Stem cells in tumors. Medical search. Frequent questions

The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with nanotechnology to serve as Trojan horses for the treatment of cancer. (mayo.edu)
Dr. Quinones-Hinojosa's lab is evaluating the efficacy of a gel for administering human fat-derived mesenchymal stem cells within the brain cancer resection cavity during surgery. (mayo.edu)
Keywords: biliary tract tumor stem TCS PIM-1 1 cells exosomes gene appearance RNA genes paracrine signalling Bone tissue marrow-derived mesenchymal stem cells (MSCs) certainly are a potential way to obtain tissue replacement for TCS PIM-1 1 their regenerative capability and multipotent capacity. (sciencepop.org)
Multipotent mesenchymal stem cells (MSCs) are recruited into tumor microenvironment in response to multiple signals produced by cancer cells. (cnr.it)
I am especially interested in the role of mesenchymal stem cells (MSCs) in this process. (essex.ac.uk)
Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability. (bvsalud.org)
It has been demonstrated that gastric cancer mesenchymal stem cells (GC-MSCs) can promote the progression, metastasis , and chemoresistance of GC through various mechanisms, but the effect of GC-MSCs on GC during chemotherapy is still unknown. (bvsalud.org)
Lynch ME , Chiou AE, Lee MJ, Polamraju P, Marcott SC, Lee Y, Fischbach C. "3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals. (lynchlab.org)
[ 9 ] They may be derived from mesenchymal stem cells. (medscape.com)

The lab is creating models to better understand cancer migration and progression, to study invasive cell populations, and to uncover novel therapeutic targets to impact tumor progression. (mayo.edu)
It has become clear that cancer stem cells - cells within tumors that exhibit stem cell characteristics and can differentiate into other specialized types of cancer cells - have a role in the progression and treatment resistance of several types of tumors, most prominently blood system tumors like leukemia. (technologynetworks.com)
This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). (whiterose.ac.uk)
Furthermore, there is an absence of a cellular hierarchy in cell lines and all cells in culture are able to drive tumor progression. (whiterose.ac.uk)
GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
A contribution of interactions between MSCs within tumour stroma and malignancy cells to tumour progression and metastases has been recognized (7-9). (sciencepop.org)
Although this stromal desmoplastic reaction has long been recognized as a hallmark histological feature the contribution of the mesenchymal compartment and desmoplastic stroma to tumour formation and progression has only recently been recognized. (sciencepop.org)
The development of novel therapeutic approaches targeting the different functions of MSCs in promoting tumor progression as well as the mechanisms underlying their activities could enhance the efficacy of conventional and immune anti-cancer therapies. (cnr.it)
Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)
While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. (emedicalbooks.com)

Investigators are starting to realize that tumor proliferation and tumor migration are two different things and should be treated as such," said Chang, the George Hoyt Whipple Distinguished Professor of Pathology, Urology, and Radiation Oncology at the University of Rochester and Wilmot Cancer Institute. (rochester.edu)
In the malignant tumor, deregulation of telomerase is thought to facilitate tumorigenesis and cellular immortality by providing cancer cells unlimited proliferation capacity. (nih.gov)
In the somatic tissues, the stem cells expressed telomerase-associated RNA, but no proliferation activity. (nih.gov)
When the proliferation activity of the stem cells increased, however, the telomerase-associated expressions decreased. (nih.gov)
In the malignant tumors, both proliferation activity and expression of the telomerase-associated RNA significantly increased. (nih.gov)
The authors then observed that only a subset of cancer stem cells in each patient was showing signs of proliferation, while all other cancer cells were not. (technologynetworks.com)
To conclude tumour cell-derived EVs can donate to the era of tumour stroma through fibroblastic differentiation of MSCs and will also selectively modulate the mobile discharge of soluble elements such as for example IL-6 by MSCs that may subsequently alter tumour cell proliferation. (sciencepop.org)
Tumour cells can connect to other cellular components within the neighborhood microenvironment by cell-cell connections and paracrine systems through the creation and discharge of a number of development elements chemokines and matrix-degrading enzymes that may improve the proliferation and invasion of tumour (21). (sciencepop.org)
Once a tissue sample is received, it is enzymatically digested, directly embedded into a 3D environment, and fed with growth factor and Wnt ligand-rich media that stimulates cancer cell proliferation and organoid formation. (corning.com)
Furthermore, the conditioned medium of GC-MSCs pretreated with chemotherapeutic drugs was more effective in promoting the proliferation, migration, and stemness of GC cell lines than the conditioned medium of GC-MSCs without chemotherapeutic drugs treatment . (bvsalud.org)
Our in vitro studies determined specific particle type- and cell type-dependent NP-induced cell proliferation, anchorage-independent growth, apoptosis evasion, and increased cell migration and invasion. (cdc.gov)
These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and survival. (medlineplus.gov)
As a result, the proteins and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells and leads to the formation of tumors. (medlineplus.gov)

