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Adipose TissueStem CellsAdipose Tissue, BrownAdipose Tissue, WhiteStem Cell TransplantationHematopoietic Stem CellsEmbryonic Stem CellsAdult Stem CellsSubcutaneous FatAdipocytesPluripotent Stem CellsCell DifferentiationHematopoietic Stem Cell TransplantationStem Cell NicheObesityNeural Stem CellsInduced Pluripotent Stem CellsIntra-Abdominal FatLipolysisMultipotent Stem CellsMesenchymal Stem Cell TransplantationMesenchymal Stromal CellsAdipogenesisStem Cell FactorMice, Inbred C57BLInsulin ResistanceLeptinInsulinSubcutaneous Fat, AbdominalCells, Cultured3T3-L1 CellsThermogenesisCell LineageMice, ObeseRNA, MessengerFatty AcidsLipid MetabolismStem Cell ResearchAdipokinesOmentumAdipocytes, WhiteBody WeightPlant StemsGene Expression RegulationAdiponectinLipoprotein LipaseFetal Stem CellsCell ProliferationDietary FatsDiet, High-FatAdiposityFatty Acids, NonesterifiedTriglyceridesLiverReverse Transcriptase Polymerase Chain ReactionAdipocytes, BrownGlycerolHematopoietic Stem Cell MobilizationMitochondrial ProteinsBone Marrow CellsGlucoseBody CompositionGene ExpressionSignal TransductionEnergy MetabolismPanniculitisNeoplastic Stem CellsMuscle, SkeletalPPAR gammaMice, KnockoutCell SeparationCell Culture TechniquesRegenerationEpididymisBlood GlucoseVisceraInflammationCold TemperatureFlow CytometryMice, TransgenicAbdomenRegenerative MedicineLipidsOctamer Transcription Factor-3Abdominal FatLipid MobilizationGene Expression ProfilingLipogenesisBiological MarkersTime FactorsBody Fat DistributionTransplantation, AutologousTranscription FactorsSubcutaneous TissueSterol EsterasePhenotypeAntigens, CD34Body Temperature RegulationHematopoiesisTissue Engineering
MSCsSubcutaneous adipose tissueDifferentiationRegenerationStromal vascular fractionRegenerative medicineProgenitor cellsTherapeuticAdipocytesADSCsScaffoldsPlacentaWhite adiposAdipocyteCanineAutologous adiposeVitroTecido adiposoVascularEmbryonicTherapyMicroenvironmentXeno-freeAngiogenesisTransplantationProliferationIliac crestEndothelialPreclinical and clinical studiesExosomesLineagesHematopoieticTherapiesMesenchymal stromal cellsBone marrow-derivedCharacteristicsHumansAdult tissuesFractionMethodsStoring stem cells derivedViabilityConnectiveIsolationASCsInduceHuman boneAdiponectinChondrocytesClinical applicationsMarkersCollagenase
MSCs46
  • Seeding of bone implants with mesenchymal stem cells (MSCs) may promote osseointegration and bone regeneration. (nih.gov)
  • Here we demonstrate that a branched poly[Lys(Ser(i)-DL-Ala(m))] polymer functionalized with cyclic arginyl-glycyl-aspartate, when immobilized by simple adsorption to tissue culture plastic, surgical titanium alloy (Ti6Al4V), or Bio-Oss(®) bovine bone substitute, significantly accelerates serum-free adhesion and enhances seeding efficiency of human adipose tissue-derived MSCs. (nih.gov)
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Compared with mesenchymal stem cells (MSCs) derived from other tissues such as umbilical cord and bone marrow, isolation of ASCs from human white adipose tissue (WAT) has great advantages due to its rich tissue source and simple surgical procedure. (edu.au)
  • MSCs can also be harvested from damaged tissues in contact with vascular and connective tissues, blood, and skeletal muscle. (pulmonologyadvisor.com)
  • However, the results indicate that bone marrow -derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet -like clusters. (bvsalud.org)
  • Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. (biomedcentral.com)
  • However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
  • The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
  • Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
  • Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
  • However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
  • There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
  • Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
  • Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)
  • 2013): Ultrastructural characteristics of sheep and horse mesenchymal stem cells (MSCs). (ankara.edu.tr)
  • 2013): Mesenchymal stem cells (Mscs) in scanning electron microscopy (SEM) world. (ankara.edu.tr)
  • Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. (ui.ac.id)
  • This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. (ui.ac.id)
  • Mean confluence period of adipose MSCs post- irradiation was 4.33 days. (ui.ac.id)
  • Confocal and transmission electron microscopy demonstrate that mono-SMBGs are internalized by human bone marrow (MSCs) and adipose-derived stem cells (ADSCs) and located within cell vesicles and in the cytoplasm. (ox.ac.uk)
