• Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. (wikipedia.org)
  • CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. (wikipedia.org)
  • Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. (wikipedia.org)
  • In different tumor subtypes, cells within the tumor population exhibit functional heterogeneity and tumors are formed from cells with various proliferative and differentiation capacities. (wikipedia.org)
  • Hence, at least for certain neoplastic tissues, dedicated stem cell compartments maintain and enlarge the size of the transformed compartment The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex (Fig. 3). (wikipedia.org)
  • Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations They have two defining features: their long-term ability to self-renew and their capacity to differentiate into progeny that is non-tumorigenic but still contributes to the growth of the tumor. (wikipedia.org)
  • The chronic inflammation eventually leads to changes in the character of the surrounding stomach cells and ultimately, over several years, to tumors. (sciencedaily.com)
  • In ovarian cancer, up-regulated miR-214 has been associated with late-stage and high-grade tumors. (sciencedaily.com)
  • The research paper presented by the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development say that anti-cancer treatments might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease though quite often they effectively shrink the size of tumors. (medindia.net)
  • The researchers first determined that Nanog and BMI1 stem cell markers were more highly expressed in metastatic tumors compared to primary tumors. (medindia.net)
  • But analysis of stem cell expression before and after treatment revealed that even as some anti-cancer treatments shrank tumors, they increased expression of Nanog and BMI1. (medindia.net)
  • If we are successful in isolating and expanding these rare cells from patient tumors, they may be an invaluable, renewable resource for identifying novel patient treatment strategies and developing better therapies, such as targeted kinase inhibitors, checkpoint inhibitors, adoptive T cell therapy or vaccines. (weeksmd.com)
  • The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. (jci.org)
  • BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
  • One crucial ability of the CSCs is to form tumors already at low cell numbers. (atlasantibodies.com)
  • Many new anti-cancer therapies are evaluated based on their ability to shrink tumors. (atlasantibodies.com)
  • On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)
  • CSCs derived from both CSCs and non-CSCs give rise to tumors through self-renewal and are able to differentiate into multiple cell types [6]-[9]. (exposed-skin-care.net)
  • Many malignancy therapies including chemotherapies that destroy the bulk of malignancy cells may ultimately fail as they do not get rid of CSCs that then cause a relapse of tumors [10]. (exposed-skin-care.net)
  • Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)
  • Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)
  • In recent years, although significant progress has been made in the diagnosis and treatment of malignant tumors, breast cancer remains the leading cause of cancer-related deaths in women, largely due to its high rate of relapse, metastasis, and drug resistance [2-5]. (researchsquare.com)
  • Cancer stem cells refer to a small subpopulation of cells that can be found in tumors . (foodscience.news)
  • Cancer stem cells are responsible not just for the development of tumors, but also for their progression, metastasis, and drug resistance. (foodscience.news)
  • As for the origin of these cells, researchers believe they are most likely the product of cell reprogramming , which has been observed in a variety of tumors. (foodscience.news)
  • By identifying a mechanism that regulates programmed cell death in precursor cells for blood, or hematopoietic stem cells, the work is the first to connect the death of such cells to a later susceptibility to tumors in mice. (scienceblog.com)
  • ARTS was originally discovered by Sarit Larisch, a visiting professor at Rockefeller, and is found to be lacking in human leukemia and other cancers, suggesting it suppresses tumors. (scienceblog.com)
  • The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
  • Accumulating data suggests that many human tumors are organized in cellular hierarchies initiated and maintained by a small population of self-renewing so called cancer stem cells. (lu.se)
  • Cells with high expression of HIF-2 α have properties rendering the tumors aggressive behavior potentially being the neuroblastoma tumor stem cells. (lu.se)
  • By microarray analysis , we found C-X-C chemokine receptor type 4 (CXCR4) can be a novel marker for highly metastatic CSCs, since CXCR4-positive cells can grow anchorage-independently, initiate tumors in mice , be resistant to cytotoxic drug , and produce differentiated daughter cells . (bvsalud.org)
  • Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
  • According to the study's lead author, Jin Q. Cheng, Ph.D., M.D., senior member of the Molecular Oncology Department and Molecular Oncology and Drug Discovery Program at Moffitt, certain miRNAs can cause therapeutic resistance and cancer metastasis by regulating multiple gene targets. (sciencedaily.com)
  • Evidence suggests that cancer stem cells are responsible for cancer initiation, progression, metastasis, chemoresistance and relapse," Cheng said. (sciencedaily.com)
  • Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
  • Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
  • is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
  • Cancer stem cells (CSCs) are small cells, 1% to 3% of all cells in a tumor, that drive the tumor's initiation, growth, and metastasis and may cause relapse. (atlasantibodies.com)
  • The formation of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. (ku.edu)
  • Inhibiting EMT and CSCs in pancreatic cancer could potentially inhibit pancreatic cancer progression, metastasis, and drug resistance. (ku.edu)
  • In an orthotopic pancreatic cancer mouse model, KH-3 significantly inhibited tumor growth and metastasis. (ku.edu)
  • Upregulated miR-143 in CSCs differentiation promotes prostate cancers cells SCH58261 metastasis by modulating FNDC3B appearance. (exposed-skin-care.net)
  • Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
  • In clinical samples, these CXCR4-positive cells were found from not only late metastasis stage (accumulated ascites ) but also earlier stage (peritoneal washings). (bvsalud.org)
  • Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer cell de-differentiation and migration. (nature.com)
  • Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)
  • The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)
  • Developmentally, it is well established that expression of the ID members is strongest in stem/progenitor cells, while their levels decrease upon differentiation. (nature.com)
  • WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
  • CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. (bmbreports.org)
  • Because of their unique expression profile and special functions, miRNAs have been used as molecular markers to define the direction and processes of cell differentiation by regulating one or several target genes. (researchsquare.com)
  • Differentiation robs stem cells of their ability to proliferate rapidly and renew themselves. (foodscience.news)