So, the body cannot resist the uncontrollable cancerous growths because those genes are already made by mutated Cancer Stem Cells. (sdgln.com)
Because stem cells haven't differentiated into specialized cells, they can easily activate genes to turn on new developmental programs that allow the cells to survive cancer treatments," said Gutmann, who directs the Washington University Neurofibromatosis Center. (medicalxpress.com)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells - one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation. (technologynetworks.com)
In the August 15 issue of Genes & Development, a Massachusetts General Hospital (MGH) research team describes finding that the protein called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. (vetscite.org)
Furthermore, many studies report the use of MSCs engineered to express different genes or as vehicle to specifically deliver novel drugs to tumors exploiting their strong tropism. (cnr.it)
Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5+ stem cells. (knaw.nl)
The KIT and PDGFRA genes provide instructions for making receptor proteins that are found in the cell membrane of certain cell types. (medlineplus.gov)

Dr. Quinones-Hinojosa's lab has research platforms on novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, and models of brain and spine cancers, and maintains a human tissue bank. (mayo.edu)
Researchers in the Brain Tumor Stem Cell Research Lab are investigating the oncostatic effects of melatonin on glioblastoma to improve treatment and provide better quality of life for patients. (mayo.edu)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned. (technologynetworks.com)
Brain tumor-initiating cells (BTICs), self-renewing multi-potent cells critical for tumor maintenance and growth, are attractive targets of glioblastoma therapy. (cns.org)
In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)
In vitro and in vivo testing of purified BTIC subsets were performed to verify multipotency, self-renewal, and capacity to generate glioblastoma tumors in murine cranial xenotransplantation models. (cns.org)
Two distinct subsets of BTICs were identified co-existing in human glioblastoma, both in de novo tumors and in recurrent tumors after initial complete surgical resection and chemoradiation. (cns.org)
Both BTIC subtypes were validated in vitro and in vivo as demonstrating multi-potency, self-renewal, and capacity to generate glioblastoma tumors in murine xenotransplants. (cns.org)
Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
This is the first demonstration of cancer stem cell heterogeneity in glioblastoma at the single-cell level, and particularly as it relates to prospective isolation and bulk tumor subtypes. (cns.org)
Understanding glioblastoma at the genetic, molecular level Glioblastoma is the most common and most lethal form of brain tumor in. (neurosciencenews.com)

Improved understanding of the underlying cancer biology of this subpopulation of cancer stem cells, thought to drive tumor formation and therapeutic resistance, could potentially lead to improved targeted therapies that prolong patient survival. (cns.org)
Understanding the efforts of MSCs to tumour biology is certainly worth focusing on because they could result in brand-new therapeutic or precautionary paradigms. (sciencepop.org)
Cell type-specific partially methylated domains and differentially methylated domains found in normal cells persist in malignant cells, researchers from Cedars-Sinai Medical Center in Los Angeles and elsewhere report in Genome Biology . (genomeweb.com)
Limited availability of in vitro and in vivo model systems has hampered efforts to understand tumor biology and test novel therapies for ependymoma, the third most common malignant brain tumor that occurs in children. (nih.gov)
This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. (emedicalbooks.com)
It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)