  • Mesenchymal stem cells (MSCs) have been considered promising tools for new clinical concepts in supporting cellular therapy and regenerative medicine. (cellmolbiol.org)
  • In this study we compared MSCs derived from three different sources (iliac crest bone marrow (ICBM), adipose tissue (AT), and (RIA)) regarding the morphology, the success rate of isolating MSCs, colony frequency, expansion potential, osteogenic and chondrogenic differentiation capacity. (cellmolbiol.org)
  • MSCs were isolated from three different sources and flow cytometric analyses were performed for cell characterization. (cellmolbiol.org)
  • A comparison of the colonogenic ability in different tissues by CFU-F assay after 10 days showed that more colonies are formed from RIA-MSCs than from ICBM-MSCs, and AT-MSCs. (cellmolbiol.org)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Based on cell source, the stem cell therapy market is segmented into adipose tissue-derived MSCs (mesenchymal stem cells), placental/umbilical cord-derived MSCs, bone marrow-derived MSCs, and other sources. (marketsandmarkets.com)
  • In 2021, the adipose tissue-derived stem cells segment dominated stem cell therapy with the highest revenue share, which was attributed to the growing adoption of these MSCs across different therapeutic indications. (marketsandmarkets.com)
  • Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
  • Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
  • Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
  • Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
  • In recent years, one of the main research strategies used to induce angiogenesis in vivo has been via stem cell therapy, especially therapy using mesenchymal stem cells (MSCs). (minervamedica.it)
  • Therefore, this study aimed to investigate the effects of hypoxia-preconditioned MSCs from human adipose tissue-derived MSCs (AT-MSCs) and from human umbilical cord-derived MSCs (UC-MSCs). (minervamedica.it)
  • METHODS: Both AT-MSCs and UC-MSCs were obtained from an established cell bank and expanded in vitro . (minervamedica.it)
  • The concentrations of growth factors (such as HGF, bFGF, and VEGF) in the cell culture supernatants collected from culture media of the hypoxia-preconditioned AT-MSCs and UC-MSCs (as well as those from AT-MSCs and UC-MSCs cultured in normoxia) were measured by ELISA. (minervamedica.it)
  • Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
  • MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
  • Mesenchymal stem cells (MSCs) have the ability to modulate the immune system and are multipotent, which allow these adult stem cells to be valuable therapeutic candidates. (irvinesci.com)
  • Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
  • Scientists in South Korea transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy. (genengnews.com)
  • The benefit of using MSCs in stem cell therapy is their ability to self-renew and differentiate into a variety of specialized cell types, such as osteoblasts, chondrocytes, adipocytes, myocardiocytes, and neuron-like cells. (genengnews.com)
  • Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. (lu.se)
  • Human integrin α10β1-selected adipose tissue-derived MSCs (integrin α10β1-MSCs) have shown immunomodulatory and regenerative effects in various disease models. (lu.se)
  • We hypothesized that integrin α10β1 selected-MSCs can be used to treat a sepsis-induced ARDS in a porcine model when administering cells after established injury rather than simultaneously. (lu.se)
  • 6 cells/kg integrin α10β1-selected MSCs and both groups were followed for 12 h. (lu.se)
Subcutaneous adipose tissue4
Differentiation17
  • The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency . (bvsalud.org)
  • 2014): Limbal Stem Cells in dogs and cats their identification culture and differentiation into keratinocytes. (ankara.edu.tr)
  • 2001): Thiazolidinediones and glucocorticoids induce differentiation of human adipose tissue stromal cells: Biochemical, cellular, and molecular analysis. (ankara.edu.tr)
  • 2010): Coculture of equine mesenchymal stem cells and mature equine articular chondrocytes results in improved chondrogenic differentiation of the stem cells. (ankara.edu.tr)
  • 2002): Myogenic differentiation by human processed lipoaspirate cells. (ankara.edu.tr)
  • 2002): Neurogenic differentiation of murine and human adipose- derived stromal cells. (ankara.edu.tr)
  • Cell viability and differentiation capacity toward the mesenchymal lineages were assessed, along with immunophenotype. (biomedcentral.com)
  • Differentiation potential cell therapy stem cells regenerative medicine orthopedic tissue engineering. (cellmolbiol.org)
