• Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
  • MDS is related to another group of conditions called myeloproliferative neoplasms (MPNs). (myleukemiateam.com)
  • The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
  • Background/ Objective: Myelofibrosis (MF) is a severe form of Myeloproliferative Neoplasms (MPNs). (bvsalud.org)
  • Response was assessed using International Working Group-Myeloproliferative Neoplasms Research and Treatment-defined response criteria, and survival endpoints were estimated using the Kaplan-Meier estimator and log-rank test. (bvsalud.org)
  • The discovery of JAK2 V617F and the demonstration that BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by abnormal JAK2 activation have led to advances in diagnostic algorithms, prognosis and ultimately also treatment strategies. (pvreporter.com)
  • JAK2 rs10974944 is associated with both V617F-positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker. (cdc.gov)
  • The differences of hemogram, myelogram, and driver gene mutations in classic myeloproliferative neoplasms. (cdc.gov)
  • Development of a Real-Time qPCR Assay for Detection of Common MPL Mutations in Myeloproliferative Neoplasms (MPNS). (cdc.gov)
  • Vascular Endothelial Dysfunction in Myeloproliferative Neoplasms and Gene Mutations. (cdc.gov)
  • Study of CALR, MPL, and c-kit Gene Mutations in Thai Patients with JAK2 V617F Negative Myeloproliferative Neoplasms. (cdc.gov)
  • The clinical relevance of broad mutational screening of myeloproliferative neoplasms at diagnosis. (cdc.gov)
  • The Clinical Impact of JAK2V617F allele burden in Philadelphia-negative Myeloproliferative Neoplasms. (cdc.gov)
  • 1990), myelodysplastic/myeloproliferative disease in 1 (Wilkinson et al. (atlasgeneticsoncology.org)
  • Myelodysplastic syndrome derives part of its name from the word "dysplastic," which refers to abnormal cell development or growth. (myleukemiateam.com)
  • PDGFRβ gene rearrangements are infrequent entities, which are mostly diagnosed in patients presenting with atypical CML, chronic myelomonocytic leukemia (CMML), myelodysplastic/myeloproliferative disorders (MDS/MPN) or juvenile myelomonocytic leukemia (JMML). (fortunejournals.com)
  • Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
  • Other types of bone marrow abnormalities, such as myeloproliferative disorder, a disease in which bone marrow cells multiply outside of the bone marrow tissue, or myelodysplastic ('preleukemia') syndromes, are the result of marrow dysfunction in either the stem cells or progenitor cell lines. (dwib.org)
  • The incidence rate of the myelodysplastic syndromes (MDS) in the United States is approximately 3.4 per 100,000 people, accounting for more than 10,000 new diagnoses annually and an estimated 60,000 people living with the disease. (jnccn.org)
  • In agnogenic and secondary myelofibrotic disorders, megakaryocytes release platelet-derived growth factors, which are fibroblastic stimulants for growth and proliferation. (medscape.com)
  • Historically, patients suffering the cited eosinophil-related syndromes were evaluated for causes of their eosinophilia such as those due to allergic disease, parasite or fungal infection, autoimmune disorders, and various well-known hematological malignancies (e.g. (wikipedia.org)
  • Myeloproliferative disorders (MPD) with eosinophilia (or chronic eosinophilic leukemia (CEL) and sporadic cases with acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia (ALL) or lymphoma. (atlasgeneticsoncology.org)
  • The chronic myeloproliferative disorders (MPDs) include the spectrum of clonal hematopoietic stem cell disorders whose phenotype derive from the primary cell expanded in a proliferative state. (elsevierpure.com)
  • Mesa, RA 2007, ' Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders ', Biologics: Targets and Therapy , vol. 1, no. 2, pp. 129-138. (elsevierpure.com)
  • Mesa, Ruben A. / Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders . (elsevierpure.com)
  • Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
  • Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
  • Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
  • Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
  • Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
  • Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. (u-tokyo-hemat.com)
  • It is related to an abnormal stem cell clone that stimulates increased myelofibrosis and damage. (medscape.com)
  • 1] PV and ET are both capable of progressing to a fibrotic stage that clinically resembles PMF, and collectively these three disease entities are termed myelofibrosis (MF). (cancernetwork.com)