  • We examined the effects of cigarette smoke condensate (CSC) on the formation of cancer stem-like cells, which are rich in octamer-binding transcription factor (OCT)-4, inhibitor of differentiation 1 (ID1), nuclear factor (NF)-κB, and B lymphoma Mo-MLV insertion region 1 homolog (BMI-1). (umn.edu)
  • Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
  • This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
  • Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
  • Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
  • From the download therapeutic potential of differentiation in cancer and normal stem cells 2009 examples of the BPH to the Dots neurons of available many eGift, from modem Radcliffe to JavaScript Rowling, the surgery computed esophageal with years. (rachelhornaday.com)
  • download therapeutic potential of differentiation in cancer and normal stem to absolute children. (rachelhornaday.com)
  • Twelve-year-old Winnie Willis tells a download therapeutic potential of differentiation in cancer and with blockers. (rachelhornaday.com)
  • Moreover, treatment with transforming growth factor -ß enhanced the anti- cancer effect of docetaxel via induction of cell differentiation / asymmetric cell division of the CXCR4-positive gastric CSCs even in a dormant state . (bvsalud.org)
  • Therefore, differentiation inducers hold promise for obtaining the maximum therapeutic outcome from currently available anti- cancer drugs through re-cycling of CSCs. (bvsalud.org)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Upon its transition to the precancerous Barrett's esophagus epithelium, however, a small dedicated stem cell compartment appears that supports proliferation of the epithelium while concomitantly evidence for a stochastically dividing compartment contributing to the maintenance of the tissue disappears. (wikipedia.org)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. (nature.com)
  • Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. (nature.com)
  • indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
  • showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
  • Then, agomir-20b-5p and antagomir-20b-5p were transfected into MCF-7 and T47D breast cancer cells to detect cell migration, wound healing and proliferation, and lentivirus vectors silencing or overexpressing miR-20b-5p were transfected into T47D-CSCs to detect proliferation and apoptosis. (researchsquare.com)
  • MiRNAs can also control the self-renewal or proliferation of stem cells [9]. (researchsquare.com)
  • Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
  • This work not only defines the role of the ARTS gene in the underlying mechanism of mammalian tumor cell resistance to programmed cell death, but also links this gene to another hallmark of cancer, stem and progenitor cell proliferation," said Marion Zatz, who oversees cell death grants, including Steller's, at the NIH's National Institute of General Medical Sciences. (scienceblog.com)
  • decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
  • It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
  • HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. (wikipedia.org)
  • Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. (wikipedia.org)
  • As CSCs form a small proportion of the tumor, this may not necessarily select for drugs that act specifically on the stem cells. (wikipedia.org)
  • Essentially this theory proposes that all cells have the ability to be tumorigenic making all tumor cells equipotent with the ability to self-renew or differentiate, leading to tumor heterogeneity while others can differentiate into non-CSCs The cell's potential can be influenced by unpredicted genetic or epigenetic factors, resulting in phenotypically diverse cells in both the tumorigenic and non-tumorigenic cells that compose the tumor. (wikipedia.org)
  • By hyperspectral-stimulated Raman scattering imaging of single living cells and mass spectrometry analysis of extracted lipids, we report here significantly increased levels of unsaturated lipids in ovarian cancer stem cells (CSCs) as compared to non-CSCs. (nih.gov)
  • Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
  • Despite improved outcome of surgical approaches and developed therapeutic modalities, CCA recurrence rates remain high with CSCs as the proposed main driver behind cancer relapse [ 10 ]. (springer.com)
  • Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
  • To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in CSCs. (jci.org)
  • Thus, selectively targeting CSCs with specific antibodies holds hope for improving cancer patients' survival and is a promising therapeutic strategy against cancer. (atlasantibodies.com)
  • Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
  • In addition, CSCs might give rise to metastases, acting as a reservoir of cancer cells, causing relapse after the surgery or treatment has eliminated the visible signs of cancer. (atlasantibodies.com)
  • CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
  • The use of CD133 (PROM1) to identify CSCs in glioma is still in question because tumorigenic cells are equally found in both CD133+ and CD133− cells in some gliomas, while some CD133+ brain tumor cells may not possess tumor-initiating capacity 23 . (atlasantibodies.com)
  • Pancreatic cancer is enriched with cancer stem cells (CSCs), which contribute to its high metastatic tendency and resistance to treatments. (ku.edu)
  • Chapter 4 and Chapter 5) Next, we investigated the role of an RNA binding protein, HuR, in pancreatic cancer EMT and CSCs. (ku.edu)
  • The data demonstrated that inhibition of HuR destabilized SNAI1 mRNA, and subsequently reduced Snail protein levels, resulting in the EMT and CSCs inhibition in pancreatic cancer cells. (ku.edu)
  • Chapter 6) We then developed a small molecule inhibitor of HuR, KH-3, and evaluated the activities of KH-3 on pancreatic cancer EMT and CSCs. (ku.edu)
  • In conclusion, KH-3 serves as a potent and specific HuR/mRNA disruptor and inhibits pancreatic cancer EMT and CSCs in vitro and in vivo. (ku.edu)
  • The current presence of cancer stem-like cells (CSCs) is one of the mechanisms responsible for chemoresistance that has been a major hindrance towards lung adenocarcinoma (LAD) treatment. (exposed-skin-care.net)
  • Taken collectively the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account SCH58261 for maintenance of CSCs and formation of chemoresistant phenotype in docetaxel-resistant LAD cells. (exposed-skin-care.net)
  • Malignancy stem-like cells (CSCs) or tumor initiating stem cells are a sub-population of tumor cells and play pivotal tasks in malignancy initiation progression recurrence and chemoresistance [2]-[5]. (exposed-skin-care.net)
  • For instance miR-34a repression causes digestive tract CSCs to execute asymmetric cell department and promotes little girl cells to stay digestive tract CSCs by regulating Notch signaling. (exposed-skin-care.net)
  • Nevertheless whether miR-200b regulates CSCs produced from docetaxel-resistant LAD cells continues to be poorly realized and must become further elucidated. (exposed-skin-care.net)
  • To the very best of our understanding there were no reviews about HDAC1/miR-200b/Suz-12/E-cadherin regulatory network in regulating CSCs maintenance and chemoresistance in human being LAD cells and the existing work provides a novel. (exposed-skin-care.net)
  • This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). (whiterose.ac.uk)
  • According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. (bmbreports.org)
