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Coronary VesselsCoronary RestenosisStentsCoronary AngiographyCoronary Artery DiseaseCoronary StenosisAngioplasty, Balloon, CoronaryCoronary CirculationUltrasonography, InterventionalCoronary DiseaseCoronary Artery BypassAtherectomy, CoronaryCoronary ThrombosisTreatment OutcomeDrug-Eluting StentsMyocardial InfarctionSirolimusCoronary VasospasmPercutaneous Coronary InterventionFollow-Up StudiesFractional Flow Reserve, MyocardialProspective StudiesProsthesis DesignTime FactorsCoronary OcclusionCardiovascular AgentsCoronary AneurysmRisk FactorsPredictive Value of TestsSeverity of Illness IndexAngina, UnstableCalcinosisTunica IntimaAngioplasty, Balloon, Laser-AssistedBioprosthesisRetrospective StudiesPlaque, AtheroscleroticTomography, X-Ray ComputedRecurrenceCardiac CathetersCardiac CatheterizationPaclitaxelMyocardial RevascularizationPlatelet Aggregation InhibitorsConstriction, PathologicHyperplasiaAngina PectorisChi-Square DistributionNeointimaMyocardial IschemiaBlood Flow VelocitySensitivity and SpecificityCoated Materials, BiocompatibleEquipment DesignSwineRisk AssessmentMetalsElectrocardiographyHemodynamicsThrombosisVascular CalcificationFeasibility StudiesVascular PatencyCoronary Care UnitsTiclopidineMucocutaneous Lymph Node SyndromeCatheterizationAspirinVasodilator AgentsAngioplasty, BalloonHyperemiaDrug ImplantsGraft Occlusion, VascularExercise TestMultidetector Computed TomographyHeart Valve ProsthesisIliac ArteryReproducibility of ResultsSingle-Blind MethodBiological MarkersIliac VeinArteriosclerosisMyocardial Perfusion ImagingDogsBlood Vessel ProsthesisTomography, Spiral ComputedEchocardiographyPrognosisAtherectomyAnticholesteremic AgentsRegistriesTomography, Emission-Computed, Single-PhotonKaplan-Meier EstimateAbsorbable ImplantsCoronary Artery Bypass, Off-PumpLogistic ModelsEquipment SafetyTomography, Optical CoherenceAlloysVascular Resistance
Drug-elutiThrombosisRestenosisArteriesBifurcationImplantationMetal stentsLeft main cVascularTarget lesionStenosisBare-metalPatientsDescending coronary arteryOcclusionCatheterAngioplastyBalloonOstialDiseaseIntravascularClinicalVesselAcute coronaryComplex LesionsInterventionsRight coronaXiencePercutaneous coronaryAtherectomyComplicationsEndothelialized stents is not well characterizedCircumflexPlacementIncidenceEverolimus-Eluting StentVersusDistalHeavily calcifiedInterventionalCardiovascularOutcomesNeointimalBioresorbable stentsSaphenous vein gScaffoldUnderwentLumenAngiography and InterventionCardiac
Drug-eluti6
  • During percutaneous coronary intervention, a drug-eluting stent was implanted into the anterior descending artery using the Szabo technique, supported by stent boost (StentBoost) imaging to pinpoint the location of the lesion. (biomedcentral.com)
  • Stent thrombosis is a low-frequency event that current drug-eluting stent (DES) clinical trials are not adequately powered to fully characterize. (bostonscientific.com)
  • Biosensors , a company based in Singapore, received European clearance for its BioMatrix NeoFlex drug eluting stent. (medgadget.com)
  • The use of a drug-eluting stent (DES) outside of the labeled indications, including use in patients with more tortuous anatomy, may have an increased risk of adverse events, including stent thrombosis, stent embolization, myocardial infarction (MI), or death. (medtronic.com)
  • Longest drug-eluting stent approved for the management of patients with clinically challenging coronary artery disease NATICK, Mass., and BARCELONA, Spain, May 24 /- Boston Scientific Corporation (NYSE:BSX) today announced that it has received CE Mark for its TAXUS® Liberte(TM) Long paclitaxel-eluting coronary stent system, allowing doctors to treat longer coronary artery lesions with a single. (thomasnet.com)
  • Boston Scientific only company to offer two distinct drug-eluting stent platforms NATICK, Mass., Jan. 11 // -- Boston Scientific Corporation (NYSE:BSX) today announced the international launch and first implantation of the PROMUS(TM) Everolimus-Eluting Stent, making Boston Scientific the only company to offer two distinct drug-eluting stent (DES) platforms. (thomasnet.com)
Thrombosis23
  • Incomplete stent expansion and poor adherence are important risk factors of restenosis or thrombosis. (biomedcentral.com)
  • Moreover, heavily calcified lesions impede stent delivery and expansion - and stent underexpansion is the leading predictor of restenosis and stent thrombosis, he observed at the meeting, sponsored by the Cardiovascular Research Foundation. (medscape.com)
  • There were two cardiac deaths and three cases of stent thrombosis, all of which were associated with known predictors of the complication. (medscape.com)
  • Delayed arterial healing, characterized by poor endothelialization, is the primary cause of late (1 month-1 year postimplantation) and very late stent thrombosis following implantation of drug-eluting stents. (nature.com)
  • The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
  • Mortality, major adverse cardiovascular events (MACEs), target vessel failure, and stent thrombosis (ST) occur more frequently as the result of calcium-mediated poor lesion preparation, stent under expansion, and stent malapposition ( 2 ). (frontiersin.org)
  • The use of this product carries the risks associated with coronary artery stenting, including stent thrombosis, vascular complications, and/or bleeding events. (bostonscientific.com)
  • Stent thrombosis is frequently associated with myocardial infarction (MI) or death. (bostonscientific.com)
  • In the clinical trials analyzed to date, differences in the incidence of stent thrombosis have not been associated with an increased risk of cardiac death, MI, or all-cause mortality. (bostonscientific.com)
  • Additional data from longer-term follow-up of the PLATINUM clinical trials and analyses of stent thrombosis related to DES are expected and should be considered in making treatment decisions as data become available. (bostonscientific.com)
  • Compared to use within the specified Indications for Use, the use of DES in patients and lesions outside of the labeled indications may have an increased risk of adverse events, including stent thrombosis, stent embolization, MI or death. (bostonscientific.com)
