Sterol carrier protein 2 protein pathways carrier proteins. Medical search. Frequent questions

In tumor-induced osteomalacia, tumor-secreted FGF-23 inhibits enzyme 1α-hydroxylase and subsequently results in decreased 1,25(OH)2 D synthesis. (medscape.com)
HIV protease inhibitors have been reported to markedly suppress the activities of 25- and 1α-hydroxylase and thus affect 1,25(OH)2 D synthesis. (medscape.com)
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. (nih.gov)
Initiation of protein synthesis in eukaryotes. (montclair.edu)
The core proteostasis network is well described and involves the synthesis, folding, trafficking and degradation of proteins 6 - 8 . (elifesciences.org)
Our lab uses a combination of structural biology, pharmacology, biochemistry, cell biology, and computational methods to decipher the molecular mechanisms underlying sterol synthesis, recognition, and signaling. (thealonlab.org)
POU5F1( OCT4), SOX2, and NANOG download proteins in the medals of synthesis families. (evakoch.com)
A primary component of mitochondrial metabolism is the TCA cycle which apart from producing NADH needed in the oxidative phosphorylation also supplies precursors for biomass synthesis, e.g. 2-oxoglutarate and oxaloacetate. (biomedcentral.com)

This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. (nih.gov)
Pathway analysis of altered lipid species indicated that sphingolipid metabolism, insulin signalling and mitochondrial function were the major metabolic pathways dysregulated in Parkinson's disease. (medscape.com)
In response to mtDNA damage, cell initiates multiple pathways including mtDNA repair, degradation, clearance and release, to recover mtDNA, and maintain mitochondrial quality and cell homeostasis. (biomed.news)
Further, mitochondrial associated ubiquitin, which recruits the autophagy receptor protein p62, was also significantly increased at 2 hours. (biomed.news)
Overall, we provide evidence that acute exercise activates hepatic mitophagic flux while also revealing specific receptor-mediated proteins by which exercise maintains mitochondrial quality control in the liver. (biomed.news)
Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. (biomedcentral.com)
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive genetic disorder caused by an abnormality in the CYP27A1 gene, resulting in a deficiency of the mitochondrial enzyme sterol 27-hydroxylase. (rarediseases.org)

This review describes the clinical, biochemical and metabolic features of Refsum's disease and shows how the biochemistry of the alpha-oxidation pathway may be linked to the regulation of metabolic pathways controlled by isoprenoid lipids, involving calcineurin or the peroxisomal proliferator activating alpha-receptor. (nih.gov)
Urbanization, sedentary life-styles, and an over abundance of high caloric foods in human populations have collectively created conditions in which the primordial metabolic pathways that evolved to extract optimal energy from the environment have begun to function out of control [ 1 ]. (ijbs.com)
This review is organized by specific metabolic pathways or processes (i.e., glucose metabolism and lipogenesis, amino acid metabolism, and nucleotide biosynthesis). (biomedcentral.com)
Metabolic pathways within mitochondria that contribute to biosynthesis in cancer and other proliferating cells. (biomedcentral.com)
At the same time, bone health worsens because calcium doesn't follow the metabolic pathway to reach bones. (nutraceuticalsworld.com)
MGP is dependent on vitamin K2 to transfer calcium through a metabolic pathway where it is deposited in bones, and not in the arteries of soft tissue. (nutraceuticalsworld.com)

Acts downstream of CTR1 and ethylene biosynthesis, in the same pathway as EIN2 and AUX1, and independent from EIN3 and EIN5/AIN1 pathway. (or.jp)
2020. The bacterial quorum sensing signal DSF hijacks sterol biosynthesis to suppress plant innate immunity. . (ncbs.res.in)

The transport and biochemical pathways of phytanic acid metabolism have recently been defined with the cloning of two key enzymes, phytanoyl-CoA 2-hydroxylase (PAHX) and 2-hydroxyphytanoyl-CoA lyase, together with the confirmation of their localization in peroxisomes. (nih.gov)
We subsequently showed that increased lipid uptake and/or disrupted lipid metabolism led to increased lysosomal protein aggregation and, concomitantly, accumulation of sphingolipids and cholesterol esters. (elifesciences.org)
This important manuscript deals with this interesting topic and applies the powerful unbiased tools of somatic cell genetics to discover evidence suggesting a link between sphingolipids/cholesterol ester metabolism and lysosomal protein aggregation. (elifesciences.org)
As you will read in the chapter on metabolism , the ability to move electrons among proteins is critical to all life, so two general types of prosthetic groups associated with proteins have evolved for this purpose. (microbiologytext.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
The proteins involved in the intra- and extracellular transport of lipids play an important role in the lipid metabolism of pro- and eukaryotic cells. (atoom.ru)
Vitamin K was first discovered in 1929 by Danish biochemist Carl Peter Henrik Dam, and was immediately found to be associated with blood coagulation during experiments on sterol metabolism. (nutraceuticalsworld.com)
Our results show that the transcriptional regulatory response resulting from the impaired respiratory function is linked to several different parts of the metabolism, including fatty acid and sterol metabolism. (biomedcentral.com)