Most of these patients developed symptoms such as pain, swelling, or chills within a few days of receiving the stem cell products. (cdc.gov)
What are the symptoms of brain tumors? (childrenshospital.org)
Each child may experience symptoms of a brain tumor differently, and symptoms vary depending on the size and location of the tumor - both in the brain and elsewhere in the central nervous system. (childrenshospital.org)
Signs and symptoms of extragonadal germ cell tumors include breathing problems and chest pain. (vicc.org)
Malignant extragonadal germ cell tumors may cause signs and symptoms as they grow into nearby areas. (vicc.org)
Clinical signs and symptoms depend on the location of the tumor. (wikipedia.org)
What are the early symptoms of a brain tumor? (medicalnewstoday.com)
Brain tumors can cause physical and mental symptoms, including headaches and mood changes. (medicalnewstoday.com)
The symptoms can differ depending on the type, location, and stage of the tumor. (medicalnewstoday.com)
This article looks at various symptoms of brain tumors, symptoms linked to different types and locations of tumor, and risk factors of each. (medicalnewstoday.com)
Brain tumor symptoms are similar regardless of whether they are cancerous (malignant) or noncancerous (benign). (medicalnewstoday.com)
In the sections below, we look at several types of brain tumors and their specific symptoms. (medicalnewstoday.com)
These tumors can secrete pituitary hormones and cause additional symptoms. (medicalnewstoday.com)
Small tumors may cause no signs or symptoms. (medlineplus.gov)
People with a family history of GISTs (called familial GISTs) often have multiple tumors and additional signs or symptoms, including noncancerous overgrowth (hyperplasia) of other cells in the gastrointestinal tract and patches of dark skin on various areas of the body. (medlineplus.gov)

Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. (medscape.com)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)
Although childhood brain tumors can be benign (non-cancerous) or malignant (cancerous), both types can be life-threatening. (childrenshospital.org)
Extragonadal germ cell tumors can be benign (noncancer) or malignant ( cancer ). (vicc.org)
Benign extragonadal germ cell tumors are called benign teratomas . (vicc.org)
A craniopharyngioma is a benign tumor that develops close to the pituitary gland. (medicalnewstoday.com)
Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)
Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Most of these tumors are benign teratomas in the sacrum or coccyx. (cigna.com)

In the context of brain tumor initiating cells (BTICs), PDX models allow for characterization of tumor formation, growth, and recurrence, in a clinically relevant in vivo system. (mcmaster.ca)

One review estimated 52% in the posterior fossa, 39% are supratentorial primitive neuroectodermal tumors (sPNET), 5% are in the pineal, 2% are spinal, and 2% are multifocal. (wikipedia.org)

Projects in the Brain Tumor Stem Cell Research Lab investigate the effect of ion transporters in brain tumor cell migration and the molecular engines that drive tumor invasion. (mayo.edu)

Inside the tumour microenvironment MSCs can differentiate into myofibroblasts cancer-associated fibroblasts fibrocytes or pericytes and thus represent a potential way to obtain tumour stroma and desmoplasia (4-6). (sciencepop.org)
A crucial role for cancer-associated fibroblasts and activated macrophages in these cancers is emerging (17 18 20 Despite this recent interest the cellular origins and mechanistic contribution of tumour stroma to tumour growth TCS PIM-1 1 remain poorly comprehended. (sciencepop.org)
Moreover, tumor associated-MSCs trans-differentiating into cancer-associated fibroblasts can induce epithelial-mesenchymal-transition program in tumor cells. (cnr.it)
Furthermore, by developing a fibroblast stem cells (FSC)-enriched fibroblast focus model to mimic in vivo fibrogenic response, we demonstrated a dose-dependent increase in fibroblast focus formation and collagen production by primary lung fibroblasts treated with multi-walled carbon nanotube s (MWCNTs). (cdc.gov)

A recent study by cancer researcher Chawnshang Chang, Ph.D. , provides additional proof of a concept he's been investigating for years: that the environment surrounding a prostate tumor plays a major role in metastasis, and new treatments should be designed to target that environment as well as the tumor itself. (rochester.edu)
Published by the International Journal of Oncology , Chang's laboratory found that bone marrow derived stem cells, which are recruited to the site of a growing tumor, are able to convert nearby normal fibroblast cells into cancer cells, resulting in tumor metastasis. (rochester.edu)
The latest paper suggests the microenvironment-the neighborhood of cells surrounding the tumor-is where stem cells can be recruited through altered cytokine-AR signals to boost prostate cancer metastasis. (rochester.edu)
Interestingly, Chang said, his laboratory also discovered that although androgen deprivation therapy shrinks tumors, it also might inadvertently promote cell metastasis due to altered cell signaling in the region of the tumor. (rochester.edu)
RT @MetastasisRS *TOMORROW* Do not miss our next FREE ECLC-organized webinar by @JulianeScience from Medical University of Vienna on tumor heterogeneity and #metastasis ! (sunrise-network.fr)
My research is focused on cellular crosstalk in the tumour microenvironment leading to metastasis formation. (essex.ac.uk)
The MCLA-158 antibody shows a potent growth inhibition of colorectal cancer organoids, blocks the initiation of metastasis, as well as cancer growth in different preclinical models, such as tumors of the head and neck, esophagus and stomach. (inuouja.com)
The possibility of disease-free survival increases after resection of primary tumor and isolated metastasis excision. (medscape.com)
The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)

