• Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. (ui.ac.id)
  • To avoid immune recipient's rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived mesenchymal stem cells, lung progenitor cells or induced pluripotent stem cells are used for biofabricating the bioengineered lung. (ibecbarcelona.eu)
  • Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease. (renudermatology.com)
  • Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee. (renudermatology.com)
  • Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. (renudermatology.com)
  • Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients. (renudermatology.com)
  • tibodies to Adv 36, and infected children had higher body In February 2000, he underwent autologous bone marrow mass index z-scores than uninfected children ( 5 ). (cdc.gov)
  • Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
  • Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
  • Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
  • Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
  • As the field of cell-based treatment develops, it has become obvious that different cell types - mesenchyme immature microorganisms (MSCs) being the model - have adequate capacity to dodge or potentially smother the invulnerable framework to the degree that they might be utilized as allografts without requiring corresponding immunosuppression [ 2 ]. (alliedacademies.org)
  • Clinical preliminaries have shown that allogeneic bone marrow-inferred MSCs might be securely managed to people without evoking clinically applicable insusceptible responses. (alliedacademies.org)
  • Ensuing to this intense MI preliminary, we played out a randomized clinical preliminary in patients with ongoing ischemic cardiomyopathy, which had as its fundamental objective the examination of transendocardial infusion of autologous and allogeneic bone marrow-determined MSCs. (alliedacademies.org)
  • Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. (ui.ac.id)
  • This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. (ui.ac.id)
  • Mean confluence period of adipose MSCs post- irradiation was 4.33 days. (ui.ac.id)
  • Therefore, it is proposed that "kidney-triple energizers" might be the essence of mesenchymal stem cells (MSCs) system. (magtechjournal.com)
  • Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). (biomedcentral.com)
  • This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate the potential underlying mechanisms. (biomedcentral.com)
  • PCR analysis showed that human bone marrow MSCs expressed two subtypes of PARs, PAR-1 and PAR-2. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)
  • However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
  • Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
  • It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
  • When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
  • Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
  • Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
  • Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
  • MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • 2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
  • 3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
  • This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
  • The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
  • Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and the fat in bone marrow. (ijbs.com)
  • In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (ijbs.com)
  • While BM-MSCs have high cell-to-cell heterogeneity in gene expression, the cell subtypes that contribute to this heterogeneity in vivo in humans have not been characterized. (ijbs.com)
  • To investigate the transcriptional diversity of BM-MSCs, we applied single-cell RNA sequencing (scRNA-seq) on freshly isolated CD271 + BM-derived mononuclear cells (BM-MNCs) from two human subjects. (ijbs.com)
  • We successfully identified LEPR hi CD45 low BM-MSCs within the CD271 + BM-MNC population, and further codified the BM-MSCs into distinct subpopulations corresponding to the osteogenic, chondrogenic, and adipogenic differentiation trajectories, as well as terminal-stage quiescent cells. (ijbs.com)
  • The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
  • The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)
  • Bone marrow transplant is the most widely used stem cell therapy, but some therapies derived from umbilical cord blood are also in use. (allstemcells.com)
  • These cells can be harvested from various sources, such as bone marrow, adipose tissue, or umbilical cord blood, and then introduced into the affected area. (suzyfavorhamilton.com)
  • Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue[J]. Int J Mol Med, 2016, 37: 115-125. (magtechjournal.com)
  • Replenish new functional cells through spontaneous differentiation into tissue-compatible cells after homing to damaged tissue. (wikipedia.org)
  • The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
  • On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
  • The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