  • The results showed that the glass transition temperature modulated the mechanical properties of the scaffolds, affecting stem cell proliferation and adipogenic differentiation. (kth.se)
  • Based on printability and cell-scaffolds interaction results, poly (L-lactide-co-trimethylene carbonate) was used to print 3D scaffolds in different soft and pliable designs that promoted adipogenic differentiation. (kth.se)
  • The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
  • Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
  • Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
  • Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
  • Adipose mass can be controlled by inhibition of HPAd differentiation and increase of lypolysis. (cellapplications.com)
  • 13 verified that stromal cells (CD 34+) derived from the adipose tissue has the potential of osteogenic differentiation both in vitro and in vivo, being considered as a promising cellular therapy for the healing of bone defects. (bvsalud.org)
  • A fraction of ADIPOSE TISSUE prepared to enrich in STEM CELLS with the capacity for multi-lineage differentiation. (bvsalud.org)
Regeneration8
  • This knowledge can be used to engineer 3D scaffolds with adequate physio-chemical and mechanical properties along with an appropriate design that augments adipose tissue regeneration. (kth.se)
  • These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
  • Decellularized adipose tissue scaffolds for soft tissue regeneration a" by Pascal Morissette Martin, Arthi Shridhar et al. (uwo.ca)
  • Bach, E.A. JAK/STAT signaling in stem cells and regeneration: From drosophila to vertebrates. (benthamscience.com)
  • The adipose tissue is an important reservoir of adult stem cells which have capacity of differentiating in osteoblasts with potential implication in reaching bone regeneration. (bvsalud.org)
  • Despite of the great potential of repair by bone tissue, in some situations, according to the proportion of defects, the regeneration cannot be complete because the defect can be invaded by the surrounding conjunctive tissue which has a proliferation and cellular migration speed faster than those of bone tissue. (bvsalud.org)
  • Tissue bioengineering is a new branch of Science aiming to investigate and integrate techniques of tissue regeneration thorugh new biomaterials including natural markers (growth factors) and tissue and cellular components (mesenchymal stem cells). (bvsalud.org)
  • It is used in various applications for its tissue regeneration and immunomodulation activities. (bvsalud.org)
Stromal vascular fraction3
  • The stromal vascular fraction from abdominal adipose tissue was subcultured for ten passages to enrich for and expand the number of ADSCs. (vinastemcelllab.com)
  • Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
  • The pellet is the stromal vascular fraction containing endothelial cells, immune cells, blood cells and progenitor cells. (jove.com)
Regenerative medicine5
Progenitor cells4
  • The use of mesenchymal stem cells or progenitor cells has been advocated for treatment of many musculoskeletal diseases in the equine. (ivis.org)
  • Bone marrow and adipose tissue have emerged as excellent sources of progenitor cells. (ivis.org)
  • The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
  • Adipose progenitor cells vary according to their anatomical location. (jove.com)
Therapeutic14
  • Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. (bvsalud.org)
  • Mesenchymal stem cells: immunology and therapeutic benefits. (ui.ac.id)
  • 2011. http://www.intechopen.com/books/stem-cells-in-clinic-and-research/mesenchymal-stem-cells-immunology-and-therapeutic-benefits . (ui.ac.id)
  • Spherical monodispersed bioactive particles are potential candidates for nanocomposite synthesis or as injectable particles that could be internalized by cells for the local sustained delivery of inorganic therapeutic ions (e.g., calcium or strontium). (ox.ac.uk)
  • Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
  • The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Stem cell research funding has strengthened in the past few years, attributed to the need for novel therapeutic interventions in patients with cardiovascular, neurological, and autoimmune disorders. (marketsandmarkets.com)
  • Studies exploring the therapeutic potential of embryonic stem cells (ESC) are associated with various ethical issues attributed to the destruction of human embryos. (marketsandmarkets.com)
  • Based on therapeutic application, the stem cell therapy market is segmented into musculoskeletal disorders, cardiovascular diseases, wounds and injuries, neurological disorders, surgeries, inflammatory and autoimmune diseases, and other therapeutic applications. (marketsandmarkets.com)
  • In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
