• Cholesteryl esters are generated at multiple sites in the body by sterol O-acyltransferase (SOAT) 1 or SOAT2 in various cell types and lecithin cholesterol acyltransferase in plasma. (elsevierpure.com)
  • Naturally occurring structural analogues of cholesterol were tested as substrates for lecithin:cholesterol acyltransferase and cholesterol oxidase. (houstonmethodist.org)
  • The analogue showed high structural and functional similarity to cholesterol by the following criteria: comparable limiting areas in surface monolayers, precipitability by digitonin, and reactivity as a substrate in the enzymic reaction catalyzed by lecithin:cholesterol acyltransferase. (houstonmethodist.org)
  • In particular, it stimulates cholesterol efflux from peripheral cells toward liver and activates the enzyme lecithin-cholesterol acyltransferase (LCAT). (cnr.it)
  • Lecithin:cholesterol acyltransferase (LCAT) activity and cholesterol esterification rate (CER), two measures of the efficiency of the esterification process, were reduced by 29% and 16%, respectively, in the plasma of AD patients. (biomedcentral.com)
  • Among these factors, lecithin:cholesterol acyltransferase (LCAT), the enzyme responsible of cholesterol esterification in plasma, plays a major role in HDL maturation [ 3 ]. (biomedcentral.com)
  • HDL particles that contain apoproteins A-I and A-II interact with other lipoproteins, particularly VLDL and LDL, through lipolysis and the action of lecithin cholesterol acyltransferase (LCAT) enzyme. (medscape.com)
  • Sterol O-acyltransferase catalyzes the chemical reaction: acyl-CoA + cholesterol ⇌ {\displaystyle \rightleftharpoons } CoA + cholesterol ester Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and cholesteryl ester. (wikipedia.org)
  • This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups, the membrane-bound O-acyltransferases. (wikipedia.org)
  • When sterol O-acyltransferase 2, a cholesterol esterifying enzyme present in enterocytes and hepatocytes, is eliminated in NPC1-deficient mice, there is a reduction in their hepatomegaly, hepatic UC content, and cellular injury. (elsevierpure.com)
  • Acyl-CoA cholesterol acyl transferase EC 2.3.1.26, more simply referred to as ACAT, also known as sterol O-acyltransferase (SOAT), belongs to the class of enzymes known as acyltransferases. (wikipedia.org)
  • Sterol O-acylcoenzyme A: cholesterol acyltransferase 1 (SOAT1): a new predictive. (usp.br)
  • Cholesterol that has been esterified by sterol O-acyltransferases at the ER membrane to cholesteryl esters (CHESTs) are stored in lipid particles present in the cytosol (Daugherty et al. (reactome.org)
  • cholesterol acyltransferase ( EC 2.3.1.26 ) LPL, lipoprotein lipase (EC 3.1.1.34) 631st Meeting Guildford: 631st. (silverchair.com)
  • cholesterol acyltransferase ( EC 2.3.1.26 ) 600th Meeting Oxford: 600th Meeting Held at the University of Oxford on 14, 15 and 16 July 1982 390 BIOCHEMICAL SOCIETY. (silverchair.com)
  • A recent study shows that PSAT is involved in the regulation of the pool of free sterols and the amount of free sterol intermediates in the membranes. (wikipedia.org)
  • Sterols may be found either as free sterols, acylated ( sterol esters ), alkylated ( steryl alkyl ethers ), sulfated ( sterol sulfate ), or linked to a glycoside moiety ( steryl glycosides) which can be itself acylated ( acylated sterol glycosides ). (gerli.com)
  • Inhibition of triacylglycerol (TAG) synthesis via diacylglycerol acyltransferase 2 (DGAT2) antisense oligonucleotides improves liver steatosis (Yamaguchi et al. (webmedcentral.com)
  • of cholesteryl ester formation when sterol is added as a tracer. (silverchair.com)
  • In yeast, acyl-CoA:sterol acyltransferase (ASAT) is functionally equivalent to ACAT. (wikipedia.org)
  • In the neonatal liver, DNA methylation of the Gpam promoter, which is likely to be induced by Dnmt3b, inhibited recruitment of the lipogenic transcription factor sterol regulatory element-binding protein-1c (SREBP-1c), whereas in the adult, decreased DNA methylation resulted in active chromatin conformation, allowing recruitment of SREBP-1c. (nih.gov)
  • 2007). Suppression of the genes, which are involved in lipogenesis (ATP-citrate lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA-desaturase 1 or sterol regulatory element-binding protein 1(SREBP-1)), reduced proliferation and survival of hepatic carcinoma cells (Calvisi et al. (webmedcentral.com)
  • We also found increased expression of genes regulating triglyceride synthesis (sterol regulatory element-binding protein 1c, monoacylglycerol acyltransferases, and diacylglycerol acyltransferases) in db/db mice. (elsevierpure.com)
  • The deduced amino series regarding LsTAT1 revealed the phylogenetic romantic relationship (43% identity) together with that relating to sterol O-acyltransferase (AtSAT1) of Arabidopsis thaliana coupled with catalytic protein elements (Asn and his awesome) which can be typically preserved in membrane-bound O-acyltransferase (MBOAT) household protein. (hormonessignaling.com)
  • Sterol biosynthesis is nearly ubiquitous among eukaryotes, it is almost completely absent in prokaryotes. (gerli.com)
  • Sterols are derived from the same squalene precursor as hopanoids but, in marked contrast, they are known to have an oxygen-dependent biosynthesis beginning with the formation of the first intermediate, 2,3- oxidosqualene. (gerli.com)
  • Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. (unl.edu)
  • Might catalyze fatty acid transfer between phosphatidylcholine and sterols. (unl.edu)
  • Unsaturated steroids with most of the skeleton of cholestane containing a 3 b -hydroxyl group and an aliphatic side chain of 8 or more carbon atoms attached to position 17 form the group of sterols. (gerli.com)
  • The LCAT gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT). (medlineplus.gov)
  • Altered activities of high-density lipoprotein (HDL)-associated antioxidant enzyme paraoxonase 1 (PON1) and lipid transfer proteins, for example, cholesteryl ester transfer protein (CETP) and lecithin cholesterol acyltransferase (LCAT), participating in lipoprotein remodeling seem to play important roles in obesity-related accelerated atherosclerosis. (unboundmedicine.com)
  • 摘要: Objective To investigate the role of acyl-coenzyme A: cholesterol acyltransferase inhibitor (ACATI) in apoptosis induced by lipids and whether lipids-induced apoptosis is accompanied by increase of free cholesterol in endoplasmic reticulum (ER), in order to further understand the mechanism of lipids-induced apoptosis in advanced atherosclerosis. (cams.cn)
  • Therefore, the present studies measured the expression of numerous genes and related metabolic parameters in the intestine and liver of ACAT2-deficient mice fed diets containing either added cholesterol or ezetimibe, a selective sterol absorption inhibitor. (elsevierpure.com)
  • [ 161 ] In a small clinical study in 27 hyperlipidemic patients utilizing infusion of 13 C 2 -cholesterol after 6 weeks of treatment, ezetimibe significantly increased fecal neutral sterol excretion of plasma-derived cholesterol into fecal neutral sterols by 113% compared with placebo, but had no effect on fecal bile acids. (medscape.com)
  • 0.001) and also significantly increased fecal sterol excretion by 109 and 79%, respectively, while simvastatin had no effect on absorption rates. (medscape.com)
  • The effect of deleting these genes, particularly acyl CoA:cholesterol acyl transferase 2 (ACAT2), on cholesterol absorption and fecal sterol excretion is well documented. (elsevierpure.com)
  • [ 158 ] Recent studies in mice have shown that blocking NPC1L1 with ezetimibe and/or downregulation with a PPAR-δ agonist promotes fecal excretion of macrophage- and HDL-derived cholesterol by two- to six-fold while having no effect on fecal bile acids, possibly as a consequence of reduced cholesterol absorption in the small intestine and increased fecal free sterol excretion. (medscape.com)
  • These agents inhibit sterol transporter at brush border and, consequently, intestinal absorption of cholesterol. (medscape.com)
  • Livers of glutathione-deficient rats had lower mRNA abundance of sterol regulatory element-binding protein (SREBP)-1c (-47%), Spot (S)14 (-29%) and diacylglycerol acyltransferase 2 (DGAT-2, -27%) and a lower enzyme activity of fatty acid synthase (FAS, -26%) than livers of the control rats. (biomedcentral.com)
  • Sterol regulatory element-binding protein (SREBP)-1c is a key transcription factor in controlling the mRNA expression of genes which determine lipogenesis [ 4 ]. (biomedcentral.com)
  • The protein encoded by this gene belongs to the acyltransferase family. (nih.gov)
  • Targeted deletion of acyl-CoA:cholesterol acyltransferase 2 (ACAT2) (A2), especially in the liver, protects hyperlipidemic mice from diet-induced hypercholesterolemia and atherosclerosis, whereas the deletion of ACAT1 (A1) is not as effective, suggesting ACAT2 may be the more appropriate target for treatment of atherosclerosis. (elsevierpure.com)
  • Omega 3 acid agents inhibit acyl CoA:1,2-diacylglycerol acyltransferase. (medscape.com)
  • Sterols are derived from the same squalene precursor as hopanoids but, in marked contrast, they are known to have an oxygen-dependent biosynthesis beginning with the formation of the first intermediate, 2,3- oxidosqualene. (gerli.com)
  • The involved functions are known as enzyme activity and acyltransferase activity. (cmdm.tw)
  • Esta enzima se ha localizado en las glándulas suprarrenales, las gónadas, el hígado, la mucosa intestinal y la aorta de muchas especies de mamíferos. (bvsalud.org)
  • Experiments made then, and later, revealed no local biochemical defects that explained this sterol accumulation. (nih.gov)
  • In addition to its acyltransferase activity, it may act as a ligase. (nih.gov)
  • A recent study shows that PSAT is involved in the regulation of the pool of free sterols and the amount of free sterol intermediates in the membranes. (wikipedia.org)
  • Sterols may be found either as free sterols, acylated ( sterol esters ), alkylated ( steryl alkyl ethers ), sulfated ( sterol sulfate ), or linked to a glycoside moiety ( steryl glycosides) which can be itself acylated ( acylated sterol glycosides ). (gerli.com)
  • From a health point of view, plant sterols (phytosterols and phytostanols) have a very important role for cardiovascular health since, usually consumed, they have a hypocholesterolemic effect . (botanical-online.com)
  • Cholesterol is a sterol of animal origin , which, in addition to other functions, is part of the membrane of all body cells. (botanical-online.com)