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  • constitutive
  • The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis. (nih.gov)
  • cytochrome
  • Other nuclear receptors, such as CAR and PXR appear to function as xenobiotic sensors up-regulating the expression of cytochrome P450 enzymes that metabolize these xenobiotics. (wikipedia.org)
  • antagonists
  • Interestingly, antagonists for this receptor are not closely related in structure. (aspetjournals.org)
  • Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor. (wikipedia.org)
  • alcohol dehydrogenase
  • Alcohol induced GR nuclear translocation, which was enhanced by the alcohol dehydrogenase inhibitor fomepizole, suggesting that it was alcohol, not its metabolites, that engendered the effect. (frontiersin.org)
  • genes
  • These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. (embl.de)
  • Many of these regulated genes are associated with various diseases, which explains why the molecular targets of approximately 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors. (wikipedia.org)
  • pathway
  • Alternatively, PP2A might be activated through another pathway including the epidermal growth factor receptor (EGFR) and the receptor for activated C kinase 1 (RACK1). (wikipedia.org)
  • specificity
  • The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension, where residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. (embl.de)