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Paired Box Transcription FactorsPAX2 Transcription FactorPAX7 Transcription FactorTranscription FactorsHomeodomain ProteinsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticStem CellsSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsRepressor ProteinsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerGene Expression Regulation, DevelopmentalNuclear ProteinsProtein BindingCell LineTranscription Factor AP-1Forkhead Transcription FactorsSignal TransductionAmino Acid SequenceCell DifferentiationDNAMutationBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2Cells, CulturedPAX9 Transcription FactorTransfectionCell NucleusKruppel-Like Transcription FactorsGenes, ReporterChromatin ImmunoprecipitationTranscription Factors, TFIIReverse Transcriptase Polymerase Chain ReactionHeLa CellsSTAT3 Transcription FactorYY1 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDGene Expression ProfilingNFATC Transcription FactorsActivating Transcription Factor 3Transcription Initiation SiteElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticZinc FingersNF-kappa BSp3 Transcription FactorHematopoietic Stem CellsActivating Transcription Factor 2Gene ExpressionRegulatory Sequences, Nucleic AcidTranscription Factor TFIIBCloning, MolecularRecombinant Fusion ProteinsE2F1 Transcription FactorRNA Polymerase IIPlasmidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsGATA3 Transcription FactorMicrophthalmia-Associated Transcription FactorGATA2 Transcription FactorGATA1 Transcription FactorTCF Transcription FactorsCell LineagePlant StemsCell Line, TumorProtein Structure, TertiaryModels, BiologicalLuciferasesGene Expression Regulation, FungalGATA Transcription FactorsB-Cell-Specific Activator ProteinMice, TransgenicOligonucleotide Array Sequence AnalysisEye ProteinsPhenotypeMice, KnockoutSTAT1 Transcription FactorActivating Transcription FactorsChromatinMice, Inbred C57BLPhosphorylationHelix-Loop-Helix MotifsTranscription Factor RelABlotting, WesternSequence Homology, Amino AcidGene Expression Regulation, PlantE2F Transcription FactorsCell ProliferationSaccharomyces cerevisiaeProto-Oncogene Proteins
ProteinMyogenic differentiationDifferentiationProteinsSkeletalDownregulateGenesRegenerationSelf-renewalSOX2CytokinesBFGFSpinal cordFibroblastSatellite cellsEmbryoPathwayExpressionGeneticMolecularDemonstrateReceptorDevelopmentFunctionsImportantRoleGrowth factorSupportPublications
Protein4
  • The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • The basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family and is a key protein in regenerative medicine. (biomedcentral.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • To further define which neurons express Eph, antibodies were generated to the cytoplasmic portion of the Eph protein. (sdbonline.org)
Myogenic differentiation2
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
  • Their fate is regulated by the expression of various transcription factors, including paired box 7 (Pax7) and myogenic differentiation (MyoD) [ 6 ]. (biomedcentral.com)
Differentiation5
  • CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
  • Afterwards, we have comparatively evaluated the hematopoietic and erythroid as well as neural differentiation potential of human cord blood and neural stem cell derived iPS cells (Hargus et al. (ruhr-uni-bochum.de)
  • Patient-derived induced pluripotent stem cells and their differentiation derivatives hold great promise as novel in vitro model systems to study human pathogenesis. (ruhr-uni-bochum.de)
  • Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. (jefferson.edu)
  • Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. (jefferson.edu)
Proteins2
  • Drouin's team now plan to investigate Pax7 in more detail and identify the proteins that interact with it to open up compacted parts of the genome, which Drouin says could lead to the development of therapeutic targets. (blogspot.com)
  • Cytokines are a family of cell signaling proteins that include Chemokines, Interleukins, Tumor Necrosis Factors (TNFs), Transforming Growth Factors (TGFs), Inter ferons, and Colony Stimulating Factors (CSFs). (pharna.com)
Skeletal1
  • There are a number of factors that initiate myofiber remodeling in adult skeletal muscles. (arvojournals.org)
Downregulate1
Genes4
  • For transcription factors to be able to perform this function, they need access to the necessary genes at the right time. (blogspot.com)
  • The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. (nature.com)
  • In the cell, T3 binds to a nuclear receptor, resulting in transcription of specific thyroid hormone response genes. (pharmaceuticalintelligence.com)
  • Maternal THs acted upstream of pax2a, pax7 and pax8 genes but downstream of shha and fgf8a signalling. (pharmaceuticalintelligence.com)
Regeneration2
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
Self-renewal1
  • Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. (nih.gov)
SOX22
  • Somatic cells can be reprogrammed to a pluripotent embryonic stem cell-like state (induced pluripotent stem (iPS) cells) by combinations of the transcription factors OCT4, SOX2, NANOG, LIN28, KLF4 and cMYC (Takahashi et al. (ruhr-uni-bochum.de)
  • We were able to demonstrate, that mouse and human neural stem cells which express SOX2, KLF4 and cMYC, can be reprogrammed to iPS cells by retroviral expression of OCT4 (Kim, Zaehres et al. (ruhr-uni-bochum.de)
Cytokines2
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • Apart from their protective functions, keratinocytes express adhesion molecules and cytokines, further suggesting an implication in skin innate immunity, tissue homeostasis, wound healing, cancer development, and skin-based gene-therapy. (3hbiomedical.com)
BFGF1
  • Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. (biomedcentral.com)
Spinal cord1
  • Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. (biologists.com)
Fibroblast2
  • For SHH to be expressed in the developing embryo limbs, a morphogen called fibroblast growth factors must be secreted from the apical ectodermal ridge. (wikipedia.org)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
Satellite cells1
  • Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. (nih.gov)
Embryo1
  • In the embryo, zygotic transcription of Eph is confined to the nervous system. (sdbonline.org)
Pathway1
  • The sonic hedgehog transcription pathway has also been linked to the formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor and medulloblastoma, as well as the progression of prostate cancer tumours. (wikipedia.org)
Expression2
  • By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Genetic1
  • Transcription factors help this genetic information be copied into RNA at various stages throughout a person's development, including the production of new cells. (blogspot.com)
Molecular1
  • We are further developing our iSTEM (Molecular and Developmental Stem Cell Biology) master program since its inception in 2010 by incorporating state-of-the-art topics of stem cell research in the teaching modules. (ruhr-uni-bochum.de)
Demonstrate2
  • The team focused on the Pax7 molecule and were able to demonstrate the crucial role it performs. (blogspot.com)
  • We demonstrate that transgenic AAVR overexpression greatly increases the efficiency of transduction of many diverse cell types, including muscle stem cells, which are normally refractory to AAV transduction. (nature.com)
Receptor2
  • Finally, the Tumor Necrosis Factor Receptor Family include immune checkpoint molecules such as CD27, tumor markers such as CD30, and co-stimulatory molecules such as CD40. (pharna.com)
  • Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
Development1
  • A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. (jefferson.edu)
Functions1
  • This enables stem cells to differentiate into specialized cells with different properties and functions. (blogspot.com)
Important1
  • The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
Role1
  • Using the NM-ALM we discovered that non-neural extrinsic factors from differently sized host animals do not play a prominent role in determining the size of the regenerating limb. (edu.au)
Growth factor1
Support1
  • We at Dry Ice Express are ready to support the government roll out of the vaccine and are capable of supplying dry ice pellets on demand to local and national customers. (dryiceexpress.co.uk)
Publications2
  • This graph shows the total number of publications written about "PAX6 Transcription Factor" by people in this website by year, and whether "PAX6 Transcription Factor" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "PAX6 Transcription Factor" by people in Profiles. (jefferson.edu)