  • An overview of the current state of the industry-sponsored, stem cell therapeutic commercial product and clinical trial pipeline reveals some interesting insights and trends into how the sector has matured over the past decade and where it may be headed. (selectbiosciences.com)
  • They also cited the abundance of placental tissues over other sources, and the greater ease of MSC isolation from these growth factor-rich tissues as another benefit for their therapeutic use. (genengnews.com)
  • The researchers concluded that although further studies are needed to confirm the effect of AMSCs on neovascular diseases, the data collected in their study provided insights into the mechanisms by which these cells exert their therapeutic effects. (genengnews.com)
Adipocytes7
  • In contrast to white adipocytes, which contain a single lipid droplet, brown adipocytes contain numerous smaller droplets and a much higher number of (iron-containing) mitochondria, which gives the tissue its color. (wikipedia.org)
  • Brown fat cells come from the middle embryo layer, mesoderm, also the source of myocytes (muscle cells), adipocytes, and chondrocytes (cartilage cells). (wikipedia.org)
  • Both adipocytes and brown adipocyte may be derived from pericytes, the cells which surround the blood vessels that run through white fat tissue. (wikipedia.org)
  • 2004): Subcutaneous adipocytes can differentiate into bone- forming cells in vitro and in vivo. (ankara.edu.tr)
  • Adipose tissue is derived from numerous sources, and in recent years has been shown to provide numerous cells from what seemingly was a population of homogeneous adipocytes. (usda.gov)
  • Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
  • Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
ADSCs2
Scaffolds3
  • Studies of lung scaffolds may offer alternatives to patients awaiting transplant by providing transplantable ex vivo lung tissue and thus avoid the rejection of allograft lungs. (pulmonologyadvisor.com)
  • This thesis focuses on assessing cell-material interactions between degradable 3D polymer scaffolds with different designs and adipose tissue-derived stem cells. (kth.se)
  • Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
Placenta2
  • They were initially found in the bone marrow [ 11 ] but can also be found in other tissues, such as adipose, periosteum, muscle, placenta, and trabecular bone [ 12 ]. (hindawi.com)
  • The beneficial growth factors secreted by the placenta-derived stem cells included vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), the latter, a well-known natural inhibitor of angiogenesis. (genengnews.com)
White adipos1
Adipocyte3
  • 1994). Furthermore, LOX participates in the dedication of pluripotent stem cells towards the adipocyte lineage (Huang et al. (exposed-skin-care.net)
  • In obese rats, the inhibition of LOX activity through -aminopropionitrile (BAPN, a particular inhibitor of LOX activity) decreases adipose cells fibrosis, partly corrects the adipocyte-size distribution design (moving it toward smaller sized sizes) and attenuates the upsurge in bodyweight and extra fat mass. (exposed-skin-care.net)
  • [ 17 , 18 ] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)
Canine3
  • For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla province of Türkiye. (trdizin.gov.tr)
  • 2007): Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study. (ankara.edu.tr)
  • This study aimed to determine whether adipose stem cells (ASCs) from dogs with distemper disease are infected with the canine morbillivirus (CM). Materials and Methods: Twelve dogs with the neurological phase of the disease and who were positive for CM by reverse transcription polymerase chain reaction (RT-PCR), were studied. (edu.pe)
Autologous adipose1
Vitro3
  • The in vitro results asserted that the modular scaffold enhanced cell-material interactions by almost five times of those observed for the scaffold alone. (kth.se)
  • Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
  • The adult unilocular subcutaneous adipose cells have the potential in vitro to redifferentiate in osteoblast (transdifferentiation). (bvsalud.org)
Tecido adiposo5
  • Este estudo teve como objetivo avaliar se o uso de células-tronco adultas do tecido adiposo é benéfico à cicatrização da pele. (rbcp.org.br)
  • As células-tronco adultas utilizadas eram autólogas, extraídas do tecido adiposo da região infraumbilical, precedendo a realização da abdominoplastia. (rbcp.org.br)
  • Considerando-se todas as avaliações realizadas (médicos, pacientes e fotométrica), foi encontrada diferença estatisticamente significante favorável ao implante de células-tronco adultas do tecido adiposo (P (rbcp.org.br)
