• Three-year outcomes from an ongoing clinical trial suggest that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells may induce sustained remission in some people with relapsing-remitting multiple sclerosis (RRMS). (mlo-online.com)
  • Doctors collected blood-forming stem cells from participants and then gave them high-dose chemotherapy to destroy their immune systems. (mlo-online.com)
  • Stem cells were returned to the participants to rebuild and reset their immune systems. (mlo-online.com)
  • Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
  • Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
  • In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
  • At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
  • In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
  • The team decided to perform fecal transplants on mice with an experimentally induced form of MS. They discovered that swapping the mice's microbiomes with those of MS patients caused the animals to lose key immune-regulatory cells and instead develop more severe neurodegeneration, indicating that the microbiome alone could affect the progression of MS. (genomeweb.com)
  • I am especially interested in the role of mesenchymal stem cells (MSCs) in this process. (essex.ac.uk)
  • Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
  • Recent clinical trials evaluating allogeneic retinal grafts derived from human embryonic stem cells (hESCs) show the procedure to be safe and potentially effective 1 . (nature.com)
  • Using a patient's own cells for transplantation would avoid these pitfalls and is possible with induced pluripotent stem cells (iPSCs). (nature.com)
  • Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
  • Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
  • Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
  • We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
  • Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. (news-medical.net)
  • Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. (news-medical.net)
  • Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head. (nih.gov)
  • RESULTS: Cortex-specific deletion of Dicer results in a marked reduction in the cellular complexity of the cortex, due to a pronounced narrowing in the range of neuronal types generated by Dicer-null cortical stem and progenitor cells. (ox.ac.uk)
  • Instead of generating different classes of lamina-specific neurons in order over the 6-day period of neurogenesis, Dicer null cortical stem and progenitor cells continually produce one class of deep layer projection neuron. (ox.ac.uk)
  • A research team of LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has identified a role of an extracellular matrix protein (ECM), Collagen IV, in the regulation of pluripotent stem cells in the regenerative flatworm (planarian). (hku.hk)
  • This collagen plays an important role in regulating how stem cells divide or change in the planarian, crucial to its regenerative capacity and can improve our understanding of human tissue regeneration. (hku.hk)
  • The planarian uses its extensive supply of stem cells of high potency, conserved around 30% in adult worm, to regenerate any missing tissue, including even an entire brain after decapitation. (hku.hk)
  • How planarians can keep so many stem cells remains a mystery, and has fascinated biologists for over a century. (hku.hk)
  • All stem cells have a home called a 'niche' and it is formed by different types of ECM proteins, including collagens. (hku.hk)
  • This provides important information to instruct stem cells how to behave, depending on the type of signals present. (hku.hk)
  • ECM is fundamental in the building of the surrounding environment of stem cells. (hku.hk)
  • This study by researchers of the School of Biomedical Sciences, HKUMed has uncovered a means by which Collagen IV, a key building block of the niche of planarian stem cells, is involved in controlling how these stem cells are used in regenerating missing tissues. (hku.hk)
  • The extracellular matrix, in which Collagen IV is one of the components, is fundamental in the building of the surrounding environment of stem cells. (hku.hk)
  • This study also presents a major step forward in defining the home of high potency stem cells. (hku.hk)
  • This study shows that the removal of Collagen IV in planarians will cause the stem cells to divide much faster, but lose their ability to become cells of other tissue types. (hku.hk)
  • However, this causes the stem cells to continue proliferating, and they are unable to turn into other cell types to repair or maintain planarian tissues. (hku.hk)
  • While daily wear and tear or mild damage to tissues and organs can be repaired by resident adult stem cells, repair of or regeneration from major injuries is not possible in human beings. (hku.hk)
  • This will require stem cells with higher potency in the right environment to kick-start the process. (hku.hk)
  • Since our current understanding of how to regenerate tissues and organs in humans is still limited, deciphering how planarians utilise Collagen IV to keep high potency stem cells in an adult worm, which mammals cannot do, paves the way towards unlocking the mystery and wonders of tissue regeneration in humans. (hku.hk)
  • The planarian in this study can do just that, a feat enabled by the ability to keep many stem cells as an adult, and to use them in the regenerative process. (hku.hk)
