• At first, the mesenchymal stem cell was thought to be the primary component of this undifferentiated cell type, however it is now evident that within the adipose extracellular matrix are also adipocytic precursors (known as progenitor cells) adherent to adipocytes, and in close approximation to a variety of additional undifferentiated multipotent and pluripotent cells, including pericytes and endothelial cells, all thought to play important roles in mesenchymal-stromal derived tissue regeneration. (journalofprolotherapy.com)
  • Therefore we have chosen to use the term "adipose-derived stem/stromal cells" (AD-SC's), rather than simply "mesenchymal stem cells. (journalofprolotherapy.com)
  • Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair that age during organismal aging. (encyclopedia.pub)
  • Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. (ca.gov)
  • Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. (ca.gov)
  • Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
  • Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
  • The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
  • pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • The adult alae are commonly used as an indicator of hypodermal seam cell terminal differentiation. (wormatlas.org)
  • In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
  • The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
  • Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
  • The models use isolated primary support cells cultured onto a biological scaffold and within a microfluidic system to create a niche and support the desired differentiation of epithelia, germ and somatic cells from patient-derived induced pluripotent stem cells. (biomedcentral.com)
  • These cells possess both differentiation plasticity (stemness) and tissue supportive functions (stromalness) that can coexist and overlap, with differences depending on tissue source, donor characteristics, culture conditions and delivery strategies, leading to alternative best fittings for the term "stem" or "stromal" [ 7 ] . (encyclopedia.pub)
  • Homeostatic epidermal stem cell self-renewal is driven by local differentiation. (ucsf.edu)
  • In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
  • DHH/PTC1 signaling triggers differentiation of Leydig cells by up-regulating Steroidogenic Factor 1 and expression of cytochrome P450 Side-Chain Cleavage enzyme located outside testicular cord [ 145 ]. (regenmedres-journal.org)
  • In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
  • and the unique differentiation of haploid cells (spermiogenesis) (Figure 1 ). (jci.org)
  • Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
  • 1, 2 Recently, Prolotherapists have begun to utilize the potential of autologous adipose (fat)-derived stem/stromal cells (AD-SC) within non-manipulated fat graft scaffolding, combined with high-density PRP concentrates (HD-PRP) to provide a potent biological therapeutic combination. (journalofprolotherapy.com)
  • These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
  • While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
  • Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, neuronal transmission and the signal transduction pathways that integrate them. (sfu.ca)
  • On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. (biomedcentral.com)
  • Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
  • A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)
  • This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
  • You will find Cell biology by ujuzi past question PDF which can be downloaded for FREE on this page. (carlesto.com)
  • Cell biology by ujuzi is useful when preparing for BIO111 course exams. (carlesto.com)
  • Directed cell migration is one of the earliest observations in cell biology, dating back to the late XIX century. (ibecbarcelona.eu)
  • Molecular Biology of the Cell , 7th edition. (sfu.ca)
  • Nature Cell Biology 20, 979-989. (ucsf.edu)
  • Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. (ca.gov)
  • Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
  • Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
  • Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)
  • The remaining follicular cells develop into a corpus luteum that produces E and progesterone (P). In turn, P promotes more proliferation within the uterus and vagina, and cornification in the vagina. (biomedcentral.com)
  • The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
  • In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
  • Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
  • Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. (ca.gov)
  • Collectively, these studies demonstrate that the rate of endothelial cell proliferation is highest during corpus luteum formation, then decreases and remains low during the mid-luteal phase and structural regression of the corpus luteum. (biomedcentral.com)
  • The regulation of endothelial cell proliferation in the corpus luteum of pregnancy is less clear. (biomedcentral.com)
  • Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)
  • Similar to normal tissue stem cells, cancer stem cells (CSCs) are thought to be quiescent or slow-cycling and, thereby, insensitive to chemo- and radiotherapies. (elsevierpure.com)
  • One explanation for deficient repair is when undifferentiated adult stem repair cells are inadequate in number or cannot be stimulated within the damaged tissue site. (journalofprolotherapy.com)