Despite the potential role for lipids in Parkinson's disease, most research to date has been protein-centric, with large-scale, untargeted serum and CSF lipidomic comparisons between genetic and idiopathic Parkinson's disease and neurotypical controls limited. (medscape.com)
The main serum lipids that distinguished both Parkinson's disease patients and LRRK2 mutation carriers from controls included species of ceramide, triacylglycerol, sphingomyelin, acylcarnitine, phosphatidylcholine and lysophosphatidylethanolamine. (medscape.com)
Significant alterations in sphingolipids and glycerolipids were also reflected in Parkinson's disease and LRRK2 mutation carrier CSF, although no correlations were observed between lipids identified in both serum and CSF. (medscape.com)
Results from this study demonstrate that dysregulated lipids in Parkinson's disease generally, and in LRRK2 mutation carriers, are from functionally and metabolically related pathways. (medscape.com)
Lipids will self assemble and form the cellular membrane, and Section 3-2 describes this process in greater detail. (microbiologytext.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Among a variety of molecular factors of the plant innate immune system, small proteins that transfer lipids and exhibit a broad spectrum of biological activities are replica rolex womens watches of particular interest. (atoom.ru)
The first feature is the ability of plant LTPs to bind and transfer lipids, whereby these proteins got their name and were combined into one class. (atoom.ru)
These proteins reversibly bind lipids and deliver them to their destination. (atoom.ru)

There are digital pathways in which release of HAT or HDAC times interact their dolichol receptor and transcription degradation, which in Co-precipitation, trim the broader domains of these iNOS( Shahbazian & Grunstein 2007). (evakoch.com)

Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. (nih.gov)
1. Very-long-chain fatty acid sphingomyelin in nuclear lipid microdomains of hepatocytes and hepatoma cells: can the exchange from C24:0 to C16:0 affect signal proteins and vitamin D receptor? (nih.gov)
The cellular function of TM6SF2 is unknown, however a loss of function mutation (E176K) causes carriers to be susceptible to nonalcoholic fatty liver disease (NAFLD), the most common form of liver disease, caused by an aberrant accumulation of fat in the liver. (thealonlab.org)
Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study. (charite.de)

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. (genscript.com)
Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation. (elifesciences.org)
Acute exercise did not significantly increase markers of autophagic flux, however, mitophagic flux was activated 2 hours post-treadmill running as measured by accumulation of both LC3-II and p62 in isolated mitochondria in the presence of leupeptin, an inhibitor of autophagosome degradation. (biomed.news)

patek philippe replica paypalThe second feature is that LTPs are defense proteins that are components of plant innate immunity. (atoom.ru)

However, the surrounding proteins modulate these affinities. (microbiologytext.com)

Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. (dadamo.com)
Cholesterol is primarily synthesized from acetyl CoA through the HMG-CoA reductase pathway in many cells and tissues. (dadamo.com)
This phenotype allows for detection and imaging of some cancers and metastatic lesions using the glucose analog 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG), which accumulates in tumors (and some other tissues) and can be noninvasively observed when using positron emission tomography integrated with computed tomography (FDG-PET/CT) [ 2 ]. (biomedcentral.com)
They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. (hmdb.ca)

The σ 2 receptor belongs to the EXPERA family and is involved in cholesterol homeostasis, regulation of Niemann-Pick C1 (NPC1), LDL internalization, cancer, schizophrenia, and other conditions. (thealonlab.org)
This rapid nongenomic pathway is mediated by a subclass of the Progestin AdipoQ Receptor (PAQR) family of integral membrane proteins. (thealonlab.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
Moreover, the results suggest that exercise induced hepatic mitophagy is likely mediated by both poly-ubiquitination and receptor mediated signaling pathways. (biomed.news)
We developed the HTP SurFlexDock, a web server that improves SBVS campaigns by the use of ensemble docking pipeline in order to simulate the protein receptor flexibility. (ab3c.org.br)

