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  • vitro
  • For the current clinical treatment, the expansion of cells in vitro has been a promising alternative method for the bone tissue engineering strategy. (nus.edu.sg)
  • and 3) for the bioreactors application, cell seeding method can play a significant role supporting the progress of the in vitro cell culture. (nus.edu.sg)
  • In vitro, in the presence of VEGF(165), hAC133(+) cells only adopted a venous and microvascular EC phenotype, while hMAPCs differentiated into both arterial and venous ECs, possibly because hMAPCs expressed significantly more sonic hedgehog (Shh) and its receptors as well as Notch 1 and 3 receptors and some of their ligands. (cun.es)
  • These results represent the first demonstration of adult stem cells with the potential to be differentiated into different types of ECs in vitro and in vivo and provide a useful human model to study arteriovenous specification. (cun.es)
  • year
  • Although stem cell research won't come up again this year, Isakson said the Senate must continue to address it and keep the United States in the forefront of such promising research. (senate.gov)
  • Vitro
  • This breakthrough and the subsequent generation of specialized human cells in vitro led to a paradigm shift within the sci- ti?c community, which transformed this specialized endeavour from a topic of scienti?c interest to a line of investigation with the potential to generate cells - pable of treating serious ailments, including diabetes, cardiovascular diseases and neurodegenerative disorders. (springer.com)
  • They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
  • Scientists have been able to demonstrate the induction of EpiSC-like cells in vitro from mouse ESCs, which are referred to as Epiblast-like cells (EpiLC). (wikipedia.org)
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • adult stem
  • Transmission electron micrograph of an adult stem cell displaying typical ultrastructural characteristics. (wikipedia.org)
  • Among several clinical trials reporting that adult stem cell therapy is safe and effective, actual evidence of benefit has been reported from only a few studies. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • regeneration
  • The cells also have potential medical applications, especially in organ regeneration. (wikipedia.org)
  • Alternately, it was also reported that differentiated tubular epithelial cells are the driving mechanism for regeneration after injury, using proliferative expansion as the mechanism. (wikipedia.org)
  • characteristics
  • Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. (wikipedia.org)
  • The majority of stem cells present in the amniotic fluid share many characteristics, which suggests they may have a common origin. (wikipedia.org)
  • They usually involve the removal of amniotic fluid by amniocentesis and their distinction from other cells may be based on their morphology or other characteristics. (wikipedia.org)
  • These cells are called epiblast-derived stem cells (EpiSC) and have several different cellular and molecular characteristics with Embryonic Stem Cells (ESC) (De-Miguel et al. (wikipedia.org)
  • Stem cell epigenomic studies are also looking into DNA methylation patterns, specifically characteristics of hydroxy methylation versus overall methylation and the difference between methylation of CpG-island rich and CpG poor promoters. (wikipedia.org)
  • Due to this structural characteristic, once physical force is applied to it, it is easily damaged in the very process of isolation, losing its stem cell characteristics. (wikipedia.org)
  • allogeneic
  • With an allogeneic transplant, the stem cells come from a donor - often a sibling but sometimes another volunteer - whose cells are considered a "match" for the patient. (kidshealth.org)
  • therapies
  • Regenerative (reparative) medicine uses cell-based therapies to treat disease. (cnn.com)
  • The goal of therapeutic cloning research is not to make babies, but to make embryonic stem cells, which can be harvested and used for cell-based therapies. (cnn.com)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome , has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative , auto-immune and inflammatory diseases. (wikipedia.org)
  • Current research focuses on differentiating ES into a variety of cell types for eventual use as cell replacement therapies (CRTs). (wikipedia.org)
  • MSCs
  • ATCC has developed complete cell culture solutions to support human MSCs and iPS cells in the collection. (atcc.org)
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
  • Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. (wikipedia.org)
  • embryo
  • Only cells from an earlier stage of the embryo, known as the morula , are totipotent, able to become all tissues in the body and the extraembryonic placenta. (wikipedia.org)
  • Totipotent stem cells that develop into cells that make up all the cells in an embryo and fetus. (cnn.com)
  • A blastocyst is an early stage embryo-approximately four to five days old in humans and consisting of 50-150 cells. (slideshare.net)
  • The fertilized egg (day 1) undergoes cell division to form a 2-cell embryo, followed by 4-cell, etc. until a ball of cells is formed by the fourth day. (slideshare.net)
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
  • Only cells from an embryo at the morula stage or earlier are truly totipotent, meaning that they are able to form all cell types including placental cells. (wikipedia.org)
  • Is it just to destroy an embryo cell if it has the potential to cure countless numbers of patients? (wikipedia.org)
  • Political leaders are debating how to regulate and fund research studies that involve the techniques used to remove the embryo cells. (wikipedia.org)
  • Some stem cell researchers are working to develop techniques of isolating stem cells that are as potent as embryonic stem cells, but do not require a human embryo. (wikipedia.org)
  • precursor cells
  • Plant stem cells serve as the origin of plant vitality, as they maintain themselves while providing a steady supply of precursor cells to form differentiated tissues and organs in plants. (wikipedia.org)
  • molecular characterization
  • Divided into four convenient sections, topics include a focus on producing iPSC from diverse somatic sources, media systems for expanding ESC and iPSC with detailed protocols for directed differentiation into specific lineages, commonly used cellular and molecular characterization methods, and the potential application of labeled stem cells with specific methods for cloning, gene delivery and cell engineering. (springer.com)
  • Application of research in this field could lead to drug discovery and information on diseases by the molecular characterization of the pluripotent stem cell through DNA and transcriptome sequencing and looking at the epigenetic changes of stem cells and subsequent products. (wikipedia.org)
  • scientists
  • Recently named the 2018 Science Magazine "Breakthrough of the Year," single cell sequencing allows scientists to retrace the steps that cells took during development, one cell at a time. (isscr.org)
  • Scientists believe that stem cell research can be used to treat medical conditions including Parkinson's disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis and rheumatoid arthritis. (cnn.com)
  • Scientists who research stem cells are trying to identify how undifferentiated stem cells become differentiated as serious medical conditions, such as cancer and birth defects, are due to abnormal cell division and differentiation. (cnn.com)
  • germ cells
  • During foetal development gonocytes develop from primordial germ cells and following this SSCs develop from gonocytes in the testis. (wikipedia.org)
  • Fibroblast growth factor (FGF2) is another molecule crucial for the regulation of stem cell renewal and is expressed in Sertoli cells, Leydig cells and germ cells. (wikipedia.org)