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  • myocardial
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Transplants
  • Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of April 2017[update]. (wikipedia.org)
  • regenerative
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • iliac crest
  • The iliac crest is derived from endochondral bone. (wikipedia.org)
  • Abdominal external oblique muscle Abdominal internal oblique muscle Transversus abdominis muscle Quadratus lumborum muscle Erector spinae Iliocostalis pars lumborum Longissimus pars thoracis Latissimus dorsi Tensor fasciae latae Iliacus muscle Fascia lata Iliac fascia Transverse fascia The iliac crest has a large amount of red bone marrow, and thus it is the site of bone marrow harvests (from both sides) to collect the stem cells used in bone marrow transplantation. (wikipedia.org)
  • For example, oral and maxillofacial surgeons will often use iliac crest bone to fill in large osseous defects of the oral cavity caused by severe periodontal disease, excess bone resorption following tooth loss, trauma, or congenital defects including alveolar clefts. (wikipedia.org)
  • chemotherapy
  • That same year, Pecora was the lead author on the study of CD34+CD33− cells as it relates to chemotherapy treatment and bone marrow transplantation for the treatment of non-Hodgkin's lymphoma (NHL). (wikipedia.org)
  • Pecora et al discovered that patients who had received more than two cycles of chemotherapy and were shown to have "chemotherapy-resistant NHL mobilized a significantly lower percentage of CD34+CD33− cells than did chemotherapy-sensitive NHL patients. (wikipedia.org)
  • They also found the reverse that those who had received less significant levels of chemotherapy treatment had higher levels of CD34+CD33− cells. (wikipedia.org)
  • During chemotherapy, most growing cells are killed by the cytotoxic agents. (wikipedia.org)
  • differentiation
  • Replenish new functional cells through spontaneous differentiation into tissue-compatible cells. (wikipedia.org)
  • Stochastic differentiation: when one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two stem cells identical to the original. (wikipedia.org)
  • Many of the morphological features of megakaryocyte differentiation can be recapitulated in non-hematopoietic cells by the expression of Class VI β-tubulin (β6) and they provide a mechanistic basis for understanding these changes. (wikipedia.org)
  • Once the cell has completed differentiation and become a mature megakaryocyte, it begins the process of producing platelets. (wikipedia.org)
  • donors
  • PBSC donors are given a course of GCSF prior to PBSC collection, this ensures a better outcome, as stem cell proliferation increases, thus increasing the number of peripheral stem cells in circulation. (wikipedia.org)
  • functional
  • showed that human dermal fibroblast-derived Muse cells were efficiently differentiated into melanin-producing functional melanocytes by a cocktail of cytokines. (wikipedia.org)
  • Many of these genes share substantial structural and functional similarity, but they are specialized to cell type and/or conditions under which they are normally produced. (wikipedia.org)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • endogenous
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • diseases
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • spinal cord i
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • nucleus
  • It was created using SCNT - a nucleus was taken from a man's leg cell and inserted into a cow's egg from which the nucleus had been removed, and the hybrid cell was cultured, and developed into an embryo. (wikipedia.org)
  • In this case, each embryo was created by taking a nucleus from a skin cell (donated by Wood and a colleague) and inserting it into a human egg from which the nucleus had been removed. (wikipedia.org)
  • In 2011, scientists at the New York Stem Cell Foundation announced that they had succeeded in generating embryonic stem cell lines, but their process involved leaving the oocyte's nucleus in place, resulting in triploid cells, which would not be useful for cloning. (wikipedia.org)
  • In some cases, the nucleus may contain up to 64N DNA, or 32 copies of the normal complement of DNA in a human cell. (wikipedia.org)
  • After budding off platelets, what remains is mainly the cell nucleus. (wikipedia.org)
  • isolate
  • It should also be possible to isolate stem cells from the transplanted individual, which can themselves be transplanted into another individual without HSCs, demonstrating that the stem cell was able to self-renew. (wikipedia.org)
  • proliferation
  • This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through unbridled cell proliferation. (wikipedia.org)
  • organisms
  • In this experiment, the researchers developed a protocol for using SCNT in human cells, which differs slightly from the one used in other organisms. (wikipedia.org)