Instead, it is transported in the bloodstream by lipoproteins - protein "molecular-suitcases" that are water-soluble and carry cholesterol and fats internally. (dadamo.com)
Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. (hmdb.ca)

Measuring peptides, steroids, and proteins from tissue extracts is essential for studying normal physiological processes and diagnosing various pathological states with underlying endocrine etiologies. (frontiersin.org)
In-depth understanding of the changing functions of human milk (HM) proteins and the corresponding physiological adaptions of the lactating mammary gland has been inhibited by incomplete knowledge of the HM proteome. (mdpi.com)
The physiological role of most EXPERA proteins is incompletely understood, but is clearly rooted in sterol recognition as all family members are predicted to adopt a similar fold with binding pocket residues that are conserved across the family. (thealonlab.org)
Some physiological responses, including oocyte maturation and acrosome reaction, utilize a parallel signaling pathway that initiates by progesterone binding to membrane receptors. (thealonlab.org)
Along with new topics on rational drug design, mining big data and perspectives from Pharma, we will continue to focus on protein structure and dynamics, cell biology and physiological function of membrane transporters. (grc.org)

Parkinson's disease is a progressive neurodegenerative disorder involving the loss of dopamine-producing neurons in the brain, in conjunction with the pathological accumulation of α-synuclein protein in remaining neurons. (medscape.com)
and 3) stress response pathways that regulate the activity of 1) and 2) in response to accumulation of unfolded or misfolded proteins, such as ERAD and UPR. (elifesciences.org)
Severe disease results when dysregulation causes sterol accumulation or depletion. (thealonlab.org)

The biologically active form of vitamin D is 1,25-dihydroxyvitamin D (1,25(OH)2 D). Measurement of serum levels of 1,25(OH)2 D should be considered upon suspicion of deficiency or excess of this form of the vitamin. (medscape.com)
Decreased levels of 1,25(OH)2 D can result from chronic kidney disease, various heritable disorders, tumor-induced osteomalacia, the use of HIV protease inhibitors, or severe vitamin D deficiency. (medscape.com)
Severe vitamin D deficiency: 25(OH)D is the main substrate of 1,25(OH)2 D. Vitamin D deficiency can affect the production of 1,25(OH)2 D owing to the lack of substrate. (medscape.com)
Treatment with 25(OH)D can normalize 1,25(OH)2 D concentrations in patients with vitamin D deficiency. (medscape.com)
An analysis of blood samples from 42 children and 68 adults concluded that "substantial concentrations" of deactivated matrix GLA protein (MGP) and osteocalcin-which are both considered markers of vitamin K deficiency-existed in the non-supplemented population. (nutraceuticalsworld.com)

2020. Brain circuits at risk in psychiatric diseases and pharmacological pathways. . (ncbs.res.in)

The purpose of the present study was to clarify the effect of different periods of antibiotic administration on the hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries. (inrae.fr)

This protein regulates the movement of citrate across the inner membranes of the mitochondria. (nih.gov)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

These molecules have a similar structure to sterols found in eukaryotic membranes and serve to help stabilize the membrane. (microbiologytext.com)

These results suggest that lipid dysregulation may have primary effects on the stability of endogenous proteins, potentially through direct biophysical mechanisms. (elifesciences.org)
In this review, we provide our current understanding of the fate of damaged mtDNA, focus on the pathways and mechanisms of removing damaged mtDNA in the cell. (biomed.news)
CONCLUSIONS: LIPG participates in HBV infection by upregulating HBV attachment to the cell membrane by means of 2 possible mechanisms: increasing HBV attachment to HSPGs or facilitating HSPG-dependent or HSPG-independent HBV attachment to NTCP by its lipase activity. (inrae.fr)

In a study by Levin et al (2007), 13% of patients with an estimated glomerular filtration rate (eGFR) greater than 80 mL/min and more than 60% of patients with an eGFR of less than 30 mL/min had low serum levels of 1,25(OH)2 D.[2] Impaired production of the enzyme 1α-hydroxylase in kidney failure was thought to be the main mechanism. (medscape.com)
In granulomatous disease such as lymphoproliferative disorders, sarcoidosis, tuberculosis, and inflammatory bowel disease, 1α-hydroxylase enzyme activity was found in macrophages as the extrarenal source of 1,25(OH)2 D. When 1α-hydroxylase is activated, it converts 25(OH)D to 1,25(OH)2 D, just as what occurs under physiologic conditions in the kidneys. (medscape.com)
[ 2 ] Impaired production of the enzyme 1α-hydroxylase in kidney failure was thought to be the main mechanism. (medscape.com)
enzyme that has an important role in ubiquitin mediated proteolysis by conjugating ubiquitin to protein substrates [RGD, Feb 2006]. (genscript.com)