  • One of the most forceful underlying reasons is a "cancer heterogeneity" due to "CSC plasticity" A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. (bmbreports.org)
  • For the past 20 years, plenty of studies have suggested that only a small subpopulation of the cancer cells with tumor-initiating capability is the core origin of the tumorigenesis and the subset of cancer cells was named cancer stem cells (CSCs). (bmbreports.org)
  • As it can be inferred from its nomenclature, CSCs share several features of normal stem cells. (bmbreports.org)
  • Early researches on CSCs have been focused on verifying the existence of CSCs in certain types of cancer and finding molecular markers for isolation of CSCs. (bmbreports.org)
  • Resistance to the conventional anti-cancer therapies is a characteristic of CSCs which is most important from a clinical point of view. (bmbreports.org)
  • Cancer stem cells (CSCs) may represent targets for carcinogenic initiation by chemical and environmental agents. (oncotarget.com)
  • Here, we show that chronic (6-month) exposure of human lung epithelial cells to single-walled (SW) CNTs at the workplace-relevant concentration induced an emergence of lung CSCs, as indicated by the induction of CSC tumor spheres and side population (SP). (oncotarget.com)
  • These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
  • Induction of CSCs from non-tumorigenic cells may initiate carcinogenesis. (oncotarget.com)
  • called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)
  • The interplay between stem cell and tumor biology offers an exceptional opportunity to advance our knowledge about cancer, one of the leading causes of death worldwide, with potential impacts in cancer diagnosis and therapy. (hindawi.com)
  • Before this work, we knew that stem cells existed in the stomach, but we had no way to precisely identify them," says Gumucio, who directs the U-M Center for Organogenesis and is a professor in the Department of Cell and Developmental Biology at the U-M Medical School. (sciencedaily.com)
  • Small cell lung cancer, and other rare, aggressive cancers like it, is a very difficult cancer to study and treat, so applying promising technologies like KIYATEC's to advance knowledge of the biology and to expand treatment options for these patients would be a major step forward. (weeksmd.com)
  • Dr. Thomas, "father of bone marrow transplantation," first developed and reported this technique in 1957, and in the ensuing decades, this seminal study has impacted fundamental work in hematology and cancer research, including advances in hematopoiesis, stem cell biology, tumor immunology, and T-cell biology. (broadinstitute.org)
  • As the first example of cancer immunotherapy, understanding the mechanisms of antitumor biology associated with allo-HSCT has given rise to many of the principles used today in the development and implementation of novel transformative immunotherapies. (broadinstitute.org)
  • Improved understanding of the underlying cancer biology of this subpopulation of cancer stem cells, thought to drive tumor formation and therapeutic resistance, could potentially lead to improved targeted therapies that prolong patient survival. (cns.org)
  • Research associate Maria Garcia-Fernandez, Hermann Steller, head of the Strang Laboratory of Apoptosis and Cancer Biology, and their colleagues explored the activity of a gene called Sept4, which encodes a protein, ARTS, that increases programmed cell death, or apoptosis, by antagonizing other proteins that prevent cell death. (scienceblog.com)
  • Here, the authors review the novel insights that these studies have provided and present a comprehensive strategy for the use of proteomics in studying cancer SC biology. (medscape.com)
  • Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
  • As their name implies, cancer stem cells are capable of self-renewal and of transforming into any cell type. (foodscience.news)
  • Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. (tocris.com)
  • SCs are not only capable of maintaining themselves (self-renewal) but also give rise to a proliferative 'transit amplifying' compartment and ultimately to postmitotic differentiated cells with specialized functions. (medscape.com)
  • By contrast, transit amplifying cells and differentiated cells are incapable of self-renewal and tissue regeneration. (medscape.com)
  • Furthermore, pathways controlling the self-renewal capacity of normal tissue SCs are frequently deregulated in human cancer. (medscape.com)
  • Scientists have identified and described stem cells specific to several tissues and organs of the body -- key master cells that give rise to the specialized cell types characteristic of that organ. (sciencedaily.com)
  • In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
  • However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
  • Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
  • further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
  • Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
  • Hematological cancers (blood cancers) arise in the blood-forming tissues, such as bone marrow, lymph nodes, and lymphatic system. (atlasantibodies.com)
  • Finally Suz-12 was inversely correlated with miR-200b positively correlated with HDAC1 and up-regulated in docetaxel-resistant LAD cells compared with docetaxel-sensitive tissues. (exposed-skin-care.net)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
  • Stem cells, the prodigious precursors of all the tissues in our body, can make almost anything, given the right circumstances. (scienceblog.com)
  • 27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
  • Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)
  • According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
  • Studying how induced pluripotent stem cells develop into various tissues could also shed light on disorders that are due to malfunctions in development. (livescience.com)
  • Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
  • This knowledge, said the researchers, could pave the way for a therapeutic target for ovarian cancer. (sciencedaily.com)
  • Given that knowledge, the researchers concluded that miR-214 is a potential therapeutic target for treating ovarian cancer. (sciencedaily.com)
  • If scientists understood the pathways cancer stem cells use to survive treatment or increase their ranks, then therapeutic targets could be developed, Dr. Vasko said. (medindia.net)
  • Bacterial cancer therapy (BCT) is a promising therapeutic for solid tumours. (york.ac.uk)
  • The identified potential therapeutic targets of HNK (PTTH) included CCND1 , SIRT2 , AURKB , VEGFA , HDAC1 , CASP9 , HSP90AA1 , and HSP90AB1 , which can potentially inhibit the cell cycle of mBCSCs. (hindawi.com)
  • We review how these principles have been translated to novel immunotherapies currently utilized in clinical practice and describe potential future applications for allo-HSCT in cancer research and development of novel therapeutic strategies. (broadinstitute.org)
  • Recent studies revealed that RNA binding proteins have the potential to serve as a therapeutic target in cancer management. (ku.edu)
  • Together our results indicate that, despite the heterogeneity characterising pancreatic cancer tumorspheres, we can identify a functional vulnerability that represents a window for pharmacological intervention and development of novel therapeutic strategies. (lu.se)
  • Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
  • The researchers concluded that although further studies are needed to confirm the effect of AMSCs on neovascular diseases, the data collected in their study provided insights into the mechanisms by which these cells exert their therapeutic effects. (genengnews.com)