  • With improved understanding of tissue healing and regeneration, stem cell Prolotherapy is gaining significant clinical importance and potential. (journalofprolotherapy.com)
  • Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
  • This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
  • An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
  • To study cell and tissue dynamics we develop new technologies to measure physical forces at the cell-cell and cell-matrix interface. (ibecbarcelona.eu)
  • By combining these technologies with computational analysis of cell shape and velocity we obtain a full experimental characterization of epithelial dynamics during tissue growth, wound healing and cancer cell invasion. (ibecbarcelona.eu)
  • Surprisingly, some cells in the tissue barely stretch, while others become 'superstretched', increasing their area more than ten times. (ibecbarcelona.eu)
  • During aging of the organism, MSCs also age, and this implies an impairment of stem cell functions contributing to the progressive decrease in tissue maintenance and repair, a characteristic of the aging process. (encyclopedia.pub)
  • Due to the low abundance of MSCs in human adult tissues (about 1/10 6 cells in adult bone marrow and 1/10 3-4 cells in adipose tissue and umbilical cord) [ 16 ] , frequently ex-vivo expansion precedes therapeutic administration, to obtain a clinically relevant number of cells. (encyclopedia.pub)
  • Our work demonstrates that genetic deletion of endothelial cell (EC)-specific EPH receptor A4 (EphA4) using conditional EphA4f/f/Tie2-Cre and EphA4f/f/VE-Cadherin-CreERT2 knockout (KO) mice promotes blood-brain barrier (BBB) integrity and tissue protection, which correlates with improved motor function and cerebral blood flow recovery following controlled cortical impact (CCI) injury. (bvsalud.org)
  • To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. (biomedcentral.com)
  • Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
  • Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)
  • The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)
  • In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
  • The central nervous system is composed of large numbers of excitable nerve cells and their processes, called neurons, which are supported by specialized tissue called neuroglia. (medscape.com)
  • Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. (ucsf.edu)
  • DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. (ca.gov)
  • Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. (wikipedia.org)
  • Recognition of the vast number of undifferentiated cells associated with the stromal vascular fraction has resulted in extensive research demonstrating the heterogeneity of such cells, and their ability to participate in production of all mesodermal-derived tissues. (journalofprolotherapy.com)
  • When the turned on progenitor small percentage of DDC-treated tissues was likened with the dormant progenitor small percentage of neglected livers (Supplemental Desk S i90004), it was noticed that the turned on progenitor small percentage features higher phrase of cell cycle-associated genetics and lower phrase of zinc ring finger domain-containing genetics. (baxkyardgardener.com)
  • Illustrations of immunohistochemistry-visualized 372196-77-5 manufacture YFP phrase in neglected tissues 14 chemical after recombinase account activation are proven in Body 5, A and T. Little quantities of proclaimed peri-portal duct and hepatocytes cells had been discovered, suggesting that or that Cre recombinase activity was unfinished. (baxkyardgardener.com)
  • We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. (ibecbarcelona.eu)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • The adhesions between cultured cells and the material surface are called focal attachments or adhesion plaques. (omicsonline.org)
  • Gap junction adhesion is necessary for radial migration in the neocortex. (ca.gov)
  • and platelet/endothelial cell adhesion molecule-1, PECAM-1). (biomedcentral.com)
  • Guz Y, Nasir I, Teitelman G. Regeneration of pancreatic b-cells from intra-islet precursor cells in an experimental model of diabetes. (ejournals.ca)
  • The dysfunction of oligodendrocyte lineage cells is hallmarked by deficiencies in myelination and impaired self-renewal of oligodendrocyte precursor cells (OPCs). (bvsalud.org)
  • However, FOXC2-producing uSPGs were also capable of self-renewal, forming cells which feature genetic markers associated with SSCs. (elifesciences.org)
  • Depletion of SMC5/6 sensitizes male germ cells to DNA damage. (nih.gov)
  • Transplantation experiments have revealed that most cells which can perform the hallmark feature of SSCs (that is, re-establishing full spermatogenesis in testes lacking germ cells) are found within the single uSPG population, but may also be present among paired and aligned progenitors ( Kubota and Brinster, 2018 ). (elifesciences.org)
  • transplanted a population of uSPGs enriched in these cells into the testes of mice treated with busulfan, a toxic compound that kills endogenous germ cells. (elifesciences.org)
  • When a single uSPG divides, it can sometimes produce paired daughter cells that remain connected after mitosis. (elifesciences.org)
  • C ) Expansion of both the undifferentiated (A spermatogonia) and differentiated (A1 spermatogonia) spermatogonial populations occurs by mitosis of these cell types, regulated in part by FSH. (jci.org)
  • Endothelial cells are important regulators of the cerebrovascular response to TBI. (bvsalud.org)