  • The MPDs (which include polycythemia vera (PV), essential thrombocythemia (ET), chronic eosinophilic leukemia (CEL), primary myelofibrosis (PMF), chronic myelomono- cytic leukemia (CMML), and systemic mast cell disease (SMCD)) exclude chronic myeloid leukemia (CML) because of the pathognomic importance of the BCR-ABL translocation for the diagnosis and treatment of this disorder with imatinib mesylate. (elsevierpure.com)
  • Despite a weak effect on the cause of the disease itself in MPNs, ruxolitinib improves the clinical state of patients and increases survival in myelofibrosis. (pvreporter.com)
  • When myelofibrosis develops on its own (and not as the result of another bone marrow disease), it's called primary myelofibrosis . (radiationoncologyassociates.co)
  • Myelofibrosis can also result from a worsening of other bone marrow diseases, such as polycythemia vera and essential thrombocythemia. (radiationoncologyassociates.co)
  • Bone marrow examination typically reveals an increase in abnormal megakaryocytes (platelet-forming cells) and other abnormalities that are characteristic of myelofibrosis. (radiationoncologyassociates.co)
  • Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)
  • In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
  • Hematopoietic stem cells give rise to: 1) myeloid precursor cells that differentiate into red blood cells, mast cells, blood platelet-forming megakaryocytes, or myeloblasts, which latter cells subsequently differentiate into white blood cells viz. (wikipedia.org)
  • Megakaryocytes (MKs) are the cellular source of platelets. (elifesciences.org)
  • Finally, a ranking of proteins that may be relevant to the pathophysiology of ET will be made based on confirmatory testing in ET megakaryocytes and inhibition of their effect on cultures of CD34-derived megakaryocytes. (grantome.com)
  • The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
  • Agnogenic myeloid metaplasia is a stem cell abnormality associated with myeloproliferative diseases. (medscape.com)
  • In the Vivo, imatinib inhibits the growth of tumor of bcr-abl transfected murine myeloid cells as well as bcr-abl positive leukemia lines derived from the CML patients in the blast crisis. (theindianpharma.com)
  • Acute myeloid leukemia (AML) is a heterogeneous clonal stem cell malignancy. (fortunejournals.com)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • Secondary polycythemia Polycythemia vera A neoplastic disorder characterized by an insidious abnormal proliferation of myeloid stem cells dominated by a self-destructive expansion of red blood … The blood can also be donated to a blood bank, if the patient's blood is eligible. (haseloto.com)
  • The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
  • With regard to Gaucher disease, infiltration by cells with "onion-peel" cytoplasm, called Gaucher cells, is caused by a lipid storage disorder (ie, glucosylceramide lipidosis). (medscape.com)
  • 2011), chronic myeloproliferative disorder (MPD) in 2 (Darbyshire et al. (atlasgeneticsoncology.org)
  • Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. (nature.com)
  • A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (thermofisher.com)
  • Because this is a myeloproliferative disorder, blood from donors with polycythemia vera is not considered appropriate for donation in most countries. (haseloto.com)
  • This stem cell disorder , which is called aplastic anemia, may be treated by bone marrow transplant or immunosuppressive medications. (dwib.org)
  • Peptic ulcer disease can also be due to Helicobacter pylori infection, the incidence of which is increased in PV, while the pruritus associated with this disorder may be a consequence of mast cell activation by JAK2 V617F. (basicmedicalkey.com)
  • They develop from immature cells called stem cells and progenitor cells, which then develop into specific types of blood cells. (myleukemiateam.com)
  • In people with MDS, abnormal stem cells or progenitor cells produce blood cells that don't function correctly . (myleukemiateam.com)
  • FIP1L1-PDGFRA rearrangement has been found in a variety of cell lineages (neutrophils, monocytes, eosinophils, CD34+ cells, mast cells and even lymphoid) consistent with an origin in an hematopoietic stem cells or early progenitors progenitor (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)
  • Also known as progenitor cells, unipotential cells become committed to forming only one type of blood cell line - erythrocytes (red blood cells), leukocytes (white blood cells), or platelets. (dwib.org)