  • They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
  • Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
  • Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
  • Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • Background: The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. (unimore.it)
  • Methods: Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. (unimore.it)
  • Differentiation of new neurons from neural stem cells is described. (kean.edu)
  • these cells can induce neural differentiation. (kean.edu)
  • In particular, this can be performed by transplantation of cells capable of undergoing neuronal differentiation and integration into the proper structural and functional brain networks. (annaly-nevrologii.com)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • Pluripotent stem cells can be directly obtained from normal human tissues without using artificial manipulations such as gene introduction. (wikipedia.org)
  • Stem cells, which are undifferentiated cells capable of differentiating into various cell types, have the unique ability to regenerate damaged tissues. (suzyfavorhamilton.com)
  • When injected into damaged tissues, PRP stimulates cell proliferation and promotes tissue regeneration. (suzyfavorhamilton.com)
  • Tissue engineering involves creating functional, three-dimensional tissues and organs in the laboratory for transplantation or as models for research. (suzyfavorhamilton.com)
  • In orthopedic care, tissue engineering offers exciting possibilities for regenerating damaged bone, cartilage, and other musculoskeletal tissues. (suzyfavorhamilton.com)
  • Researchers are developing innovative strategies to seed cells onto biocompatible scaffolds and provide them with the necessary signals to grow and differentiate into fully functional tissues. (suzyfavorhamilton.com)
  • Marrow stromal cells as stem cells for nonhematopoietic tissues. (renudermatology.com)
  • Stem cells have the potential to regenerate damaged tissues and organs. (arthritistreatmentlab.com)
  • Embryonic stem cells are derived from embryos and have the ability to become any type of cell in the body, while adult stem cells are found in various tissues and can develop into different cell types within that tissue. (arthritistreatmentlab.com)
  • Cells Tissues Organs. (cancercentrum.se)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
  • In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
  • Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
  • Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation. (unimore.it)
  • In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
  • Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)
  • In vitro experiments withcardiac fibroblasts and H9c2 cells confirmed the exceptional biocompatibilityof BC-Ppy composites. (ibecbarcelona.eu)
  • A brief note on allogeneic cell therapy. (alliedacademies.org)
  • Jager M. A brief note on allogeneic cell therapy. (alliedacademies.org)
  • An open door that extraordinarily upgrades the capacity to foster such an item is the utilization of allogeneic treatment, which offers a proficient method for accomplishing both quick accessibility of item and the proper number of cells [ 1 ]. (alliedacademies.org)
  • Stream kilometric crosscoordinate with serum from the second understanding to new contributor T cells showed a powerless positive response, demonstrating low titer, once more allogeneic refinement with class I benefactor antigens. (alliedacademies.org)
  • Likewise, in another clinical preliminary where allogeneic mesenchyme antecedent cells (MPCs) were conveyed to patients with left ventricular help gadgets, contributor explicit HLA refinement created after randomization in two MPC and three control patients, which were all settled by 1 year. (alliedacademies.org)
  • Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
  • Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. (ucsf.edu)
  • Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. (ucsf.edu)
  • Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. (ucsf.edu)
  • Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. (ucsf.edu)
  • Allogeneic cells represent a robust business model for tissue banks and ultimately for big pharma who will industrialize them once approved through the FDA. (cellsurgicalnetwork.com)
  • From a scientific and physician's point of view, the proof that allogeneic cells are equal or superior to one's own cells is certainly lacking and has kept us, for now, working with autologous stem cells. (cellsurgicalnetwork.com)
  • Do we know the long-term consequences of a person receiving a significant load of foreign DNA through multiple stem cell treatments over time with allogeneic cells? (cellsurgicalnetwork.com)
  • This has also been documented with recent reports on matched bone marrow transplants (Holmqvist, Chen, Wu, Assessment of Late Mortality Risk After Allogeneic Blood or Marrow Transplantation in Children, JAMA Oncology, July 26, 2018). (cellsurgicalnetwork.com)
  • These immune and infectious risks are generally low enough that a risk-benefit analysis generally supports the use of allogeneic cells for certain cases. (cellsurgicalnetwork.com)