  • The identification of the ARTS gene and its role in cancer cell death provides a potential target for new therapeutic approaches. (scienceblog.com)
  • Investigators at the Department of Clinical Genetics have a strong track record in identifying novel cell surface markers on leukemia stem cells and were the first to demonstrate the potential therapeutic use of recombinant antibodies directed against the marker IL1RAP (interleukin-1 receptor accessory protein) on cancer stem cells in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). (lu.se)
  • The strategy used to identify new therapeutic markers on leukemia stem cells will also be explored in other tumor types studied within the MAD for Cancer Program. (lu.se)
  • Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. (wikipedia.org)
  • Researchers have recently debated the notion that some therapies are not capable of eradicating cancer because they do not target the cancer stem cells responsible for tumor development. (medindia.net)
  • Some novel therapies are already being tested against cancer stem cells, he added. (medindia.net)
  • Breast cancer (BC) is the most common cancer among women, and current available therapies often have high success rates. (wjgnet.com)
  • What can genetics tell us about individualizing cancer therapies? (nyscf.org)
  • The scientists believe that their technique may advance stem cell therapy toward clinical practice and offer novel therapies for eye diseases in people. (genengnews.com)
  • As such, this work could help lead to novel stem cell therapies and shed light on a variety of mental disorders, such as schizophrenia , autism and bipolar disorder, which may stem from problems with development, researchers say. (livescience.com)
  • Cells from corpses might play a key role in developing future stem cell therapies . (livescience.com)
  • Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
  • There were no effective markers or tags that we could use to clearly discriminate the stem or progenitor cells from other cells. (sciencedaily.com)
  • To spot and watch the progenitor cells at work, Gumucio's team, under lead author Xiaotan T Qiao, Ph.D., a U-M Medical School research associate, had to get past the hurdle that has deterred the search for stomach stem cells so far -- finding effective markers, which act like identification tags to make tracing possible. (sciencedaily.com)
  • This may help explain why the expression of stem cell markers has been associated with resistance to chemotherapy and radiation treatments and poor outcome for patients with cancers including prostate, breast and lung cancers," Dr. Vasko said. (medindia.net)
  • That tells us that understanding how to target these markers and these cells could prove useful in treating these cancers. (medindia.net)
  • The cancer stem cell markers include Nanog and BMI1, both of which contribute to stem cells' defining ability to renew themselves and differentiate into different cell types, Dr. Vasko said. (medindia.net)
  • To test this hypothesis, Dr. Vasko, along with scientists from the CRTRC Institute for Drug Development in San Antonio and from the Johns Hopkins University, set out to measure both stem cells markers and tumor volume before and after treatment in a mouse model. (medindia.net)
  • These treatments were not enough to completely inhibit tumor growth, and the cancer stem cell markers were still present," Dr. Vasko said. (medindia.net)
  • Use of the agents Velcade and Docetaxel led to the most significant increase in stem cell markers within the treated tumor, while ifosfamide and Avastin inhibited expression of the markers in this cancer subtype. (medindia.net)
  • Dr. Vasko doesn't know how this happens, but theorizes that "dying cells could secrete a lot of factors that induce expression of stem cell markers in other cancer cells. (medindia.net)
  • Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)
  • The objective of this article was to evaluate how these chemotherapeutic regimens affect the proportion of cancer stem cells and the expression of stemness markers. (isciii.es)
  • After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them. (isciii.es)
  • The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
  • Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
  • For lung cancers, CSC markers include CD44 and CD133 (PROM1), but also CD117 (KIT), CD90 (or THY1), CD166, EpCAM for non-small-cell lung carcinoma (NSCLC), and PODXL-1, PTCH, and CD87 for small-cell lung carcinoma (SCLC) 25 . (atlasantibodies.com)
  • Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
  • In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
  • Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
  • Pancreatic cancer tumorspheres display a heterogeneous pattern of surface and stemness markers, nevertheless they are characterised by an increased tumorigenic potential and higher chemoresistance. (lu.se)
  • In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
  • Surface markers of distinct BTIC subpopulations were validated in fluorescence-activated cell sorting (FACS) and colony forming assays. (cns.org)
  • Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)
  • Methods: Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. (whiterose.ac.uk)
  • Within the MAD for Cancer Program, a previously unexplored combination of strategies will be used to identify new cell surface markers on AML stem cells. (lu.se)
  • Here, the stem cells are shown expressing various markers and differentiating into neurons. (livescience.com)
  • In glioma CSC (GCSC), the expression of some neural stem markers, such as SOX2 and Musa-shi-1, has been reported[6,7]. (123dok.net)
  • This model suggests that only certain subpopulations of cancer stem cells have the ability to drive the progression of cancer, meaning that there are specific (intrinsic) characteristics that can be identified and then targeted to destroy a tumor long-term without the need to battle the whole tumor. (wikipedia.org)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
  • The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
  • Furthermore, there is an absence of a cellular hierarchy in cell lines and all cells in culture are able to drive tumor progression. (whiterose.ac.uk)
  • Abnormal changes in miRNAs have been discovered in breast cancer, and miRNAs have been demonstrated to be associated with the tumorigenesis and progression of breast cancer [8, 10]. (researchsquare.com)
  • Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
  • MiR-21 regulates EMT phenotype and hypoxia-inducible aspect-1α appearance in third-sphere developing breast SCH58261 cancer SCH58261 tumor stem cell-like cells. (exposed-skin-care.net)
  • Last, we show that established UM cell lines and UM STCs are plastic in nature and switch their phenotype in response to environmental stimuli. (whiterose.ac.uk)
  • In work performed by Division of Translational Cancer Research it is shows that the hypoxic state pushes neuroblastoma and breast cancer towards an immature, stem cell-like phenotype. (lu.se)
  • This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity: the cancer stem cell (CSC) and stochastic model. (wikipedia.org)
  • Microfluidic genetic profiling of BTICs at the single-cell level was performed to characterize intra-tumoral BTIC heterogeneity. (cns.org)
  • This is the first demonstration of cancer stem cell heterogeneity in glioblastoma at the single-cell level, and particularly as it relates to prospective isolation and bulk tumor subtypes. (cns.org)