The most common brain tumor in children with NF1 is the optic glioma. (medicalxpress.com)
We have used patient-derived, typically resistant, glioma stem-like cells (GSCs) in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DDRi. (nature.com)

Trying to understand as much as we can about genetic versus non-genetic determinants of tumor organization is key to our understanding of tumor propagation and to the design of new therapies. (technologynetworks.com)
Some clinics may falsely advertise that it is not necessary for FDA to review and approve their stem cell therapies. (cdc.gov)
Brain tumors are commonly treated with surgery and/or other therapies including chemotherapy and radiation . (childrenshospital.org)
Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)

Results: We demonstrate that expression of ALDH, CD44, and CD133 does not select for a subpopulation of stem-like cells in either UM cell lines or UM STCs. (whiterose.ac.uk)
The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
The "cancer stem cell" hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). (emedicalbooks.com)

Individuals with an SDH-deficient GIST have a high risk of developing other types of tumors, particularly noncancerous tumors in the nervous system called paragangliomas and noncancerous lung tumors called pulmonary chondromas. (medlineplus.gov)

Hence malignant cells can "educate" MSCs to induce regional microenvironmental adjustments that enhance tumour cell development. (sciencepop.org)

Gliomas also can be named according to the type of glial cells involved or the location of the tumor. (childrenshospital.org)

At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)

Cancer Stem Cells are a type of stem cell that is mutated at various stages and can cause cancerous growth. (sdgln.com)
As we discussed, Cancer Stem Cells are too dangerous, and treating them could be the only solution for removing cancerous growth from your body completely. (sdgln.com)
These Cancer Stem Cells can cause spreading cancers because ordinary cancer treatments only eliminate the traces of Cancer growth, not the cause behind it. (sdgln.com)
The remaining Cancer Stem Cell can generate cancer again even if the complete growth is removed due to the capacity of cell generation like usual stem cells. (sdgln.com)
Treatment for NF1-related optic gliomas often includes drugs that inhibit a cell growth pathway originally identified by Gutmann. (medicalxpress.com)
The Brain Tumor Stem Cell Research Lab studies genetic controls and mediators of tumor growth, invasion, and migration to understand how tumors move into the healthy brain. (mayo.edu)
A study analyzing brain tumor genomics on a single-cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow-growing but incurable form of brain cancer. (technologynetworks.com)
Our work strongly supports that cancer stem cells are the main source of growth in these tumors and, as such, should be considered promising targets for treatment," says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper. (technologynetworks.com)
but if that growth is blocked or those cells are damaged, a population of less-differentiated progenitor cells will start to expand. (vetscite.org)
MSCs may contribute to tumour propagation or dissemination by preventing recognition of the tumour cells by the immune system or by promoting tumour cell invasiveness (10 11 However MSCs could also suppress tumour growth (12-15). (sciencepop.org)
If your child is diagnosed with a brain tumor, you will learn there are many different brain tumor types and classifications based upon the tumor's cell structure, composition, rate of growth, location, and other characteristics. (childrenshospital.org)
Molecules involved in their homing to tumors are the same inflammatory mediators produced by injured tissues: chemokines, cytokines and growth factors. (cnr.it)
When asked how this impacts his work, Tiriac explained: 'We know that, for many cancers, the environment is what stimulates the growth of cells. (corning.com)
A stem cell vital for vertebral growth also drives spine metastases, and the use of MDMA in the treatment of PTSD. (nature.com)
Some of these proteins move to the cell membrane and serve as channels for water and nutrients, creating favourable conditions for bacterial growth beside plant cells. (nature.com)
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. (knaw.nl)
In vitro, growth of organoids derived from these adenomas is arrested when Wnt secretion is inhibited, indicating a dependence of the adenoma stem cells on Wnt produced by adenoma Paneth cells. (knaw.nl)
Under the trade name of Petosemtamab, the MCLA-158 antibody blocks the appearance of metastases (that is, the spread of cancer to other vital organs) and slows the growth of primary tumors in experimental models of cancer. (inuouja.com)
EGFR activity promotes uncontrolled cell growth, while LGR5 marks the surface of cancer stem cells, which are responsible for tumor expansion. (inuouja.com)
In this way, it blocks growth and survival pathways in cells that start and spread cancer. (inuouja.com)
He was wobbly from his tumor growth and puffy from steroids. (cdc.gov)
Through their efforts, we are gaining a better understanding of cancer formation and developing diagnostic tools for early detection, while also exploring ways to prevent tumor growth and much more. (lu.se)

