• This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • This site provides information, referrals, and support by trained peer volunteers who are transplant survivors, caregivers, and donors. (myeloma.org)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • It can also happen through voluntary registries that seek suitable donors for people in need of a transplant. (healthline.com)
  • To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have no matched bone marrow donors. (schoolandyouth.org)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • High dose chemotherapy treatment for lymphoma is followed by the infusion of patients' own bloodforming stem cells to restore the function of the bone marrow. (mitacs.ca)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
  • Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. (biologynews.net)
  • The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
  • Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
  • This process is called stem cell mobilisation and usually involves the use of chemotherapy in combination with colony stimulating growth factor injections - usually G-CSF. (leukaemia.org.au)
  • In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • The tumor was successfully treated with chemotherapy, but 3 years later she was diagnosed with T-cell lymphoblastic lymphoma. (bvsalud.org)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • With greater experience and analysis of significant numbers of cases, lung transplant recipients are living longer, and follow-up regimens are becoming streamlined. (medscape.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Blood advances 2018 9 2 (17): 2254-2261. (cdc.gov)
  • This site provides information for patients and their families ranges from data about transplant outcomes to best practices in follow-up care for patients post-transplant. (myeloma.org)
  • We conduct research to improve transplant outcomes provide support and resources for patients, and partner with a global network. (bethematch.org)
  • For help with understanding these statistics, please see Understanding Transplant Outcomes . (bethematch.org)
  • The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML. (cdc.gov)
  • A temporary catheter will be placed in your neck while you are there, and then you will be transferred to the apheresis area for your stem cell collection. (upstate.edu)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
  • During apheresis, blood comes out of your body through a needle in one arm. (healthline.com)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
  • The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
  • Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
  • The collection of adult stem cells from peripheral blood is performed by a process known as apheresis, in which blood that is removed from one arm is passed through an apparatus that extracts the stem cells and then returns the remaining blood cells to the other arm. (cellmedicine.com)
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • Analysis is performed on metaphase of peripheral blood lymphocytes. (medscape.com)
  • Although the cells of origin are lymphocytes, PCNSL should be considered a brain tumor, because the therapeutic challenges resemble those of other brain tumors. (medscape.com)
  • T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)
  • Therefore, this prospective study aimed to investigate the influence of transplanted cells with cluster of differentiation (CD)184+ expression, CD26+ lymphocytes and monocytes, and reconstitution of CD3+ lymphocytes on overall survival (OS) and progression-free survival (PFS) after auto-SCT in MM. Forty-eight patients with MM underwent auto-SCT at our center from 2011 to 2013. (bvsalud.org)
  • The numbers of CD184+ cells, CD26+ lymphocytes, and CD26+ monocytes were measured in the harvested material. (bvsalud.org)
  • In addition, the number of lymphocyte subpopulations (CD3+ lymphocytes, helpers, suppressors, natural killer (NK), cytotoxic NK, and B lymphocytes) was measured in peripheral blood during regeneration after auto-SCT. (bvsalud.org)
  • Our analysis revealed a statistically significant effect of the number of transplanted CD184+ cells on OS and a statistically significant correlation between PFS and the number of transplanted CD184+ cells and reconstitution of CD3+ lymphocytes. (bvsalud.org)
  • In conclusion, our study showed that the increasing numbers of transplanted CD184+ cells, CD26+ lymphocytes, and CD26+ monocytes augmented the risk of death. (bvsalud.org)
  • CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • The scientists believe that their technique may advance stem cell therapy toward clinical practice and offer novel therapies for eye diseases in people. (genengnews.com)
  • This site provides information about stem cell transplants provided by the American Society of Clinical Oncology (ASCO). (myeloma.org)
  • To advance the clinical application of newborn stem cells by partnering with leading research institutions to establish FDA-regulated clinical trials, exclusive to CBR families, for conditions that have no cure today. (schoolandyouth.org)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • Dr. Hirano's results are most encouraging, but a few more cases need to be studied with objective clinical measures pre-and post-transplant over a few years before we can conclude this treatment is definitely the right thing to do. (lww.com)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
  • We are currently performing clinical study to characterize the phenotype and gene expression profile of peripheral blood monocytes in patients with stroke. (lu.se)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • This site provides information about bone marrow or cord blood transplant process for patients, their families, and health care providers. (myeloma.org)
  • About 18,000 people each year need a bone marrow or cord blood transplant to treat a life threatening illness. (healthline.com)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Several studies are analyzing the effectiveness of rituximab in improving morbidity and mortality in pediatric transplant patients. (oncologynurseadvisor.com)
  • The stem cell (or progenitor cell) collection is a portion of the bone marrow transplant process. (upstate.edu)