  • The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • Mechanistically, we identified the Inhibitor of DNA binding 1 and 3 ( ID1, ID3 ), drivers of cancer stemness and plasticity, as previously uncharacterized targets of transcriptional repression by ZNF148. (nature.com)
  • With the addition of a preface on lessons learned and an epilogue on identity changes, this compelling story documents and reflects upon his diagnosis, treatment, and recovery, including a detailed account of the stem cell transplant that saved his life. (barnesandnoble.com)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
  • As a stem cell transplant patient, you have new opportunities for a healthy and full life. (cdc.gov)
  • Stem cells from your own body (also called an autologous transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • As you recover from your transplant, your white blood cell count can become very low, also known as neutropenia pdf icon [PDF - 4 pages] . (cdc.gov)
  • Fungal infections can happen days, weeks, or months after the stem cell transplant. (cdc.gov)
  • Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
  • Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • Results: We demonstrate that expression of ALDH, CD44, and CD133 does not select for a subpopulation of stem-like cells in either UM cell lines or UM STCs. (whiterose.ac.uk)
  • According to the "stochastic model" (or "clonal evolution model") every cancer cell in a tumor could gain the ability to self-renew and differentiate to the numerous and heterogeneous lineages of cancer cells that compromise a tumor These mutations could progressively accumulate and enhance the resistance and fitness of cells that allow them to outcompete other tumor cells, better known as the somatic evolution model. (wikipedia.org)
  • The benefit of using MSCs in stem cell therapy is their ability to self-renew and differentiate into a variety of specialized cell types, such as osteoblasts, chondrocytes, adipocytes, myocardiocytes, and neuron-like cells. (genengnews.com)
  • This suggested that the extract can cause cancer stem cells to differentiate into a specific mature cell type. (foodscience.news)
  • They can differentiate into cells of the mesodermal lineage, such as adipocytes, and osteocytes. (tocris.com)
  • You and your colleagues found amniotic fluid-derived (AFS) stem cells to have the potential to differentiate into muscle, bone, fat, blood vessel, nerve and liver cells. (scitizen.com)
  • Tras analizar mediante RT-qPCR diferentes marcadores de células madre tumorales (SOX2, OCT4, CD133, CD44 y CD24) en células de cáncer de páncreas tratadas con diferentes protocolos quimioterapéuticos, el Oxaliplatino y la Gemcitabina en monoterapia fueron los quimioterápicos que seleccionaron en mayor medida las células madre cancerosas mientras que el protocolo FOLFIRI las disminuyó. (isciii.es)
  • The miRNA profile between breast cancer stem cells(BCSCs, CD44+CD24-/low) and control MCF-7 breast cancer cells was obtained in a previous study. (researchsquare.com)
  • Previous studies have confirmed that miRNAs play an important role in gene regulation in CD44 + CD24 -/low breast cancer stem cells (BCSCs). (researchsquare.com)
  • In our previous research, we performed miRNA profiling between sorted CD44 + CD24 -/low BCSCs and the control MCF-7 breast cancer cells [8]. (researchsquare.com)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • The epithelial cells that make up the millions of glands of the stomach are constantly turning over. (sciencedaily.com)
  • The researchers also tested the effects of pomegranate extracts on epithelial-to-mesenchymal transition (EMT), a reprogramming process associated with the formation of cancer stem cells and the maintenance of their characteristics. (foodscience.news)
  • Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. (isciii.es)
  • Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
  • However, very little is known about the regulation of SC maintenance pathways in cancer and how these are affected by cancer-specific genetic alterations and by treatment. (medscape.com)
  • The role of BCSCs in cancer formation, growth, invasiveness, therapy resistance and tumor recurrence is becoming increasingly clear. (wjgnet.com)
  • Recurrence and chemoresistance in pancreatic cancer are largely related to cancer stem cells. (isciii.es)
  • By continuously analyzing breath particles, we anticipate the ability to detect any signs of lung cancer recurrence at an early phase, facilitating prompt medical attention and tailored treatment strategies," explains Sandra Linstedt. (lu.se)
  • In past research, miR-214 has also been associated with resistance to the chemotherapy drug cisplatin, but the role played by miR-214 in cancer stem cells had not been determined. (sciencedaily.com)
  • We hypothesize that the tumor escapes from chemotherapy by induction of stem cell marker expression," he said. (medindia.net)
  • Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
  • Pancreatic cancer treatment in advanced stages is based on different chemotherapy regimens. (isciii.es)
  • Although surgical resection can be applied when the tumor is well defined (20% of cases) 1 , most patients with pancreatic cancer are treated with chemotherapy. (isciii.es)
  • The cells also showed resistance to chemotherapy and rapidly replenished the leukemic cell population right after therapy. (foodscience.news)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • High doses of chemotherapy drugs or radiation therapy can kill cancer cells but often also kills the person's stem cells, which prevents the bone marrow from producing normal blood cells. (msdmanuals.com)
  • Stem cell transplants allow doctors to give high doses of chemotherapy to treat leukemias and some lymphomas. (msdmanuals.com)
  • Mason endured more than 9 months of chemotherapy and stem cell transplants. (cdc.gov)
  • Now, for the first time, we have the experimental tools to ask important questions, like, 'Does stomach cancer really arise from mutations in this progenitor cell population? (sciencedaily.com)
  • Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
  • Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • Lately we have discovered miR-200b as an integral regulator of chemoresistance and repair of miR-200b considerably reverses chemoresistance of docetaxel (DTX)-resistant LAD cells by inducing cell routine arrest and apoptosis improvement [19]. (exposed-skin-care.net)
  • They have more stem cells with enhanced resistance to apoptosis. (scienceblog.com)
  • We make a connection between apoptosis, stem cells and cancer that has not been made in this way before: this pathway is critically important in stem cell death and in reducing tumor risk," Steller says. (scienceblog.com)
  • The work supports the idea that the stem cell is the seed of the tumor and that the transition from a normal stem cell to a cancer stem cell involves increased resistance to apoptosis. (scienceblog.com)
  • ARTS interferes with molecules called inhibitor of apoptosis proteins (IAPs), which prevent cells from killing themselves. (scienceblog.com)
  • By inhibiting these inhibitors, under the right circumstances ARTS helps to take the brakes off the process of apoptosis, permitting the cell to die on schedule. (scienceblog.com)
  • Silencing of ZNF148 increased the stemness and tumorigenicity in TNBC cells. (nature.com)