Further, these malignant cells have more immunity and the capacity to form tumors in the future will still be there. (sdgln.com)
First author Yi-Hsien Chen, PhD, a senior postdoctoral research associate in Gutmann's laboratory, used a mouse model of neurofibromatosis type 1 (NF1) low-grade brain tumors to identify cancer stem cells and demonstrate that they could form tumors when transplanted into normal, cancer-free mice. (medicalxpress.com)
In this form, tumors are almost always in the stomach. (medlineplus.gov)

At least four cases of spinal tumors have now been reported following experimental nasal stem cell transplants for paralysis. (ipscell.com)
The article starts with "At least four cases of spinal tumors have now been reported…", but I could only find two documented cases. (ipscell.com)

This type of tumor creates pressure on the pituitary gland and optic tract, which is an extension of the optic nerve . (medicalnewstoday.com)
A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. (medlineplus.gov)
This type of tumor is thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. (medlineplus.gov)
rarely, children and young adults develop this type of tumor. (medlineplus.gov)

Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma. (technologynetworks.com)
Last, we show that established UM cell lines and UM STCs are plastic in nature and switch their phenotype in response to environmental stimuli. (whiterose.ac.uk)
This process determinates a more aggressive phenotype of cancer cells by increasing their motility and invasiveness and favoring their dissemination to distant sites. (cnr.it)
Tumors characterized as positive for the CD44+/CD24- phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S) isoform, which lacks all variant exons. (lu.se)

We found that mutation of the NF2 tumor suppressor gene in the mouse liver led to a dramatic overproliferation of liver stem cells - the cells that contribute to the liver's remarkable ability to regenerate," says Andrea McClatchey, PhD, of the MGH Center for Cancer Research, who led the study. (vetscite.org)
Previous research also indicated that liver stem cells may be the source of some tumors in animals, and suggested that the tumor suppressor gene NF2 may help prevent tumor development. (vetscite.org)
The chromosome 22 area contains the hSNF5/INI1 gene that appears to function as a classic tumor suppressor gene. (wikipedia.org)
AT/RT is the first pediatric brain tumor for which a candidate tumor suppressor gene has been identified. (wikipedia.org)

Brain tumor stem cells (orange) in mice express a stem cell marker (green). (medicalxpress.com)
Although the mice the researchers studied were bred to model NF1 optic gliomas, the researchers said the findings could be applied more broadly to other brain tumors . (medicalxpress.com)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
In this model, 6 to 8 week old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) immunocompromised mice receive the thy/liv implant as in the SCID-hu mouse model only to be followed by a second human hematopoietic stem cell transplant (4). (ca.gov)
These mice go on to develop the two forms of liver cancer that are most common in humans, suggesting that liver stem cells may be the cells of origin of these tumors. (vetscite.org)
The researchers found that infant mice lacking functioning NF2 in their livers developed dramatic overgrowth of liver stem cells, to the point of crowding out hepatocytes. (vetscite.org)
Mice that did not die from a lack of functioning liver cells soon developed the two major types of liver cancer, and the fact that stem cell overgrowth preceded tumor development strongly suggested that the undifferentiated progenitors were the source of the tumors. (vetscite.org)
Blocking the expression of NF2 in the livers of adult mice had minimal effect on the animals unless a portion of the liver was surgically removed, setting off the regeneration process and leading to the same stem cell overproliferation and tumor development. (vetscite.org)
All five mice receiving the initial transplantation of the patient tumor developed intracerebral xenografts, which have since been serially subtransplanted in vivo in mouse brains for 4 generations and can be cryopreserved for long-term maintenance of tumorigenicity. (nih.gov)
The permanent cell line (BXD-1425EPN), which was derived from a passage II xenograft tumor and has been passaged in vitro more than 70 times, expressed similar differentiation markers of the xenograft tumors, maintained identical chromosomal abnormalities, and formed tumors in the brains of SCID mice. (nih.gov)
Scientists showed in mice that disabling a gene linked to a common pediatric tumor disorder, neurofibromatosis type 1 (NF1), made stem cells from one part of the brain proliferate rapidly. (neurosciencenews.com)