  • Although stem cells are few in number - composing no more than 3% to 5% of all cells in the marrow - they are the only cells capable of producing the progenitor cells that eventually form all of the blood elements. (dwib.org)
  • Depending on which progenitor cells cease to work, the person may develop pure red cell aplasia (lack of red blood cells), megakaryocytic aplasia (absence of platelets) or leukopenia (low white blood cell count). (dwib.org)
  • Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
  • Rearrangements in the platelet-derived growth factor receptor β (PDGFRβ) gene result in greater constitutive enzymatic activity (tyrosine kinase) and deregulation of haematopoiesis, similarly to BCR-ABL1 in chronic myeloidleukemia (CML). (fortunejournals.com)
  • The red pulp also serves as a reservoir for blood elements, especially white blood cells (WBCs) and platelets. (msdmanuals.com)
  • von Willebrand factor activity levels are influenced by driver mutation status in polycythemia vera and essential thrombocythemia patients with well-controlled platelet counts. (cdc.gov)
  • Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease. (unicatt.it)
  • Future research should clarify how to decide between JAK2 inhibitors and allogeneic hematopoietic cell transplantation, how to lower high transplant-related mortality, how to choose a stem cell source, how to create the best pretransplant treatment, and how to incorporate JAK2 inhibitors before transplantation. (bvsalud.org)
  • These findings identify emperipolesis as a new cell-in-cell interaction that enables neutrophils and potentially other cells passing through the megakaryocyte cytoplasm to modulate the production and membrane content of platelets. (elifesciences.org)
  • Platelets are formed after fragmentation of the megakaryocyte cytoplasm. (lecturio.com)
  • Neither phlebotomy nor iron deficiency increases the platelet count relative to the effect of the disease itself, and thrombocytosis is not correlated with thrombosis in PV, in contrast to the strong correlation between erythrocytosis and thrombosis in this disease. (basicmedicalkey.com)
  • Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
  • The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
  • This phenomenon occurs in otherwise unmanipulated murine marrow in vivo, resulting in circulating platelets that bear membrane from non-megakaryocytic hematopoietic donors. (elifesciences.org)
  • Emperipolesis is amplified in models of murine inflammation associated with platelet overproduction, contributing to platelet production in vitro and in vivo. (elifesciences.org)
  • Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. (phoenixpeptide.com)
  • Membrane budding is a major mechanism of in vivo platelet biogenesis. (edu.au)
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • Clinical characteristics of steroid-responsive but dependent chronic graft-versus-host disease: a multicenter retrospective analysis. (u-tokyo-hemat.com)
  • Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
  • As the disease progresses, patients may experience the following symptoms which are the result of an enlarged spleen, abnormal blood cell production, and the release of too many cytokines into the blood. (radiationoncologyassociates.co)
  • In addition, the WBC and platelet counts are also increased, which differentiates PV from erythrocytosis seen with chronic hypoxia and other chronic conditions. (lecturio.com)
  • These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise. (phoenixpeptide.com)
  • Microarray analysis showed 272 gene sequences significantly increased and 419 gene sequences decreased in ET compared with normal platelets. (grantome.com)
  • It is also not prescribed by the doctor if you have ever suffered with low blood platelets level, swelling, low white blood cells, bone marrow, pulmonary fibrosis, etc. (theindianpharma.com)
  • Stem cells within the bone marrow continuously divide to form new cells. (dwib.org)
  • Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
  • Pediatric patients with Ph+ CML in chronic phase who are newly diagnosed or whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. (theindianpharma.com)
  • Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. (nature.com)
  • The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. (nature.com)
  • PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. (nature.com)
  • The present study describes SP as a non-inflammatory disease and compares the differences between the cytokine profile in SP and PV patients. (nature.com)