  • KIYATEC's focus is small cell lung cancer (SCLC), one of the deadliest forms of cancer today with little advancement in treatments in 4 decades. (weeksmd.com)
  • These promising options are not currently available for patients with small cell lung cancer, but, with this work, we hope to change that. (weeksmd.com)
  • Intro Lung malignancy accounts for probably the most cancer-related mortalities in both women and men worldwide [1]. (exposed-skin-care.net)
  • Lung cancer is the leading cause of cancer-related death, and environmental and occupational exposure is a major cause of most cases [ 1 , 2 ]. (oncotarget.com)
  • It has been seen that ALDH1 expression in non-small cell lung cancer (NSCLC) and the presence of marker was linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in NSCLC patients with platinum treatment. (ijpmonline.org)
  • Hence, our objective was to detect association of cancer stem cell (CSC) marker aldehyde dehydrogenase 1 (ALDH1) with clinicopathological profile in lung carcinoma patients. (ijpmonline.org)
  • It was a Pilot study where biopsies from 55 fresh previously untreated lung cancer patients visiting the Pulmonary Medicine Department of Era's Lucknow Medical College and Hospital Lucknow and King George's Medical University were taken for 18 months November 2014-April 2016, after taking proper informed consent from them. (ijpmonline.org)
  • [1] The absolute and relative frequency of lung cancer has risen dramatically over the decade. (ijpmonline.org)
  • In 1985, Lung carcinoma became the leading cause of cancer deaths in women and now causes approximately twice as many deaths as breast cancer. (ijpmonline.org)
  • Of late as per WHO Lung cancer deaths are declining in men, and the death rate in women has plateaued secondary to decreases in smoking. (ijpmonline.org)
  • [1] Still, it is seen that more women die annually of lung cancer than breast cancer which could be attributed to the increasing trend of smoking and passive smoke inhalation in women. (ijpmonline.org)
  • [1] However, 9.3% of cancer-related deaths in both the sexes is still attributed to lung cancer. (ijpmonline.org)
  • Despite a number of factors like the increasing numbers of new cases (171,600) per year, the large numbers of current and ex-smokers at risk in the United States (50 million each), position of lung cancer as a predominant cause of death among Americans (6%), and a constant 72% mortality rate among lung cancer patients, there is almost no strategy or research funding for this epidemic even in the developed world. (ijpmonline.org)
  • Lung cancer is a severe form of cancer and detecting it at an early stage is critical for effective treatment. (lu.se)
  • Dr. Sandra Lindstedt, a senior consultant in thoracic surgery at SkÃ¥ne University Hospital and an adjunct professor at Lund University, is leading a team to develop a non-invasive diagnostic tool for lung cancer. (lu.se)
  • The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)
  • That's why, say proponents, it can be relatively easy to get a patient into remission, but extremely difficult to prevent the cancer stem cells from roaring back and causing a relapse months or years later. (ca.gov)
  • The overall goal of the contract is to develop culture systems which can grow and maintain the rare population of malignant cells referred to by some as cancer stem cells, which are believed to lead to therapy resistance, relapse and death from metastatic disease. (weeksmd.com)
  • Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
  • Dr. Domchek always tests patients for mutations in genes called BRCA1 and BRCA2 , as these mutations can significantly increase a woman's risk for developing ovarian cancer. (nyscf.org)
  • Modulation of pro and anti-apoptotic genes in cervical cancer cells after exposure to MNBE. (biomedcentral.com)
  • This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
  • In vitro assays have also been performed to assess whether the lentiviral vector could potentially transform cells. (ca.gov)
  • Importantly, loss of target analyses showed that KH-3 exerted its anti-pancreatic cancer effect in an HuR dependent way in vitro and in vivo. (ku.edu)
  • Anti-WNT1 and anti-WNT2 monoclonal antibodies show in vitro effects in cancer treatment. (aacrjournals.org)
  • Materials and Methods: We used in vitro, in vivo, and archival human HNSCC tissue analysis to evaluate the effects of CSC on cancer stem-like cell formation. (umn.edu)
  • Basically, we came to this conclusion by harvesting the cells from amniotic fluid making sure they were a true stem cell population and going through the reverse studies that need to be done to show that the cells truly are pluripotent. (scitizen.com)
  • Researchers produced pluripotent stem cells from the fibroblast cells in the brain lining of human corpses. (livescience.com)
  • Mature cells can be made or induced to become immature cells, known as pluripotent stem cells , which have the ability to become any tissue in the body and potentially can replace cells destroyed by disease or injury. (livescience.com)
  • Cadaver-collected fibroblasts can be reprogrammed into induced pluripotent stem cells using chemicals known as growth factors that are linked with stem cell activity. (livescience.com)
  • Now scientists have taken fibroblasts from the scalps and the brain linings of 146 human brain donors and grown induced pluripotent stem cells from them as well. (livescience.com)
  • Successfully reprogramming induced pluripotent stem cells so they behave like the cells they are meant to replace means that samples of the mimicked cells must be present for comparison. (livescience.com)
  • Researchers have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. (sciencedaily.com)
  • Their current study found that miR-214 regulates ovarian cancer stem cell properties by direct repression of p53, which led to induction of a stem cell transcription factor (Nanog). (sciencedaily.com)
  • The researchers demonstrated that p53 mediated miR-214-induced Nanog in ovarian cancer stem cells and also induced chemoresistance. (sciencedaily.com)
  • Our study demonstrates direct evidence that miR-214 plays a critical role in maintaining ovarian cancer stem cells. (sciencedaily.com)
  • July 7, 2023 A group has discovered previously unidentified ovarian cancer-specific membrane proteins. (sciencedaily.com)
  • Feb. 11, 2022 Researchers discovered how ovarian cancer hides from the body's immune system. (sciencedaily.com)
  • Higher lipid unsaturation levels were also detected in CSC-enriched spheroids compared to monolayer cultures of ovarian cancer cell lines or primary cells. (nih.gov)
  • ovarian cancer. (nih.gov)
  • Five years after diagnosis, ovarian cancer survival rates are just 47% - a number that has not changed in the past 25 years. (nyscf.org)
  • The American Cancer Society estimates that roughly 21,000 women will receive an ovarian cancer diagnosis in 2020, and roughly 13,000 of these patients will die. (nyscf.org)
  • Through our Women's Reproductive Cancers Initiative, NYSCF is aiming to improve outcomes for patients with ovarian cancer and enable personalized treatments. (nyscf.org)
  • What makes ovarian cancer so hard to treat? (nyscf.org)
  • There are many factors that make ovarian cancer tough to treat, but one of the most important ones is the highly personalized nature of the disease. (nyscf.org)
  • It should be the standard of care that every patient with ovarian cancer undergoes genetic testing to see if they carry certain genetic mutations," remarked Dr. Domchek, Executive Director of the Basser Center for BRCA at the University of Pennsylvania Perelman School of Medicine and a member of the NYSCF Women's Reproductive Cancers Initiative Scientific Advisory Board. (nyscf.org)
