• StAR related lipid transfer domain containing 3 (STARD3) is a protein that in humans is encoded by the STARD3 gene. (wikipedia.org)
  • The closest homolog to STARD3 is the steroidogenic acute regulatory protein (StAR/StarD1), which initiates the production of steroids by moving cholesterol inside the mitochondrion. (wikipedia.org)
  • STARD3 is a multi-domain protein composed of a N-terminal MENTAL (MLN64 N-terminal) domain, a central phospho-FFAT motif (two phenylalanines in an acidic tract), and a C-terminal StAR-related transfer domain (START) lipid transport domain. (wikipedia.org)
  • PCTP-like protein (STARD10) is a member of the steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins that are implicated in lipid transport, metabolism, and signaling. (reactome.org)
  • STARD10 is thought to function as a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes. (reactome.org)
  • Its lipid transfer activity is negatively regulated by casein kinase, a serine/threonine-protein kinase which phosphorylates STARD10 on a serine residue at position 284 (Olayioye et al. (reactome.org)
  • In addition to the MENTAL domain, MLN64 contains a cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]. (silverchair.com)
  • This process depends on the endo-lysosomal sterol transfer protein Niemann Pick C2 (NPC2). (nature.com)
  • Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
  • The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
  • Regional differences between BDNF mRNA levels and protein concentrations in the CNS are often reported ( 7 , 51 , 192 , 193 ), which may be related to regulatory mechanisms, mRNA decay ( 164 ), or BDNF anterograde transport ( 7 ). (hyperthermicwellness.com)
  • Genomic and sequence variants of protein kinase A regulatory subunit type 1beta (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome. (ukw.de)
  • This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. (wikipedia.org)
  • 210 residues that binds lipids, including sterols, and is present in 15 distinct proteins in mammals. (silverchair.com)
  • Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). (thermofisher.com)
  • The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
  • Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute Workshop. (skanestugan.se)
  • Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. (thermofisher.com)
  • This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. (thermofisher.com)
  • The availability of cholesterol constitutes the rate-limiting step of steroidogenesis and is regulated by STARD1 which transfers cholesterol from the outer to the inner mitochondrial membrane 5 . (nature.com)
  • Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. (hyperthermicwellness.com)
  • Designs with exposed NH groups can be made membrane permeable through the design of an alternative isoenergetic fully hydrogen-bonded state favored in the lipid membrane. (bvsalud.org)
  • StAR promotes the transfer of cholesterol to the inner mitochondrial membrane and initiates steroidogenesis. (illnesshacker.com)
  • In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
  • Moreover, our recent transcriptomic analysis reveals a decline in mRNA levels of Cyp17a1 , encoding a steroidogenic enzyme, in 4- to 30-day cultures of 6 d pp mouse testes ( 10 ). (elifesciences.org)
  • Once advanced atherosclerotic plaques are established, the process by which they undergo a reduction in one or more standard parameters (size, lipid content, foam cell content, and macrophage inflammation) is termed atherosclerosis regression. (skanestugan.se)
  • Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
  • 1][2][3] The protective functions of HDL are due to its role in reverse cholesterol transport (RCT) but also may be related to antioxidant and anti-inflammatory activities. (skanestugan.se)
  • Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
  • These lipid disorders may occur in primary (inherited) [ 5 - 7 ] or secondary form [ 8 ]. (hindawi.com)
  • Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)
  • This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)
  • Mature BDNF is considered the biologically active form, which has a high affinity for the tropomyosin-related kinase B (TrkB) receptor ( 130 ). (hyperthermicwellness.com)
  • In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
  • We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity. (hyperthermicwellness.com)
  • Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
  • Potassium is generally not needed in acute situations, especially in patients with primary adrenal insufficiency, who are often hyperkalemic. (medscape.com)
  • Decision guide for identifying substance-specific data needs related to toxicological profiles. (cdc.gov)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • Mares were killed 7.5-8.5 days after transfer and the uterus and oviducts flushed for embryo recovery. (bioone.org)
  • These data are discussed in terms of three exposure periods: acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). (cdc.gov)
  • In vivo development was assessed after transfer of injected oocytes to the oviducts of recipient mares. (bioone.org)
  • Antibodies to one or more steroidogenic enzymes, particularly 21-hydroxylase , are often found in patients with autoimmune adrenal disease. (medscape.com)