  • There could be times where allogeneic sources are vital, such as end of life scenarios, or times when the patient is too frail for surgery and requires cell therapy. (cellsurgicalnetwork.com)
  • Functional recovery of spinal cord injury following application of intralesional bone marrow mononuclear cells embedded in polymer scaffold? (ui.ac.id)
  • Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated. (kean.edu)
  • Muse cells do not express CD34 (markers for hematopoietic stem cells, adipose stem cells, VSELs) and CD117 (hematopoietic stem cells markers), Snai1 and Slug (skin-derived precursors markers), CD271 and Sox10 (neural crest-derived stem cells markers), NG2 and CD146 (perivascular cells) or CD31 and von Willebrand factor (endothelial progenitor markers). (wikipedia.org)
  • Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
  • Muse cells are shown to home into the damage site by S1P-S1P recptor 2 axis and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
  • Mesenchymal stem cells and their microenvironment[J]. Stem Cell Res Ther, 2022, 13: 429. (magtechjournal.com)
  • Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
  • These physical stimuli to the organ are translated into the stem cell local microenvironment - e.g. shear stress and cyclic stretch - so that cells sense the physiological conditions in normally functioning mature lungs. (ibecbarcelona.eu)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
  • Biopsy of adipose in glucose transport ( 14 ). (cdc.gov)
  • Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
  • Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. (jamanetwork.com)
  • Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions[J]. Exp Hematol, 2010, 38: 922-932. (magtechjournal.com)
  • This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
  • 4. Mesenchymal stem cell therapy for knee osteoarthritis. (allstemcells.com)
  • Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. (renudermatology.com)
  • The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)
  • Moreover, the transplantation of BMMSCs can decrease aberrant amyloid-beta peptides as well as tau aggregates, inhibit neuroinflammation, and stimulate synaptogenesis. (biomedcentral.com)
  • To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
  • BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
  • BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
  • Although these initial results suggest that Modulatist TM transplantation is a promising therapy, more clinical studies in COPD patients are warranted to evaluate efficacy. (vinastemcelllab.com)
  • This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
  • Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
  • Is to compare between cell-assisted lipotransfer (CAL) and ALA therapy in improvement of fat graft survival. (magnusconferences.com)
  • Stem Cell therapy means the transplant or use of stem cells or other cells to treat or prevent a disease or condition. (allstemcells.com)
  • Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. (jamanetwork.com)
  • Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease. (jamanetwork.com)
  • Stem cell therapy has emerged as a game-changer in orthopedic care. (suzyfavorhamilton.com)
  • Gene therapy is a cutting-edge technique that aims to correct genetic abnormalities or enhance the body's natural healing processes by introducing therapeutic genes into target cells. (suzyfavorhamilton.com)
  • In orthopedic care, gene therapy holds promise for conditions with a genetic component, such as certain types of muscular dystrophy and bone disorders. (suzyfavorhamilton.com)
  • Mesenchymal stem cells:Emerg-ing mechanisms of immunomodulation and therapy[J]. World J Stem Cells, 2014, 6: 526-39. (magtechjournal.com)
  • Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics[J]. Int J Nanomed, 2022, 17:1757-1781. (magtechjournal.com)
  • Collectively, although scientists are increasingly aware of mitochondria's dynamic and transferable capabilities of mitochondria, the unclear mechanism and effectiveness of mitochondrial transfer/transplantation therapy limit its widespread application in diseases. (biomedcentral.com)
  • Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy. (renudermatology.com)
  • Mesenchymal stem cell-based HLA-independent cell therapy for tissue engineering of bone and cartilage. (renudermatology.com)
  • Stem cell therapy has emerged as a breakthrough treatment option for arthritis. (arthritistreatmentlab.com)
  • Recent scientific studies and clinical trials have demonstrated the effectiveness of stem cell therapy in relieving pain and improving joint function in individuals with arthritis. (arthritistreatmentlab.com)
  • While each approach to stem cell therapy has its advantages and limitations, all have shown promising results in improving pain relief, joint function, and overall quality of life in individuals with arthritis. (arthritistreatmentlab.com)