In vitro studies of monocytes/macrophages indicate that gamma interferon is an important regulator of 1α-hydroxylase but only when other key signaling pathways are also activated (eg, JAK-STAT and MAP-Kinase). (medscape.com)
Previous studies suggest MAPK-activated protein kinase 2 (MK2) inhibition may limit VSMC proliferation and IH, although the molecular mechanism underlying the observation remains unclear. (jci.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

2016 marks the 10th anniversary of the Gordon Research Conference on Membrane Transport Proteins, which has been held every two years since 1998. (grc.org)
2016. - 8(2). (atoom.ru)

The contribution of a particular amino acid residue to the overall peptide retention undecylenate, vitamin C, Euro Pharma Halotestin hepatorenal damage, oxidative stress, heat shock protein 90, androgen receptors. (econohomes.com)
Comparison of the amino acid sequences of the proteins of the listed classes demonstrated no significant structural homology among them. (atoom.ru)

In particular, the extent to which lipid dysregulation occurs in mutation carriers of one of the most common Parkinson's disease risk genes, LRRK2 , is unclear. (medscape.com)

The proteins forming the surface of the given lipoprotein particle determine from what cells cholesterol will be removed and to where it will be supplied. (dadamo.com)

Have been demonstrated in pneumococcal vaccines at doses of 20 mg of prednisone or greater onwards) require sterol carrier proteins (SCP) to ensure the solubilisation of these highly lipophilic molecules (see ref. (econohomes.com)
Small molecules in the cell also serve as carriers of important carbon compounds. (microbiologytext.com)

6. Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals. (nih.gov)

Modulating this cellular proteostasis state can influence the stability of multiple endogenous proteins, yet the factors contributing to this state remain incompletely characterized. (elifesciences.org)

A theta of the PP2A phosphorylation of atoms mutations both globular and preferential cones of ChREBP( Carbohydrate Response Elemant Binding Protein). (evakoch.com)

Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs as a result of gene knockout of SREBP cleavage-activating protein (SCAP), a protein required for nuclear localization of SREBPs. (nih.gov)
Here, we use oligonucleotide arrays hybridized with RNA from livers of three lines of mice (transgenic for SREBP-1a, transgenic for SREBP-2, and knockout for SCAP) to identify genes that are likely to be direct targets of SREBPs in liver. (nih.gov)
A total of 1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers. (nih.gov)

Normally, mtDNA binds to certain proteins to form a nucleoid that is stable in mitochondria. (biomed.news)

Essentially, these carriers have the right chemical properties that make it relatively easy for enzymes to add or remove a particular carbon unit. (microbiologytext.com)
Sterols are sensed by numerous classes of receptors and synthesized by a multitude of tightly regulated enzymes. (thealonlab.org)
Tumors or cancer cell types where enzymes in each pathway have been specifically observed to by dysregulated are described within the text and summarized in Table 1 . (biomedcentral.com)

In this study, we present a novel sample processing strategy for the simultaneous extraction and detection of peptides, steroids, and proteins using high-resolution liquid chromatography tandem mass spectrometry. (frontiersin.org)
However, the diverse chemical structures of peptides, steroids, and proteins have traditionally required separate LC-MS/MS analyses of different biological samples, which limits project scope and the ability to simultaneously collect integrated data ( 1 - 3 ). (frontiersin.org)

Pro-tumorigenic role may be described through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, upregulation of indoleamine 2,3-dioxygenase, and checkpoint inhibitors such as programmed cell death ligand 1. (biomedcentral.com)

Traditionally, steroid, peptide, and protein hormones are analyzed in individual experiments using different extraction methodologies. (frontiersin.org)
For peptide and steroid methodologies, proteins are typically precipitated out of extracts and discarded, while for proteomics, the protein analytes are precipitated and preserved, and the supernatants are discarded ( 4 - 6 ). (frontiersin.org)
The homogenization solution consists of a high percentage of methanol and acetic acid to precipitate proteins from tissue homogenates, while keeping peptide and steroid analytes in solution. (frontiersin.org)
Figure 1 Comprehensive Workflow for Analyzing Peptide, Steroid, and Protein Components in Pituitary Samples. (frontiersin.org)
LIPG was shown to be involved in HBV attachment to the cell surface by using 2 sodium taurocholate cotransporting peptide (NTCP)-expressing cell lines, and the direct interaction of LIPG and HBV large surface protein was revealed. (inrae.fr)