They analyzed the whole-genome bisulfite sequencing profiles of 45 esophageal tumors, representing both the squamous cell carcinoma and adenocarcinoma subtypes, and matched nonmalignant tissue. (genomeweb.com)
This clinical trial investigates the safety, tolerability, and antitumor activity of MCLA-158 monotherapy in head and neck squamous cell carcinomas (HNSCC). (inuouja.com)

Researchers found that if a gene called Apc is lost or damaged, then its normal function of controlling the adult stem cell population breaks down and ultimately leads to a tumor. (genengnews.com)
The researchers working on PromoCell can bring many differences and potential changes to treat cancers and remove Cancer Stem Cells. (sdgln.com)
Researchers at Washington University School of Medicine in St. Louis are studying how cancer stem cells make tumors harder to kill and are looking for ways to eradicate these treatment-resistant cells. (medicalxpress.com)
By comparing healthy stem cells with stem cells from these brain tumors, the researchers discovered the reasons behind treatment resistance, pointing to new therapeutic strategies. (medicalxpress.com)
To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single-cell level, gene expression in samples from six early-stage human tumors. (technologynetworks.com)
Using a sequence-aware multi-model PMD caller they developed, dubbed MMSeekR, the researchers uncovered a high level of heterogeneity at the methylation level and in the distribution of PMDs across tumor samples. (genomeweb.com)
Meanwhile, at the DMR level, the researchers found more than 10,000 hypo-DMRs between the two esophageal cancer types and also note that many of the methylation changes there were also present in normal cells. (genomeweb.com)
To our knowledge, this is the first demonstration of the prominent cell-type specificity of PMDs across normal, precursor, and malignant states," the researchers write. (genomeweb.com)
Researchers have created a living 3-D model of a brain tumor and its surrounding blood vessels. (neurosciencenews.com)
Researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital have identified several gene mutations responsible for the most common childhood brain tumor, called medulloblastoma, adding evidence to the theory that the diagnosis is a group of genetically distinct cancers with different prognoses. (neurosciencenews.com)
It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology. (emedicalbooks.com)
At Lund Stem Cell Center, researchers are using innovative approaches to advance the field, offering exciting possibilities for the future. (lu.se)

The paper entitled "Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft" is from authors Claire F. Woodworth , Gregory Jenkins , Jane Barron and Nanette Hache. (ipscell.com)
Both family physicians and specialists may need to counsel patients on stem cell transplantation or diagnose complications in those who have had these procedures. (ipscell.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

Incorporating organoids in the earliest phases of drug generation (in this case, therapeutic antibodies) makes it possible to identify those that are effective for most patients or even for tumors carrying a particular mutation. (inuouja.com)
Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)

Around 17% of all pediatric cancers involve the CNS, making these cancers the most common childhood solid tumor. (wikipedia.org)
This cell line and model will facilitate the biological studies and preclinical drug screenings for pediatric ependymomas. (nih.gov)

Importantly, these three developmental signatures were found in distinct genetic clones - cells with identical patterns of genetic mutations - of tumor cells. (technologynetworks.com)
However, as scientists continue to learn more about the specific genetic mutations that occur in childhood brain tumors, they are starting to develop targeted treatments (precision medicine) that can be used in brain tumor treatment. (childrenshospital.org)
Scientists have discovered genetic mutations in brain tumors that alter brain tumor metabolism. (neurosciencenews.com)

GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)

An alternative solution mechanism where tumour cells can connect to the neighborhood microenvironment consists of inter-cellular communication relating to the discharge of extracellular vesicles (EVs) such as for example exosomes (22). (sciencepop.org)
When MSCs arrive into the tumor microenvironment these are "educated" to have pro-metastatic behaviour. (cnr.it)

Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties. (medicalxpress.com)
Dr. Quinones-Hinojosa's lab is studying how the NKCC1 protein maneuvers the cell during migration and using findings to develop new molecular targets for targeted cancer therapy. (mayo.edu)
Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
Through use of a library of close to 70 patient-derived organoids, Tiriac has demonstrated that organoids reflect the molecular details of the tumor from which they were derived. (corning.com)
Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. (lu.se)
Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

We have generated a modified version of this model in which we use genetically modified human hematopoietic stem cells (hHSC) to construct the thy/liv implant followed by injection of transduced autologous hHSC (7, 9). (ca.gov)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)

This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. (dkfz.de)

Telomerase, an enzyme associated with cellular immortality, is expressed by malignant tumor and stem cells, especially germ cells. (nih.gov)
Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)