  • The planarian can become a new planarian after being cut into several parts, its ability to keep many stem cells and use them in the regenerative process inspired our research. (hku.hk)
  • Our finding of an extracellular matrix protein as part of the environment in which planarians can keep stem cells is an important step, with the hope that we can mimic this in humans to rebuild missing tissues. (hku.hk)
  • Although there are extensive data implicating a pivotal role of TET2 in hematopoietic stem/progenitor cell (HSPCs), the importance of TET2 in bone marrow mesenchymal stromal cells (BMSCs) remains unknown. (ox.ac.uk)
  • The recent discovery of cancer stem cells (CSCs), or tumor initiating cells (TICs), in a variety of cancers, including breast cancer, provides a key to understand the processes of tumor initiation, progression and recurrence. (wustl.edu)
  • Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. (wakehealth.edu)
  • Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (wikipedia.org)
  • Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. (wikipedia.org)
  • Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability to differentiate into any embryonic cell type and by their ability to self-renew. (wikipedia.org)
  • Embryonic stem cells of the inner cell mass are pluripotent, meaning they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. (wikipedia.org)
  • Pluripotency distinguishes embryonic stem cells from adult stem cells, which are multipotent and can only produce a limited number of cell types. (wikipedia.org)
  • Under defined conditions, embryonic stem cells are capable of self-renewing indefinitely in an undifferentiated state. (wikipedia.org)
  • Pluripotent stem cells have shown promise in treating a number of varying conditions, including but not limited to: spinal cord injuries, age related macular degeneration, diabetes, neurodegenerative disorders (such as Parkinson's disease), AIDS, etc. (wikipedia.org)
  • In addition to their potential in regenerative medicine, embryonic stem cells provide a possible alternative source of tissue/organs which serves as a possible solution to the donor shortage dilemma. (wikipedia.org)
  • According to a 2002 article in PNAS, "Human embryonic stem cells have the potential to differentiate into various cell types, and, thus, may be useful as a source of cells for transplantation or tissue engineering. (wikipedia.org)
  • In tissue engineering, the use of stem cells are known to be of importance. (wikipedia.org)
  • How to stop the cancer and let the good stem cells control the pathways? (huffpost.com)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
  • primary human leukemic stem cells and human glioblastoma models. (helsinki.fi)
  • They report that they have been able to grow miniature eyes in the laboratory from stem cells. (com.pk)
  • For example, the authors of the study published in Stem Cell Reports found that Muller cells might have a role to play in the development of Usher syndromes. (com.pk)
  • By using a small biopsy of skin, we now have the technology to reprogram the cells into stem cells and then create lab-grown retina with the same DNA, and therefore same genetic conditions, as our patients," said the first study author Dr Yeh Chwan Leong in a media release. (com.pk)
  • What are stem cells? (mdanderson.org)
  • A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • It involves using stem cells, which are undifferentiated cells capable of becoming various specialized cell types, to repair damaged tissues and promote healing. (corporatewellnessmagazine.com)
  • Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
  • In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
  • Stem cells are generally divided into two groups, embryonic stem cells and adult stem cells. (vin.com)
  • Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
  • Obtaining adult stem cells also does not raise ethical concerns. (vin.com)
  • Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
  • Mesenchymal stem cells or mesenchymal stromal cells (MSC) are plastic adherent and assume a fibroblast-like morphology during culture. (vin.com)
  • Most importantly stem cells possess the ability to differentiate into cell types of multiple lineages including adipocytes, chrondrocytes, and osteocytes. (vin.com)
  • Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
  • Cells from the blood samples are reprogrammed into clinical-grade human induced pluripotent stem cells, which can be distributed to recipients for regenerative medicine. (wjgnet.com)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
  • mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Carbon nanotube s promote lung tumor progression through the induction of cancer-associated fibroblasts and cancer stem-like cells. (cdc.gov)
  • Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers. (lu.se)
  • Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers significant implications for the study of cartilage biology and the discovery of potential therapeutic interventions for cartilage-related and associated disorders. (lu.se)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
  • Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres. (lu.se)
  • In vitro maintenance of multipotent neural crest stem cells as crestospheres. (lu.se)
  • The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression. (lu.se)
  • Aim: Tet2 loss may dysregulate the integrity of bone marrow niche, by which affects the malignant progression. (ox.ac.uk)