  • 8 - 10 Because this finding may be associated with adverse clinical events such as late stent thrombosis 10 , 11 in the coronary circulation, we sought to identify the presence of any ISA within the intracranial circulation in patients undergoing stent-mediated coiling by using the self-expanding intracranial EN (Cordis, Miami Lakes, Florida). (ajnr.org)
  • Bifurcation stenting is complex and associated with a high risk of stent thrombosis and restenosis. (medtronic.com)
  • And of the nine stents that fractured most severely, 67 percent showed signs of thrombosis (blood clots), restenosis (scar tissue) or other adverse conditions. (massdevice.com)
  • The use of this product carries the same risks associated with coronary artery stent implantation procedures, which include subacute and late vessel thrombosis, vascular complications, and bleeding events. (medtronic.com)
  • Stent thrombosis is a low-frequency event that is frequently associated with MI or death. (medtronic.com)
  • The concern of stent thrombosis still an issue and dual antiplatlets therapy (DAPT) is mandatory for variable time ranging from one month to one year. (scirp.org)
  • Various anticoagulation and antiplatelet regimens are used during and after PCI to reduce the incidence of thrombosis at the site of balloon dilation and stent placement. (msdmanuals.com)
  • The rate of stent thrombosis at 12 months was 1.5% in both stent arms. (medscape.com)
  • Despite their potential benefit, Kristensen homed in on the rate of stent thrombosis in ABSORB Japan. (medscape.com)
  • In studies with the Xience stent, the rate of stent thrombosis in an all-comer population has been reported to be as low as 0.2%, a number that is tough to beat. (medscape.com)
  • Other registries have reported a fairly high incidence of stent thrombosis in patients with bioresorbable stents," writes Kristensen. (medscape.com)
  • The occurrence and clustering of stent thrombosis in the subacute phase suggests that the risk is associated with factors related to the scaffold, the lesion, implantation technique, or a combination of these factors (calcium, adequate predilatation, expansion, apposition etc). (medscape.com)
Restenosis21
  • The lesion is not easy to expand, as it is rich in elastic fiber tissue and easily retracts, and the rate of restenosis and calcification is high. (biomedcentral.com)
  • these clots and cell proliferation may sometimes cause standard ("bare-metal") stents to become blocked (restenosis). (wikipedia.org)
  • Drug-eluting stents were developed with the intent of dealing with this problem: by releasing an antiproliferative drug (drugs typically used against cancer or as immunosuppressants), they can help reduce the incidence of "in-stent restenosis" (re-narrowing). (wikipedia.org)
  • One of the drawbacks of vascular stents is the potential for restenosis via the development of a thick smooth muscle tissue inside the lumen, the so-called neointima. (wikipedia.org)
  • In 23 lesions, IVL was used for the treatment of in-stent restenosis (ISR). (frontiersin.org)
  • When used in relatively simple lesions, randomized studies have demonstrated efficacy of drug-eluting stents in significantly reducing restenosis compared with bare metal stents. (eur.nl)
  • However, lesions such as chronic total occlusions and bifurcations which are at increased risk of restenosis were excluded. (eur.nl)
  • Patients with diabetes mellitus have more extensive coronary artery disease, more disease progression, and restenosis. (lu.se)
  • The number of lesions treated with DES to prevent one restenosis ranged from 11 to 47 in various subgroups. (lu.se)
  • This real-life registry study shows that restenosis was halved by DES in diabetic patients with stable or unstable coronary disease, with similar risk of death or MI up to 4 years compared with BMS. (lu.se)
  • Coronary artery restenosis is an important side effect of percutaneous coronary intervention. (springer.com)
  • We report on an approach for validation of an in silico 3D model of in-stent restenosis in porcine coronary arteries and illustrate this approach by comparing the modelling results to in vivo data for 14 and 28 days post-stenting. (springer.com)
  • This in turn causes a healing response in the vessel wall, which, if it becomes excessive, can cause a new narrowing of the vessel, or in-stent restenosis (ISR). (springer.com)
  • Subsequent stent restenosis or occlusion may require repeat catheter-based treatments (including balloon dilatation) of the arterial segment containing the stent. (medtronic.com)
  • Uses of balloon catheters or BMS for the treatment of coronary artery lesions shows good short-term results but long-term follow up revealed restenosis in up to 20%-30% of patients. (scirp.org)
  • DES reduced the incidence of in-stent restenosis. (scirp.org)
  • 1987) Intravascular Stents to Prevent Occlusion and Restenosis after Transluminal Angioplasty. (scirp.org)
  • 1996) Patterns and Mechanisms of In-Stent Restenosis. (scirp.org)
  • Genetic risk of restenosis after percutaneous coronary interventions in the era of drug-eluting stents. (cdc.gov)
  • CYP2C192 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls. (cdc.gov)
  • Coronary stent restenosis and the association with allergy to metal content of 316L stainless steel. (cdc.gov)
Arteries16
  • A coronary stent is a tube-shaped device placed in the coronary arteries that supply blood to the heart, to keep the arteries open in the treatment of coronary heart disease. (wikipedia.org)
  • The interventional cardiologist uses angiography to assess the location and estimate the size of the blockage ("lesion") by injecting a contrast medium through the guide catheter and viewing the flow of blood through the downstream coronary arteries. (wikipedia.org)
  • Dealing with lesions near branches in the coronary arteries presents additional challenges and requires additional techniques. (wikipedia.org)
  • Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
  • Acute coronary syndrome (ACS) refers to any group of symptoms attributed to obstruction of the coronary arteries. (researchgate.net)
  • Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. (researchgate.net)