  • Os resultados da cicatrização da pele, após implante de células-tronco adultas derivadas de tecido adiposo, foram satisfatórios. (rbcp.org.br)
  • Diante disso, a criopreservação de células-tronco mesenquimais provenientes de tecido adiposo (CTDAs) poderia ser uma maneira de realizar a coleta em um tempo cirúrgico e após realizar a lipoenxertia de forma fracionada. (bvsalud.org)
Vascular1
  • This protocol is used to answer key questions related to the function of human adipose progenitors in the vascular microenvironment. (jove.com)
Embryonic2
Therapy21
  • However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
  • However, one important question that remains to be answered is which cell is more effective and suitable for cell therapy. (biomedcentral.com)
  • Fetal bovine serum is the supplement most widely used for cell culture, but it has disadvantages and it is not safe for cell therapy due to the risks of pathogen transmission and immune reaction. (biomedcentral.com)
  • The global stem cell therapy market in terms of revenue was estimated to be worth $257 million in 2022 and is poised to reach $558 million by 2027, growing at a CAGR of 16.8% from 2022 to 2027. (marketsandmarkets.com)
  • Market growth is driven mainly by factors such as robust funding for stem cell research, an increase in the number of cell therapy production facilities that have GMP certification, and growth in the number of clinical trials associated with stem cell therapies. (marketsandmarkets.com)
  • Lack of proper federal policies that define what can be funded in embryo-based stem cell research or therapy development may restrain the market's expansion in the future to a certain extent. (marketsandmarkets.com)
  • The stem cell therapy market is segmented into allogeneic and autologous stem cell therapies based on type. (marketsandmarkets.com)
  • The adipose tissue-derived stem cell segment dominated the stem cell therapy indsutry. (marketsandmarkets.com)
  • The musculoskeletal disorders segment has generated highest revenue in the stem cell therapy industry. (marketsandmarkets.com)
  • This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
  • Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
  • Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
  • Too many thermal transitions may result in a lower viability cord blood cell therapy product. (parentsguidecordblood.org)
  • This may result in clinicians opting out of pursuing this choice of stem cell therapy. (ivis.org)
  • This presentation will provide meaningful data and a detailed discussion related to the commercial penetration and revenue generated by existing products as well as a breakdown of industry-sponsored stem cell therapy clinical trials (excluding basic stem cell transplantation) including stages, product types and indications. (selectbiosciences.com)
  • Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
  • The scientists believe that their technique may advance stem cell therapy toward clinical practice and offer novel therapies for eye diseases in people. (genengnews.com)
  • Towards cell replacement therapy in Parkinson's disease. (lu.se)
Microenvironment1
  • Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
Xeno-free1
  • This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
Angiogenesis2
  • BACKGROUND: Angiogenesis plays an important role in tissue repair. (minervamedica.it)
  • Their study ("Retinal angiogenesis effects of TGF-ß1, and paracrine factors secreted from human placental stem cells in response to a pathological environment") is freely available on-line as an unedited early e-pub of Cell Transplantation. (genengnews.com)
Transplantation3
Proliferation4
  • The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. (trdizin.gov.tr)
  • According to the results of our study's cell proliferation assay and wound healing test, bee venom had no proliferative effect on mesenchymal stem cells within the defined dose range. (trdizin.gov.tr)
  • The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)
  • Cells were maintained in the proliferation medium, which is composed of DMEM (low glucose) containing 10% fetal calf serum (FCS), 0.01 M HEPES, 100 U/ml penicillin and streptomycin. (nih.gov)
Iliac crest1
Endothelial2
  • 2004): Plasticity of human adipose lineage cells toward endothelial perspectives. (ankara.edu.tr)
  • They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
Preclinical and clinical studies1
Exosomes3
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • Periosteal cells treated with exosomes exhibited higher levels of microRNA (miR)‑145 and miR‑221. (spandidos-publications.com)
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
Lineages1
  • it is involved in the development of a wide variety of cell lineages and organs. (medscape.com)
