• The last part of this chapter outlines the development of diastereoselective variant for the construction of contiguous stereogenic centers, which represent the first example of this type of process. (queensu.ca)
  • Palladium-catalyzed asymmetric allylic alkylation (AAA) has proven to be an exceptionally powerful method for the efficient construction of stereogenic centers. (sigmaaldrich.com)
  • One of the interests of our laboratory is the synthesis of tertiary and quaternary stereogenic centers using diastereoselective radical transfers on acyclic substrates. (umontreal.ca)
  • Chapter III focuses on a stereodivergent synthesis of fluorinated lactams bearing two vicinal stereogenic centers by multicomponent reaction. (miun.se)
  • It has two contiguous stereogenic centers with S,S configurations, one of which being a quaternary center, which has been developed as a clinical candidate for the treatment of inflammatory and autoimmune conditions. (researchgate.net)
  • Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation steps. (uni-saarland.de)
  • and stereogenic centers, with high structural diversity. (bvsalud.org)
  • Asymmetric organocatalysis, cooperative dual catalysis and one-pot multicomponent reaction strategies were applied for the construction of continuous and quaternary stereogenic center. (miun.se)
  • The approach features a new Lewis acid mediated [2,3]-Stevens rearrangement of N-allylated prolineamide to generate a key quaternary stereogenic center. (jyu.fi)
  • In this section the treatment of chiral and achiral stereogenic elements will be extended to axes and planes. (msu.edu)
  • The majority of chiral phosphines currently used as ligands in asymmetric metal-catalysed transformations are axial-chiral, planar-chiral or C-stereogenic phosphines. (nature.com)
  • Without giving up too much information, we plan to target a largely unexplored class of C1-Symmetric, P-Stereogenic ligands, rationally designed multidentate ligands for dinitrogen reduction, and phosphaalkene-based ligands as redox active / non-innocent platforms for interesting chemical transformations. (hawaii.edu)
  • The group of Professor Wei-Liang Duan at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (P. R. of China) now present their research regarding the enantioselective C-H arylation strategy for the synthesis of useful P-stereogenic compounds. (thieme.de)
  • Few organofluorine compounds exist naturally ( C&EN, May 22, page 12 ), meaning that almost all must be made. (acs.org)
  • Drawing on the fact that such amino-substituted stereogenic centres may themselves control the conformation of amides, with amido-substituted benzaldimines we found it becomes possible to relay stereochemistry from one amide to another via this intervening stereogenic centre. (bris.ac.uk)
  • Darunavir contains 5 stereogenic carbon centres. (who.int)
  • Dans la littérature, il n'y a aucun précédent pour la création de centres stéréogéniques en utilisant une approche radicale faisant usage des NHC-boranes. (umontreal.ca)
  • Indicate the stereochemistry at the stereogenic center. (zuoti.pro)
  • Indicate the stereochemistry via wedge/dash bonds, including explicit H and D atoms, at the stereogenic center. (zuoti.pro)
  • Indicate the stereochemistry, including H's, at each stereogenic center. (zuoti.pro)
  • Addition of laterally lithiated tertiary aromatic amides to benzaldimines controls the formation of a new stereogenic centre adjacent to the benzaldimine aromatic ring. (bris.ac.uk)
  • This normally involves converting one of the carbons of the double bond to a stereogenic centre. (britannica.com)
  • A group of dihydrostilbene-2,2′-dicarboxamide derivatives bearing one or two stereogenic axes are made by this method, which demonstrates the use of combined kinetic and thermodynamic control for the relay of stereochemical information. (bris.ac.uk)
  • Une étude SAR a permis la synthèse d'une librairie de plus de 60 ANs en incorporant différentes bases azotées, des phosphoramidates en position C3' et/ou C5', mais également des lipoates sur l'amine de la base azotée. (umontreal.ca)
  • An enantioseparation method was developed for P-stereogenic thiophosphonates using (S)-1-phenylethylamine as the resolving agent. (researchgate.net)
  • By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. (acs.org)
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  • Transformation of triple helicene (TH) to double helicene (DH) with adjacent stereogenic carbon atoms and axial stereogenicity was achieved by the unexpected conjugate addition to the central aromatic ring of TH- 1 . (rsc.org)
  • Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms. (nih.gov)
  • Dr. Cotman conducted his research in the field of homogeneous catalysis for the preparation of enantiomerically pure secondary alcohols using several consecutive stereogenic carbon atoms. (ki.si)
  • Over the past decade or so, there has been a tremendous surge in the development of processes, both catalytic and non-catalytic, that result in the enantioselective construction of compounds bearing boronic ester functional groups attached to stereogenic carbon atoms. (thieme.de)
  • or atoms which are not stereogenic center. (chemaxon.com)
  • Darunavir contains 5 stereogenic carbon centres. (who.int)
  • Synthesis of P-Stereogenic Cyclic Phosphines Containing Conjugated Linkers (Grad. (csj.jp)
  • List, B. Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silyl Ethers. (mpg.de)
  • Rendler, S., Auer, G. & Oestreich, M. Kinetic resolution of chiral secondary alcohols by dehydrogenative coupling with recyclable silicon-stereogenic silanes. (nature.com)
  • The stereoselective conversion of epimerized alkoxyl phosphine-borane to P,C, axial -stereogenic tertiary phosphine via cleavage of P-O bond. (bvsalud.org)
  • 18. Syntheses, stereogenic properties, structural and electrochemical investigations, biological activities, and DNA interactions of new spirocyclic mono- and bisferrocenylphosphazene derivatives. (nih.gov)
  • The smallest subclass (only 12 alkaloids), also showing a high degree of structural originality, are naphthylisoquinolines with an unprecedented stereogenic N -iminium aryl axis like e.g., ancistrocladinium A. (uni-wuerzburg.de)
  • A fluorine-containing tetrasubstituted stereogenic center is a highly valued structural feature in medicinal chemistry. (elsevierpure.com)
  • List, B. Organocatalytic DYKAT of Si-Stereogenic Silanes. (mpg.de)