  • The Promus ELITE Everolimus-Eluting Platinum Chromium Coronary Stent System is indicated for improving luminal diameter in patients, including those with diabetes mellitus, with symptomatic heart disease or documented silent ischemia due to de novo lesions in native coronary arteries ≥2.25 mm to ≤4.00 mm in diameter in lesions ≤34 mm in length. (bostonscientific.com)
  • There were plaques at LAD and %50 stenosis at proximal Circumflex arteries, the lesions were considered to be insignificant (Figure 1 ), and the patient had woven RCA (Figures 2 and 3 ). (hindawi.com)
  • Diseased, extra-small coronary arteries with diameters between 2.0-2.25 mm are encountered frequently and, despite size, may require treatment. (medtronic.com)
  • Cardiac catheterization was generally followed by interventional or therapeutic procedures to open blocked arteries-e.g., atherectomy, stent placement, grafting, or pacemaker implantation. (uspharmacist.com)
  • Epicardial adipose tissue (EAT) is located between the surface of the heart and the visceral layer of the pericardium and surrounds the coronary arteries. (go.jp)
  • The Onyx Frontier™ zotarolimus-eluting coronary stent system is indicated for improving coronary luminal diameters in patients, including those with diabetes mellitus or high bleeding risk, with symptomatic ischemic heart disease due to de novo lesions of length ≤ 35 mm in native coronary arteries with reference vessel diameters of 2.0 mm to 5.0 mm. (medtronic.com)
  • Products are designed to assist with placement and support of guidewires used in peripheral vascular procedures to deliver stents and balloons to open blockages in legs and other peripheral arteries. (thomasnet.com)
  • The new updates, aimed at innovating and advancing procedures including percutaneous coronary intervention (PCI) to treat the narrowing of coronary arteries, are being announced at the Transcatheter Cardiovascular Therapeutics (TCT) annual meeting (Orlando, USA, November 4-6). (philips.com)
  • Stents for coronary arteries are expandable wire mesh cylinders that help hold stenotic areas open. (msdmanuals.com)
  • Still, he suspects metallic stents in the coronary arteries "will be a minority in 2020. (medscape.com)
Bifurcation5
  • The bifurcation of the anterior descending branch and the circumflex branch lesions at the end of the left main trunk are always difficult to repair. (biomedcentral.com)
  • Despite improvement in stent technology and operator experience, management can be challenging especially in LMCA bifurcation lesions and, therefore, an integrated approach combining advanced devices, tailored techniques, adjunctive support of physiological evaluation, and adjunctive pharmacological agents should be reinforced to improve clinical outcome. (amrita.edu)
  • Resolute Onyx is the only DES with randomised data supporting provisional and dual-stent strategies in LM bifurcation PCI. (medtronic.com)
  • In addition, the Onyx Frontier™ zotarolimus-eluting coronary stent system is indicated for treating de novo chronic total occlusions and non-left main bifurcation lesions utilizing the provisional bifurcation stenting technique. (medtronic.com)
  • Stents are used frequently for acute myocardial infarction, ostial or left main disease, chronic total occlusions, and bifurcation lesions. (msdmanuals.com)
Implantation12
  • A total of 87 de novo lesions were treated by IVL with the following indications: 25 before attempting other balloon-based devices (primary IVL), 51 after the failure of non-compliant balloon dilatation (secondary IVL), and 11 after stent implantation because of stent under expansion (bailout IVL). (frontiersin.org)
  • In this thesis, contemporary percutaneous coronary intervention of these lesion subsets are evaluated, including assessment of the efficacy of sirolimus- and paclitaxel-eluting stent implantation. (eur.nl)
  • Only physicians who have received adequate training should perform implantation of the stent. (bostonscientific.com)
  • All patients underwent coronary angiography, IVUS and IVUS-virtual histology before and after device implantation. (tctmd.com)
  • Dilatation pressure was higher ( P =.01) and balloon diameter at the highest pressure during implantation or postdilatation was larger ( P =.02) in the metallic stent group. (tctmd.com)
  • Herein we report a case with right woven coronary artery managed with drug-eluted stent implantation without complication. (hindawi.com)
  • TIMI III flow was ensured after stent implantation. (hindawi.com)
  • Right coronary artery and WCA after first distal stent implantation. (hindawi.com)
  • The risks and benefits of the stent implantation should be assessed for patients with a history of severe reaction to contrast agents. (medtronic.com)
  • 1994) A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease. (scirp.org)
  • 2009) 5-Year Clinical Outcomes after Sirolimus-Eluting Stent Implantation Insights from a Patient-Level Pooled Analysis of 4 Randomized Trials Comparing Sirolimus-Eluting Stents with Bare-Metal Stents. (scirp.org)
  • Dual Antiplatelet Therapy Guided by CYP2C19 Polymorphisms after Implantation of Second-Generation Drug-Eluting Stents for Management of Acute Coronary Syndrome. (cdc.gov)
Metal stents8
Left main c1
  • For several decades, coronary artery bypass grafting (CABG) has been considered as the gold standard treatment of unprotected left main coronary artery (LMCA) disease. (amrita.edu)
Vascular5
  • [ 6 ] Julio C Palmaz, an interventional vascular radiologist, and Richard Schatz, an interventional cardiologist, designed this bare-metal coronary stent, which was manufactured and sold by Cordis. (medscape.com)
  • Patients were randomly assigned to receive either the Orsiro (Biotronik) or the Xience Prime stent (Abbott Vascular). (escardio.org)
  • In contrast, Abbott Laboratories Laboratories was the least affected, with less impact on its entire vascular segment in 2020, which includes coronary stent devices, in its 2020 annual results. (grandviewresearch.com)
  • LONDON, UK - Data from two new studies presented last week at the European Society of Cardiology (ESC) 2015 Congress provide some evidence the everolimus -eluting stent with a bioabsorbable vascular scaffold ( Absorb , Abbot Vascular) is as good as the current standard of care [ 1 ] . (medscape.com)