Hematopoietic1
  • Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)
Therapies5
  • Human Adipose-derived Stem/Stromal Cells (ASCs) have been widely used in stem cell and obesity research, as well as clinical applications including cell-based therapies, tissue engineering and reconstruction. (edu.au)
  • The surge in the expanding number of clinical trials is further triggered by the COVID-19 pandemic, with a vast number of clinical trials studying the potential of stem cell therapies in the treatment of SARS-CoV-2 infection. (marketsandmarkets.com)
  • Comparatively fewer complications are associated with the development and manufacturing of allogeneic stem cell therapies, which is the key attributive reason for their largest share in the market. (marketsandmarkets.com)
  • This has also led to an increase in the number of clinical trials regarding the development of allogeneic stem cell therapies, making it the fastest growing segment during the forecast period. (marketsandmarkets.com)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
Mesenchymal stromal cells1
Bone marrow-derived3
Characteristics2
  • Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells. (ui.ac.id)
  • Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites. (ui.ac.id)
Humans2
  • The presence of brown adipose tissue in adult humans was discovered in 2003 during FDG-PET scans to detect metastatic cancers. (wikipedia.org)
  • Brown fat in humans in the scientific and popular literature refers to two cell populations defined by both anatomical location and cellular morphology. (wikipedia.org)
Adult tissues1
Fraction1
Methods1
Storing stem cells derived1
  • GeneCell International is a privately owned laboratory specialized in collecting, processing and cryogenically storing stem cells derived from umbilical cord blood, cord tissue, adipose (fat) tissue, and other cells and tissues that can later be used to treat a variety of diseases. (parentsguidecordblood.org)
Viability5
  • Cell viability test was performed on mesenchymal stem cells exposed to various concentrations (40 ppm, 20 ppm, 10 ppm, 5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm and 0.312 ppm) of bee venom. (trdizin.gov.tr)
  • Minimally invasive MSC injections need C-arm as guidance that potentially influence the cell viability and doubling time. (ui.ac.id)
  • Stem cell viability was measured, and then the cells were cultured to assess their PDT. (ui.ac.id)
  • Generalized linear models test was used to compare cell viability between post-thaw, post-propagation, post-radiation, post-culture post-radiation, and control and between radiation dose groups. (ui.ac.id)
  • After 30 and 90 days, the samples were thawed, and cell viability was assessed using the MTT technique. (bvsalud.org)
Connective2
  • This is also consistent with the recognition of aneurysmal disease and connective-tissue disorders as significant risk factors for hernia formation. (medscape.com)
  • The laparotomy, as tenotomy, leads to myocyte replacement with fibrotic connective tissue and disordered arrangement of sarcomere structure, manifesting as a decrease in abdominal wall compliance that predisposes the abdominal wall to further injury. (medscape.com)
Isolation1
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
ASCs1
Induce2
  • and (2) through the paracrine release of trophic factors to induce tissue repair by endogenous cells [ 6 ]. (biomedcentral.com)
  • Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. (who.int)
Human bone1
  • Mesenchymal stem cells have the ability to differentiate in osteoblasts with potential implications for the engineering of human bone tissue 11 . (bvsalud.org)
Adiponectin3
  • Furthermore, in white adipose cells from obese pets, BAPN avoided the downregulation of adiponectin and blood sugar transporter 4 (GLUT4), aswell as the upsurge in suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4 (DPP4) amounts, triggered from the HFD. (exposed-skin-care.net)
  • Also, in these pets, BAPN ameliorates the disruptions in the adipose cells manifestation of adiponectin, blood sugar transporter 4 (GLUT4), buy 76584-70-8 suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4, all protein mixed up in control of insulin level of sensitivity. (exposed-skin-care.net)
  • The cumulative loss of fat leads to a decrease in adipose-derived adiponectin and leptin. (medscape.com)
Chondrocytes1
  • Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Clinical applications2
  • Orbay H, Tobita M, Mizuno H (2012): Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications. (ankara.edu.tr)
  • Mesenchymal stem cells: clinical applications and biological characterization. (ui.ac.id)
Markers2
Collagenase1