• The information presented here covers the legal implications of embryonic stem cells (ES), rather than induced pluripotent stem cells (iPSCs). (wikipedia.org)
  • While embryonic stem cells are taken from embryoblasts, induced pluripotent stem cells are undifferentiated from somatic adult cells. (wikipedia.org)
  • In contrast to multipotent stem cells, embryonic stem cells are pluripotent and are thought to be able to give rise to all cells of the body. (wikipedia.org)
  • In addition to generating pluripotent stem cells, the team showed that mice bred using the cells grew up healthy. (sciencedaily.com)
  • We've demonstrated that we don't have to manipulate the pluripotent genes to get to the ground state, but rather that we can block all other options of where the cell 'wants' to go. (sciencedaily.com)
  • But they could still function as healthy pluripotent stem cells. (sciencedaily.com)
  • Researchers produced pluripotent stem cells from the fibroblast cells in the brain lining of human corpses. (livescience.com)
  • Mature cells can be made or induced to become immature cells, known as pluripotent stem cells , which have the ability to become any tissue in the body and potentially can replace cells destroyed by disease or injury. (livescience.com)
  • Cadaver-collected fibroblasts can be reprogrammed into induced pluripotent stem cells using chemicals known as growth factors that are linked with stem cell activity. (livescience.com)
  • Now scientists have taken fibroblasts from the scalps and the brain linings of 146 human brain donors and grown induced pluripotent stem cells from them as well. (livescience.com)
  • Successfully reprogramming induced pluripotent stem cells so they behave like the cells they are meant to replace means that samples of the mimicked cells must be present for comparison. (livescience.com)
  • Studying how induced pluripotent stem cells develop into various tissues could also shed light on disorders that are due to malfunctions in development. (livescience.com)
  • Jack Hubbard One possible use for pluripotent stem cells is to screen drugs for toxic side effects. (ca.gov)
  • In the future, keratinocytes produced from pluripotent stem cells could be an alternative to adult stem cells in certain reconstructed tissue bio-engineering applications. (cea.fr)
  • The findings, reported yesterday in Nature, suggest a process that doesn't require the reprogrammed adult somatic cells called induced pluripotent stem (iPS) cells. (stanforddaily.com)
  • Promotes differentiation of nociceptors from human pluripotent stem cells, in combination with several other small molecules (Chambers et al. (stemcell.com)
  • Promotes differentiation of pancreatic cells from human pluripotent stem cells (D'Amour et al. (stemcell.com)
  • Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures. (the-scientist.com)
  • S tem cell research that uses pluripotent stem cells derived from human skin or blood cells has led to numerous discoveries, aided drug development , and proven useful in gene therapies. (the-scientist.com)
  • However, many of these human induced pluripotent stem cell (hiPSC) lines banked in repositories or developed in labs likely harbor thousands of undetected mutations, casting doubt on how generalizable the findings made with them can be, according to research published yesterday (August 11) in Nature Genetics . (the-scientist.com)
  • Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
  • A research team from the Salk Institute and Kyoto University have published findings utilizing cerebral organoids derived from induced pluripotent stem cells (iPSCs) to monitor nerve cell activity. (rndsystems.com)
  • Basically, we came to this conclusion by harvesting the cells from amniotic fluid making sure they were a true stem cell population and going through the reverse studies that need to be done to show that the cells truly are pluripotent. (scitizen.com)
  • He and his fellow researchers then used the snow leopard cells to create induced pluripotent stem (iPS) cells, also known as embryonic stem-like cells. (scientificamerican.com)
  • The discovery in 2006 that human and mouse fibroblasts could be reprogrammed to generate induced pluripotent stem cells (iPSCs) with qualities remarkably similar to embryonic stem cells has created a valuable new source of pluripotent cells for drug discovery, cell therapy, and basic research. (thermofisher.com)
  • Our products have been an integral part of induced pluripotent stem cell research from the initial discovery of iPSCs to current breakthroughs. (thermofisher.com)
  • Gibco media, supplements, substrates, growth factors and cytokines provide you with an easy-to-use, flexible set of tools for targeted differentiation of induced pluripotent stem cells. (thermofisher.com)
  • The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
  • Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," says Cheng, who explains that rigorous follow-up tests are required to determine if the reprogrammed cells really behave like pluripotent embryonic stem cells. (hopkinsmedicine.org)
  • Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
  • May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
  • The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
  • Recent data from in vitro models demonstrating the essential role of stromal support in hematopoiesis shaped the view that cell-cell interactions in the marrow microenvironment are critical for normal hematopoietic function and differentiation. (nih.gov)
  • If this differentiation of adult stem cells can be controlled in the laboratory, these cells may become the basis of therapies for many serious common diseases. (news-medical.net)
  • Promotes differentiation of neurons from human and mouse embryonic stem (ES) cells (Crawford and Roelink, Elkabetz et al. (stemcell.com)
  • Promotes differentiation of retinal pigment epithelium from mouse ES cells (Osakada et al. (stemcell.com)
  • Our complete portfolio of stem cell research products and services provides optimized tools for each step of the stem cell workflow: from reprogramming somatic cells to iPSC expansion, validation, and differentiation. (thermofisher.com)
  • Our differentiation portfolio allows optimal growth, expansion and storage of differentiated cells-enabling faster, more efficient systems. (thermofisher.com)
  • The metaphor of a potential epigenetic differentiation landscape broadly suggests that during differentiation a stem cell approaches a stable equili- brium state from a higher free energy towards a stable equilibrium state which represents the final cell type. (lu.se)
  • In order to assess these predictions, we compute the Shannon entropy for time- resolved single-cell gene expression data in two different experimental set-ups of haematopoietic differentiation. (lu.se)
  • Single cells in these populations exhibit different com- binations of regulator activity that suggest the presence of multiple configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • At the heart of this trade-off is stem cell capacity - while stem cell maintenance is crucial for longevity (e.g., for tissue regeneration to repair damage), stem cell differentiation is required for fertility (i.e., to produce gametes). (lu.se)
