Loading...
  • genes
  • This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. (wikipedia.org)
  • regulatory
  • The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. (wikipedia.org)
  • It also may involve the formation or dissociation of protein quaternary structures or oligomeric complexes, and specific binding of ions, ligands, or regulatory lipids. (wikipedia.org)
  • These proteins may be anchored to the bilayer as a result of hydrophobic interactions between the bilayer and exposed nonpolar residues at the surface of a protein, by specific non-covalent binding interactions with regulatory lipids , or through their attachment to covalently bound lipid anchors. (wikipedia.org)
  • Notably, sterols control FPPS expression through two cis regulatory factors (an inverted CAAT box and SRE-3) in the proximal FPPS promoter. (wikipedia.org)
  • Uptake
  • The relation between the uptake of atmospheric CO(2) and insect's production of silk fiber has not yet been reported. (biomedsearch.com)
  • lipids
  • StAR or STARD1) and lipids like phosphatidylcholine (phosphatidylcholine transfer protein, also called PCTP or STARD2) and have enzymatic activities. (wikipedia.org)
  • ligand
  • Ligand binding by the START domain in multidomain proteins can also regulate the activities of the other domains, such as the RhoGAP domain, the homeodomain and the thioesterase domain. (wikipedia.org)
  • ligands
  • Thousands of proteins containing at least one START domain have been determined in invertebrates, bacteria and plants to form a larger superfamily, variously known as START, Bet v1-like or SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) domain proteins, all of which bind hydrophobic ligands. (wikipedia.org)
  • Representatives of the START domain family bind different substances or ligands such as sterols (e.g. (wikipedia.org)
  • enzyme
  • Acetyl-Coenzyme A acyltransferase 2 is an acetyl-CoA C-acyltransferase enzyme. (wikipedia.org)
  • subunits
  • Immunochemical, molecular sieving, and chemical cross-linking experiments indicated that these isoforms represent thiolytically active homo- and heterodimeric combinations of the 46- and 58-kDa subunits (2 x 58, 58-46, and 2 x 46-kDa proteins). (kuleuven.be)
  • The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. (wikipedia.org)
  • Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. (wikipedia.org)
  • Human
  • A synthetic peptide made to the C-terminal region of the human SCP3 protein. (novusbio.com)
  • Other proteins also exist in the human with domains that are members of the START-based superfamily such as PITP, but are not part of the START domain itself. (wikipedia.org)
  • domains
  • Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity. (wikipedia.org)
  • receptors
  • In order to be active, steroid hormones must free themselves from their blood-solubilizing proteins and either bind to extracellular receptors, or passively cross the cell membrane and bind to nuclear receptors. (wikipedia.org)
  • Chromosome
  • CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. (wikipedia.org)
  • bind
  • Some steroid antagonists: Androgen: cyproterone acetate Progestins: mifepristone, gestrinone Steroid hormones are transported through the blood by being bound to carrier proteins-serum proteins that bind them and increase the hormones' solubility in water. (wikipedia.org)
  • family
  • SCP3 (Synaptonemal complex protein 3) is a DNA-binding nuclear protein that belongs to XLR/SYCP3 family and is an essential structural component of the transverse filaments of synaptonemal complexes formed between homologous chromosomes during meiotic prophase. (novusbio.com)