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  • Proliferation
  • Autophagy, Apoptosis, and Cell Proliferation in Exstrophy-Epispadias Complex. (abcam.com)
  • S1P is a lipid signaling molecule that controls the movement and proliferation of many human cell types. (newswise.com)
  • Clearance duced dysregulation of cytogenesis, proliferation, and in- of senescent cells delays the induction of various geri- flammation in multiple TSCs, and discuss functional atric pathologies, supporting the concept that the similarities of microRNAs across different types of TSCs SASP promotes aging in a non-cell-autonomous in aging. (deepdyve.com)
  • For instance, Notch signaling is involved in fate determination and regulates satellite cell proliferation, and previous studies have shown that physical exercise increases the expression of Notch signaling pathway components-including ligands, Notch receptor, and downstream effectors-in myogenic cells [ 8 - 10 ]. (hindawi.com)
  • miR-133 enhances myoblast proliferation by repressing serum response factor (SRF) mIR-133 suppresses SP1 expression In rats, miR-133b is expressed in retinal dopaminergicamacrine cell, and this expression is significantly increased during early stage during retinal degeneration. (wikipedia.org)
  • It has been demonstrated that aged satellite cells express S100B, an antimyogenic protein stimulating proliferation but inhibiting differentiation . (thefreelibrary.com)
  • homeostasis
  • Our results show that, during normal prostate homeostasis, sequentially proliferating cells are detected at a rate that is consistent with a stochastic process. (jove.com)
  • Based on that observation, I became convinced that S1P signaling played an important role in muscle stability and homeostasis, not just in flies but in mammals, including humans. (newswise.com)
  • growth
  • Other markers such as DLK1/FA1, a member of the EGF-like family and c-Met, the receptor for hepatocyte growth factor showed that satellite cell heterogeneity in human muscle is far greater than previously shown. (diva-portal.org)
  • Placental Stem Villus Arterial Remodeling Associated with Reduced Hydrogen Sulfide Synthesis Contributes to Human Fetal Growth Restriction. (abcam.com)
  • The study drug is a myostatin inhibitor, and myostatin is one of the main factors that prevents muscle growth. (kennedykrieger.org)
  • How the body responds to muscular overload to elicit muscle growth is still under much scientific investigation. (ideafit.com)
  • Here's the keystone: muscle growth above baseline is expensive and noncritical to survival. (corpuscompendium.com)
  • Physical stress sets the stage for muscle growth by placing a new demand on the body, and thus a subsequent need for adaptation. (corpuscompendium.com)
  • It turns out that as far as muscle growth is concerned, it doesn't matter. (corpuscompendium.com)
  • The growth of a plant cell encompasses a complex set of subcellular components interacting in a highly coordinated fashion. (biomedsearch.com)
  • proliferate
  • Satellite cells are myogenic stem cells that can be activated from a quiescent state to proliferate for self-renewal or differentiate into myogenic cells. (diva-portal.org)
  • The study, led by Julie D. Saba, MD, PhD, senior scientist at Children's Hospital Oakland Research Institute (CHORI), shows that a lipid signaling molecule called sphingosine-1-phosphate or "S1P" can trigger an inflammatory response that stimulates the muscle stem cells to proliferate and assist in muscle repair. (newswise.com)
  • S1P, acting through S1P receptor 2, leads to activation of STAT3, resulting in changes in gene expression that cause the satellite cell to leave its "sleeping" state and start to proliferate and assist in muscle repair. (newswise.com)
  • In response to muscle damage or under increased workload these cells activate, migrate into damaged sites, proliferate, and fuse with existing myofibers or with each other to form new myofibers, whereas a small portion of these cells returns into quiescence [11, (thefreelibrary.com)
  • autologous
  • METHODS: 222 male patients with stress urinary incontinence and sphincter damage after uroloical procedures were treated with transurethral injection of autologous muscle-derived cells. (biomedsearch.com)
  • identifies
  • We show that CD11b and CD206 double IHC effectively identifies macrophages in human skeletal muscle. (bio-protocol.org)
  • Newswise - May 14, 2012 - Oakland, Calif. - A study conducted by Children's Hospital & Research Center Oakland scientists identifies how skeletal muscle stem cells respond to muscle injury and may be stimulated to improve muscle repair in Duchenne Muscular Dystrophy, a severe inherited disease of muscle that causes weakness, disability and, ultimately, heart and respiratory failure. (newswise.com)
  • intrinsic properties
  • Although environmental manipulations have shown good promise in the reversal of these conditions, recently we demonstrated that muscle stem cell aging is, in fact, a progressive process that results in persistent and irreversible changes in stem cell intrinsic properties. (fightaging.org)
  • MSCs
  • Cholesterol supplementation to MSCs increased membrane cholesterol, and resulted in decreased membrane fluidity and localization of elevated numbers of caveolae and CAV-1 to the cell membrane. (springer.com)
  • Conversely, knockdown of CAV-1 expression or cholesterol depletion on MSCs caused a parallel decrease in caveolae content and an increase in membrane fluidity due to decreased delivery of cholesterol to the cell membrane. (springer.com)
  • microenvironment
  • Macrophages are pleotropic immune cells capable of adapting to changes in the local microenvironment. (bio-protocol.org)
  • Findings from this study will contribute to the understanding of how cholesterol/CAV-1/caveolae regulates aspects of the cell membrane important to cell adhesion, substrate sensing, and microenvironment interaction. (springer.com)
  • senescent cells
  • Steve - It is probably easier just to remove the senescent cells. (fightaging.org)
  • I still suspect it will be easier to remove senescent cells/damaged mitochondria/cross links/inter&intra cellular aggregates than trying to modify potentially hundreds of downstream signaling protein and molecule changes. (fightaging.org)
  • We know that these cells exert deleterious effects just like other senescent cells: both Kirkland's earlier study in the BubR1-hypotrophic mice and the newer study in mice with irradiated hindlegs subsequently administered "senolytics" found that clearing these cells improved muscle quality and exercise performance on the treadmill test. (fightaging.org)
  • Senescent cells secrete a myriad of several types of TSCs. (deepdyve.com)