Encodes an auxin efflux carrier that is similar to bacterial membrane transporters. (or.jp)
also HA encodes tumors, the FZD collagens are couples to remove it into skeletal ions, the most 3M-2 pathway binding a size. (evakoch.com)

Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. (elifesciences.org)
Protein aggregation is a hallmark of aging and age-related pathologies, including multiple neurodegenerative diseases and amyloidoses that affect individual or multiple organs 1 , 2 . (elifesciences.org)
Dozens of proteins that are normally soluble may form aggregates that are traditionally associated with specific diseases -- e.g. tau tangles and amyloid plaques with Alzheimer's Disease, and transthyretin deposits with transthyretin amyloidosis 2 . (elifesciences.org)
The conference will highlight translational aspects of membrane transport proteins as targets in neurological and psychiatric disorders as well as the gamut of human diseases including cardiovascular, diabetes and cancer. (grc.org)

Moreover, the hallmark Parkinson's disease pathological protein, α-synuclein, has lipid membrane function and pathways dysregulated in Parkinson's disease such as the endosome-lysosome system and synaptic signalling rely heavily on lipid dynamics. (medscape.com)

Heritable disorders associated with low 1,25(OH)2 D levels include vitamin D-dependent rickets type 1 (inactivating mutation in the 1-hydroxylase gene),[4] autosomal-dominant hypophosphatemic rickets (mutation of the gene coding for FGF-23, which prevents its breakdown),[5] and X-linked hypophosphatemic rickets (mutations that elevate levels of FGF-23). (medscape.com)
Increased 1,25(OH)2 D levels can result from extrarenal 1α-hydroxylation or hereditary vitamin D-resistant rickets. (medscape.com)
Shortly after Vitamin D was discovered in 1922, the Nobel Prize in Chemistry was awarded to Adolf Windhaus in 1928 for his studies on sterols and their connection with vitamins,[3] which increased the research interest in this field. (vitamindwiki.com)
Do Statins Interfere with the Function of Vitamin D-Binding Protein? (westonaprice.org)
2 It is therefore crucial for us to understand just how much vitamin D is necessary for optimal health and just how much can be toxic. (westonaprice.org)

These proteins have an intra- or extracellular localization, relatively low molecular weight (7-30 kDa), a high isoelectric point (pl ~ 9-11), and a compact structure stabilized by disulfide bonds. (atoom.ru)

They concluded that activation of MΦ through the alternative pathway possibly contributes to intracellular persistence of S. aureus during mastitis in dairy cattle. (biomedcentral.com)

KEGG, GO and IPA analytical tools were used to reconstruct pathways, networks and to map out molecular and cellular functions of differentially expressed genes (DE) in stimulated cells. (biomedcentral.com)
The topmost DE genes in poly(I:C)-stimulated cells had thousand-fold changes with highly significant p -values, whereas in CpG DNA stimulated cells had 2-5-fold changes with less stringent p -values. (biomedcentral.com)
By contrast, poly(I:C) highly induced exclusively canonical pathways directly related to antiviral immune functions mediated by interferon signalling genes. (biomedcentral.com)
We examine how recent molecular genetic advances in the characterisation of the ARPKD and NPHP genes provide insights into the "common developmental pathway" hypothesis for the aetiology of these clinically heterogeneous group of disorders. (bmj.com)
The molecular basis of a number of rarer HRFC syndromes remains unknown, and it is hoped that these insights might provide a rationale for the selection of candidate genes in the future, on the basis of protein function. (bmj.com)

In silico analysis is the beginning of many researches and it can predict which way follow it's possible to evaluate the promisor compounds and the pathways of action. (ab3c.org.br)
The Fragment-based Drug Design (FBDD) strategy consists of screening low molecular weight compounds against macromolecular targets (usually proteins) of clinical relevance. (ab3c.org.br)

A sterol-carrier protein-2 (SCP-2) knockout mouse model shares a similar clinical phenotype to Refsum's disease, but no mutations in SCP-2 have been described to-date in man. (nih.gov)

Our vision for the upcoming conference is to link molecular and mechanistic insights on clinically important membrane transporters - including carriers, ion channels and pumps, to human disease. (grc.org)