  • For patients who received the Absorb stent, the primary end point of target lesion failure at 12 months was 4.2% compared with 3.8% among patients who received the everolimus-eluting stent with a nonabsorbable cobalt- chromium scaffold ( Xience , Abbott Vascular), a difference that was not statistically significant. (medscape.com)
Target lesion7
  • The target lesion was located in a heavily calcified right coronary artery (rca). (fda.gov)
  • 00 x 48mm synergy stent to the target lesion, it crumbled. (fda.gov)
  • Using a guidezilla, another of the same sized stent was delivered to the target lesion. (fda.gov)
  • Target lesion failure may be more frequent when IVL is performed for the treatment of ISR due to calcium-mediated stent under expansion. (frontiersin.org)
  • Rates of target lesion failure were also similar at nine months (4.8% vs. 5.3%, p=0.47). (escardio.org)
  • target lesion is in left main stem. (who.int)
  • To verify the non-inferiority of Magic Touch SCB hypothesized in target lesion failure (TLF), a composite of cardiac death, ischemia-driven target-lesion revascularization (TLR), target vessel myocardial infarction (MI), at 12 months. (who.int)
Stenosis7
  • We used StentBoost to verify the accuracy of stent placement and the Szabo technique to rectify long-term coronary stenosis, which achieved satisfactory results. (biomedcentral.com)
  • The procedural success rate, defined as successful stent delivery with less than a 50% residual stenosis and no in-hospital MACE, was 92.4% in Disrupt CAD III, compared to 83.4% for orbital atherectomy in ORBIT II. (medscape.com)
  • The mean diameter stenosis preprocedure was 65.1%, dropping to 37.2% post lithotripsy, with a final in-stent residual stenosis diameter of 11.9%, with a 1.7-mm acute gain. (medscape.com)
  • The marked improvement in technique and technology makes percutaneous coronary interventions (PCIs) feasible for patients with unprotected LMCA stenosis. (amrita.edu)
  • Woven pattern was confirmed at RCA with no apparent coronary stenosis. (hindawi.com)
  • Gruntzig, A. (1978) Trans Luminal Dilatation of Coronary-Artery Stenosis. (scirp.org)
  • An 86 symptomatic year old male with left main trunk stenosis and osteal LAD stenosis evaluated by IVUS for stenosis assessment, step procedures, and expansion of stenting. (incathlab.com)
Bare-metal2
  • Bare-metal coronary artery stents are used in percutaneous coronary intervention (PCI) for a variety of indications, including stable and unstable angina, acute myocardial infarction (MI), and multiple-vessel disease. (medscape.com)
  • [ 5 ] Cesar Gianturco, a radiologist, and Gary Roubin, an interventional cardiologist, designed this bare-metal coronary stent, which was manufactured and sold by Cook Inc. The Gianturco-Roubin stent was a balloon-expandable and coil-type stent manufactured using a flat 316 L stainless steel wire coil attached to a single longitudinal strut. (medscape.com)
Patients41
  • Since platelets are involved in the clotting process, patients must take dual antiplatelet therapy starting immediately before or after stenting: usually an ADP receptor antagonist (e.g. clopidogrel or ticagrelor) and aspirin for up to one year and aspirin indefinitely. (wikipedia.org)
  • The value of stenting in rescuing someone having a heart attack (by immediately alleviating an obstruction) is clearly defined in multiple studies, but studies have failed to find reduction in hard endpoints for stents vs. medical therapy in stable angina patients (see controversies in Percutaneous coronary intervention). (wikipedia.org)
  • Instead, the comparator group selected under regulatory guidance was comprised of patients who had received orbital atherectomy for severe coronary calcifications in the earlier, similarly designed ORBIT II trial, which led to FDA marketing approval of that technology. (medscape.com)
  • A total of 105 consecutive patients with 110 calcified lesions underwent IVL. (frontiersin.org)
  • Up to 30% of patients undergoing percutaneous coronary intervention (PCI) have calcified lesions ( 1 ). (frontiersin.org)
  • This retrospective, observational study included consecutive patients with calcified coronary lesions treated with IVL from December 31, 2018 to December 31, 2020 at the Centro Cardiologico Monzino, University of Milan, Italy. (frontiersin.org)
  • Has anyone ever done a critical analysis on the effect of antiplatelet therapy in patients with acute coronary syndrome? (researchgate.net)
  • The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
  • Large, multicenter randomized trials of various pharmacologic modalities have recently achieved great success in the treatment of patients with coronary artery atherosclerosis. (medscape.com)
  • Patients judged to have a lesion that prevents complete inflation of an angioplasty balloon or proper placement of the stent or delivery device. (bostonscientific.com)
  • The use of drug-eluting stents (DES) in these patients is widespread, despite uncertain long-term safety and efficacy. (lu.se)
  • All consecutive patients with diabetes mellitus in Sweden who underwent percutaneous coronary intervention were entered into the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) during 2003-06 with complete follow-up for 1-4 years (median 2.5). (lu.se)
  • Myocardial infarction was significantly less common with DES in patients who received only one stent RR, 0.80 (95% CI, 0.66-0.96). (lu.se)
  • Stenting has become standard treatment for patients undergoing percutaneous coronary intervention. (bmj.com)
  • In the first randomized trial pitting an everolimus-eluting bioresorbable scaffold against a metallic stent that releases the same drug, researchers found similar safety and efficacy at 1 year in patients with up to two de novo lesions. (tctmd.com)
  • 166 patients and 182 lesions) at 46 sites in Europe and New Zealand. (tctmd.com)
  • The BIOFLOW-II substudy used intravascular ultrasound (IVUS) and optical coherence tomography (OCT) to quantitatively assess neointimal hyperplasia and stent apposition at nine months after treating patients with symptomatic coronary artery disease due to de novo stenotic lesions. (escardio.org)
