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  • markers
  • Cloned SP cells cultured in medium with fibroblast growth factor-2 lost ABCG2 and PAX6 expression and upregulated several molecular markers of keratocytes, including keratocan, aldehyde dehydrogenase 3A1, and keratan sulfate. (mendeley.com)
  • Cloned corneal SP cells under chondrogenic conditions produced matrix staining with toluidine blue and expressed cartilage-specific markers: collagen II, cartilage oligomatrix protein, and aggrecan. (mendeley.com)
  • The differentiated cells acquired lineage-specific markers and demonstrated appropriate functions in tissue culture, according to each cell type. (webwire.com)
  • The cells express key stem cell markers including Oct4, Sox2 and Nanog, and secrete a distinctive composition of growth factors and other proteins known to stimulate stem cells in the body, regenerate tissues, and promote scarless healing. (bio-medicine.org)
  • Pericytes are multipotent cells that are heterogeneous in their origin, function, morphology and surface markers. (springer.com)
  • Tbx6 overexpression was not sufficient by itself to induce the differentiation of P19CL6 cells to cardiac myocytes as assessed by expression of myocyte markers and spontaneous beating of the cultured cells. (yu.edu)
  • The MPeM stem cells MPeMSCs express stem cell markers c-MYC, NES and VEGFR2 and in the presence of matrix components cells form colony spheres. (duhnnae.com)
  • cardiac myocytes
  • Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts," Nature , vol. 428, no. 6983, pp. 664-668, 2004. (hindawi.com)
  • I found that the abundance of Tbx6 protein was increased during DMSO-induced differentiation of P19CL6 cells to cardiac myocytes. (yu.edu)
  • In contrast, knockdown of endogenous Tbx6 inhibited DMSO-induced differentiation of P19CL6 cells to cardiac myocytes as assessed by the above parameters, while ablating the expression of Nkx2.5, a homeobox protein that plays an early and critical role in cardiogenesis. (yu.edu)
  • embryonic development
  • Basic science in the field of embryonic development, stem cell differentiation, and tissue engineering has offered important insights into key pathways and scaffolds that regulate hESC differentiation, which have produced advances in modeling gastrulation in culture and in the efficient induction of endoderm, mesoderm, ectoderm, and many of their downstream derivatives. (hindawi.com)
  • lineage
  • Herein, global and single-cell analyses revealed a hierarchical organization of transcriptional lineage programs, with downregulation of megakaryocyte-erythroid genes from HSCs to LMPPs, sustained granulocyte-monocyte priming, and upregulation of common lymphoid (but not B and T cell-specific) genes. (lu.se)
  • d lineage, and that IL-3 acted not only on these two subpopulation but also on more primitive stem cell population which was resistant to 5FU. (nii.ac.jp)
  • Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. (gulfcoaststemcell.com)
  • Cardiopoietic stem cell therapy in heart failure the C-CURE multicenter randomized trial with lineage-specified biologics," Journal of the American College of Cardiology , 2013. (hindawi.com)
  • Limiting dilution experiments using MPeMSCs and endothelial lineage-induced cells derived from a single MPeMSC resulted in early tumor growth in the latter group indicating that endothelial differentiation of MPeMSCs is important for MPeM tumor initiation. (duhnnae.com)
  • human
  • These appear to be the first human cells identified with keratocyte progenitor potential. (mendeley.com)
  • The new cells also expressed biomarkers typical of pigment cells and when placed in an artificial human skin construct, produced melanin and responded to chemical cues from normal epidermis skin cells. (webwire.com)
  • In addition, the human multipotent cell conditioned media produced through Histogen's process can be found in the ReGenica line of skincare products, currently being distributed by Suneva Medical in partnership with Obagi Medical Products. (bio-medicine.org)
  • Histogen's technology focuses on stimulating a patient's own stem cells by delivering a proprietary complex of multipotent human proteins that have been shown to support stem cell growth and differentiation. (bio-medicine.org)
  • We have identified a subpopulation of stem cells within adult human BM, isolated at the single-cell level, that self-renew without loss of multipotency for more than 140 population doublings and exhibit the capacity for differentiation into cells of all 3 germ layers. (jci.org)
  • Human umbilical vein ECs (lane 4) and immortalized cell lines with high telomere length, provided by the Roche Diagnostics Corp. (lane 5), were used as controls. (jci.org)
  • This excellently performed demonstration in the human brain confirms previous work in the mouse that showed cerebral ischemia induced multipotent stem cells that were restricted to areas of the brain damaged by stroke," says Editor-in-Chief Graham C. Parker, PhD , The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. (healthcanal.com)
  • giving rise to any of the three germ layers of human (endoderm, ectoderm or mesoderm) as well as extra embryonic cells which include cytotrophoblast layer and a syncytiotrophoblast layer of the placenta . (medcraveonline.com)
  • The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. (semanticscholar.org)
  • article{Tavian2001TheHE, title={The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. (semanticscholar.org)
  • developmental
  • EB has the advantage of providing a three-dimensional structure, which enhances cell-cell interactions that may be important for some developmental processes. (hindawi.com)
  • tissues
  • Although the experiment was designed to investigate blood formation specifically, Weissman was still disappointed that the MAPC cells did not join repair mechanisms in any other damaged tissues in the animals. (bionews.org.uk)
  • Stem cells hold great promise for the regeneration of injured tissues in a wide variety of important medical conditions. (yu.edu)
  • These cells seem to be easily changed to carry out repairs to damages in tissues and organs during the aging process and due to certain processes caused by diseases. (stem-cells-news.com)
  • novel
  • Catherine Verfaillie and colleagues at the University of Minnesota first described these novel stem cells in 2002, but other teams have had difficulty in replicating the work. (bionews.org.uk)
  • molecular
  • Further analysis of these cells will aid elucidation of molecular mechanisms of corneal development, differentiation, and wound healing. (mendeley.com)
  • Recent studies have revealed that endogenous small non-coding microRNA (miRNA) play important roles in the conversion of GS cells into maGS cells and may form a miRNA signature that may be used as a molecular tool to distinguish the GS cells from maGS cells. (springer.com)
  • Identification
  • These findings have lead to identification of several pathways controlling the differentiation of hESCs into mesodermal derivatives such as myoblasts, mesenchymal cells, osteoblasts, chondrocytes, adipocytes, as well as hemangioblastic derivatives. (hindawi.com)
  • In the Issues in Development article "The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells (VSELs), and Some Nomenclature Issues," the authors present the most current descriptions and terminology for characterizing VSELs . (phys.org)
  • demonstrate
  • B ) Morphologically, most hBMSCs demonstrate round morphology with a cell size of less than 15 μm in diameter. (jci.org)
  • Glial
  • Exposure of cloned SP cells to neurogenic culture medium upregulated mRNA and protein for glial fibrillary acidic protein, neurofilament protein, and beta-tubulin II. (mendeley.com)