  • It is unclear which core events drive the malignant progression of gliomas. (biomedcentral.com)
  • Additionally, inhibition of GAPDH activity on 2D surfaces induced alterations in the profiles of key differentiation markers, indicating that GAPDH activity can impact lineage progression. (unab.edu.co)
  • Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. (ox.ac.uk)
  • Based on their function in developmental timing in other systems, Dicer and microRNAs are potential candidate regulators of cellular pathways that control lineage progression in neural systems. (ox.ac.uk)
  • However, gliogenesis in the Dicer-null cerebral cortex was not delayed, despite the loss of multipotency and the failure of neuronal lineage progression. (ox.ac.uk)
  • Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)
  • NEW YORK (GenomeWeb) - A pair of newly published studies has established a potential role for specific gut bacteria in the progression of multiple sclerosis (MS), suggesting therapeutic targeting of the microbiota as a potential treatment for the disease. (genomeweb.com)
  • Their role in cartilage homeostasis and response to inflammation is crucial for understanding the progression and potential therapeutic interventions for various cartilage-related disorders. (lu.se)
  • Our translation goal is to value what other disciplines already do and know, and find pathways to incorporate that knowledge both within and outside STEM. (carleton.edu)
  • We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. (researchgate.net)
  • Professor Danny Chan, Assistant Dean (Research Postgraduate Studies), HKUMed and Professor at the School of Biomedical Sciences, S Y and H Y Cheng Professorship in Stem Cell Biology and Regenerative Medicine, who initiated the study, said, 'The immortality of an animal under the knife fascinates me as a scientist. (hku.hk)
  • Due to their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
  • The author or co-author of 363 published papers, Dr. Witte is the director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. (huffpost.com)
  • Stem cell therapy is a cutting-edge approach in the field of regenerative medicine. (corporatewellnessmagazine.com)
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
  • The disorder may appear in infancy with rapid progression and severe neurological deterioration. (medlineplus.gov)
  • Patients with early-stage CLL are not treated with chemotherapy until they become symptomatic or display evidence of rapid progression of disease. (medscape.com)
  • Chemotherapy is not needed in CLL until patients become symptomatic or display evidence of rapid progression of disease. (medscape.com)
  • Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem cell cycle. (wikipedia.org)
  • The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. (nih.gov)
  • Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. (biomedcentral.com)
  • Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies. (rochester.edu)
  • The goal of this project was to use cognitive performance data to model Alzheimer's progression by creating an LSTM machine learning model that allows a patient to get regular updates about their Alzheimer's status. (wpi.edu)
  • The result of my project was a model that was able to predict Alzheimer's progression with 80% accuracy and correctly identified which stage of Alzheimer's a patient is in. (wpi.edu)
  • On the other hand, reaction time and other cognitive measures are some of the first indicators of Alzheimer's progression and can be easily measured and acquired in comparison to other methods of tracking the progression of Alzheimer's, such as MRI scans, CT scans, or tracking cerebrospinal fluid (Christ et al. (wpi.edu)
  • Could reducing asthma-related inflammation diminish neural injury and stem progression to dementia? (medpagetoday.com)
  • Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma. (lu.se)
  • Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
  • Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
  • Pulmonary exposure to carbon nanotube s (CNTs) has recently been shown to promote the growth and neoplastic progression of lung adenocarcinoma in animals, but the underlying mechanisms are unknown. (cdc.gov)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. (lu.se)
  • Abstract: Cell traction forces, biochemical signals, and cell metabolism are each known to regulate mesenchymal stem cell (MSC) differentiation. (unab.edu.co)
  • Nanog, as a key cancer stem cell marker in tumor progression. (nih.gov)
  • CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. (lu.se)
  • The main cause of death was disease progression in both groups. (scielo.br)
  • Characteristics of the disease at diagnosis, first-line treatment and response, date of progression or death and cause of mortality were detailed. (scielo.br)
  • The functional outcome was assessed in terms of Harris hip score, and disease progression was assessed radiologically by comparing the preoperative and follow-up MRI at the end of 2 years. (nih.gov)
  • Stem cell therapy holds immense potential in the treatment of MS due to its ability to target the root causes of the disease. (corporatewellnessmagazine.com)
  • It may not be suitable for those with primary progressive MS (PPMS) as the disease progression differs. (corporatewellnessmagazine.com)
  • Candidates often consider stem cell therapy when traditional MS treatments, such as disease-modifying drugs, have not provided sufficient relief or have caused intolerable side effects. (corporatewellnessmagazine.com)