  • Historically, patients with this debilitating disease have had limited treatment options, and disease-modifying agents were not available. (cancernetwork.com)
  • The majority of patients had Dynamic International Prognostic Scoring System-plus intermediate-2 or high-risk disease at the time of allo-HCT. (bvsalud.org)
  • Therefore, we aimed to determine the potential of monomeric CRP in serum as a biomarker of disease severity in COVID-19 patients (admission to intensive care unit [ICU] and/or in-hospital mortality). (bvsalud.org)
  • Patients with severe disease had higher levels of both pentameric and monomeric CRP. (bvsalud.org)
  • Using an unbiased approach and validation in MPN patients, we identified that the differential spatial expression of the chemokine CXCL4/platelet-factor-4 (PF4) marks the progression of fibrosis. (phoenixpeptide.com)
  • Here we characterized platelet-erythrocyte interactions by microscopy and flow cytometry in patients with malaria naturally infected with Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, or Plasmodium knowlesi Blood samples from 376 participants were collected from malaria-endemic areas of Papua, Indonesia, and Sabah, Malaysia. (phoenixpeptide.com)
  • Platelets were observed binding directly with and killing intraerythrocytic parasites of each of the Plasmodium species studied, particularly mature stages, and was greatest in P vivax patients. (phoenixpeptide.com)
  • These relationships, taken together with the frequency of platelet-associated parasite killing observed among the different patients and Plasmodium species, suggest that platelets may control the growth of between 5% and 60% of circulating parasites. (phoenixpeptide.com)
  • Platelet-erythrocyte complexes made up a major proportion of the total platelet pool in patients with malaria and may therefore contribute considerably to malarial thrombocytopenia. (phoenixpeptide.com)
  • Among 20 patients, four (20%) had a partial response and 14 (66.7%) had stable disease, 11 of which continued for ≥ 1 year. (e-crt.org)
  • Erythropoiesis stimulating agents are used by more than 50% of patients, although the use of disease-modifying agents is increasing, and may ultimately have an impact on the number of patients living with MDS. (jnccn.org)
  • As one would expect of a disease primarily affecting older adults, incidence rates were lowest for people younger than 40 years, at 0.14 per 100,000, and highest with increasing age, reaching a level of 36 per 100,000 for patients aged 80 years and older. (jnccn.org)
  • Of course, in patients with associated acid-peptic disease, occult gastrointestinal bleeding may lead to a presentation with hypochromic, microcytic anemia, masking the presence of PV. (basicmedicalkey.com)
  • The electroencephalographic pattern is distinctive in many but not in all patients with Creutzfeldt-Jakob disease (CJD). (annals.edu.sg)
  • To address this lack of knowledge about ET we have performed preliminary DMA microarray and proteomic analysis of the platelets from patients with ET and normal subjects and have found major differences in their expression patterns. (grantome.com)
  • Specificity of these proteins for ET will be assessed by comparison with platelets from patients with other MPD and reactive thrombocytosis. (grantome.com)
  • Dr. Tallman focuses on the molecular genetics of APL, current curative treatment strategies and approaches for patients with relapsed and refractory disease. (ashpublications.org)
  • Clinically, clonal eosinophilia resembles various types of chronic or acute leukemias, lymphomas, or myeloproliferative hematological malignancies. (wikipedia.org)
  • Importantly, patient platelet counts, infected erythrocyte-platelet complexes, and platelet-associated parasite killing correlated inversely with patient parasite loads. (phoenixpeptide.com)
  • Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation. (phoenixpeptide.com)
  • Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. (phoenixpeptide.com)
  • Intracytoplasmic neutrophils develop membrane contiguity with the demarcation membrane system, thereby transferring membrane to the megakaryocyte and to daughter platelets. (elifesciences.org)
  • Many of the clinical complications of PV relate directly to the increase in blood viscosity associated with red cell mass elevation and indirectly to the increased turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production. (basicmedicalkey.com)
  • Students should be able to identify the complications of the disease due to drugs. (edu.pk)