  • Your own stem cells provide your patients with the safest cell therapy option we know of for now. (cellsurgicalnetwork.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Mesenchymal stem cells: immunology and therapeutic benefits. (ui.ac.id)
  • 2011. http://www.intechopen.com/books/stem-cells-in-clinic-and-research/mesenchymal-stem-cells-immunology-and-therapeutic-benefits . (ui.ac.id)
  • Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. (ca.gov)
  • Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)
  • Therapeutic Candidate or Device Autologous blood stem cells edited to restore iduronidase expression Indication Severe Mucopolysaccharidosis Type 1 (MPS1/ Hurler's syndrome) Therapeutic Mechanism Autologous blood stem cells undergo genome editing to restore the production of the missing enzyme. (ca.gov)
  • In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
  • Use of stem cell lines in therapeutic applications is discussed. (kean.edu)
  • Neurotransplantation of neural progenitors derived from iPSCs had a clear therapeutic effect and reinforced the passive avoidance reflex. (annaly-nevrologii.com)
  • The advantages of exosomes provide a therapeutic benefit for younger patients who require more adjustable and sustainable treatments rather than one-time fixed dosing such as MSC transplantation. (biomedcentral.com)
  • Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
  • Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
  • BC-Ppy scaffolds improved cell viability andattachment, promoting a desirable cardiomyoblast morphology. (ibecbarcelona.eu)
  • Immune reactions to receiving someone else's DNA are well documented and reports show that foreign cell transplants are not as safe as suggested (Jacobsohn, Acute Graft Versus Host Disease, Orphanet Journal of Rare Diseases, 2007). (cellsurgicalnetwork.com)
  • The cells might be safe initially, but as they grow and differentiate into functional tissue, your patients could have a serious problem and end up with acute graft versus host disease. (cellsurgicalnetwork.com)
  • They are also positive for general mesenchymal stem cell markers such as CD105, CD90 and CD29. (wikipedia.org)
  • Therefore, Muse cells are double positive for pluripotent and mesenchymal stem cell markers. (wikipedia.org)
  • AIM OF THE STUDY: The study was designed to investigate the effect of Arnica montana (A. montana) mother tincture and homeopathic dilutions on inflammation markers, oxidative stress and cell migration in diverse cell culture models. (bvsalud.org)
  • MATERIALS AND METHODS: We tested A. montana mother tincture and a range of homeopathic dilutions in different human and murine cell culture models to demonstrate their anti-inflammatory properties by measuring the inflammatory markers: tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule (ICAM-1), reactive oxygen species (ROS) and cell migration. (bvsalud.org)
  • CONCLUSIONS: Mother tincture and 1C dilution of A. montana showed anti-inflammatory properties assessed by measurement of several markers (pro-inflammatory cytokines, adhesion molecule, ROS) in various human and murine cell models. (bvsalud.org)
  • When foreign cells are introduced in the stem state, they have few immune markers and will generally have little to no immune reaction for that reason. (cellsurgicalnetwork.com)
  • There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
  • Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold? (renudermatology.com)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
  • They reside in the connective tissue of nearly every organ including the umbilical cord, bone marrow and peripheral blood. (wikipedia.org)
  • The expression of ICAM-1 was significantly reduced with A. montana mother tincture and 1C, 3C, 5C, and 9C dilutions in inflamed human endothelial cells compared with vehicle. (bvsalud.org)
  • In addition, A. montana 3C, 5C, 9C dilutions have anti-inflammatory and antioxidant effects as highlighted on both primary endothelial cells and murine microglial cells. (bvsalud.org)
  • They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
  • Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. (kean.edu)
  • PRP is derived from the patient's own blood and contains a concentrated amount of platelets, growth factors, and other bioactive proteins. (suzyfavorhamilton.com)
  • Muse cells do not undergo teratoma formation when transplanted into a host environment in vivo. (wikipedia.org)
  • In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC). (unimore.it)
  • The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
  • Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. (biomedcentral.com)
  • Methods for transplantation of stem cells are presented. (kean.edu)
  • The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
  • The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
  • Associate editor in Journal of Stem Cell Research and therapeutics. (magnusconferences.com)
  • Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. (ucsf.edu)
  • In his early career Dr. Cogle discovered that blood stem cells make blood vessels and used that biology to invent new therapeutics and diagnostics for people with cancer and heart disease. (ufl.edu)
  • Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
  • We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
  • They are collectable from commercially obtainable mesenchymal cells such as human fibroblasts, bone marrow-mesenchymal stem cells and adipose-derived stem cells. (wikipedia.org)
  • Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
  • They significantly reduced both IL-6 and MCP-1 in inflamed human microglial cells and significantly decreased COX-2 expression in inflamed murine fibroblasts. (bvsalud.org)
  • Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier's disease, and neurogenerative diseases in general, is explained. (kean.edu)
  • While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
  • Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model. (jamanetwork.com)
  • However, transplantation and received a conditioning regimen of in animals and adults in the United States, serum choles- etoposide, cytoxan, and fractionated total-body irradiation. (cdc.gov)
  • Donor-Muse cells can be directly used for treatment without HLA-matching test or immunosuppressant treatment due to the specific immune privilege. (wikipedia.org)
  • In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. (researchgate.net)
  • New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell carcinoma, actinic keratosis, and cosmetic applications. (researchgate.net)
  • Cell based treatment is at the front of clinical examination for cardiovascular infection, upheld by more than 10 years of thorough pre-clinical investigation of cell science, mechanism(s) of activity, immunology, and phenotypic adequacy. (alliedacademies.org)
  • Critically, making an interpretation of cell treatment into standard clinical practice requires the capacity to direct a protected and strong item at the ideal measurements promptly. (alliedacademies.org)
  • 5. Adipose Tissue-derived Stem Cells Treatment for Crohn's Fistula. (allstemcells.com)
  • Indication AiPSC-RPE cell product will be indicated for the treatment of maculopathies related to RPE atrophy. (ca.gov)
  • Hematopoietic stem cell (HSC) transplantation provides an effective platform for the treatment of hematological disorders. (rsc.org)
  • When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
  • In this review, we show that the application of MSC-derived EV for the treatment of CSU has positive effects, including accelerating healing and decreasing scar formation. (frontiersin.org)
  • Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. (renudermatology.com)
  • The good news is that stem cells have emerged as a breakthrough treatment option for arthritis. (arthritistreatmentlab.com)
  • But, are stem cells different just because the effect is not detected the first weeks after treatment? (cellsurgicalnetwork.com)
  • A Muse cell (Multi-lineage differentiating stress enduring cell) is an endogenous non-cancerous pluripotent stem cell. (wikipedia.org)
  • However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
  • Reduce Inflammation: Stem cells can differentiate into cells that produce anti-inflammatory cytokines, reducing inflammation in the affected joints. (arthritistreatmentlab.com)
  • Has anyone looked at what happens down the road when those cells differentiate into the cells that came from the donor? (cellsurgicalnetwork.com)
  • Exosomes are a non-cellular resource and therefore free from the potential to differentiate into unintended cellular lineages, which is a major problem of MSC transplantation [ 18 ]. (biomedcentral.com)
  • Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)
  • Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity. (ucsf.edu)
  • A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
  • Although the development of cyclosporine A and tacrolimus, which suppress interleukin (IL)-2 expression and T cell-mediated immune responses, was a breakthrough, their adverse effects are still a major problem in the long-term follow-up of transplant recipients. (biomedcentral.com)
  • This type of liver injury is mediated through activation of the adaptive immune system including natural killer and Kupffer cells, which is employed as a method to evaluate the induction liver tolerance [ 19 - 21 ]. (biomedcentral.com)
  • has completed her Ph.D. in Histology & cell biology at Ain Shams University from 2000 to 2005. (magnusconferences.com)
  • His pioneering work spans discoveries in basic biology of blood stem cells and leukemia to first-in-human clinical trials for people with cancer and heart diseases, alongside shaping innovative policies in state health and healthcare financing. (ufl.edu)
  • Dr. John is the CEO and chief scientist at Cellese, with a passion for stem cell biology as it relates to skin and wound healing. (barefacedtruth.com)
  • Our interest in stem cell biology grew out of our work in diabetes. (barefacedtruth.com)
  • The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
  • Minimally invasive MSC injections need C-arm as guidance that potentially influence the cell viability and doubling time. (ui.ac.id)