• In other words, D and L configurations do not fully designate absolute stereochemistry, rather they are determined on the basis of the anomeric carbon center and how its orientation compares to glyceraldehyde, the most basic and simple chiral sugar molecule. (wikibooks.org)
  • Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents. (nih.gov)
  • Thus, the effect of absolute stereochemistry of the amino alcohol antimalarial agents on antimalarial activity appears to depend upon both the flexibility of the amine portion of the molecule and the structure of the aromatic portion of the molecule. (nih.gov)
  • The study of stereochemistry focuses on stereoisomers, which by definition have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space. (wikipedia.org)
  • stereochemistry Study of the chemical and physical properties of compounds as affected by the ways in which the atoms of their molecules are arranged in space. (encyclopedia.com)
  • Oliver Trapp (Professor of Organic Chemistry at LMU since September 2016) and Golo Storch (a member of his previous research group at Heidelberg University, and currently at Yale University) now report the development of a catalyst that dynamically adapts to the stereochemistry of the compounds with which it interacts, and can progressively select for the desired enantiomer. (nanowerk.com)
  • Determining the stereochemistry of such compounds is no small task, and natural product chemists are some of the few people still routinely performing (a form of) functional group tests. (wordpress.com)
  • Central to stereochemistry is the concept of isomerism. (encyclopedia.com)
  • Stereochemistry also deals with optical isomerism, in which the configuration of one molecule is the mirror image of another. (encyclopedia.com)
  • The basis of stereochemistry was provided by L. Pasteur in his study of the isomerism of tartaric acids in 1848 and by J. van't Hoff and J. le Bel, who simultaneously in 1874 and working independently, proposed the fundamental stereochemical concept that the four valence bonds of a saturated carbon atom are directed to the corners of a tetrahedron. (thefreedictionary.com)
  • Stereochemistry also involves the study of spatial isomerism (stereoisomerism). (thefreedictionary.com)
  • The Stereochemistry and Reactivity of Metal-Schiff Base Complexes. (go.jp)
  • The synthesis and stereochemistry of monomeric ruthenium(II) complexes containing the unsymmetrical bidentate ligand pmbipy [4-(2,2-dimethylpropyl)-4'-methyl-2,2'-bipyridine] have been studied. (edu.au)
  • Taken together, these results provide a predictive model for vicinal diol stereochemistry in enediyne biosynthesis and set the stage for further elucidating the origins of EH regioselectivity. (ucsd.edu)
  • The determination of stable conformations has also played a large role in the establishment of the concept of asymmetric induction and the ability to predict the stereochemistry of reactions controlled by steric effects. (wikipedia.org)
  • Fischer was able to manipulate a series of reactions to assign stereochemistry among sugars. (wikibooks.org)
  • The mixed function oxidase (MFO) catalyzed C19 hydroxylations of ent-kaur-16-ene (1) and of ent-kaur-16-en-19-ol (2) precede a complex cascade of enzyme catalyzed reactions leading to the plant growth regulator gibberellic acid. (illinois.edu)
  • stereochemistry, study of the three-dimensional configuration of the atoms that make up a molecule and the ways in which this arrangement affects the physical and chemical properties of the molecule. (encyclopedia.com)
  • Replacing hydrogen by fluorine in polytetrafluoroethylene changes the stereochemistry from the zigzag geometry to that of a helix due to electrostatic repulsion of the fluorine atoms in the 1,3 positions. (wikipedia.org)
  • The linear model can account for no stereochemistry of a polypeptide beyond the sequential arrangement of amino acids. (codefun.com)
  • The synthetic accessibility of chiral beta-amino acids and the recent observation of novel helical folds in oligomers of cyclic beta-amino acids has led to renewed interest in the stereochemistry of omega-amino acid containing peptides. (iisc.ac.in)
  • A novel double labelling experiment involving (15S,17 E)-[15-3H1,17-2HCPP gave [16-3H1,16-2Habietadiene where the stereochemistry of the methyl was established as R by degradation and enzymatic analysis of the generated chiral methyl acetic acid. (illinois.edu)
  • In particular, it assesses approaches to the pre-determination of the stereochemistry of poly-nuclear assemblies incorporating Ru(II) and related centers {e.g. (edu.au)
  • Although the most common coordination number is 4, the coordination stereochemistry is closer to the expected geometry when the coordination number is 5, suggesting that this is the coordination number towards which the chlorides tend when they interact with proteins. (biomedcentral.com)
  • abstract = "To elucidate the stereochemistry of microbial hydrogenation of (+)- and (-)-2'-de-methoxydehydrogriseofulvin (1 and 2) by Streptomyces cinereocrocatus NRRL 3443, deu-terated substrates (la, lb, 2a, and 2b) were synthesized from (+)-griseofulvin (9) and subjected to microbial transformation. (elsevier.com)
  • By the Cahn-Ingold-Prelog rules for naming stereochemistry, the hydroxy group will always be priority 1, the carbon of the primary alcohol (the terminal carbon) will always be priority 3, the rest of the carbon chain will be priority 2, leaving hydrogen as priority 4 (as shown below). (wikibooks.org)
  • Chirality/Stereochemistry Video Series: Video 5 R and S configurations are found by ranking substituents on a chiral carbon. (leah4sci.com)
  • The C19 isotopic configurations were assigned through chemical and NMR spectral correlations with synthetic decalin analogs of 2, for which the stereochemistry was established by a novel method involving stereospecific proton-phosphorus NMR coupling in a phosphorinane derivative. (illinois.edu)
  • Chirality/Stereochemistry Video Series: Video 4 R and S configurations are pretty straight-forward when priority group #4 is conveniently in the back of the molecule. (leah4sci.com)
  • At the time when this experiment was conducted, all they had was optical rotation to determine stereochemistry. (wikibooks.org)
  • Anet , F. A. L.: Structure, Stereochemistry and Interrelation of some Lycopodium Alkaloids. (springer.com)
  • In this experiment teams of students are given optically-pure amines of known structure but unknown stereochemistry. (ed.gov)
  • Structure-activity and stereochemistry-activity relationships are studied in relation with antiproliferative, neuroprotective and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. (tsijournals.com)
  • Natural derivatives of aplysinopsin differ in the bromination pattern of the indole moiety ( Figure 1 ), variation in the structure of the C ring, including its oxidation state ( Figure 3 ) and number and position of N -methylation ( Figure 1 ), the presence and absence of the C-8-C-1′ double bond ( Figure 2 ), and the stereochemistry. (mdpi.com)