  • 10. Luteal and placental characteristics of carnivore gestation: expression of genes for luteotrophic receptors and steroidogenic enzymes. (nih.gov)
  • These low-molecular mass, disulfide-rich and Ca 2+ -dependent enzymes are secreted from a variety of cells and act in autocrine or paracrine manners on cell membranes and other extracellular phospholipids, including lipoprotein particles, surfactant and dietary lipids, microbial membranes and microvesicles[ 12 ]. (biomedcentral.com)
  • However, much uncertainty remains concerning precisely how glyphosate kills plants or affects cellular redox homeostasis and related processes in glyphosate-sensitive and glyphosate-resistant crop plants. (ban-glyphosate.com)
  • The relationship between the synthesis, storage and use of lipids and their importance in cancer is poorly understood. (biomedcentral.com)
  • At the core of this metabolic reprogramming is a shift towards macromolecular biosynthesis, based largely on the use of mitochondrial metabolites as anabolic precursors, and supported by changes in lipid synthesis, degradation and signaling[ 2 - 4 ]. (biomedcentral.com)
  • These results suggest that MC delivery via microvesicles can mediate gene transfer to an extent that enables effective prodrug conversion and tumor cell death such that it comprises a promising approach to cancer therapy. (regenerativemedicine.net)
  • A total of 1,410 sequences were confirmed to be related to reproduction and key genes involved in sex differentiation and maturation were identified for the first time in turbot ( AR , AMH , SRY -related genes, CYP19A , ZPG s, STAR FSHR, etc. (biomedcentral.com)
  • StAR mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, where cholesterol is then converted by cytochrome P450 scc to pregnenolone, the precursor for all steroids. (jneurosci.org)
  • To best our understanding of the regulatory mechanism, this review discusses the recent evidence involving the potential molecular pathways of the inter-organ communications, and the interactions between signalings and irisin in regulating the impact of exercise on organ functions are also discussed. (bvsalud.org)
  • In order to complete the strategies for raising testosterone, the regulatory pathways need to be addressed for optimal long term results. (lifekick.us)
  • Cellular senescence independently contributes to aging and age-related diseases, such as Alzheimer's disease and renal fibrosis [ 9 , 10 , 12 , 13 ]. (thno.org)
  • 2003 . The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health? (nih.gov)
  • Here we demonstrate that hGX sPLA 2 induces lipid droplet (LD) formation in invasive breast cancer cells, stimulates their proliferation and prevents their death on serum deprivation. (biomedcentral.com)
  • An acute complication of hyperthyroidism characterized by fever, tachycardia, nausea, agitation and/or coma that may result in death. (nih.gov)
  • Expressed sequence tags were generated by Sanger sequencing of cDNA libraries from different immune-related tissues after several parasitic challenges. (biomedcentral.com)
  • HN - 2008 MH - Acute Radiation Syndrome UI - D054508 MN - C21.866.733.188 MN - G3.850.810.300.360.158 MS - A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. (nih.gov)
  • These data are discussed in terms of three exposure periods: acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). (cdc.gov)
  • Another important risk factor, in particular with regards to occupational settings, is the chronic exposure to polycyclic aromatic hydrocarbons (PAH) which are formed during incomplete combustion of organic material and thus can be found in coal tar, creosote, bitumen and related working materials. (frontiersin.org)
  • This trend might be exacerbated by environmental, occupational and life style-related exposure to carcinogenic chemicals, especially combustion-derived PAHs, alone or in combination with UV exposure ( 3 ). (frontiersin.org)
  • Potassium is generally not needed in acute situations, especially in patients with primary adrenal insufficiency, who are often hyperkalemic. (medscape.com)
  • Related compounds cyclize to MACROLIDES. (nih.gov)
  • The alterations while in the expression of these two genes and other individuals neurogenesis genes raises the likelihood that SNCA overexpression could influence the recruitment of newly born cells into the striatum as well as other brain regions and could impair adult neurogenesis, a deficit documented in related lines of mice overex pressing SNCA. (chk2inhibitor.com)
  • Decision guide for identifying substance-specific data needs related to toxicological profiles. (cdc.gov)
  • The objective of this study was to generate a comprehensive transcriptomic database in turbot, a highly priced farmed fish species in Europe, with potential expansion to other areas of the world, for which there are unsolved production bottlenecks, to understand better reproductive- and immune-related functions. (biomedcentral.com)
  • A related decreased Bdnf expression was reported in PD striatum. (chk2inhibitor.com)
  • Notably, the kidney-associated co-expression links were inferred from samples of cancer-related GEO series. (coexpedia.org)
  • A resource for kids, parents, and teachers to find fun and educational materials related to health, science, and the environment we live in today. (nih.gov)
  • Strong evidence indicates that these two reserves are functionally related. (bioone.org)