  • As such, this work could help lead to novel stem cell therapies and shed light on a variety of mental disorders, such as schizophrenia , autism and bipolar disorder, which may stem from problems with development, researchers say. (livescience.com)
  • Cells from corpses might play a key role in developing future stem cell therapies . (livescience.com)
  • The scientists believe that their technique may advance stem cell therapy toward clinical practice and offer novel therapies for eye diseases in people. (genengnews.com)
  • Researchers have recently debated the notion that some therapies are not capable of eradicating cancer because they do not target the cancer stem cells responsible for tumor development. (medindia.net)
  • Some novel therapies are already being tested against cancer stem cells, he added. (medindia.net)
  • Embryonic stem cells have the potential to help treat 70 or more diseases, but developing those new therapies will take time. (ca.gov)
  • At this stage, we can''t confirm whether the cells'' ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes," he added. (medindia.net)
  • While most panelists felt that clinical use of pancreatic stem cells as a cure for diabetes was 15-20 years away, they also believed that application of stem cell therapies would likely include spinal cord injuries, Parkinson's disease and dementia. (news-medical.net)
  • He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
  • I had intended to write about the changes to regulation of stem cell therapies being debated in Italy but Orac beat me to the punch and I am not going to attempt to out Orac Orac. (skeptoid.com)
  • The X-Cell centre in Düsseldorf offered patients from all over Europe highly experimental stem cell therapies for a wide range of conditions from Parkinson's disease to diabetes. (skeptoid.com)
  • This scientific advance, reported in the July 2 issue of Nature , could potentially lead to therapies for patients with blood disorders from their own cells. (businesswire.com)
  • Because these cells secrete and display factors essential for stem cell growth and proliferation, they can be used to support cell-based therapies, stem cell transplant, and regenerative medicine applications. (businesswire.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • A discovery of how stem cells are protected from viruses could inform the development of therapies for use in medicine, research suggests. (ed.ac.uk)
  • Unveiling how this crucial antiviral mechanism is switched off, and methods to switch this back on in a controlled manner, could make stem cell therapies much more efficient. (ed.ac.uk)
  • Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies. (hopkinsmedicine.org)
  • The course covers complications from dysfunctional stem cells in connection with stem cell therapies and tissue engineering, and highlights the legal and ethical issues surrounding stem cell research. (lu.se)
  • Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
  • The function of limbal stem/progenitor cells (LSCs) is critical to maintain corneal epithelial homeostasis. (ca.gov)
  • Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
  • Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)
  • Within the MAD for Cancer Program we aim to clarify the link between kidney cancer and the kidney progenitor cells, and to develop novel biomarkers for kidney cancer based on our understanding of adult kidney progenitor cells. (lu.se)
  • Stem cell treatments are a type of cell therapy that introduce new cells into adult bodies for possible treatment of cancer, somatic cell nuclear transfer, diabetes, and other medical conditions. (wikipedia.org)
  • In the current issue of the same journal [6], researchers compared the frequency and type of mutation induced in embryonic stem cells and embryonic somatic cells. (i-sis.org.uk)
  • They found that the spontaneous mutation frequency in ES cells is 100-fold lower than that in mouse embryonic fibroblasts (a somatic cell line), which is similar to adult cells in vivo . (i-sis.org.uk)
  • Researchers make hiPSCs by harvesting somatic cells-often from skin-from a person and then reprogramming them to enter an embryonic-like state. (the-scientist.com)
  • Stem cells derived from adult somatic cells "will carry the mutational history of their past, as well as of any new mutations that occur when you are reprogramming them or growing them in culture," Nik-Zainal says. (the-scientist.com)
  • Reprogramming of somatic cells for iPSC generation can be accomplished with a number of technologies. (thermofisher.com)
  • Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
  • In January 2007, researchers at Wake Forest University reported that "stem cells drawn from amniotic fluid donated by pregnant women hold much of the same promise as embryonic stem cells. (wikipedia.org)
  • According to modern stem cell researchers, Spain is one of the leaders in stem cell research and currently has one of the most progressive legislations worldwide with respect to human embryonic stem cell (hESC) research. (wikipedia.org)
  • MLL1 plays a key role in the uncontrolled explosion of white blood cells that's the hallmark of leukemia, which is why U-M researchers originally developed MM-401 to interfere with it. (sciencedaily.com)
  • Researchers are questioning the notion that infertility can be treated with stem cells. (sciencedaily.com)
  • The classical theory is based on the idea that the eggs a woman has are the ones she has had from birth, but there are researchers who claim that stem cell research could lead to the creation of new eggs. (sciencedaily.com)
  • New studies done by researchers at the University of Gothenburg and Karolinska Institute now show that the dream of successfully treating infertility with stem cells will probably not be realized. (sciencedaily.com)
  • In the first report [2], researchers from Edinburgh and Oxford took cells from the mouse brain marked with transgene 1, and cultured them together with ES cells marked with a second transgene, 2. (i-sis.org.uk)
  • These researchers pointed out that the spontaneous fusion rate (without interleukin-3) was extremely low, between 2-11 per million bone marrow cells, and is unlikely to account for all the findings with adult stem cells. (i-sis.org.uk)
  • The researchers reported that the AMSCs successfully migrated to the retinas of the test animals and, because of the growth factors secreted by the cells, were able to suppress retinal neovascularization. (genengnews.com)
  • The researchers concluded that although further studies are needed to confirm the effect of AMSCs on neovascular diseases, the data collected in their study provided insights into the mechanisms by which these cells exert their therapeutic effects. (genengnews.com)
  • The researchers tracked 103 patients after stem cell transplants (median, 45 months), 204 patients on alemtuzumab (median, 45 months), and 314 patients on ocrelizumab (median, 35 months). (medscape.com)
  • 18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
  • 6 Jun, 2007 07:00 pm Researchers have reprogrammed skin cells into embryonic stem cells. (scitizen.com)
  • The researchers first determined that Nanog and BMI1 stem cell markers were more highly expressed in metastatic tumors compared to primary tumors. (medindia.net)