  • The DESolve Nx trial treated target lesions in 126 patients with single de novo coronary artery lesions with the DESolve device. (escardio.org)
  • Postprocedural 3T-MRA was performed in a cohort of 39 patients undergoing EN stent-assisted intracranial aneurysm coiling. (ajnr.org)
  • In this study, ISA was detectable by 3T-MRA in a significant proportion of patients undergoing EN stent-assisted coiling of ICA aneurysms in a vessel geometry− and stent-deployment location−dependent manner. (ajnr.org)
  • Follow-up imaging of patients who have undergone stent-mediated coil embolization procedures has traditionally focused on the presence or absence of residual filling in the dome. (ajnr.org)
  • Since January 2009, all patients undergoing stent-mediated coiling in our service have routinely undergone prospective 3T-MRA postprocedurally. (ajnr.org)
  • An additional 6 patients who underwent prospective 3T-MRA imaging within 3 days of EN deployment between June 2007 and September 2008, as part of a pilot study on the utility of 3T-MRA in randomly selected patients following stent-coiling, were also included in the study. (ajnr.org)
  • The clinical unit is located at the Department of Cardiology and focuses on prospective studies of patients with ST-elevation myocardial infarction (STEMI) who are treated with primary percutaneous coronary intervention. (gu.se)
  • Patients and lesions can be complex, increasing the burden on your practice. (medtronic.com)
  • They recruited 212 patients with intermittent claudication who had never had invasive treatment-which immediately made me realise the study couldn't have been done in America, where at the first twinge of calf pain you get a stent or balloon stuck down your femoral artery. (bmj.com)
  • Over and Under PCS is especially suitable for patients with degenerated SVG where the lesions are less calcified than those in native coronaries," says Efri Argaman, CEO of ITGI Medical. (salesandmarketingnetwork.com)
  • Over and Under , as the rest of our heterologous covered stents, brings a new message to the interventional medicine and the therapeutic solutions the physicians can provide their patients. (salesandmarketingnetwork.com)
  • 2009) EUROASPIRE III: A Survey on the Lifestyle, Risk Factors and Use of Cardioprotective Drug Therapies in Coronary Patients from Twenty-Two European Countries. (scirp.org)
  • Patients with saphenous vein graft lesions undergoing PCI were randomized to DES (n = 292) versus BMS (n = 305). (acc.org)
  • Among patients with a saphenous vein graft lesion undergoing PCI, DES were not superior to BMS at preventing target vessel failure. (acc.org)
  • Biodegradable polymer sirolimus -eluting stents versus durable polymer everolimus -eluting stents in patients with ST-segment elevation myocardial infarction (BIOSTEMI): a single-blind, prospective, randomised superiority trial. (msdmanuals.com)
  • Clinical characteristics of octogenarian patients under- going percutaneous coronary intervention. (bvsalud.org)
  • Kimura, who presented the results to the media, said the ABSORB trial was designed to support regulatory approval of the Absorb stent in Japan, and because of that the trial has limitations, one of the most notable being the inclusion of highly selected coronary artery disease patients typical of stent trials designed for regulatory approval. (medscape.com)
  • Like ABSORB Japan, patients were randomized to treatment with the Absorb stent or the Xience everolimus-eluting stent. (medscape.com)
  • Impact of CYP2C19 polymorphism on clinical outcome following coronary stenting is more important in non-diabetic than diabetic patients. (cdc.gov)
  • Characterization of patients with angioscopically-detected in-stent mural thrombi - genetics of clopidogrel responsiveness and generations of drug-eluting stents. (cdc.gov)
  • The Diagnostic Utility of the Point-of-Care CYP2C19 Genotyping Assay in Patients with Acute Coronary Syndrome Dosing Clopidogrel: Comparison with Platelet Function Test and SNP Genotyping. (cdc.gov)
  • CYP2C19 loss-of-function alleles are not associated with clinical outcome of clopidogrel therapy in patients treated with newer-generation drug-eluting stents. (cdc.gov)
  • Association between high on-treatment platelet reactivity and occurrence of cerebral ischemic events in patients undergoing percutaneous coronary intervention. (cdc.gov)
  • High On-Treatment Platelet Reactivity Determinants on Dual Antiplatelet Therapy in Patients With Ischemic Heart Disease Before Elective Percutaneous Coronary Intervention]. (cdc.gov)
Descending coronary artery1
  • Combining the Szabo technique with StentBoost imaging was helpful to accurately evaluate the area and locate the stent when treating this ostial lesion of the anterior descending coronary artery. (biomedcentral.com)
Occlusion3
Catheter11
  • Drug-eluting stents are most often sold as a unit, with the stent in its collapsed form attached to the outside of a balloon catheter. (wikipedia.org)
  • Predilation is accomplished by threading the lesion with an ordinary balloon catheter and expanding it to the vessel's original diameter. (wikipedia.org)
  • The physician withdraws this catheter and threads the stent on its balloon catheter through the lesion. (wikipedia.org)
  • These devices differ from each other with respect to composition (eg, stainless steel, cobalt chromium alloy, nickel chromium alloy), architectural design, and delivery system (ie, a balloon catheter that delivers the stent, self-expanding, or balloon expandable). (medscape.com)
  • If a broken catheter tip can not be retrieved from the coronary artery, 'fix' it! (manipal.edu)
  • Other drug-eluting stents feature irregular cell shapes which may obstruct wire or catheter advancement through the cell's opening. (medtronic.com)
  • The long-term outcome following repeat catheter-based treatments of previously implanted stents is not well characterized. (medtronic.com)
  • Care should be taken to control the position of the guide catheter tip during stent delivery, stent deployment, and balloon withdrawal. (medtronic.com)
  • Before withdrawing the stent delivery system, confirm complete balloon deflation using fluoroscopy to avoid arterial damage caused by guiding catheter movement into the vessel. (medtronic.com)
