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  • Monooxygenase
  • The report provides comprehensive information on the Steroid 17 Alpha Hydroxylase/17,20 Lyase 17 Alpha Hydroxyprogesterone Aldolase or Cytochrome P450 17A1 or Cytochrome P450 C17 or Steroid 17 Alpha Monooxygenase or CYP17 or CYP17A1 or EC 1.14.14.19 or EC 4.1.2.30, targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action MoA, route of administration RoA and molecule type. (bioportfolio.com)
  • Additionally, the report provides an overview of key players involved in Steroid 17 Alpha Hydroxylase/17,20 Lyase 17 Alpha Hydroxyprogesterone Aldolase or Cytochrome P450 17A1 or Cytochrome P450 C17 or Steroid 17 Alpha Monooxygenase or CYP17 or CYP17A1 or EC 1.14.14.19 or EC 4.1.2.30 targeted therapeutics development and features dormant and discontinued projects. (bioportfolio.com)
  • hydroxylation
  • Expression of the recombinant protein demonstrated 7alpha-hydroxylation activity for steroids (DHEA, pregnenolone) and oxysterols including 25- and 27-hydroxycholesterol, confirmed by knockout in mouse that abolished oxysterol hydroxylation in liver and brain and steroid hydroxylation in multiple tissues. (wikipedia.org)
  • genetic
  • Her current primary research emphasis is on genetic steroid disorders. (wikipedia.org)
  • She has published more than 640 academic articles in a wide range of prestigious journals and published a genetics book entitled Genetic Steroid Disorders in 2014. (wikipedia.org)
  • Pediatrics
  • In 2004, Dr. New was recruited to the Mount Sinai School of Medicine as Professor of Pediatrics and Human Genetics and Director of the Adrenal Steroid Disorders Program. (wikipedia.org)
  • Disorders
  • Although steroid physiology was well understood when Dr. New began her scientific career, little of the knowledge had been applied to the understanding of steroid disorders in children. (wikipedia.org)
  • specific
  • She was a research pediatrician to the Diabetic Study Group of the Comprehensive Care Teaching Program at the New York Hospital-Cornell Medical Center from 1958 to 1961, and had a second NIH fellowship under Ralph E. Peterson from 1961 to 1964, to study specific steroid hormone production during infancy, childhood and adolescence. (wikipedia.org)
  • androgens
  • Since 21-hydroxylase activity is not involved in synthesis of androgens, a substantial fraction of the large amounts of 17α-hydroxypregnenolone is diverted to synthesis of DHEA, androstenedione, and testosterone beginning in the third month of fetal life in both sexes. (wikipedia.org)
  • naturally
  • Estetrol, also known as 15α-hydroxyestriol or as estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol, is a naturally occurring estrane steroid and derivative of estrin (estratriene). (wikipedia.org)