  • The idea is that researchers could grow those stem cells into mature cell types such as heart, liver, or brains cells, expose them to new drugs or potential environmental hazards, then look for toxic side effects. (ca.gov)
  • Blue H2O Productions In recent years researchers have found cancer stem cells at the heart of blood cancers as well as some cancers of the brain, breast, colon, head and neck, and others. (ca.gov)
  • Describing the process as "dedifferentiation", the researchers say that it highlights the plasticity of this cell type. (medindia.net)
  • The researchers say that clinical trials with INGAP have shown that it is possible to regrow new functional insulin-producing cells in diabetic patients. (medindia.net)
  • The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
  • The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
  • In order to deposit a cell line someplace like HipSci, researchers only have to demonstrate that the stem cells don't have any missing or duplicated chromosomes or other largescale genetic errors-analyses that would miss the myriad single-nucleotide mutations identified in the new paper. (the-scientist.com)
  • NEW YORK--( BUSINESS WIRE )--Angiocrine Bioscience, Inc. announced today that it has licensed the rights to a new technology developed by a team of researchers at the Ansary Stem Cell Institute at Weill Cornell Medical College. (businesswire.com)
  • Utilizing a well-known mouse mesenchymal stem cell (MSC) model of fat browning, researchers from the Nottingham School of Medicine suggest that caffeine could help in the battle to lose weight and prevent type 2 diabetes . (rndsystems.com)
  • Researchers from the University of Edinburgh studied stem cells from mouse embryos to understand how stem cells can develop resistance to viruses, before they become specialised cells. (ed.ac.uk)
  • Researchers hope that their findings will make the use of stem cells more efficient, to one day be given to patients to replace cells lost or damaged by degenerative diseases such as Parkinson's or diabetes. (ed.ac.uk)
  • And the researchers have already accomplished the first step, creating embryonic stem-like cells from the tissue of an endangered adult snow leopard ( Panthera uncia ). (scientificamerican.com)
  • Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
  • Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)
  • One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," says Cheng. (hopkinsmedicine.org)
  • Each module contains lectures by experienced stem cell researchers, followed by preparation, analysis and discussion of material in compulsory practical exercises, and concludes with an assessed assignment. (lu.se)
  • A team of researchers led by Dr. Cristian Bellodi recently discovered a hardwired genetic control mechanism modulating individual spliceosomal components, known as splicing factors, in cells harboring oncogenic lesions common in human cancers. (lu.se)
  • This creates uncertainty about whether it is at all possible to create new eggs with the help of stem cells," says Kui Liu, a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg. (sciencedaily.com)
  • The interplay between stem cell and tumor biology offers an exceptional opportunity to advance our knowledge about cancer, one of the leading causes of death worldwide, with potential impacts in cancer diagnosis and therapy. (hindawi.com)
  • Professor Dominko's research focuses on stem cell biology, nuclear reprogramming and gene expression, epigenetics, regenerative biology and stem cell niche. (wpi.edu)
  • Research associate Maria Garcia-Fernandez, Hermann Steller, head of the Strang Laboratory of Apoptosis and Cancer Biology, and their colleagues explored the activity of a gene called Sept4, which encodes a protein, ARTS, that increases programmed cell death, or apoptosis, by antagonizing other proteins that prevent cell death. (scienceblog.com)
  • Goldstein presented an overview of the basic principles and concepts of stem cell biology and stem cell clinical trial development. (ca.gov)
  • An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
  • The course covers stem cell biology and regenerative medicine with a focus on the stem cell research areas that are particularly strong at Lund University. (lu.se)
  • You will learn about life-history evolution and molecular cell biology. (lu.se)
  • Strong interests in life-history evolution and molecular cell biology. (lu.se)
  • State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. (bvsalud.org)
  • As a stem cell transplant patient, you have new opportunities for a healthy and full life. (cdc.gov)
  • Stem cells from your own body (also called an autologous transplant). (cdc.gov)
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • As you recover from your transplant, your white blood cell count can become very low, also known as neutropenia pdf icon [PDF - 4 pages] . (cdc.gov)
  • Fungal infections can happen days, weeks, or months after the stem cell transplant. (cdc.gov)
  • Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
  • Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
  • This latest anti-publicity on adult stem cells comes on the heels of a paper announcing success in embryonic stem (ES) cell transplant in a Parkinson rat model published in the house journal of the United States National Academy of Sciences [5]. (i-sis.org.uk)
  • Neither the title of the paper, nor the abstract mentioned that in the experiment, five out of 25 rats receiving the transplant died with "teratoma-like tumors" in their brains, a well-known hazard of ES cells. (i-sis.org.uk)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • A report from a medical panel of academic and community-based endocrinologists and transplant surgeons acknowledged that a recent study supports the use of stem cells as a future cure for type I diabetes. (news-medical.net)
  • This technology nicely complements our efforts in applying our VeraVec TM platform to the expansion of umbilical cord blood stem cells, another approach toward making stem cell transplant safer and more broadly available to patients in need, " added Geoff Davis, Angiocrine's CEO. (businesswire.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • On 13th of February, 2023, a transplant of stem cell-derived nerve cells was administered to a person with Parkinson's at Skåne University Hospital, Sweden. (lu.se)
  • Those of us who lived through the great embryonic stem cell controversy are enjoying the sweet aroma of vindication. (lifeissues.org)
  • Obviously, it's a different cell type: it is neither a embryonic stem cell nor an adult stem cell. (scitizen.com)
  • Without large T, cells form embryonic stem cell-like clusters in three to four weeks. (hopkinsmedicine.org)
  • Recent efforts demonstrated that the multiple mesenchymal lineages can be clonally derived from a single mesenchymal stem cell, supporting the proposed paradigm. (nih.gov)
  • Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • Scientists in South Korea transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy. (genengnews.com)
  • It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
  • These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
  • Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
  • These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
  • Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
  • Jack Hubbard Any cells derived from embryonic stem cells that are transplanted as a therapy will likely be rejected by the immune system much like a transplanted heart or liver. (ca.gov)
  • The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
  • A common example of a stem cell is the hematopoietic stem cell (HSC) which are multipotent stem cells that give rise to cells of the blood lineage. (wikipedia.org)
  • These multipotent bone marrow-derived stem cells could only ever differentiate to become one of a number of blood cell types, making their injection into nervous tissue not only pointless but totally without rationale. (skeptoid.com)
  • The endothelial cells are acquired from a biopsied piece of skin and are then "educated" on a bed of VeraVec TM cells (proprietary to Angiocrine Bioscience) to form multipotent blood cells that are capable of producing red cells that carry oxygen, white cells that provide immunity, and platelets to prevent bleeding. (businesswire.com)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. (medscape.com)
  • Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)
  • Neither report cited a paper published last year in the journal Blood [4], where a group from the Stem Cell Institute, Department of Medicine, and Cancer Center, University of Minnesota Medical School, Minneapolis, reported the most comprehensive experiments proving that a single adult stem cell can differentiate into all cell types in culture. (i-sis.org.uk)
  • The cells could be made to differentiate into bone forming cells, cartilage forming cells, fat cells, skeletal muscle cells and endothelial cells. (i-sis.org.uk)
  • The benefit of using MSCs in stem cell therapy is their ability to self-renew and differentiate into a variety of specialized cell types, such as osteoblasts, chondrocytes, adipocytes, myocardiocytes, and neuron-like cells. (genengnews.com)
  • The cancer stem cell markers include Nanog and BMI1, both of which contribute to stem cells' defining ability to renew themselves and differentiate into different cell types, Dr. Vasko said. (medindia.net)
  • Certain kinds of adult stem cells seem to have the ability to differentiate into a number of different cell types, given the right conditions. (news-medical.net)
  • You and your colleagues found amniotic fluid-derived (AFS) stem cells to have the potential to differentiate into muscle, bone, fat, blood vessel, nerve and liver cells. (scitizen.com)
  • The power of stem cells is that they can differentiate into all the cell types in the body," Verma said in a prepared release . (scientificamerican.com)
  • Stem cells have been used to repair tissue damaged by disease. (wikipedia.org)
  • Two reports appeared as advance online publications in the top British journal Nature , accompanied by a news report that begins, "The hyped ability of adult stem cells to sprout replacement tissue types is being called into question. (i-sis.org.uk)
  • In other words, dead people can yield living cells that can be converted into any cell or tissue in the body. (livescience.com)
  • Fibroblasts are the most common cells of connective tissue in animals, and they synthesize the extracellular matrix, the complex scaffolding between cells. (livescience.com)
  • Detection of the transplanted cells in the retina illustrated their ability to migrate from the site of injection to the injured tissue. (genengnews.com)
  • 8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
  • A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
  • Human skin completely renews itself every month thanks to the presence of stem cells in the deepest layer, which generate all the upper layers of this tissue. (cea.fr)
  • The discoveries of a French research team from the CEA, INSERM and the University of Paris, produced in collaboration with I-Stem, the AFM-Téléthon laboratory, and the University of Évry, opens perspectives for regenerative cutaneous medicine, in particular for the bio-engineering of skin grafts for tissue reconstruction. (cea.fr)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • Scientists have created a way to isolate neural stem cells - cells that give rise to all the cell types of the brain - from human brain tissue with unprecedented precision, an important step toward developing new treatments for conditions of the nervous system, like Parkinson's and Huntington's diseases and spinal cord injury. (medicaldaily.com)
  • A more realistic service is offered by a few cord blood banks that preserve the stem cells from placental blood and placental tissue. (parentsguidecordblood.org)
  • The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
  • By contrast, transit amplifying cells and differentiated cells are incapable of self-renewal and tissue regeneration. (medscape.com)
  • The uses of stem cells in bioengineering have been much investigated and it is showing a promising research line also in tissue engineering, although there are some controversies and discussions. (bvsalud.org)
  • In this project, we will manipulate stem cell capacity in Drosophila melanogaster flies by controlling their oxygen-sensing conditions (e.g., by keeping them under different oxygen concentrations or by using transgenic flies), and we will investigate whether and how fertility, longevity, and (potentially) tissue repair differ between flies with high or low stem cell capacity . (lu.se)
  • This shows not only that the use of stem cell research in the clinical treatment of childlessness is unrealistic but also that clinics should focus on using the eggs that women have had since birth in treating infertility," says Professor Kui Liu. (sciencedaily.com)
  • As it stands now, scientists using these hiPSCs for research or clinical applications only need to screen and characterize their cell lines, whether they're developed in-house or taken from a repository, to whatever extent is required by a journal or the reviewers assessing their work. (the-scientist.com)
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • We fund adult stem cell research and clinical trials in four focus areas - neurodegenerative disease, autoimmune disease, regenerative repair and rare childhood disease - and cover deductibles and co-pays for children of limited means participating in clinical trials for rare diseases. (greaterlouisville.com)
  • We offer choices in integration-free reprogramming technologies and services that fit your research and translational needs including our Cell Therapy Systems (CTS) Products, which are designed for clinical and translational research applications. (thermofisher.com)
  • The fetal membranes - amnion and chorion - also contain stem cells and stem cell-like cells that can be isolated and banked for clinical use. (parentsguidecordblood.org)
  • 6) Do you know any clinical application perspective of stem cells related to dentistry? (bvsalud.org)
  • Investigators at the Department of Clinical Genetics have a strong track record in identifying novel cell surface markers on leukemia stem cells and were the first to demonstrate the potential therapeutic use of recombinant antibodies directed against the marker IL1RAP (interleukin-1 receptor accessory protein) on cancer stem cells in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). (lu.se)
