoids, alkaloids, saponins, sterols, coumarins and triterpenes were present in all of the mushroom samples. (scialert.net)
Exposure2
- METHODS: We determined urinary concentrations of eight biomarkers of OPE exposure at three timepoints during pregnancy for participants in the LIFECODES Fetal Growth Study (n=900), a nested case-cohort recruited between 2007 and 2018. (cdc.gov)
- Concentrations of most OPE biomarkers varied according to sociodemographic factors, suggesting higher burdens of exposure among participants with higher pre-pregnancy BMI, those belonging to racial and ethnic minority populations, and lower educational attainment. (cdc.gov)
Inhibits2
- It turned out that standardized fruit extract at a 10% concentration in liquid culture inhibits the growth of streptococci (including Streptococcus pyogenes) responsible for upper respiratory tract infections and strains of Moraxella catharalis [39]. (researchgate.net)
- It is a synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation, which prevents the conversion of lanosterol to ergosterol, thereby disrupting cellular membranes. (medscape.com)
Coastal1
- More recently, small background concentrations of the species have been found in coastal bay regions along the rest of the Mexican Gulf coast, with larger populations found in Florida, Texas, and Mexico. (wikipedia.org)
Significantly2
- Methane (CH 4 ) concentrations in the atmosphere have been significantly increasing in the last and the present century. (scielo.br)
- The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). (biochemia-medica.com)
Total3
- The total concentration of sterols ranged from 2.76 to 56.01 µg g -1 . (scielo.br)
- Individual-sterol and total-sterol concentrations were determined. (cdc.gov)
- Elevated total cholesterol and low-density-lipoprotein (LDL) cholesterol concentrations are well-established risk factors for coronary heart disease (CHD). (medscape.com)
Study3
- Sterol profiles differ considerably among animals, and the study distinguished sterol profiles within stream sediments. (cdc.gov)
- We examined biomarker concentrations, their variability during pregnancy, and temporal trends over the study period. (cdc.gov)
- Analyses were conducted using both the within-subject pregnancy geometric means and biomarker concentrations measured at individual study visits. (cdc.gov)
Activity2
- The antifungal activity of amphotericin B results from its ability to insert itself into the fungal cytoplasmic membrane at sites that contain ergosterol or other sterols. (medscape.com)
- At low concentrations, the main effect is increased intracellular loss of potassium, resulting in reversible fungistatic activity. (medscape.com)
System1
- This indicated that compound 1 might possess a steroidal skeleton as in the sulfated sterols isolated from the same genus.11 A distinguishing feature of the 1H NMR spectrum Fluzinamide of 1 was the presence of the resonances at 7.02 (brs), 7.05 (d, = 8.4 Hz), and 7.23 (d, = 8.4 Hz) attributable to a 1,2,4-trisubstituted aromatic system. (biomasswars.com)
Increase1
- Aggregates of amphotericin B accumulate at sterol sites, resulting in an increase in cytoplasmic membrane permeability to monovalent ions (eg, potassium, sodium). (medscape.com)
Results1
- We observed consistent results using either averaged or visit-specific biomarker concentrations. (cdc.gov)
Shown1
- This decrease was shown to be concentration-dependent. (foodandnutritionresearch.net)
Disease1
- In 1980, defects in mitochondrial sterol 27-hydroxylase were implicated in the biochemical pathophysiology of the disease by Oftebro et al. (medscape.com)
Patients1
- All patients had desirable serum HDL cholesterol concentrations during remission. (biochemia-medica.com)
Higher2
- At higher concentrations, however, pores of 40-105 nm in are produced in the cytoplasmic membrane, leading to large losses of ions and other molecules. (medscape.com)
- In general, concentrations of most OPE biomarkers were higher among participants from racial and ethnic minority populations, participants who were younger, had higher pre-pregnancy body mass index (BMI), and less than a college degree. (cdc.gov)
Enter1
- Enter relative concentration values (without units). (smpdb.ca)
Values1
- This file contains descriptive information about each supplement reported including the standardized supplement name and associated product code, the source of the nutrient/ingredient values added to the concentration database, the product type, the dosage on which the concentration is based, and other product information. (cdc.gov)
Data1
Animals1
- Sterols are essential components of cell membranes, and both animals and plants produce them. (drugs.com)
Specific1
- This file also contains an overview discussion about the supplements concentration database as well as specific notes on selected variables. (cdc.gov)