  • research
  • Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. (wikipedia.org)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • During his medical training he was greatly influenced by Dr. Ross Langley, a research-oriented hematologist who suggested that Eaves do a PhD at the Princess Margaret Hospital in Toronto where Dr. Robert Bruce was collaborating with Drs. James Till and Ernest McCulloch (Lasker Award) on how different types of cancer chemotherapeutic agents killed tumour stem cells while sparing normal stem cells. (wikipedia.org)
  • 1998
  • The first hybrid human clone was created in November 1998, by Advanced Cell Technology. (wikipedia.org)
  • tissues
  • Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. (wikipedia.org)
  • Reproductive cloning would involve making an entire cloned human, instead of just specific cells or tissues. (wikipedia.org)
  • cellular
  • He then went to Dalhousie University, completing his MSc in cell physiology under Dr. Gordon Kaplan on A Radiological Investigation of Two Cellular Enzyme Systems of Yeast (1964). (wikipedia.org)
  • procedure
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • 1996
  • With the cloning of a sheep known as Dolly in 1996 by somatic cell nuclear transfer (SCNT), the idea of human cloning became a hot debate topic. (wikipedia.org)
  • study
  • In 1995, Hackensack was part of a large clinical study sponsored by National Cancer Institute to study the use of bone marrow transplantation to treat women with advanced breast cancer. (wikipedia.org)
  • In 2002, Pecora was an investigator in a study of PV701, a virus that selectively attacks cancer cells. (wikipedia.org)
  • Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests. (wikipedia.org)
  • A study in mice has shown that G-CSF may decrease bone mineral density. (wikipedia.org)
  • develops
  • The megakaryocyte develops through the following lineage: CFU-Me (pluripotential hemopoietic stem cell or hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. (wikipedia.org)
  • function
  • Apart from this it is said that stem cell function is regulated in a feed back mechanism. (wikipedia.org)
  • Working under the supervision of Bruce (AACR Award), and in association with Till and McCulloch and a vibrant group of graduate students and post-doctoral fellows, Eaves completed his PhD in Medical Biophysics at the University of Toronto with a thesis entitled Studies on the Control of Murine Bone Marrow Function (1974). (wikipedia.org)
  • cancer cells
  • This false appearance of increase in cancer cells was confirmed by a later trial of the same oncolytic virus and also in Onyx 015, an oncolytic adenovirus. (wikipedia.org)
  • precursors
  • This is in line with the recent knowledge that BPDCN are derived from the precursors of plasmacytoid dentritic cells (2-4). (czytelniamedyczna.pl)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • A diagnosis of DBA is made on the basis of anemia, low reticulocyte (immature red blood cells) counts, and diminished erythroid precursors in bone marrow. (wikipedia.org)
  • cancer
  • The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). (clinicaltrials.gov)
  • Doctors evaluate the results of various blood tests to confirm that new blood cells are being produced and that the cancer has not returned. (stemcellcordblood.net)
  • The study has currently met its primary end point and is now recruiting patients to be treated at the RD expansion cohort of selected tumor types, specifically: endometrial adenocarcinomas, neuroendocrine tumors, and small-cell lung cancer (SCLC). (careacross.com)
  • A new study using cryoablation to decrease pain for patients who have cancer metastases in the bone is now underway throughout Emory Healthcare . (advancingyourhealth.org)
  • Emory interventional radiologists freeze tumors in order to kill cancer cells in contact with the bone and reduce the size of the tumor. (advancingyourhealth.org)
  • Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. (clinicaltrials.gov)
  • Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • Procedure
  • Called the "Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases", or MOTION, the study aims to assess the effectiveness and safety of cryoablation therapy to treat patients with painful bone metastases and document the effects the procedure has on their condition. (advancingyourhealth.org)
  • If created, a "female sperm" cell could fertilize an egg cell, a procedure that, among other potential applications, might enable female same-sex couples to produce a child that would be the biological offspring of its two mothers. (wikipedia.org)
  • citation needed] A variation on the Carticel technique, called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable tissue which is implanted via an open or arthroscopic procedure. (wikipedia.org)