  • The Cancun Riviera facility reflects Dr. Srivastava's belief that stem cell therapy patients will maximize their success rate when they're in a relaxed state of mind. (prnewswire.com)
  • These results suggest that MSC-Exo effectively ameliorate EAU by inhibiting the migration of inflammatory cells, indicating a potential novel therapy of MSC-Exo for uveitis. (nature.com)
  • Our experiments suggest that some treatments could be producing more cancer stem cells that then are capable of metastasizing, because these cells are trying to find a way to survive the therapy," said one of the study's investigators, Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences in Bethesda, Md. (medindia.net)
  • This work has been extended to other types of cells of interest for cutaneous cell therapy. (cea.fr)
  • 2. University of Évry, University of Paris-Saclay, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • 3. Centre for the Study of Stem Cells (CECS), Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • Italy's health minister, Renato Balduzzi, has been impressed by the blandishments and claims regarding adult stem cell therapy and on March 21 decreed that that a controversial (actually, let's be honest, a quack) stem cell therapy can continue in 32 terminally ill patients, mostly children, even though the stem cells were not isolated according to Italy's safety standards. (skeptoid.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • How far away do you think we are from possibly using AFS stem cells for regenerative therapy? (scitizen.com)
  • Multiple Sclerosis patient, Sam Harrell has no more use for his walker after stem cell therapy! (cellmedicine.com)
  • From feeder-based and feeder-free media to optimized passaging reagents and substrates to media for stem cell therapy research, Gibco products enable you to culture with confidence. (thermofisher.com)
  • Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
  • High doses of chemotherapy drugs or radiation therapy can kill cancer cells but often also kills the person's stem cells, which prevents the bone marrow from producing normal blood cells. (msdmanuals.com)
  • These cells are not killed by conventional cancer therapy and thus it is critical to identify those cancer stem cells to be able to improved diagnostics and treatment of cancer. (lu.se)
  • Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • Stem Cell Transplants for Early MS: Who Benefits Most? (medscape.com)
  • Compared with ocrelizumab, patients who received stem cell transplants had a 60% lower risk of relapse but the same risk of MS activity detected via MRI. (medscape.com)
  • These findings have led scientists to ask whether adult stem cells could be used for transplants. (news-medical.net)
  • Adult blood forming stem cells from bone marrow have been used in transplants for 30 years. (news-medical.net)
  • This approach could potentially provide an abundant and safe source of new blood stem cells capable of treating a variety of diseases without the risk of graft versus host disease, a serious, life-threatening complication often associated with stem cell transplants derived from a donor. (businesswire.com)
  • Stem cell transplants allow doctors to give high doses of chemotherapy to treat leukemias and some lymphomas. (msdmanuals.com)
  • The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
  • However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. (nature.com)
  • This work not only defines the role of the ARTS gene in the underlying mechanism of mammalian tumor cell resistance to programmed cell death, but also links this gene to another hallmark of cancer, stem and progenitor cell proliferation," said Marion Zatz, who oversees cell death grants, including Steller's, at the NIH's National Institute of General Medical Sciences. (scienceblog.com)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • They are responsible for triggering cellular events such as activating the maternal regulatory T cells that maintain tolerance and promoting their proliferation, while concurrently inducing the death of activated T cells that could compromise the pregnancy. (parentsguidecordblood.org)
  • Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)
  • The HLA-G molecule plays a major role in immune tolerance during pregnancy, particularly at the maternal-fetal interface, where HLA-G inhibits the migration and proliferation of maternal immune cells. (parentsguidecordblood.org)
  • Sweden forbids reproductive cloning, but allows therapeutic cloning and authorized a stem cell bank. (wikipedia.org)
  • Britain s House of Lords final approval of therapeutic human cloning and embryonic stem cells research has intensified the battle for ascendancy between adult and embryonic stem cells. (i-sis.org.uk)
  • The identification of the ARTS gene and its role in cancer cell death provides a potential target for new therapeutic approaches. (scienceblog.com)
  • The research paper presented by the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development say that anti-cancer treatments might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease though quite often they effectively shrink the size of tumors. (medindia.net)
  • If scientists understood the pathways cancer stem cells use to survive treatment or increase their ranks, then therapeutic targets could be developed, Dr. Vasko said. (medindia.net)
  • In a recent study from the non-profit, Breast Cancer Now, a new potential therapeutic targeting cancer stem cells (CSCs) may have been uncovered. (rndsystems.com)
  • The strategy used to identify new therapeutic markers on leukemia stem cells will also be explored in other tumor types studied within the MAD for Cancer Program. (lu.se)
  • Because ES cells are cultured from the embryoblast 4-5 days after fertilization, harvesting them is most often done from donated embryos from in vitro fertilization (IVF) clinics. (wikipedia.org)
  • France prohibits reproductive cloning and embryo creation for research purposes, but enacted laws (with a sunset provision expiring in 2009) to allow scientists to conduct stem cell research on imported a large amount of embryos from in vitro fertilization treatments. (wikipedia.org)
  • Italy has a 2004 law that forbids all sperm or egg donations and the freezing of embryos, but allows, in effect, using existing stem cell lines that have been imported. (wikipedia.org)
  • In 2003, Spain's laws state that embryos left over from IVF and donated by the couple that created them can be used in research, including ES cell research, if they have been frozen for more than five years. (wikipedia.org)
  • Currently, embryos left over from infertility treatments are the only source of human embryonic stem cells. (sciencedaily.com)
  • But it also plays a much more mundane role in regular cell development, and the formation of blood cells and the cells that form the spinal cord in later-stage embryos. (sciencedaily.com)
  • The hybrid cells carrying four sets of chromosomes (instead of the usual two) behaved as stem cells when injected into mouse embryos. (i-sis.org.uk)