  • In addition we will use several novel functional proteomics approaches to study the phosphoproteins, protein kinases, and membrane proteins in ET platelets. (grantome.com)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
  • Platelets clot the blood after a blood vessel is injured. (myleukemiateam.com)
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
  • In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
  • Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. (hhs.gov)
  • Macrophages derived from blood monocytes and resident macrophages produced during embryonic development can be activated to amplify control of infection, but they can also produce substances that induce unwanted excessive inflammation. (msdmanuals.com)
  • Polycythemia vera (PV) is a disease that causes thick blood because the body makes too many red blood cells. (haseloto.com)
  • The number of blood cells produced every day is enormous: in the normal adult, production amounts to about 2.5 billion erythrocytes, 2.5 billion platelets, and 1.0 billion granulocytes (granular leukocytes) per kilogram of body weight. (dwib.org)
  • If the stem cells stop functioning because of drugs, radiation, infection, or other toxic event, they become unable to make any of the blood cells. (dwib.org)
  • The adult spleen - which holds the largest collection of blood-filtering lymphatic tissue in the body - is roughly 5 inches long and weighs about 5 to 7 ounces, but these measurements vary greatly with age, nutrition, disease status, and other factors. (dwib.org)
  • 2011 - 2018, ARC Stem Cells Australia program - blood theme. (edu.au)
  • Blood cells, molecules & diseases 2022 8 97 102698. (cdc.gov)
  • The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
  • These PF4+TUNEL+ parasites were not associated with measures of systemic platelet activation. (phoenixpeptide.com)
  • We have a growing emphasis on the application of our new knowledge to understand and target diseases including thrombocytopenia and neonatal stroke. (edu.au)
  • It is also an specific inhibitor of the receptor tyrosine kinases for the PDGF (platelet-derived growth factor) and stem cell factor (SCF), c-kit, and inhibits PDGF- and cellular events of SCF-mediated. (theindianpharma.com)
  • Veenat 400mg(Imatinib 400mg) also prevent receptor kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-kit, PDGF- and SCF-mediated cellular effects. (myapplepharma.com)
  • Significant benefits were obtained when empiric use of imatinib in CEL and CMML led to significant clinical benefit and the discovery of the role of rearrangements of the platelet derived growth factor receptor-alpha (PDGFRa-FIP1L1 in CEL and SMCD) and -beta (PDGFRb through TEL-PDGFRb) for CMML). (elsevierpure.com)
  • Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). (thermofisher.com)
  • PDGFRb is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (thermofisher.com)
  • The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. (thermofisher.com)
  • A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (lookformedical.com)
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Malignant transformation of these stem or precursor cells results in the development of various hematological malignancies. (wikipedia.org)
  • Polycythemia vera (PV) and secondary polycythemia (SP) are hematological diseases characterized by erythropoiesis exacerbation. (nature.com)
  • Genomic amplification of FLT3 has not been reported in hematological disease. (hindawi.com)
  • Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner. (costalab.org)
  • Programs also support the development of novel cell-based therapies to bring the expertise of transfusion medicine and stem cell technology to the repair and regeneration of human tissues and organs. (hhs.gov)
  • This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel drugs into the pipeline of clinical trials that target pathogenetic mechanisms of the disease. (ashpublications.org)
  • Once activated, platelets have two major mechanisms to recruit additional platelets to the growing hemostatic plug. (medscape.com)
  • Our results show the potential of mCRP levels as a marker of clinical severity in COVID-19 disease. (bvsalud.org)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
  • Therapeutic phlebotomy may be indicated for hemochromatosis, polycythemia vera, porphyria cutanea tarda, and polycythemia secondary to arterio-venous fistulae, cyanotic congenital heart disease or cor pulmonale. (aetna.com)
  • Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)