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
  • Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
  • Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
  • The benefit of using MSCs in stem cell therapy is their ability to self-renew and differentiate into a variety of specialized cell types, such as osteoblasts, chondrocytes, adipocytes, myocardiocytes, and neuron-like cells. (genengnews.com)
  • In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
  • Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
  • My condition improved a lot after stem cell therapy and ozone bath. (placidway.com)
  • Aplastic anemia is diagnosed with blood and bone marrow studies. (medscape.com)
  • Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • Occasionally, a recipient needs an additional infusion of peripheral blood stem cells (PBSC) to help the transplant fully take hold. (giftoflife.org)
  • Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. (medscape.com)
  • Corticosteroids have a cytotoxic effect on lymphoma cells and can induce a radiographic response in up to half of patients, which limits the sensitivity of diagnostic tools like biopsy or lumbar puncture. (medscape.com)
  • [ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)
  • The DLBCL type of primary central nervous system lymphoma (PCNSL) is composed of immunoblasts or centroblasts that have a predilection for blood vessels and thus demonstrate a typical angiocentric growth pattern. (medscape.com)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • This center has been performing allogeneic transplants since 1985 and has been an NMDP/Be The Match transplant center since February 2000. (bethematch.org)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
  • If you are between the ages of 18 and 60, in good health, and would like to do a good deed, the 'Be The Match' registry would like to solicit the donation of your adult stem cells. (cellmedicine.com)
  • Although originally begun for bone marrow donations, the registry has now expanded to include adult stem cell donations, for which the process is relatively simple, quick, and provides a valuable, life-saving service to others. (cellmedicine.com)
  • and the benefit of the transplant to the recipient. (cdc.gov)
  • When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
  • After a blood test confirmed that she was the best match for her recipient, Gift of Life helped organize Julia's donation at a local collection center. (giftoflife.org)
  • Cytotoxic T cells mount a response on the body and target recipient cells are lysed. (oncologynurseadvisor.com)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • Five days before the scheduled transplant day, or day minus 5, the recipient tested positive for Klebsiella pneumoniae infection of the central venous catheter. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
  • The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • An in-depth discussion of the challenges of caring for a child through transplant and survivorship. (bmtinfonet.org)
  • External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
  • Over time, the cells will make it harder for a child's body to fight infections. (epnet.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
  • These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
  • Learn how marrow donation works, the steps of a patient transplant, steps of donation, and factors that can impact the likelihood of finding a match. (bethematch.org)
  • For overall survival for all patients transplanted with a specific disease, please see U.S. Patient Survival report at bloodcell.transplant.hrsa.gov. (bethematch.org)
  • Patient navigators can answer your questions about choosing a transplant center and provide support and education to help you throughout your transplant journey. (bethematch.org)
  • Dr. Hirano said he hopes the case will alert neurologists to be more vigilant in considering the possibility of MNGIE when faced with a patient with the syndrome of ophthalmoplegia, severe GI dysmotility, extreme cachexia, peripheral neuropathy, and leukoencephalopathy. (lww.com)
  • The other patient who had the transplant, however, died three months after the procedure, his condition having already reached a more severe stage before the transplant. (lww.com)
  • In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
  • These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
  • Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
  • When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
  • Cells Tissues Organs. (cancercentrum.se)
  • Scientists in South Korea transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy. (genengnews.com)
  • One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
  • Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)
  • Wisplinghoff H , Reinert RR , Cornely O , Seifert H . Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. (cdc.gov)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
  • This cancer starts in a type of lymph cell called a lymphocyte. (epnet.com)
  • Blood tests may be done to look for signs of cancer. (epnet.com)
  • If a lump in the breast is found, the doctor may need to cut out a small piece of the lump and look at it under the microscope to see if there are any cancer cells. (stopgettingsick.com)
  • If the biopsy shows that there is cancer, it is important that certain tests (called estrogen and progesterone receptor tests) be done on the cancer cells. (stopgettingsick.com)
  • Tissue from the tumor needs to be taken to the laboratory for estrogen and progesterone tests at the time of biopsy because it may be hard to get enough cancer cells later, although newer techniques can be used on tissue that is not fresh. (stopgettingsick.com)
  • The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
  • When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
  • The cure for blood cancer is in the hands of ordinary people. (bethematch.org)
  • Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • 3: Mörner M, Gunnarsson U, Jestin P, Egenvall M. Volume of blood loss during surgery for colon cancer is a risk determinant for future small bowel obstruction caused by recurrence--a population-based epidemiological study. (cancercentrum.se)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)