  • Since that time, these cells have given us a wealth of information of how mammalian embryos, including human babies, develop in the womb and how development continues following birth. (scitizen.com)
  • In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an 'embryonic' state. (sciencedaily.com)
  • It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers. (sciencedaily.com)
  • Now scientists have harvested such cells from the scalps and brain linings of human corpses and reprogrammed them into stem cells. (livescience.com)
  • Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)
  • To test this hypothesis, Dr. Vasko, along with scientists from the CRTRC Institute for Drug Development in San Antonio and from the Johns Hopkins University, set out to measure both stem cells markers and tumor volume before and after treatment in a mouse model. (medindia.net)
  • Insulin-producing beta cells from the pancreas can return to more primitive developmental state called stem-like cells, scientists from the McGill University Health Centre (MUHC) and the Centre hospitalier de l'Universite de Montreal (CHUM) have proved. (medindia.net)
  • One panelist even added, "If the political hurdle would be removed, I believe there is a lot of pent-up momentum from both scientists and drug companies [for stem cell research]. (news-medical.net)
  • Since adult stem cells avoid the ethical debate surrounding embryonic stem cells , most scientists on the panel feel more comfortable pursuing this line of research. (news-medical.net)
  • Stem cell laws are the law rules, and policy governance concerning the sources, research, and uses in treatment of stem cells in humans. (wikipedia.org)
  • The European Union has yet to issue consistent regulations with respect to stem cell research in member states. (wikipedia.org)
  • Whereas Germany, Austria, Italy, Finland, Portugal and the Netherlands prohibit or severely restrict the use of embryonic stem cells, Greece, Sweden, Spain and the United Kingdom have created the legal basis to support this research. (wikipedia.org)
  • Germany has restrictive policies for stem cell research, but a 2008 law authorizes "the use of imported stem cell lines produced before May 1, 2007. (wikipedia.org)
  • The United Kingdom is one of the leaders in stem cell research, in the opinion of Lord Sainsbury, Science and Innovation Minister for the UK. (wikipedia.org)
  • A new £10 million stem cell research centre has been announced at the University of Cambridge. (wikipedia.org)
  • Under Dr. Anand Srivastava's leadership, the San Diego -based Institute has a tradition of groundbreaking research in the field of stem cell science spanning more than two decades. (prnewswire.com)
  • Ever since 2004, the studies on stem cell research and infertility have been surrounded by hype. (sciencedaily.com)
  • Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
  • We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
  • 8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
  • 27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
  • 21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
  • 6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
  • 25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
  • Now research from Rockefeller University shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer. (scienceblog.com)
  • Stem cell research, like any biomedical research, poses social and ethical concerns that CIRM, and the broader research community, takes very seriously. (ca.gov)
  • The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," said lead researcher Dr. Lawrence Rosenberg, Chief of the Division of Surgical Research at McGill''s Faculty of Medicine. (medindia.net)
  • The panel was responding to recently published research where pancreatic insulin-producing islet cells were discovered in mice. (news-medical.net)
  • The panelists were unanimous in their enthusiasm that this research, conducted jointly at the Universities of Alberta and Toronto, adds more hope to the goal of getting human stem cells to produce insulin, and thus finding a cure for diabetes. (news-medical.net)
  • In addition to the current federally imposed restrictions on stem cell research, they also saw cost as a major inhibiting factor, including sterilization, preservation of cells, consistency of product and delivery of cells. (news-medical.net)
  • The panelists acknowledged the current ethical concerns surrounding stem cell research, but most felt that the impediments to research put in place by the current administration were unfortunate, and that science preceded ethics on most issues. (news-medical.net)
  • Recent research on adult stem cells has found adult stem cells in many more tissues than once thought possible. (news-medical.net)
  • In 2010, the same research group showed that a similar method worked on mouse skin cells, although it works much less efficiently with human cells. (stanforddaily.com)
  • According to study coauthor and Cambridge Biomedical Research Campus medical geneticist Serena Nik-Zainal , the study reveals that the level of quality control involved in such stem cell research may not be up to snuff. (the-scientist.com)
  • It's a problem, but it's solvable," says Jeanne Loring , a stem cell researcher at the Scripps Research Institute who didn't work on the study. (the-scientist.com)
  • A cell line can harbor thousands of mutations and still be usable for research as long as those mutations are concentrated in irrelevant noncoding areas or don't hit important genes, Nik-Zainal says. (the-scientist.com)
  • Just as importantly, research on these cells has been providing us with what happens when foetal development goes wrong, either because of a genetic defect or one that is imposed, for example, by a chemical or drug. (scitizen.com)
  • The real value of over two decades of ES-cell research currently lies with these advances but there has been relatively little external acclaim or general interest. (scitizen.com)
  • These debates will, and must, rage on but it interesting that two things in particular seem to be lost to most debates on the issue: (i) the value of research to this point in time, and (ii) the likelihood that the use of stem cells of any type to treat most if not all these diseases remains, for a variety of reasons, a distant possibility. (scitizen.com)
  • The finding could help research aimed at boosting the immune response of stem cells - early stage cells with the potential to become specialised tissues - for use in treating disease or damaged tissues. (ed.ac.uk)
  • The research identified ways to switch on a key part of the immune system that protects against viruses in stem cells, known as the interferon response. (ed.ac.uk)
  • Analyze stem cells and their derivatives using a wide range of cellular and molecular characterization methods, as validation is critical in iPSC research. (thermofisher.com)
  • The research was funded by the National Institutes of Health and the Johns Hopkins Institute for Cell Engineering. (hopkinsmedicine.org)
  • reflect on current scientific challenges within stem cell research and how this research influences society in general · reflect on ethical issues relating to sustainable stem cell research and regenerative medicine. (lu.se)