The genetic mutation happening to the stem cells pushes them to generate cells in unwanted places and organs of the body. (sdgln.com)
The mutation happening around Cancer Stem Cells is the main reason behind the generation of Cancer Stem Cells. (sdgln.com)
A mutation or deletion in the INI1/hSNF5 gene occurs in the majority of AT/RT tumors. (wikipedia.org)
Additionally, evidence also exists for a genetic predisposition to desmoid tumors in FAP, independent of the APC mutation. (medscape.com)
[ 11 ] Desmoid tumors show biallelic APC mutation, with one change usually occurring distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)

Meningioma, the most common primary brain tumor in the United States, accounts for about 33 percent of all primary brain. (neurosciencenews.com)

Dr. Quinones-Hinojosa's lab is studying ways to engineer human fat cells to turn them into cancer-fighting Trojan horses and evaluating a gel to locally administer to patients during brain cancer surgery. (mayo.edu)
The finding that both BTIC subsets were present in reproducible proportions across patients, and from both de novo and recurrent tumors, suggest these subpopulations are not differentially affected by current clinical interventions. (cns.org)
do a nice job of putting this tumor in context of previous reports of similar tumors in other patients who also have nasal stem cell transplants. (ipscell.com)
Given the vulnerability of patients who are chronically ill, especially those with spinal cord injury or neurologic disorders who may be targets of Internet-based marketing for stem cell therapy), physicians in Canada should be aware of the rationale behind stem cell therapy as well as the reported adverse events. (ipscell.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
While all medical treatments have benefits and risks, unapproved stem cell and exosome products expose patients to potential risks without a clear benefit. (cdc.gov)
Patients who have had stem cell or exosome therapy should discuss any concerns and abnormal reactions with their healthcare provider. (cdc.gov)
CDC is investigating bacterial infections in patients who have received stem cell products from the ReGen Series® (distributed by Liveyon, LLC). (cdc.gov)
HDCT with stem-cell support has been also explored as a part of first-line strategy for poor-prognosis patients. (unipv.it)
Tumor shrinkage was seen in all seven patients. (inuouja.com)
Desmoid tumors occur at a rate of 10-15% in patients with FAP, an autosomal inherited disease caused by germline mutations in the APC gene. (medscape.com)
However, unknown genetic factors independent of APC may be important in the susceptibility to desmoid tumors in patients with FAP. (medscape.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)

Dr. Eduard Batlle's laboratory is recognized worldwide for its work in the identification and characterization of colorectal cancer stem cells, and has led research not only in the development of MCLA-158/Petosemtamab, but also in the characterization of its mechanism of action. (inuouja.com)

Until now, stem cells had been identified only in aggressive, fast-growing tumors. (medicalxpress.com)
Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
Gastric cancer (GC) is one of the most aggressive tumors and has a poor prognosis . (bvsalud.org)
Desmoid tumors often appear as infiltrative, usually well-differentiated, firm overgrowths of fibrous tissue, and they are locally aggressive. (medscape.com)

Whill risks of tumor formation come along even with standard bone marrow and whole organ transplants (both extremely low), there's a lot more data in those contexts to understand these tiny risks. (ipscell.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)

Thus while MSCs may interact with tumour cells the consequences of these interactions and impact on tumour behaviour warrant definition and likely depend on other factors. (sciencepop.org)
In addition, MSCs are involved in the formation and modelling of pre-metastatic niches creating a supportive environment for colonization of circulating tumor cells. (cnr.it)
Co-Treatment of Prostate Cancer Cells with Mscs Expressing Trail and Iap Inhibitors Reduce Trail Resistance and Production of Trail-Induced Cytokines. (essex.ac.uk)
Our results showed that GC-MSCs were resistant to 5-FU and Taxol at the IC50 concentration for GC cells , and 5-FU could promote the migration of GC-MSCs at low doses. (bvsalud.org)
Correspondingly, the inhibition of p-AKT reversed the tumor -promoting effect of the conditioned medium of GC-MSCs pretreated with chemotherapeutic drugs . (bvsalud.org)
Taken together, our data demonstrated that GC-MSCs gained more tumor -promoting abilities during chemotherapy . (bvsalud.org)

At the same time, Cancer Stem Cells are invigilated with the help of the Primary Cancer Cultural System and it preserved the Cancer Stem Cells for further studies of what's happening around them to support the generation of cancerous cells. (sdgln.com)
Using nanoparticles and alternating magnetic fields, University of Georgia scientists have found that head and neck cancerous tumor cells in. (neurosciencenews.com)

Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)

The team manipulated intestinal stem cells and mimiced the process by which a part of the intestine called the crypts is regenerated following high levels of DNA damage or injury. (genengnews.com)

Becoming a member of the SUNRiSE Network is being part of an active network made up of students, scientists and clinicians with a common interest for the cancer stem cell field in solid tumors. (sunrise-network.fr)
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. (lu.se)
The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. (lu.se)

This course and the tendency for recurrence make the treatment of these relatively rare fibrous tumors challenging. (medscape.com)

Based on these new findings, we will have to develop additional strategies to keep these tumors from evading our best treatments. (medicalxpress.com)
Currently, the only stem cell treatments approved by the Food and Drug Administration (FDA) are products that treat certain cancers and disorders of the blood and immune system. (cdc.gov)
If you are considering stem cell treatments, check to make sure the product you are considering is on the FDA's approved list of stem cell treatments external icon . (cdc.gov)
These 3D models are used to study how cells interact with each other within an organ, to gain insight into how disease processes disrupt these interactions, as well as to test the impacts of potential treatments. (corning.com)
We hope that this new method will foster a culture of proactive health management and shift the paradigm towards preventive care, in addition to paving the way for more effective treatments," says Sandra Linstedt, research group leader at Lund Stem Cell Center. (lu.se)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)

Maybe you know about stem cells, the capacity of generating new cells and organs, and even treating cancers like Leukemia. (sdgln.com)
The oncogenes can attack these cells and that could be a hazardous situation to completely treat cancers. (sdgln.com)
Malignant tumors contain stem cells, prompting worries among medical experts that the cells' transformative powers help cancers escape treatment. (medicalxpress.com)
Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. (emedicalbooks.com)

Between 10 and 20 percent of brain tumors that occur within the first year of life are choroid plexus tumors. (childrenshospital.org)
Although usually a brain tumor, AT/RT can occur anywhere in the central nervous system (CNS), including the spinal cord. (wikipedia.org)
Since many of the tumors occur in the posterior fossa, they present like other posterior fossa tumors, often with headache, vomiting, lethargy, and ataxia (unsteady gait). (wikipedia.org)
Most rhabdoid tumors have INI1 deletions whether they occur in the CNS, kidney, or elsewhere. (wikipedia.org)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
[ 4 ] . Implant-associated breast desmoid tumors may occur. (medscape.com)

Methods: Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. (whiterose.ac.uk)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
Partial or radical nephrectomy may be used, depending on tumor and patient characteristics. (medscape.com)

Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

These tumours are characterized by tumour cells closely intertwined with a dense fibrous stroma (16-19). (sciencepop.org)
In particular the TCS PIM-1 1 source of tumour stroma and the nature of the connections between tumour cells and stroma are unidentified. (sciencepop.org)
Hence our aims had been to examine the consequences of tumour cell-MSC connections regarding EVs and their contribution to tumour stroma development and tumour development. (sciencepop.org)

2021). The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells . (essex.ac.uk)

Organoids are patient-derived samples that can be cultured and reproduce certain aspects of the tumor compartment in the laboratory. (inuouja.com)

Anatomy38

Organisms13

Diseases46

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care6

Mesenchymal stem9

Progression10

Proliferation13

Genes8

Glioblastoma14

Biology6

Symptoms15

Benign11

Brain tumor initi1

Primitive neuroectodermal tumors1

Drive tumor1

Fibroblasts4

Metastasis9

Glioma2

Therapies4

Subpopulation3

Types of tumors1

Enhance tumour1

Location of the tumor1

20231

Growth22

Form tumors3

Spinal tumors2

Type of tumor4

Phenotype4

Suppressor gene4

Mice12

Squamous2

Researchers12

Transplantation5

Therapeutic3

Pediatric2

Genetic mutations3

Responsible for tumor1

Microenvironment2

Molecular8

Hematopoietic2

Neural1

Germ cells2

Mutation5

Meningioma1

Patients16

Colorectal Cancer Stem1

Aggressive4

Bone marrow2

MSCs6

Cancerous2

Surgical resection1

Intestinal stem cells1

Cancer Stem3

Recurrence1

Treatments5

Malignancy1

Cancers4

Occur7

Methods2

Characteristics2

Differentiation1

Stroma3

20211

Compartment1