  • Next-generation balloon catheter offers enhanced deliverability and expanded options for treating coronary artery lesions NATICK, Mass. - Boston Scientific Corporation (NYSE: BSX) announces CE Mark and European market launch of the Emerge(TM) PTCA[1] Dilatation Catheter. (thomasnet.com)
  • A guiding catheter is inserted into a large peripheral artery and threaded to the appropriate coronary ostium. (msdmanuals.com)
Angioplasty5
Balloon6
  • The physician expands the balloon, which deforms the metal stent to its expanded size. (wikipedia.org)
  • The Palmaz-Schatz stent was a balloon-expandable and slotted-tube type stent manufactured using 316 L stainless steel. (medscape.com)
  • Balloon-expandable stents are currently used with satisfactory results in percutaneous coronary interventions. (minervamedica.it)
  • The STENTYS® stent (STENTYS, Paris, France), with its self-expandable capacity and peculiar Z-shape design, has been recently introduced in the clinical arena as an alternative to balloon-expandable stents for challenging lesion subsets. (minervamedica.it)
  • After dilatation, two 2.5/28 mm everolimus-eluted stents were implanted to the anomalous portion after balloon dilatation (Figures 6 and 7 ). (hindawi.com)
  • During the stenting procedure, the narrowed artery is damaged by the stent struts being pressed into the vessel wall, as well as by the expanding balloon which is used to distend the artery and deploy the stent. (springer.com)
Ostial1
  • Plaques at left anterior descending artery and borderline lesion ostial Circumflex artery. (hindawi.com)
Disease13
  • Similar stents and procedures are used in non-coronary vessels (e.g., in the legs in peripheral artery disease). (wikipedia.org)
  • Results of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial confirmed that this practice independently associated with improved graft patency, as demonstrated by coronary angiography and saphenous vein graft intravascular ultrasonography. (medscape.com)
  • The death certificate completed by the attending physician stated the cause of death as "acute myocardial infarction" (otherwise known as a heart attack) due to coronary artery disease (CAD). (cdc.gov)
  • 28 133 in 1999, stent rate 79%) and consequently their impact on budgets, concern among some clinicians and purchasers about clinical benefits and cost effectiveness, and because heart disease had been a declared government priority. (bmj.com)
  • Woven coronary artery (WCA) disease is an extremely rare congenital anomaly with unexplained etiology [ 1 ]. (hindawi.com)
  • Coronary artery disease is one of the most widespread causes of mortality in industrialized countries. (springer.com)
  • Many clinical studies suggest that an increase in EAT volume is associated with coronary artery disease. (go.jp)
  • These benefits and lower costs compared to surgical treatment make the DES an attractive alternative for the treatment of coronary artery disease. (scirp.org)
  • Shamiri, M. , Al Mobeirek, A. , Albackr, H. and Albacker, T. (2014) Percutaneous Coronary Interventional Treatment for Coronary Artery Disease and the Role of Antiplaplatelets Therapy: A Review of the Literature. (scirp.org)
  • 2007) Optimal Medical Therapy with or without PCI for Stable Coronary Disease. (scirp.org)
  • IntraSight Mobile brings together imaging and physiology applications on a mobile system for coronary and peripheral artery disease therapy. (philips.com)
  • According to research published by the National Library of Medicine in June 2021, one of the CVDs, coronary artery disease (CAD), causes roughly 6,10,000 fatalities yearly (an estimated 1 in 4 deaths) and is the major cause of mortality in the U.S. As a result, the unprecedented rise in CAD incidence is predicted to boost demand for an effective coronary stent device for treatment. (grandviewresearch.com)
  • Coronary artery disease 2014 Dec 25 (8): 658-64. (cdc.gov)
Intravascular8
  • Intravascular lithotripsy proved highly effective, safe, and user friendly as an adjunct to stenting for severely calcified coronary lesions at 30 days of follow-up in the pivotal Disrupt CAD III study aimed at gaining U.S. regulatory approval. (medscape.com)
  • In so doing, the intravascular lithotripsy device developed by Shockwave Medical successfully addressed one of the banes of contemporary interventional cardiology: heavily calcified coronary lesions. (medscape.com)
  • Currently available technologies targeting such lesions, including noncompliant high-pressure balloons, intravascular lasers, cutting balloons, and orbital and rotational atherectomy, often yield suboptimal results, noted Kereiakes, medical director of the Christ Hospital Heart and Cardiovascular Center in Cincinnati. (medscape.com)
  • Intravascular lithotripsy was used to prepare these severely calcified lesions for stenting. (medscape.com)
  • This study aims to describe the outcome of intravascular lithotripsy (IVL) when used with different indications and to assess the short- and long-term outcomes of IVL-facilitated percutaneous coronary intervention (PCI). (frontiersin.org)
  • Intravascular lithotripsy can improve the results of PCI of calcified coronary lesions with a low rate of periprocedural complications. (frontiersin.org)
  • The IntraSight platform allows interventional cardiologists to perform intravascular ultrasound (IVUS) imaging and physiologic measurements of fractional flow reserve (FFR) and instant wave-free ratio (iFR) to accurately identify the location of lesions causing ischemia. (philips.com)
  • Here we used machine/deep learning to analyze calcifications in pre-stent intravascular optical coherence tomography (IVOCT) images and predicted the success of vessel expansion. (bvsalud.org)
Clinical9
  • Acute coronary syndrome is quite chalanging to diagnose when clinical appearance or ECG pattern is not spesific and cardiac marker is not available. (researchgate.net)
  • HTA groups such as NICE and ANAES (Agence Nationale d'Accreditation et d'Evaluation en Sante) in France are seen as being much more influential since they impact on clinical practice and reimbursement. (bmj.com)
  • Stenting was not at the time of the report a clinical innovation, having been increasingly used before the NICE review. (bmj.com)