  • In addition, a safety study showed safety better than surgical alternatives for this cultured cell injection procedure at a 3-year follow-up. (wikipedia.org)
  • The automated red blood cell collection procedure for donating erythrocytes is referred to as 'Double Reds' or 'Double Red Cell Apheresis. (wikipedia.org)
  • Malignancy
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • tumors
  • Embryonal carcinoma cells from several sources, including spontaneous and embryo-derived tumors and cultured lines selected to carry specific mutations or even human chromosomes, have contributed to normal chimeras. (thefreedictionary.com)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • malignant
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • Disorders
  • They can differentiate into many cell types including bone, fat, and muscle which allow them to treat a large range of disorders. (wikipedia.org)
  • MSCs have been used to treat a variety of disorders including cardiovascular diseases, spinal cord injury, bone and cartilage repair, and autoimmune diseases. (wikipedia.org)
  • chromosomes
  • While many genes on the Y chromosome have backups (homologues) on other chromosomes, a few genes such as RBMY on the Y chromosome do not have such backups, and their effects must be compensated for to convert cells from a woman into sperm. (wikipedia.org)
  • In 2007, a patent application was filed on methods for creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. (wikipedia.org)
  • phenotype
  • The kind of mature, fully differentiated cell phenotype and the number of those cells created though this can be influenced in three ways. (wikipedia.org)
  • hematopoiesis
  • while a numbers of key growth factors that regulates hematopoiesis have been identified and some of them are currently used for clinical purpose, how bone marrow microenvironment that presents those signals to the hematopoietic progenitors is constructed remains totally obscure. (nii.ac.jp)
  • therapy
  • When these findings are taken together, combination therapy with MNC transplantation and AM infusion may have additional or synergetic effects on therapeutic angiogenesis for the treatment of severe peripheral vascular disease. (ahajournals.org)
  • immune system
  • One potential roadblock to injecting a woman's cells into a man's testicles is that the man's immune system might attack and destroy the woman's cells. (wikipedia.org)
  • In usual circumstances, when foreign cells (such as cells or organs from other people, or infectious bacteria) are put into a human body, its immune system will reject such cells or organs. (wikipedia.org)
  • However, a special property of a man's testicles is that they are immune-privileged, that is, a man's immune system will not attack foreign cells (such as a woman's cells) injected into the sperm-producing part of the testicles. (wikipedia.org)
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • germ cells
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • They develop spontaneously from germ cells in the gonads of certain mouse strains, or from cells in early embryos transplanted to ectopic sites. (thefreedictionary.com)
  • adult T-cell l
  • There is some evidence of a relationship with human T-lymphotropic virus (HTLV) with the adult T-cell leukemia/lymphoma subtype. (wikipedia.org)
  • lymphocytes
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • Antibodies
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Creating female sperm was first raised as a possibility in a patent filed in 1991 by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes (to correct genetic diseases). (wikipedia.org)
  • dendritic cell
  • Artykuł zawiera opis dwóch przypadków chorych z rozpoznaniem bardzo rzadko występujących nowotworów z blastycznych plazmacytoidalnych komórek dendrytycznych ( blastic plasmacytoid dendritic cell neoplasms - BPDCN). (czytelniamedyczna.pl)
  • In this paper we report two cases of very rare blastic plasmacytoid dendritic cell neoplasms (BPDCN). (czytelniamedyczna.pl)
  • endothelial cell
  • Background- Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. (ahajournals.org)
  • 8 Furthermore, AM has been shown to inhibit vascular endothelial cell apoptosis and induce angiogenesis through the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. (ahajournals.org)
  • phenotypes
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • Lymphoma
  • A point-based algorithm for the diagnosis for early forms of cutaneous T cell lymphoma was proposed by The International Society for Cutaneous Lymphomas in 2005. (wikipedia.org)
  • Cutaneous T-cell lymphoma may be divided into the several subtypes. (wikipedia.org)
  • Elorac, Inc. Announces Orphan Drug Designation for Novel Topical Treatment for Pruritus in Cutaneous T-cell Lymphoma (CTCL) website Turgeon, Mary Louise (2005). (wikipedia.org)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. (wikipedia.org)