  • The purpose of the course is to prepare students for work in a field that includes stem cells and regenerative medicine by introducing ongoing research in the area. (lu.se)
  • In work performed by Division of Translational Cancer Research it is shows that the hypoxic state pushes neuroblastoma and breast cancer towards an immature, stem cell-like phenotype. (lu.se)
  • Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
  • We make a connection between apoptosis, stem cells and cancer that has not been made in this way before: this pathway is critically important in stem cell death and in reducing tumor risk," Steller says. (scienceblog.com)
  • The work supports the idea that the stem cell is the seed of the tumor and that the transition from a normal stem cell to a cancer stem cell involves increased resistance to apoptosis. (scienceblog.com)
  • It also suggests that the premature silencing of the Sept4/ARTS pathway at the stem cell level may herald cancer to come. (scienceblog.com)
  • But analysis of stem cell expression before and after treatment revealed that even as some anti-cancer treatments shrank tumors, they increased expression of Nanog and BMI1. (medindia.net)
  • These treatments were not enough to completely inhibit tumor growth, and the cancer stem cell markers were still present," Dr. Vasko said. (medindia.net)
  • Use of the agents Velcade and Docetaxel led to the most significant increase in stem cell markers within the treated tumor, while ifosfamide and Avastin inhibited expression of the markers in this cancer subtype. (medindia.net)
  • Dr. Vasko doesn't know how this happens, but theorizes that "dying cells could secrete a lot of factors that induce expression of stem cell markers in other cancer cells. (medindia.net)
  • Reduces mammosphere-forming efficiency of breast cancer cell lines and ductal carcinoma in situ cells (Farnie et al. (stemcell.com)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
  • In an interesting study from the University of Michigan, the team in the Kleer Lab have observed cancer stem cells (CSCs) engulfing other cell types to take on characteristics that would be beneficial to the metastases. (rndsystems.com)
  • The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
  • According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
  • The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
  • Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
  • Accumulating data suggests that many human tumors are organized in cellular hierarchies initiated and maintained by a small population of self-renewing so called cancer stem cells. (lu.se)
  • This was first demonstrated in acute myeloid leukemia (AML) but during recent years, cancer stem cells have also been demonstrated in other cancer types. (lu.se)
  • Within the MAD for Cancer Program, a previously unexplored combination of strategies will be used to identify new cell surface markers on AML stem cells. (lu.se)
  • In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. (lu.se)
  • Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al. (stemcell.com)
  • A promising new study for the future of neural stem cell (NSCs) from the University of Plymouth sheds light on how NSCs are activated to regenerate neurons and glial cells when damage or deterioration occurs. (rndsystems.com)
  • By identifying a mechanism that regulates programmed cell death in precursor cells for blood, or hematopoietic stem cells, the work is the first to connect the death of such cells to a later susceptibility to tumors in mice. (scienceblog.com)
  • Cells with high expression of HIF-2 α have properties rendering the tumors aggressive behavior potentially being the neuroblastoma tumor stem cells. (lu.se)
  • He and his colleagues have identified a new stem cell found in amniotic fluid and placentas, named "AFS" cells. (scitizen.com)
  • We want as many people as possible to be able to use this website, and this page describes how Lund Stem Cell Center complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. (lu.se)
  • How accessible is Lund Stem Cell Center? (lu.se)
  • Welcome to stemcellcenter.lu.se, which is managed by the Lund Stem Cell Center at Lund University. (lu.se)
  • If you need information from Lund Stem Cell Center in any other format, such as available PDF, large text, Easy to read, audio recording or Braille, then notify us. (lu.se)
  • They may instead be fusing with existing cells, creating genetically mixed-up tissues with unknown health effects" [1]. (i-sis.org.uk)
  • 27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
  • Stem cells, the prodigious precursors of all the tissues in our body, can make almost anything, given the right circumstances. (scienceblog.com)
  • In summary, the placenta and other perinatal tissues are a rich source of stem cells and stem-like cells, which can potentially be banked in a similar manner to cord blood. (parentsguidecordblood.org)
  • Adult stem cells (ASCs) are present in organs and tissues, where it remains in a not proliferative state 12 . (bvsalud.org)
  • 3) From which tissues stem cells are possibly obtained? (bvsalud.org)
  • 5) Is it possible to obtain stem cells from dental tissues? (bvsalud.org)
  • Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
  • The stem cells may be taken from a donor's bone marrow, but it is easier and almost as effective to get the stem cells from the donor's blood. (msdmanuals.com)
  • SCs are defined as undifferentiated cells with great capacity of self-renewal and production of at least a highly specialized cell type 11 . (bvsalud.org)
  • SCs are not only capable of maintaining themselves (self-renewal) but also give rise to a proliferative 'transit amplifying' compartment and ultimately to postmitotic differentiated cells with specialized functions. (medscape.com)
  • His group specialises in the study of the genetic and epigenetic regulation of female germ cell development. (sciencedaily.com)
  • Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
  • The course begins with perspectives on cell plasticity and re-programming, and how regeneration functions. (lu.se)
  • Stem cells are unspecialized unique body cells that may help patients better manage symptoms of multiple sclerosis, arthritis, and other degenerative diseases. (prnewswire.com)
  • Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
  • This may help explain why the expression of stem cell markers has been associated with resistance to chemotherapy and radiation treatments and poor outcome for patients with cancers including prostate, breast and lung cancers," Dr. Vasko said. (medindia.net)
  • Doctors infused stem cells derived from umbilical cords into the patients. (lifeissues.org)
  • Part one of this short series looked at unregulated stem cell clinics fleecing patients of their savings and robbing them of their health and even their lives. (skeptoid.com)
  • For a short time, I corresponded with a former member of staff from the centre whom I shall call T*. I asked T if the patients (s)he had contact with were aware of just how experimental the procedures on offer at the X-Cell Centre were. (skeptoid.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • The study carries cells from patients with Parkinson's disease and progressive MS to space for observations not possible on Earth. (greaterlouisville.com)