  • Gap junctions: multifaceted regulators of embryonic cortical development. (ca.gov)
  • Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. (ca.gov)
  • MSCs represent a lifelong reservoir for the generation of somatic cells and for cell replacement. (encyclopedia.pub)
  • Mol Biol Cell, 2018 Dec 1. (nih.gov)
  • More specifically, the lineage-tracing experiments showed that FOXC2-producing uSPGs could produce paired uSPGs that would then either divide to form two single uSPGs (including some that retained Foxc2 expression), or form chains of aligned uSPGs containing at most one FOXC2-producing cell ( Figure 1A ). (elifesciences.org)
  • Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. (ca.gov)
  • Another system of nomenclature divides gap junction proteins into two categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. (wikipedia.org)
  • this protein) are called beta-1 and beta-2 gap junction proteins, respectively. (wikipedia.org)
  • Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
  • The uterotubal junction of the fallopian tube widens to allow the passage of the ovulated oocyte or fertilized embryo. (biomedcentral.com)
  • In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
  • Intra-endodermal interactions are required for pancreatic beta cell induction. (ca.gov)
  • We aimed to investigate the laser acupuncture at BL20 point in type 1 diabetes mellitus in stimulating pancreatic beta cell. (ejournals.ca)
  • Rats in L2 showed a significant decrease in FBG level, a significant increase pancreatic beta cell and Langerhans area.41 patients undergo hysteroscopy procedure dan endometrial biopsy. (ejournals.ca)
  • This finding indicated that laser acupuncture at BL20 point could reduce FBG level, increase pancreatic beta cell and wider Langerhans area in type 1 diabetes mellitus. (ejournals.ca)
  • history, demonstrates that it is certainly feasible to derive hepatocytes in vivo after transplantation of progenitor cells. (baxkyardgardener.com)
  • phrase, turned on in response to liver organ damage, marks progenitor cells that provide rise to both hepatocytes and cholangiocytes in vivo (Sackett et al. (baxkyardgardener.com)
  • Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. (biomedcentral.com)
  • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. (ca.gov)
  • Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. (wikipedia.org)
  • The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
  • Furthermore, each expanded CD44 + gland in gastric tumor of K19-Wnt1/C2mE mouse contains a few BrdU label-retaining quiescent or slow-cycling cells, suggesting that the CD44 + SCJ cells in normal mouse are candidates for the cell-of-origin of gastric CSCs. (elsevierpure.com)
  • New evidence in mice suggests that cells expressing the transcription factor FOXC2 may form a reservoir of quiescent stem cells that contributes to sperm formation. (elifesciences.org)
  • The first step was for the team to follow the fate of these cells for six weeks following transplantation. (elifesciences.org)
  • Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. (ca.gov)
  • Innate immune cells play a decisive role in host fate by enabling high bacterial loads and minimizing the immunological impact of this burden in the gastric mucosa. (nimml.org)
  • Organoids from many organs have now been obtained from embryonic stem cells, induced pluripotent stem cells and organ progenitors. (ibecbarcelona.eu)
  • Here, we use human induced pluripotent stem cells (hiPSCs) derived from controls and subjects with 16p11.2 deletion and 16p11.2 duplication to understand the underlying mechanisms regulating brain overgrowth. (bvsalud.org)
  • Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)
  • Geometrical confinement controls the asymmetric patterning of brachyury in cultures of pluripotent cells. (ucsf.edu)
  • CD44, a cell surface component that interacts with the extracellular matrix, has been found to be highly expressed in CSCs of several solid tumors. (elsevierpure.com)
  • Both cell-derived microstructures and extracellular matrix components play critical roles in the preorganization and oriented deposition of calcium phosphate and serve as passive supports in dentine and enamel. (researchsquare.com)
  • Furthermore, Cx26 over-expression is suggested to promote cancer development by facilitating cell migration and invasion and by stimulating the self-perpetuation ability of cancer stem cells. (wikipedia.org)
  • Also known as taxis, directed cell migration has been commonly associated with chemotaxis, i.e. the ability of a broad variety of cell types to migrate following gradients of chemical factors. (ibecbarcelona.eu)
  • This new migration mode emerges only in cell collectives and, strikingly, does not require isolated cells to exhibit gradient sensing. (ibecbarcelona.eu)
  • Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)
  • Seam cells are linked to the hypodermis by small adherens junctions along their apical borders and by small gap junctions on their lateral membranes ( SeamFIG 2 ).In a newly hatched animal, there are ten seam cells on each side of the animal (H1-H2, V1-V6 and T). All seam cells, except for H0, divide in a stem-cell-like pattern before each molt. (wormatlas.org)
  • The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. (biomedcentral.com)
  • The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)
  • Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of eosinophils and macrophages. (biomedcentral.com)