  • I never finalize my recommendation for an ovarian cancer patient without complete sequencing of their tumor. (nyscf.org)
  • Mutations can either be acquired over time by a tumor, or you can be born with them-both are important for understanding ovarian cancer. (nyscf.org)
  • If you have ovarian cancer, I highly recommend this testing," she said. (nyscf.org)
  • What are some other current strategies for treating ovarian cancer? (nyscf.org)
  • Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • If you receive stem cells from a donor, the transplanted stem cells may attack your body. (cdc.gov)
  • Donor stem cells can be collected in two ways. (medlineplus.gov)
  • Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
  • First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
  • replaces the killed stem cells with healthy stem cells from a donor. (msdmanuals.com)
  • Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
  • Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. (researchsquare.com)
  • Our emerging clinical data demonstrates that these gene-modified T cells are very active in killing tumor cells initially, but they lose their ability to function within a few weeks. (ca.gov)
  • This experience points to the need to have a continuous source of gene-modified cells to maintain the ability to kill cancer cells. (ca.gov)
  • In this study, we hypothesize that gene-modified stem cells will allow a sustained production of active T cells with antitumor activity. (ca.gov)
  • Since there is a delay in the appearance of the T cells that come from stem cells to get out of the bone marrow and into the blood, we will give patients both gene-modified T cells for a first wave of antitumor activity and gene-modified stem cells which will provide a bridge until the stem cells have produced more T cells. (ca.gov)
  • The purpose of the current study is to give gene-modified T cells in combination with gene-modified stem cells to reprogram the immune system to recognize and kill cancer cells that have the NY-ESO-1 protein with sustained killing activity. (ca.gov)
  • Gene modification of cells involves the transfer of foreign genetic material (DNA) into a cell, in this case the immune system cells and stem cells. (ca.gov)
  • In this study, the gene-modified immune cells will be given in combination with the gene-modified stem cells. (ca.gov)
  • To date, we have manufactured a batch of the lentiviral vector necessary to transfer the NY-ESO-1 TCR into stem cells and have demonstrated that this vector can gene-modify human stem cells. (ca.gov)
  • We have demonstrated that when mouse stem cells are gene-modified with this lentiviral vector, the stem cells take up residence in the bone marrow and produce appropriate blood cells. (ca.gov)
  • A preclinical study is also ongoing in mice to assess the safety of combining the gene-modified T cells and stem cells in mice. (ca.gov)
  • The vector includes a suicide gene which we have shown can be used to kill cells if necessary. (ca.gov)
  • Using gene manipulation strategies, we reveal for the first time that Cav-1 plays an essential role in CSC regulation and aggressiveness of SWCNT-transformed cells partly through p53 dysregulation, consistent with their suggested role by microarray and gene ontology analysis. (oncotarget.com)
  • The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
  • Since the early 2000s they have been an intense cancer research focus. (wikipedia.org)
  • We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
  • The mission of the American Association for Cancer Research is to prevent and cure cancer. (medindia.net)
  • Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. (medindia.net)
  • Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. (medindia.net)
  • In addition, a preclinical study was performed to demonstrate that the stem cells are able to be specifically eliminated using ganciclovir, which provides a safety feature in case there was a problem when translating this research to humans. (ca.gov)
  • Now, finally after I have lectured on the need to address the cancer STEM cell for the past 8 years the research is focusing on this important target. (weeksmd.com)
  • GREENVILLE, S.C.-( BUSINESS WIRE )-SCRA Technology Ventures' SC Launch company KIYATEC announced today an award of a Fast Track Phase I and Phase II Small Business Innovation Research (SBIR) Contract for $1.725M from the National Cancer Institute (NCI), one of the 27 institutes and centers that comprise the National Institutes of Health (NIH). (weeksmd.com)
  • More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research. (broadinstitute.org)
  • The existence of stem cells in hematological tissue prompted research in other tissue cancer types. (atlasantibodies.com)
  • Even two patients with the same tumor type can have very different disease experiences," explained Dr. Andres Martin, a Research Investigator in Oncology at the NYSCF Research Institute and leader of the Women's Reproductive Cancers Initiative. (nyscf.org)
  • MicroRNAs (miRNAs) have become a hot topic in cancer research, but the underlying mechanism of its involvement in cancer remains unclear. (researchsquare.com)
  • Our Cancer Research Guide highlights over 750 products for cancer research. (tocris.com)
  • Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products. (tocris.com)
  • Now research from Rockefeller University shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer. (scienceblog.com)
  • 8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
  • 27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
  • 21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
  • 6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
  • 25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
  • At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
  • World Cancer Day, celebrated on 04 February, is a time to reflect on the progress being made in cancer research. (lu.se)
  • At the end of 2023, their work received a significant boost through generous funding of SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society and the Swedish Childhood Cancer Fund. (lu.se)
  • We hope that this new method will foster a culture of proactive health management and shift the paradigm towards preventive care, in addition to paving the way for more effective treatments," says Sandra Linstedt, research group leader at Lund Stem Cell Center. (lu.se)
  • The Childhood Cancer Survivorship, Treatment, Access, and Research (STAR) Act was signed into law to address childhood cancer. (cdc.gov)
  • Salamanders have a unique ability to regenerate their limbs and have shown resistance to cancer in previous studies, making them a fascinating animal species for researchers in the field of regenerative medicine. (lu.se)
  • Our experiments suggest that some treatments could be producing more cancer stem cells that then are capable of metastasizing, because these cells are trying to find a way to survive the therapy," said one of the study's investigators, Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences in Bethesda, Md. (medindia.net)
  • Any therapy that doesn't wipe out these elite cancer stem, or initiating, cells has no chance of completely eradicating the disease even if it destroys nearly all other tumor cells. (ca.gov)
  • Consequently, in order to develop effective targeted therapy, there is a pressing need to identify all molecular regulators that define cancer stem cell traits in TNBC. (nature.com)