  • Likewise, in asplenic ALPS patients with, stress the infection risks, including the pneumococcal sepsis associated with asplenia (which may be compounded by lack of memory B cells and autoimmune neutropenia). (medscape.com)
  • Because of deficient memory B-cell function, these patients are often unable to produce or maintain protective antibodies against polysaccharide antigens after vaccination. (medscape.com)
  • What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
  • However, the role of stem cell capacity in life-history trade-off has not been investigated. (lu.se)
  • Dexter demonstrated in 1982 that an adherent stromal-like culture was able to support maintenance of hematopoietic stem as well as early B lymphopoeisis. (nih.gov)
  • Maintenance of the hematopoietic stem cell population has been used to increase the efficiency of hematopoietic stem cell gene transfer. (nih.gov)
  • Newborn ARTS-deprived mice had about twice as many hematopoietic stem cells as their normal, ARTS-endowed peers, and those stem cells were extraordinary in their ability to survive experimentally induced mutations. (scienceblog.com)
  • Although hematopoietic stem cells (HSC) are the best characterized and the most clinically used adult stem cells, efforts are still needed to understand how to best ex vivo expand these cells. (stemcell.com)
  • As described in the first part of this series , there are different types of stem cells. (skeptoid.com)
  • 2) What are the types of stem cells? (bvsalud.org)
  • That tells us that understanding how to target these markers and these cells could prove useful in treating these cancers. (medindia.net)
  • Those 'normal' cell lines have as many mutations as [some] cancers," Nik-Zainal tells The Scientist . (the-scientist.com)
  • The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
  • A vertebral skeletal stem cell lineage driving metastasis. (bvsalud.org)
  • Here we identify a vertebral skeletal stem cell (vSSC) that co-expresses ZIC1 and PAX1 together with additional cell surface markers. (bvsalud.org)
  • Together, our results indicate that vSSCs are distinct from other skeletal stem cells and mediate the unique physiology and pathology of vertebrae , including contributing to the high rate of vertebral metastasis . (bvsalud.org)
  • Limbal stem cell diseases. (ca.gov)
  • Will embryonic stem cells ever be used to treat human diseases? (scitizen.com)
  • Instead, as we know, interest and debate has centred largely on the ethics and morals of using human ES cells to treat, potentially, a range of human diseases, many of which are virtually intractable with respect to a cure. (scitizen.com)
  • In addition, validation of preliminary findings of solute carrier molecules (usually used for drug-delivery) selectively expressed in tumor cells with the aim to develop imaging-led theranostic approaches of personalized treatment will be performed. (lu.se)
  • The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
  • Massive ex vivo expansion of epidermal cells (called keratinocytes) is needed for the production of grafts. (cea.fr)
  • Reprogrammed cells could then develop into a multitude of cell types, including the neurons found in the brain and spinal cord. (livescience.com)
  • With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
  • This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
  • it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
  • The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
  • While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
  • Now, they're working to see if the MM-401 eraser technique works with human stem cells that bear some resemblance to mouse epiblast stem cells. (sciencedaily.com)
  • Other techniques can reprogram "adult" cells in the human body taken from skin, for example -- but the cells still carry baggage from their previous state. (sciencedaily.com)
  • The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
  • Stem cells have an enormous amount of potential to increase the health, and overall living standards of the human species in general. (scienceblog.com)
  • Adult human stem cells should have less controversy compared to embryonic human stem cells in terms of ethical issues. (news-medical.net)
  • Further analysis revealed that mutations, especially the BCOR mutations in the blood-derived lines, can occur after reprogramming, meaning they didn't originate from the human donors but rather arose as the cells replicated in the lab, likely through selective pressures the cells experience while growing and dividing in a dish. (the-scientist.com)
  • Several controversies surround the use of human embryonic stem cells: Is it ethical to use them? (scitizen.com)
  • During the mid- to late-nineties, this possibility was realised, with the isolation of ES cells from various species including rabbit, pig, cow, and primates (monkey and marmoset), culminating with the publication in 1998 of two articles on the isolation of human ES cells 2 . (scitizen.com)
  • Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)
  • Ethical Stem Cell Breakthrough! (scitizen.com)
  • Will AFS cells solve the ethical debate about how stem cells are acquired? (scitizen.com)
  • We hypothesize that the tumor escapes from chemotherapy by induction of stem cell marker expression," he said. (medindia.net)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • The results of the paper published in Nature Biomedical Engineering show that reducing the expression of the KLF4 gene during graft preparation promotes rapid expansion of functional stem cells1, without damaging their genomic stability. (cea.fr)
  • Choose from Invitrogen gene editing and transfection technologies to build cell models that can better answer biological questions. (thermofisher.com)
  • In this context, in the undifferentiated state, the entropy would be large since fewer constraints exist on the gene expression programmes of the cell. (lu.se)
  • KLF4 is therefore a new molecular target for preserving the functionality of stem cells and making progress in the bio-engineering of skin grafts. (cea.fr)
  • More recently, I have moved from the fields of protein structure and medicinal chemistry to the cell and molecular. (scitizen.com)
  • In the end, that leads to more cells accumulating mutations that cannot be eliminated. (scienceblog.com)
  • Jack Hubbard One hallmark of embryonic stem cells is that they cause a particular type of tumor called a teratoma. (ca.gov)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • Our group recently reported that CD73 on the cell membrane also contributes to the immunomodulatory capacity of MSCs 3 , suggesting that MSCs exert their immunomodulatory properties in a multifactorial manner. (nature.com)
  • Mesenchymal Stem Cells (MSCs) have been successfully isolated from first-, second-, and third-trimester placental compartments, including the amnion, chorion, decidua parietalis and decidua basalis. (parentsguidecordblood.org)
  • Unlike MSCs, which are all plastic adherent, primary AECs have three subpopulations of cells that are adherent, loosely adherent, and free-floating. (parentsguidecordblood.org)