  • On quantitative IVUS, both preprocedural vessel area ( P =.02) and plaque ( P =.01) were larger in the metallic stent group compared with the bioresorbable scaffold group, but rates of clinical success were similar. (tctmd.com)
  • Reporting the results, Stephan Windecker, Professor and Chief of Cardiology, Swiss Cardiovascular Center and Clinical Trials Unit Bern, Bern University Hospital, Switzerland, said, "The Orsiro sirolimus-eluting stent with a biodegradable polymer was non-inferior to the Xience Prime everolimus-eluting stent with a durable polymer for the primary angiographic endpoint of in-state late loss at nine months in this prospective, randomised trial. (escardio.org)
  • In addition, clinical event rates were low and comparable with both stents. (escardio.org)
  • pharmacological stents were implanted in almost all cases, and angiographic and clinical success rates were high. (bvsalud.org)
  • Dr Steen Kristensen (Aarhus University Hospital, Denmark), the discussant following the late-breaking clinical-trials presentation, who wrote an editorial accompanying the study's publication in European Heart Journal [ 3 ] , said the new stents have the benefit of delivering the drug and then disappearing, changing a "coronary intervention from treatment with a permanent metallic stent to a resorbable cure. (medscape.com)
  • At the present time, the bioabsorbable scaffold might offer a clinical advantage, and with that the use of metallic stents might wane in the future, but "we currently do not know," said Kristensen. (medscape.com)
Vessel13
  • It is critically important that the framework of the stent be in direct contact with the walls of the vessel to minimize potential complications such as blood clot formation. (wikipedia.org)
  • This multiscale model includes single-scale models for stent deployment, blood flow and tissue growth in the stented vessel, including smooth muscle cell (SMC) proliferation and extracellular matrix (ECM) production. (springer.com)
  • The validation procedure uses data from porcine in vivo experiments, by simulating stent deployment using stent geometry obtained from micro computed tomography (micro-CT) of the stented vessel and directly comparing the simulation results of neointimal growth to histological sections taken at the same locations. (springer.com)
  • For 14 days post-stenting the relative neointimal area, averaged over all vessel sections considered, was 20 ± 3% in vivo and 22 ± 4% in silico . (springer.com)
  • 17 Since it is formed by growth and proliferation of smooth muscle cells (SMCs) in the vessel wall, the composition of a restenotic lesion is different from the initial lesion: a restenotic lesion mainly consists of SMCs and the extracellular matrix (ECM) they produce. (springer.com)
  • ISR is associated with excessive damage to the vessel wall and with disturbed flow patterns in the stented vessel, in particular with low values of wall shear stress (WSS). (springer.com)
  • Little data are available on the ability of the stent struts to maintain vessel-wall apposition once deployed in the tortuous cerebral vasculature and the prevalence of ISA. (ajnr.org)
  • The purpose of this study was to evaluate the relationship between geometric features of the parent vessel at the stent deployment site and prevalence of ISA. (ajnr.org)
  • Parent vessel diameter, curvature radius, and stent-subtended arc angle were measured at the site of deployment and analyzed for prediction of ISA in the ICA. (ajnr.org)
  • 1 - 4 Stents serve as a physical barrier to prevent coil protrusion into the parent vessel during coiling of wide-neck or fusiform lesions. (ajnr.org)
  • Several studies have evaluated the architecture of stents within coronary vessels and have noted the presence of ISA to the vessel wall. (ajnr.org)
  • Correlating our findings with angiographic FPCT, we describe here a new crescent-shaped flow signal intensity external to the stent struts on 3T-MRA as a marker for ISA in EN-treated aneurysms and describe the morphologic characteristics of target vessels that predispose to poor stent−vessel wall apposition. (ajnr.org)
  • Over and Under is a stent 100% covered with a heterologous tissue, designed to set a barrier between the coronary blood vessel wall and its lumen. (salesandmarketingnetwork.com)
Acute coronary1
  • Woven coronary artery (WCA) is a very rare congenital anomaly which can affect both RCA and LAD and may lead to acute coronary syndromes in some circumstances [ 4 ]. (hindawi.com)
Complex Lesions1
  • Growing aging population and a rising prevalence of noncommunicable diseases such as cardiovascular diseases (CVDs), complex lesions, diabetes, obesity, and others are expected to drive demand for coronary stents over the forecast period. (grandviewresearch.com)
Interventions2
  • Over the last few years our fellows have averaged performing 400 coronary interventions and almost 100 peripheral interventions during training. (mainlinehealth.org)
  • Freitas1 coronary interventions (PCI) in octogenarians are increasingly indicated. (bvsalud.org)
Right corona3
  • Herein, we report a case of WCA in right coronary artery (RCA) successfully managed with percutaneous coronary intervention (PCI) after abnormal myocardial perfusion scintigraphy. (hindawi.com)
  • Woven coronary artery anomaly at the midsegment of the right coronary artery. (hindawi.com)
  • Right coronary artery and TIMI III flow after floppy guidewires. (hindawi.com)
Xience5
  • The Orsiro stent, which is a novel stent platform eluting sirolimus from a biodegradable polymer, demonstrated non-inferiority to the Xience Prime everolimus-eluting stent for the primary angiographic endpoint of in-stent late lumen loss at nine months in the results of an imaging substudy reported at EuroPCR 2013 today. (escardio.org)
  • The IVUS substudy showed somewhat less neointimal hyperplasia over nine months with the Orsiro stent (0.16) than the Xience stent (0.43, p=0.043) with 100% stent apposition. (escardio.org)
  • Similarly, neointimal area as assessed by OCT at nine months was somewhat less with the Orsiro stent (0.74+0.38mm2 ) than with the Xience stent (1.00+0.44mm2, p=0.024). (escardio.org)