  • A strategy in the treatment of cancer by harnessing the immune system, called adoptive cell therapy, is to use an individual's own immune cells (T cells) and genetically modify them to target them to kill the cancer. (ca.gov)
  • BCSCs are mostly dormant, and therefore, activating them and modulating the cell cycle are important for successful therapy against BCSCs. (hindawi.com)
  • We used the pancreatic adenocarcinoma cell line PANC-1 as a model to apply different chemotherapeutic protocols (monotherapy and combined therapy) using 5-Fluorouracil, Oxaliplatin, Irinotecan, Gemcitabine and Abraxane. (isciii.es)
  • In conclusion, these findings could improve and personalize pancreatic cancer therapy. (isciii.es)
  • Brain tumor-initiating cells (BTICs), self-renewing multi-potent cells critical for tumor maintenance and growth, are attractive targets of glioblastoma therapy. (cns.org)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
  • In a recent study published in Nutrition and Cancer , researchers from the University at Albany in New York revealed that pomegranates can be used in the prevention of breast cancer due to their ability to suppress cancer stem cells, which have become important targets of cancer therapy. (foodscience.news)
  • How far away do you think we are from possibly using AFS stem cells for regenerative therapy? (scitizen.com)
  • These cells are not killed by conventional cancer therapy and thus it is critical to identify those cancer stem cells to be able to improved diagnostics and treatment of cancer. (lu.se)
  • The finding is significant because the existence of such a cell in the aggressive skin cancer has been a source of debate. (ca.gov)
  • These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
  • Current knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC, the so-called "BC stem cells" (BCSCs). (wjgnet.com)
  • Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. (springer.com)
  • Cholangiocarcinoma (CCA) is an aggressive type of liver cancer, which arises from the epithelium of the biliary tract. (springer.com)
  • Glioblastoma is the most common and aggressive primary human brain cancer. (cns.org)
  • Colorectal cancer is the third-leading cause of cancer related mortality in the United States. (mdpi.com)
  • Introduction: Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. (jcancer.org)
  • The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
  • The ability to see and trace these cells gives a green light to efforts to understand the origins of one of the world's most common cancers. (sciencedaily.com)
  • Breast cancer is one of the most common cancers in women worldwide [1]. (researchsquare.com)
  • This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
  • In this study, we established highly metastatic GC cell lines by in vivo selection designed for the enrichment of PD-associated GC cells . (bvsalud.org)
  • Our data showed that knockdown of HuR in pancreatic cancer cells significantly inhibited cell migration, invasion, and stem-like features. (ku.edu)
  • Restoration of HuR in HuR deleted (KO) pancreatic cancer cells enhanced migration and enriched CSC population. (ku.edu)
  • At Lund Stem Cell Center, researchers are using innovative approaches to advance the field, offering exciting possibilities for the future. (lu.se)
  • In the end, that leads to more cells accumulating mutations that cannot be eliminated. (scienceblog.com)
  • Despite ZNF148 being an established node of the MYC-network in ES cells, and the significance of MYC in driving cancer stem cells traits, the role of ZNF148 in breast cancer remains elusive. (nature.com)
  • Breast cancer was the most prevalent cancer in 2020 (in terms of new cases) and the leading cause of cancer-related deaths among females [ 1 ]. (hindawi.com)
  • According to the World Health Organization, breast cancer has the highest incidence rate in Indonesia, with a mortality rate of 22,692 cases per year [ 1 ]. (hindawi.com)
  • Breast cancer is the leading cause of cancer mortality in women worldwide. (researchsquare.com)
  • Oncogenic miR-20b-5p was confirmed to promote the malignant behaviors of breast cancer cells and BCSCs. (researchsquare.com)
  • Therefore, it is of great significance to explore the mechanism of tumorigenesis in breast cancer and further identify key regulatory factors. (researchsquare.com)
  • For their study, the American researchers investigated the effects of pomegranate extract on two different breast cancer cell lines. (foodscience.news)
  • They took particular note of the cells' ability to form mammospheres or clumps of mammary gland cells - a hallmark of breast cancer stem cells. (foodscience.news)
  • They reported that pomegranate extract reduced the formation of mammospheres in both breast cancer cell lines, suggesting that it can affect the ability of cancer stem cells to self-renew. (foodscience.news)
  • The researchers reported that pomegranate extract reduced the ability of breast cancer stem cells to migrate. (foodscience.news)
  • Because of this, they believe that pomegranates can be used in the prevention of breast cancer . (foodscience.news)
  • 27 Jun, 2008 05:23 pm A new article in Live Science predicts that adult stem cells may replace silicone breast implants and other contemporary plastic surgery techniques. (scitizen.com)
  • Expression of stem cell marker ALDH1 with the staging of the tumor was observed in 62.5% of Stage I, 80% of Stage II, 94.1% of Stage III, and 100% of Stage IV cases. (ijpmonline.org)
  • Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
  • A ) Active caspase-3 expression was detected by flow cytometry in HeLa, SiHa, and ME-180 cells after treatment with IC 25 and IC 50 of MNBE for 24 h. (biomedcentral.com)
  • B ) Western blot analysis of the expression of NFkB-p65 and p53 in HeLa, SiHa, and ME-180 cells treated with MNBE at indicated dose for 24 h. (biomedcentral.com)
  • Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
  • In mature B and T cells, she could not find any, however, so she began to look at cells earlier and earlier in development, until finally she was comparing hematopoietic progenitor and stem cells. (scienceblog.com)
  • The increase in the number of hematopoietic progenitor and stem cells in Sept4-deficient mice brings with it the possibility of accelerating the accumulation of mutations in stem cells," says Garcia-Fernandez. (scienceblog.com)
  • The efficacy of cancer treatments is, in the initial stages of testing, often measured by the ablation fraction of tumor mass (fractional kill). (wikipedia.org)
  • According to numerous studies, certain plants possess powerful chemicals that can do what conventional cancer treatments cannot: stop drug-resistant cancer stem cells. (foodscience.news)
  • It also provides evidence of the potentially carcinogenic downside to stem cell treatments, and suggests that nature has sought to balance stem cells' regenerative power against their potentially lethal potency. (scienceblog.com)
  • At the time of Mason's diagnosis in 2006, I was shocked by how slow the progress on treatments for childhood cancer had been since my sister was diagnosed in 1981. (cdc.gov)
  • We had to watch our children suffer and die not only from cancer, but also from the side effects of the treatments they endured. (cdc.gov)
  • A team led by Irving Weissman at Stanford University School of Medicine has found the cancer-initiating stem cells in melanoma. (ca.gov)
  • Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)