  • PARIS - The French National Agency for Medicines and Health Products Safety (ANSM) has conditionally authorized AMX0035, a new medication aimed at slowing the progression of Charcot disease. (medscape.com)
  • Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
  • Currently, many ALF treatment strategies are aimed at simply preventing complications and decelerating disease progression. (springer.com)
  • The interplay between stem cell and tumor biology offers an exceptional opportunity to advance our knowledge about cancer, one of the leading causes of death worldwide, with potential impacts in cancer diagnosis and therapy. (hindawi.com)
  • Could stem cell therapy stabilise MS progression? (europeanpharmaceuticalreview.com)
  • Over the years, researchers and medical professionals have explored various treatment options to improve the quality of life for individuals living with MS. One promising avenue that has gained significant attention is stem cell therapy. (corporatewellnessmagazine.com)
  • In this comprehensive guide, we will delve into the world of MS and stem cell therapy, helping you determine if you are a candidate for this groundbreaking treatment. (corporatewellnessmagazine.com)
  • Before we delve into the details of stem cell therapy, let's first understand what Multiple Sclerosis is. (corporatewellnessmagazine.com)
  • Are You a Candidate for Stem Cell Therapy? (corporatewellnessmagazine.com)
  • Determining if you are a candidate for stem cell therapy requires a thorough evaluation by a medical professional specializing in MS treatment. (corporatewellnessmagazine.com)
  • Accurate diagnosis is essential to ensure that stem cell therapy is the right treatment option for you. (corporatewellnessmagazine.com)
  • Stem cell therapy is often considered for individuals with relapsing-remitting MS (RRMS) or secondary progressive MS (SPMS). (corporatewellnessmagazine.com)
  • Your willingness to undergo stem cell therapy and your understanding of the potential risks and benefits are crucial considerations. (corporatewellnessmagazine.com)
  • Stem cell therapy can 'reset' the immune system, potentially halting the autoimmune attack on myelin. (corporatewellnessmagazine.com)
  • In some cases, stem cell therapy may slow the progression of MS, reducing the frequency and severity of relapses. (corporatewellnessmagazine.com)
  • Successful stem cell therapy can reduce or eliminate the need for ongoing MS medications. (corporatewellnessmagazine.com)
  • Stem cell therapy is an intensive procedure that involves chemotherapy to prepare the body for the transplant. (corporatewellnessmagazine.com)
  • Although stem cell therapy has shown promise, its long-term effectiveness is still being studied. (corporatewellnessmagazine.com)
  • Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
  • In addition, it is also important to keep the immune modulatory properties of MSC in mind when interpreting the results of many stem cell therapy studies. (vin.com)
  • CONCLUSIONS: We conclude that Dicer is required for regulating cortical stem cell multipotency with respect to neuronal diversity, without affecting the larger scale switch from neurogenesis to gliogenesis. (ox.ac.uk)
  • For most studies, the adult stem cell in question is actually a mesenchymal stem cell or mesenchymal stromal cell. (vin.com)
  • The report advises employers to establish a healthy circle of attention, retention, and progression in STEM roles, which will work towards boosting gender diversity in the future. (stemwomen.com)
  • Employer-offered benefits and programs play a critical role in ensuring that women succeed and feel supported, particularly related to the retention of women in STEM fields. (metlife.com)
  • This is supported by the recent STEM Women whitepaper , which found that students and graduates are more likely to want to work for an organisation if they can see clear role models in senior positions. (stemwomen.com)
  • The STEM Women whitepaper found that many graduates are uncertain about their career prospects, and have a lack of confidence that they will have a successful career. (stemwomen.com)
  • The STEM Women whitepaper found that diversity focused careers events hugely impact the career path a graduate chooses to take. (stemwomen.com)
  • The mechanism by which SWCNT-exposed fibroblasts promote tumor growth was shown to involve cancer stem cell (CSC) induction, as determined by tumor sphere formation and side population assays. (cdc.gov)
  • A host of issues need to be addressed to improve two-year college mathematics and prepare more students for STEM-related careers. (ed.gov)
  • For years women have been underrepresented in STEM (science, technology, engineering and mathematics) university courses and occupations. (stemwomen.com)
  • Our program provides a challenging undergraduate progression plan solely designed to prepare mathematics and science teachers for grades 6-12. (nau.edu)
  • Eight in 10 of those are considering careers in science, technology, engineering, and mathematics (STEM), reflecting a shift in the paradigm from the "Great Resignation" to the "Great Reevaluation. (metlife.com)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
  • Conclusion: These results highlight the critical role of TET2 in the maintenance of BMSC functions and osteoblast differentiation, and provide evidence that dysregulation of epigenetic modifier in BMSCs contributes to the progression of myeloid malignancies. (ox.ac.uk)