  • The study provides some welcome good news for BSX's Taxus, which took a beating in recent studies when compared with the Cypher and Abbott 's (ABT) Xience stent. (massdevice.com)
  • Regarding the secondary end point, which was an angiographic end point measuring in-segment late lumen loss, the loss was 0.13 mm with the Absorb stent and 0.12 for the Xience stent ( P =0.74). (medscape.com)
Percutaneous coronary9
Atherectomy3
  • A new coronary atherectomy system, the Diamondback-360, is the first in more than 20 years to be FDA-approved to treat severely calcified lesions. (uspharmacist.com)
  • Additionally, the safety and effectiveness of using atherectomy devices with the stent have not been established. (medtronic.com)
  • Promising results suggest that such methods can identify lesions at risk of under-expansion that would be candidates for intervention lesion preparation (e.g., atherectomy). (bvsalud.org)
Complications2
  • Treatment of calcified coronary lesions with IVL in a "real-world" setting can be performed with high success, low rate of procedural complications, and an acceptable MACEs rate. (frontiersin.org)
  • Under-expanded stents are linked to later complications. (bvsalud.org)
Endothelialized stents is not well characterized1
Circumflex1
  • His previous coronary angiogram showed proximal LAD and proximal circumflex 90% stenotic lesions. (mhmedical.com)
Placement1
Incidence1
Everolimus-Eluting Stent1
  • Investigators reported that "Absorb in the setting of STEMI resulted in nearly complete arterial healing, which was comparable to that of the metallic [everolimus-eluting stent] at 6 months. (medscape.com)
Versus1
  • Univariate analysis revealed ISA in the ICA to correlate with a large stent-subtended angle, a small curvature radius, and a large diameter but not stent length or jailing versus a sequential technique. (ajnr.org)
Distal1
Heavily calcified1
  • It can be difficult/impossible to fully expand a coronary artery stent in a heavily calcified coronary artery lesion. (bvsalud.org)
Interventional5
  • Therefore, accurately positioning the stent to ensure a stable open artery has become an important concern of interventional physicians [ 3 ]. (biomedcentral.com)
  • We hope this article will help make interventional doctors aware of technology to accurately locate and repair a lesion of the LAD with a single stent. (biomedcentral.com)
  • There is great unmet medical need for stents that are 100% covered, biocompatible and flexible," noted Dr. Haim Danenberg, Head of Interventional Cardiology Unit and the company's medical director. (salesandmarketingnetwork.com)
  • The notable competitors in the market for coronary stents announced revenue falls in their interventional cardiology portfolios, which include coronary stent devices, in 2020, due to the impact of the COVID-19 pandemic. (grandviewresearch.com)
  • Boston Scientific, for instance, reported a significant decrease in annual revenues in its Interventional Cardiology segment, which includes coronary stent devices, in 2020, but the company performed relatively well in the first quarter of 2021, reporting revenue growth of approximately 7% globally compared to the first quarter of 2020. (grandviewresearch.com)
Cardiovascular3
  • In 1999 NICE examined the use of coronary stents as the first in a number of cardiovascular exercises, being followed by glycoprotein IIb/IIIa receptor blockers, and implantable defibrillators. (bmj.com)
  • In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
  • Association of CYP2C19*2 polymorphism with clopidogrel response and 1-year major adverse cardiovascular events in a multiethnic population with drug-eluting stents. (cdc.gov)
Outcomes3
  • The recent introduction of drug-eluting stents (DESs), together with advances in periprocedural and postprocedural adjunctive pharmacotherapies, has improved outcomes of PCIs of these lesions. (amrita.edu)
  • Unfortunately, in challenging anatomical patterns such as high thrombotic burden lesions, outcomes are often impaired. (minervamedica.it)
  • Technological advancements in coronary stents, such as the development of bifurcated stents and the use of biodegradable materials, have led to efficient and improved outcomes of CVD treatment. (grandviewresearch.com)
Neointimal2
  • This may cause scar tissue (cell proliferation) to rapidly grow over the stent and cause a neointimal hyperplasia. (wikipedia.org)
  • He added, " We need to be careful in interpreting the results of a trial set up for an angiographic endpoint but we can speculate that neointimal hyperplasia may be somewhat less with the Orsiro stent platform. (escardio.org)
Bioresorbable stents1
  • Serruys commented in a press conference that when ABSORB II commenced, common practice was to be "overcautious" with deploying bioresorbable stents because of concern over the fragility of the polymer. (tctmd.com)
Saphenous vein g1
Scaffold1
  • The DESolve bioresorbable coronary scaffold system achieves good efficacy and safety with low rates of late lumen loss and major coronary adverse events at six months, show first results from the pivotal DESolve Nx trial reported at EuroPCR 2013 today. (escardio.org)
Underwent1
  • Different components of DES which include the polymers, drugs and the stents underwent progressive evolution, and these led to development of new generations of DES with variable types of drugs and polymers to fully absorbable stents. (scirp.org)
Lumen4
  • Thereafter these channels merge again in order to form the main coronary lumen after twisting along anomalous artery axis [ 2 ]. (hindawi.com)
  • Results showed the primary endpoint of in-stent late lumen loss was 0.21mm (+0.34) at six months. (escardio.org)
  • Lumen and calcifications in pre-stent images were segmented using deep learning, and lesion features were extracted. (bvsalud.org)
  • We trained regression models to predict the post-stent lumen area and then computed the stent expansion index (SEI). (bvsalud.org)
Angiography and Intervention1
Cardiac3
  • Local hemodynamics worsened with luminal protrusion of the stent and with stent malapposition, adverse high WSS and WSSG were identified around peak flow and throughout the cardiac cycle respectively. (researchgate.net)
  • The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)