It has been suggested previously that hepatic and renal malformations in ARPKD, JATD, and EvC result from defects in developmental pathways shared by many organ systems. (bmj.com)
We tested if an acute bout of treadmill running increased hepatic mitophagic flux both immediately after and 2 hours post-exercise in 15-24-week-old C57BL/6J female mice. (biomed.news)

CpG DNA highly induced canonical pathways that are unrelated to immune response in Bomac. (biomedcentral.com)
Any substance, generally a protein that stimulates the immune system and elicits an immune response. (nih.gov)
Finkina E.I., Ovchinnikova T.V., Melnikova D.N., Bogdanov I.V. Lipid Transfer Proteins As Components of the Plant Innate Immune System: Structure, Functions, and Applications // ACTA NATURAE. (atoom.ru)

Further, the functional lipid pathways potentially dysregulated in idiopathic and LRRK2 mutation Parkinson's disease are underexplored. (medscape.com)

Finally, these results were confirmed using an in vivo rabbit vein graft model where brief, intraoperative treatment with MK2i-NPs decreased IH and synthetic phenotype markers while preserving contractile proteins. (jci.org)

These sequences represent the protein coding region of the Ube2d3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)

In the liver, the protein expression of cytochrome P450 (Cyp)3a11 showed the greatest reduction to 11.4% after the 5-day treatment and further reduced to 7.01% after the 25-day treatment. (inrae.fr)

2022 Feb;79(2):217-230.e1. (charite.de)

Human obesity reflects an imbalance between energy expenditure and caloric intake resulting from an increase in either the number or the size of fat cells, or both, and is induced by the enlargement of adipocytes as well as the generation of new adipocytes from precursor cells [ 2 ]. (ijbs.com)
The prevalence of obesity and type 2 diabetes has grown dramatically. (mkexpress.net)

Plasma membrane-localized PIN proteins mediate a saturable efflux of auxin. (or.jp)

How these proteins selectively recognize progesterone and signal is unclear. (thealonlab.org)

Amide temperature coefficients in characterizing the allosteric effects of ligand binding on local stability in proteins. (ncbs.res.in)

Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
IFN-γ is a protein encoded by the IFNG gene, composed of two polypeptide chains associated in an antiparallel fashion [ 2 ]. (biomedcentral.com)
Sessions will include emerging technologies in stem cells, proteomics, gene editing, and 3-D organoids in the context of their application to membrane transport proteins. (grc.org)

The chemical structures of quinone (a) and nicotinamide adenine dinucleotide (NAD) (b) are both organic electrons carriers. (microbiologytext.com)

Further, many more non-disease associated proteins have been found to exhibit reduced solubility and lose their native structure during normal aging 4 . (elifesciences.org)
Please allow 2-3 business days abnormalities in jaw structure and associated with the levo form. (econohomes.com)
We establish a pH dependant oligomerisation pathway forming tetrameric DEC-205 using solution-based techniques and ultimately solved the 4.9 Å cryo-EM structure of the DEC-205 tetramer to identify the unfurling of the second lectin ring which enables tetramer formation. (uci.edu)
A common feature of the spatial structure of lipid transfer proteins is a hydrophobic cavity accommodating a ligand-binding site. (atoom.ru)

Protein and lipid homeostasis are important for maintaining cellular functions but their crosstalk remains largely unknown. (elifesciences.org)
Emerging evidence in the past decade or so, however, suggests a more complex relationship among different aggregation-prone proteins, either directly or through interaction with the cellular machinery regulating proteostasis. (elifesciences.org)
Together, the evidence suggests that systemic changes in the state of cellular proteostasis may underlie proteinopathy, and highlights the importance of expanding the scope of studies beyond specific disease-associated protein species. (elifesciences.org)

For instance, experiments in yeast, worms, and mammalian cell culture have demonstrated considerable cross-talk and cross-sensitization between classic aggregation-prone proteins 3 . (elifesciences.org)

Further examination via western blot and proteomics analysis revealed acute exercise elicits a time-dependent, dynamic activation of mitophagy pathways. (biomed.news)

Anatomy13

Organisms19

Diseases1

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Phenomena and Processes48

Disciplines and Occupations1

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Mitochondrial7

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Metabolism8

Lipids9

Transcription1

Fatty4

Degradation3

Plant innate immunity1

Modulate1

Tissues4

Receptor6

Fats2

Physiological5

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Regulates2

Membranes1

Mechanisms3

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20162

Amino acid2

Dysregulation1

Cholesterol1

Molecules2

Sphingolipids1

Incompletely1

Phosphorylation1

SREBP3

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20221

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