  • A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain. (ucsf.edu)
  • Babatz, F., Naffin, E., and Klämbt, C. The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate Junctions. (ucsf.edu)
  • The long processes of a nerve cell are called axons or nerve fibers. (medscape.com)
  • Focal attachments have 10-15 nm distance between the cell membrane and the material surface and they are tight connections. (omicsonline.org)
  • Among these candidates can be apical membrane antigen 1 (AMA-1) (8, 15, 20, 25, 31, 37), which can be indicated in the past due schizont stage from the asexual existence cycle from the parasite (31). (sipurpashut.net)
  • Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy . (wikipedia.org)
  • Cancer cell invasion and metastasis remain the leading cause of death in patients with cancer. (ibecbarcelona.eu)
  • The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)
  • Although people from the Apicomplexa infect different cell and sponsor types, they have identical sponsor cell invasion procedures. (sipurpashut.net)
  • Even though the natural function of AMA-1 can be unfamiliar, the subcellular localization, stage-specific manifestation, and secretion during sponsor cell invasion claim that it is involved with merozoite invasion. (sipurpashut.net)
  • MSH6 Furthermore, unaggressive transfer of rabbit AMA-1 antibodies shielded mice against disease (1), and antibodies against (24) and AMA-1 (23) had been proven to inhibit reddish colored bloodstream cell invasion. (sipurpashut.net)
  • For metabolic labeling, a tradition (8 to 10% parasitemia) was centrifuged (2,000 in vitro cell invasion. (sipurpashut.net)
  • The4 cell invasion treatment was performed as referred to previously (12), with minor adjustments. (sipurpashut.net)
  • We focus on the interaction between epithelial cancer cells and Cancer Associated Fibroblasts (CAFs), the most abundant cell type in the tumour stroma. (ibecbarcelona.eu)
  • The molecular identification of adult hepatic stem/progenitor cells has been hampered by the lack of truly specific markers. (baxkyardgardener.com)
  • Although most of a eukaryotic cell's DNA is contained in the cell nucleus , the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes. (wikipedia.org)
  • [20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)
  • The purpose of this study was to investigate the expression pattern of Mage-D1 in rat tooth germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. (researchsquare.com)
  • Gap junction beta-2 protein (GJB2), also known as connexin 26 (Cx26) - is a protein that in humans is encoded by the GJB2 gene. (wikipedia.org)
  • This nomenclature emphasizes that GJB1 and GJB2 are more homologous to each other than either of them is to gap junction protein, alpha GJA1. (wikipedia.org)
  • Among the top ten genes preferentially enriched in these cells, Foxc2 was the only one to code for a protein exclusively present in the nucleus of uSPGs that also expressed ZBTB16, a protein important for SSCs to self-renew. (elifesciences.org)
  • We have developed optogenetic tools based on controlling the activity of endogenous RhoA to upregulate or downregulate cell contractility and to control cell shape and mechanotransduction. (ibecbarcelona.eu)
  • Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (ca.gov)
  • The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)
  • T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
  • Lectures are given by Department of Genetics, Cell- and Immunobiology (DGCI) in Békési Lecture Hall (EOK Building, Tűzoltó utca 37-47 Budapest) at Thursday, 815 - 900. (semmelweis.hu)
  • The system reaches homeostasis, with a depolarized core (proliferative cells) surrounded by a rim of polarized cells (non-proliferative in this condition). (nature.com)
  • In the mature brain cortex, OPCs are the major proliferative cells (comprising ~5% of total brain cells) and control new myelin formation in a neural activity-dependent manner. (bvsalud.org)
  • This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
  • In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. (biomedcentral.com)
  • Regulatory T cells (Tregs) play a pivotal role in this context. (biomedcentral.com)
  • 7 There has been some variation and question regarding the correct terminology for this population of stromal adipose cells. (journalofprolotherapy.com)
  • In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
  • These cells are also sometimes referred to as lateral hypodermal cells, because they share some functions with the major hypodermis, including secreting cuticle and generating the contractile force during elongation of the embryo. (wormatlas.org)
  • Sokullu E, Dağcı T, Gözen O, Ersoy F, Öztarhan A (2017) The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal Stem Cells' Functions. (omicsonline.org)
  • One of our main lines of research is to study how tumours exploit the functions of non-cancer cells in their microenvironment to invade and metastasize. (ibecbarcelona.eu)
  • This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
  • This function of the cutaneous system is mediated by a myriad of highly specialized immune cells. (biomedcentral.com)
  • In interaction with other non-immune cells, such immune cell subsets ensure the functionality and integrity of the skin layers [ 1 ]. (biomedcentral.com)
  • Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e ., other vascular cells, steroidogenic cells, and immune cells. (biomedcentral.com)